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Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor

Electron Microscopy
2.62Å resolution
PDB entry 9bfh coloured by chain, front view.
PDB entry 9bfh coloured by chain, side view.
PDB entry 9bfh coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Multidrug efflux pump subunit AcrB
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Multimeric state: homo trimer
Accessible surface area: 109894.51 Å2
Buried surface area: 18653.89 Å2
Dissociation area: 6,126.85 Å2
Dissociation energy (ΔGdiss): 48.53 kcal/mol
Dissociation entropy (TΔSdiss): 18.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151927

Macromolecules

Multidrug efflux pump subunit AcrB
Chains: A, B, C
Length: 1049 amino acids
Theoretical weight: 113.67 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P31224 (Residues: 1-1049; Coverage: 100%)
Gene names: JW0451, acrB, acrE, b0462
Pfam: AcrB/AcrD/AcrF family
Multidrug efflux pump subunit AcrB in PDB entry 9bfh, assembly 1, front view.
Multidrug efflux pump subunit AcrB in PDB entry 9bfh, assembly 1, side view.
Multidrug efflux pump subunit AcrB in PDB entry 9bfh, assembly 1, top view.
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