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Cryo-EM structure of mink variant Y453F trimeric spike protein bound to two mink ACE2 receptors

Electron Microscopy
3.36Å resolution
PDB entry 8t20 coloured by chain, front view.
PDB entry 8t20 coloured by chain, side view.
PDB entry 8t20 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 uncleaved Spike protein complex and Angiotensin-converting enzyme
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Multimeric state: hetero pentamer
Accessible surface area: 204456.83 Å2
Buried surface area: 25740.01 Å2
Dissociation area: 1,438.73 Å2
Dissociation energy (ΔGdiss): -18.81 kcal/mol
Dissociation entropy (TΔSdiss): 31.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232597

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1269 amino acids
Theoretical weight: 140.24 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Pfam:
Spike glycoprotein in PDB entry 8t20, assembly 1, front view.
Spike glycoprotein in PDB entry 8t20, assembly 1, side view.
Spike glycoprotein in PDB entry 8t20, assembly 1, top view.
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Angiotensin-converting enzyme
Chains: D, E
Length: 771 amino acids
Theoretical weight: 89.38 KDa
Source organism: Neogale vison
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7T0Q2W2 (Residues: 1-739; Coverage: 92%)
Pfam:
Angiotensin-converting enzyme in PDB entry 8t20, assembly 1, front view.
Angiotensin-converting enzyme in PDB entry 8t20, assembly 1, side view.
Angiotensin-converting enzyme in PDB entry 8t20, assembly 1, top view.
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