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Human VPS29/VPS35L Complex (Locally refined map)

Electron Microscopy
3.2Å resolution
PDB entry 8sym coloured by chain, front view.
PDB entry 8sym coloured by chain, side view.
PDB entry 8sym coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vacuolar protein sorting-associated protein 29 and VPS35 endosomal protein-sorting factor-like
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Multimeric state: hetero dimer
Accessible surface area: 25254.9 Å2
Buried surface area: 5028.2 Å2
Dissociation area: 2,514.1 Å2
Dissociation energy (ΔGdiss): 24.22 kcal/mol
Dissociation entropy (TΔSdiss): 13.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-234831

Macromolecules

VPS35 endosomal protein-sorting factor-like
Chain: A
Length: 963 amino acids
Theoretical weight: 109.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z3J2 (Residues: 1-963; Coverage: 100%)
Gene names: 101F10.2, C16orf62, VPS35L
VPS35 endosomal protein-sorting factor-like in PDB entry 8sym, assembly 1, front view.
VPS35 endosomal protein-sorting factor-like in PDB entry 8sym, assembly 1, side view.
VPS35 endosomal protein-sorting factor-like in PDB entry 8sym, assembly 1, top view.
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Vacuolar protein sorting-associated protein 29
Chain: B
Length: 205 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBQ0 (Residues: 2-182; Coverage: 100%)
  • Best match: Q9UBQ0-2 (Residues: 1-186)
Gene names: DC15, DC7, MDS007, VPS29
Pfam: Calcineurin-like phosphoesterase superfamily domain
Vacuolar protein sorting-associated protein 29 in PDB entry 8sym, assembly 1, front view.
Vacuolar protein sorting-associated protein 29 in PDB entry 8sym, assembly 1, side view.
Vacuolar protein sorting-associated protein 29 in PDB entry 8sym, assembly 1, top view.
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