Summary for clan GA
| Clan type peptidase | G01.001 - scytalidoglutamic peptidase (Scytalidium lignicolum), MEROPS Accession MER0001320 (peptidase unit: 58-260); PDB accession 1S2B |
| History | MEROPS 6.6 (27 March 2004) |
| Description | Water nucleophile; water bound by Gln and Glu; all endopeptidases |
| Contents of clan | The clan contains a glutamic endopeptidases. |
| Evidence | Clan GA contains the only family of glutamic peptidases, G1. |
| Catalytic mechanism | (See family G1.) |
| Peptidase activity | (See family G1.) |
| Protein fold | Tertiary structures have been determined for aspergilloglutamic peptidase (G01.002: Sasaki et al., 2004) and scytalidoglutamic peptidase (G01.001: Fujinaga et al., 2004). These are all-beta proteins containing two beta sheets arranged in a sandwich. The partial two-fold symmetry of the structure is evidence of an ancient gene duplication event. |
| Homologous non-peptidase families | There are a number of families that have a similar fold to that of clan GA, including lectins, glucanases, sialidases and xylanases (see SCOP sunid 101656). Toxins from Clostridium, including tentoxilysin (M27.001) and bontoxilysin (M27.002) are multidomain proteins, and the N-terminal receptor binding domain also has a fold similar to that of clan GA. |
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Other databases
| SCOP | 49899 |
Families
| G1 |
scytalidoglutamic peptidase (Scytalidium lignicolum) |
Yes |
Distribution of clan GA among Kingdoms of Organisms
