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Dephosphorylated (E1371Q)CFTR in complex with PKA-C

Electron Microscopy
3.5Å resolution
PDB entry 9dw8 coloured by chain, front view.
PDB entry 9dw8 coloured by chain, side view.
PDB entry 9dw8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha and Cystic fibrosis transmembrane conductance regulator
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Multimeric state: hetero dimer
Accessible surface area: 63514.18 Å2
Buried surface area: 2807.98 Å2
Dissociation area: 718.81 Å2
Dissociation energy (ΔGdiss): -9.95 kcal/mol
Dissociation entropy (TΔSdiss): 14.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-281424

Macromolecules

Cystic fibrosis transmembrane conductance regulator
Chain: A
Length: 1480 amino acids
Theoretical weight: 168.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13569 (Residues: 1-1480; Coverage: 100%)
Gene names: ABCC7, CFTR
Pfam:
Cystic fibrosis transmembrane conductance regulator in PDB entry 9dw8, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 9dw8, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 9dw8, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P13569  
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cAMP-dependent protein kinase catalytic subunit alpha
Chain: G
Length: 351 amino acids
Theoretical weight: 40.76 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00517 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 9dw8, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 9dw8, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 9dw8, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P00517  
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