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Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

Source organisms:
Biochemical function: protein binding
Biological process: cellular response to brain-derived neurotrophic factor stimulus
Cellular component: postsynaptic membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF03311
Domain description: Cornichon protein
Occurring in:
  1. Protein cornichon homolog 2
The deposited structure of PDB entry 8ss2 contains 4 copies of Pfam domain PF03311 (Cornichon protein) in Protein cornichon homolog 2. Showing 2 copies in chain E.

PF13903
Domain description: PMP-22/EMP/MP20/Claudin tight junction
Occurring in:
  1. Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit
The deposited structure of PDB entry 8ss2 contains 4 copies of Pfam domain PF13903 (PMP-22/EMP/MP20/Claudin tight junction) in Glutamate receptor 2. Showing 1 copy in chain A.

PF00060
Domain description: Ligand-gated ion channel
Occurring in:
  1. Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit
The deposited structure of PDB entry 8ss2 contains 4 copies of Pfam domain PF00060 (Ligand-gated ion channel) in Glutamate receptor 2. Showing 1 copy in chain A.

PF10613
Domain description: Ligated ion channel L-glutamate- and glycine-binding site
Occurring in:
  1. Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit
The deposited structure of PDB entry 8ss2 contains 4 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor 2. Showing 1 copy in chain A.

PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit
The deposited structure of PDB entry 8ss2 contains 4 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor 2. Showing 1 copy in chain A.

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