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Transporter associated with antigen processing (TAP) bound to the 9-mer peptide QYDDAVYKL

Electron Microscopy
3.5Å resolution
PDB entry 8t4g coloured by chain, front view.
PDB entry 8t4g coloured by chain, side view.
PDB entry 8t4g coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 51757.49 Å2
Buried surface area: 10451.25 Å2
Dissociation area: 852.75 Å2
Dissociation energy (ΔGdiss): -0.87 kcal/mol
Dissociation entropy (TΔSdiss): 7.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246072

Macromolecules

Antigen peptide transporter 1
Chain: A
Length: 748 amino acids
Theoretical weight: 81.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03518 (Residues: 1-748; Coverage: 100%)
Gene names: ABCB2, PSF1, RING4, TAP1, Y3
Pfam:
Antigen peptide transporter 1 in PDB entry 8t4g, assembly 1, front view.
Antigen peptide transporter 1 in PDB entry 8t4g, assembly 1, side view.
Antigen peptide transporter 1 in PDB entry 8t4g, assembly 1, top view.
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Antigen peptide transporter 2
Chain: B
Length: 686 amino acids
Theoretical weight: 75.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03519 (Residues: 1-686; Coverage: 100%)
Gene names: ABCB3, PSF2, RING11, TAP2, Y1
Pfam:
Antigen peptide transporter 2 in PDB entry 8t4g, assembly 1, front view.
Antigen peptide transporter 2 in PDB entry 8t4g, assembly 1, side view.
Antigen peptide transporter 2 in PDB entry 8t4g, assembly 1, top view.
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HLA-C4 specific peptide
Chain: C
Length: 9 amino acids
Theoretical weight: 1.12 KDa
Source organism: synthetic construct
Expression system: Not provided
HLA-C4 specific peptide in PDB entry 8t4g, assembly 1, front view.
HLA-C4 specific peptide in PDB entry 8t4g, assembly 1, side view.
HLA-C4 specific peptide in PDB entry 8t4g, assembly 1, top view.
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