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Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor

X-ray diffraction
2.5Å resolution
PDB entry 8vuc coloured by chain, front view.
PDB entry 8vuc coloured by chain, side view.
PDB entry 8vuc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 18860.08 Å2
Buried surface area: 5412.3 Å2
Dissociation area: 2,129.87 Å2
Dissociation energy (ΔGdiss): 24.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-247038
Assembly 2
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 19218.98 Å2
Buried surface area: 4004.7 Å2
Dissociation area: 1,929.73 Å2
Dissociation energy (ΔGdiss): 26.37 kcal/mol
Dissociation entropy (TΔSdiss): 13.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-247038

Macromolecules

S1CE2 VARIANT OF FAB-EPR-1 heavy chain
Chains: A, B
Length: 224 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S1CE2 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vuc, assembly 1, front view.
S1CE2 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vuc, assembly 1, side view.
S1CE2 VARIANT OF FAB-EPR-1 heavy chain in PDB entry 8vuc, assembly 1, top view.
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S1CE3 VARIANT OF FAB-EPR-1 light chain
Chains: C, G
Length: 212 amino acids
Theoretical weight: 23.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vuc, assembly 1, front view.
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vuc, assembly 1, side view.
S1CE3 VARIANT OF FAB-EPR-1 light chain in PDB entry 8vuc, assembly 1, top view.
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