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Cryo-EM structure of the PP2A:B55-ARPP19 complex

Electron Microscopy
2.77Å resolution
PDB entry 8ttb coloured by chain, front view.
PDB entry 8ttb coloured by chain, side view.
PDB entry 8ttb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 55102.79 Å2
Buried surface area: 13169.97 Å2
Dissociation area: 3,076.96 Å2
Dissociation energy (ΔGdiss): 18.47 kcal/mol
Dissociation entropy (TΔSdiss): 16.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232849

Macromolecules

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Chain: A
Length: 584 amino acids
Theoretical weight: 64.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30153 (Residues: 9-589; Coverage: 99%)
Gene name: PPP2R1A
Pfam: HEAT repeat
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 8ttb, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 8ttb, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 8ttb, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Chain: B
Length: 450 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63151 (Residues: 2-447; Coverage: 100%)
Gene name: PPP2R2A
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform in PDB entry 8ttb, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform in PDB entry 8ttb, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform in PDB entry 8ttb, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Chain: C
Length: 311 amino acids
Theoretical weight: 35.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Gene name: PPP2CA
Pfam: Calcineurin-like phosphoesterase
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 8ttb, assembly 1, front view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 8ttb, assembly 1, side view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 8ttb, assembly 1, top view.
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cAMP-regulated phosphoprotein 19
Chain: D
Length: 114 amino acids
Theoretical weight: 12.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56211 (Residues: 1-112; Coverage: 100%)
Gene name: ARPP19
Pfam: cAMP-regulated phosphoprotein/endosulfine conserved region
cAMP-regulated phosphoprotein 19 in PDB entry 8ttb, assembly 1, front view.
cAMP-regulated phosphoprotein 19 in PDB entry 8ttb, assembly 1, side view.
cAMP-regulated phosphoprotein 19 in PDB entry 8ttb, assembly 1, top view.
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