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Structure of the SARS-CoV-2 EG.5.1 spike glycoprotein in complex with ACE2 (1-up state)

Electron Microscopy
3.22Å resolution
PDB entry 8xlm coloured by chain, front view.
PDB entry 8xlm coloured by chain, side view.
PDB entry 8xlm coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 uncleaved Spike protein complex and Processed angiotensin-converting enzyme 2
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Multimeric state: hetero tetramer
Accessible surface area: 170332.58 Å2
Buried surface area: 39962.72 Å2
Dissociation area: 809.07 Å2
Dissociation energy (ΔGdiss): -10.26 kcal/mol
Dissociation entropy (TΔSdiss): 15.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-144662

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1245 amino acids
Theoretical weight: 138.06 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 12-1210; Coverage: 95%)
Gene names: 2, S
Pfam:
Spike glycoprotein in PDB entry 8xlm, assembly 1, front view.
Spike glycoprotein in PDB entry 8xlm, assembly 1, side view.
Spike glycoprotein in PDB entry 8xlm, assembly 1, top view.
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Processed angiotensin-converting enzyme 2
Chain: D
Length: 608 amino acids
Theoretical weight: 70.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 19-617; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Pfam: Angiotensin-converting enzyme
Processed angiotensin-converting enzyme 2 in PDB entry 8xlm, assembly 1, front view.
Processed angiotensin-converting enzyme 2 in PDB entry 8xlm, assembly 1, side view.
Processed angiotensin-converting enzyme 2 in PDB entry 8xlm, assembly 1, top view.
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