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Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation

Electron Microscopy
3.5Å resolution
PDB entry 9bh9 coloured by chain, front view.
PDB entry 9bh9 coloured by chain, side view.
PDB entry 9bh9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase theta and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 72357.65 Å2
Buried surface area: 4750.72 Å2
Dissociation area: 2,375.36 Å2
Dissociation energy (ΔGdiss): 7.12 kcal/mol
Dissociation entropy (TΔSdiss): 16.05 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-271039

Macromolecules

DNA polymerase theta
Chains: A, B
Length: 893 amino acids
Theoretical weight: 99.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75417 (Residues: 2-894; Coverage: 35%)
Gene names: POLH, POLQ
Pfam:
DNA polymerase theta in PDB entry 9bh9, assembly 1, front view.
DNA polymerase theta in PDB entry 9bh9, assembly 1, side view.
DNA polymerase theta in PDB entry 9bh9, assembly 1, top view.
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DNA chains X, Y
Name: Stem-loop DNA with microhomology in the 3' overhang
Representative chains: X, Y
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 56 nucleotides
Theoretical weight: 17.26 KDa
Stem-loop DNA with microhomology in the 3' overhang in PDB entry 9bh9, assembly 1, front view.
Stem-loop DNA with microhomology in the 3' overhang in PDB entry 9bh9, assembly 1, side view.
Stem-loop DNA with microhomology in the 3' overhang in PDB entry 9bh9, assembly 1, top view.
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