8yn2

Electron Microscopy
2.66Å resolution

Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-279919 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Engineered guanine nucleotide-binding protein G(q) subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.08 KDa
Source organism: synthetic construct
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 376 amino acids
Theoretical weight: 40.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Antibody fragment scFv16 Chain: E
Histamine H1 receptor Chain: R

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.66Å
Relevant EMDB volumes: EMD-39412
Expression systems:
  • Spodoptera frugiperda
  • Trichoplusia ni