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P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc

Electron Microscopy
2.54Å resolution
PDB entry 8y6i coloured by chain, front view.
PDB entry 8y6i coloured by chain, side view.
PDB entry 8y6i coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-dependent translocase ABCB1 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 44822.21 Å2
Buried surface area: 13143.05 Å2
Dissociation area: 952.9 Å2
Dissociation energy (ΔGdiss): 2.45 kcal/mol
Dissociation entropy (TΔSdiss): 14.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-246336

Macromolecules

ATP-dependent translocase ABCB1
Chain: A
Length: 1534 amino acids
Theoretical weight: 170.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08183 (Residues: 1-1280; Coverage: 100%)
Gene names: ABCB1, MDR1, PGY1
Pfam:
ATP-dependent translocase ABCB1 in PDB entry 8y6i, assembly 1, front view.
ATP-dependent translocase ABCB1 in PDB entry 8y6i, assembly 1, side view.
ATP-dependent translocase ABCB1 in PDB entry 8y6i, assembly 1, top view.
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UIC2 Fab light chain
Chain: B
Length: 220 amino acids
Theoretical weight: 24.32 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UIC2 Fab light chain in PDB entry 8y6i, assembly 1, front view.
UIC2 Fab light chain in PDB entry 8y6i, assembly 1, side view.
UIC2 Fab light chain in PDB entry 8y6i, assembly 1, top view.
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UIC2 Fab heavy chain
Chain: C
Length: 225 amino acids
Theoretical weight: 24.38 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UIC2 Fab heavy chain in PDB entry 8y6i, assembly 1, front view.
UIC2 Fab heavy chain in PDB entry 8y6i, assembly 1, side view.
UIC2 Fab heavy chain in PDB entry 8y6i, assembly 1, top view.
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