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The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

Electron Microscopy
2.4Å resolution
PDB entry 8st0 coloured by chain, front view.
PDB entry 8st0 coloured by chain, side view.
PDB entry 8st0 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero undecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 and antibody
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Multimeric state: hetero undecamer
Accessible surface area: 134836.3 Å2
Buried surface area: 51201.22 Å2
Dissociation area: 8,524.06 Å2
Dissociation energy (ΔGdiss): -9.63 kcal/mol
Dissociation entropy (TΔSdiss): 86.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-239669

Macromolecules

Neuronal acetylcholine receptor subunit alpha-4
Chains: A, D
Length: 601 amino acids
Theoretical weight: 67.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Neuronal acetylcholine receptor subunit alpha-4 in PDB entry 8st0, assembly 1, front view.
Neuronal acetylcholine receptor subunit alpha-4 in PDB entry 8st0, assembly 1, side view.
Neuronal acetylcholine receptor subunit alpha-4 in PDB entry 8st0, assembly 1, top view.
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Neuronal acetylcholine receptor subunit beta-2
Chains: B, C, E
Length: 487 amino acids
Theoretical weight: 55.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Neuronal acetylcholine receptor subunit beta-2 in PDB entry 8st0, assembly 1, front view.
Neuronal acetylcholine receptor subunit beta-2 in PDB entry 8st0, assembly 1, side view.
Neuronal acetylcholine receptor subunit beta-2 in PDB entry 8st0, assembly 1, top view.
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IgG1 Kappa Light Chain
Chains: F, H, J
Length: 238 amino acids
Theoretical weight: 26.38 KDa
Source organism: Mus musculus
IgG1 Kappa Light Chain in PDB entry 8st0, assembly 1, front view.
IgG1 Kappa Light Chain in PDB entry 8st0, assembly 1, side view.
IgG1 Kappa Light Chain in PDB entry 8st0, assembly 1, top view.
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IgG1 Heavy Chain
Chains: G, I, K
Length: 462 amino acids
Theoretical weight: 51.2 KDa
Source organism: Mus musculus
IgG1 Heavy Chain in PDB entry 8st0, assembly 1, front view.
IgG1 Heavy Chain in PDB entry 8st0, assembly 1, side view.
IgG1 Heavy Chain in PDB entry 8st0, assembly 1, top view.
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