Summary for clan ND
| Clan type peptidase | N04.001 - Tsh-associated self-cleaving domain (Escherichia coli) and similar (Escherichia coli), MEROPS Accession MER0187148 (peptidase unit: 1100-1377); PDB accession 3AEH_A |
| History | MEROPS 9.3 (7 September 2010) |
| Description | Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases |
| Contents of clan | Peptidase clan ND contains autolytic endopeptidases. |
| Evidence | The tertiary structure of the Tsh C-terminal propeptide (Escherichia coli; N04.001) has been solved, and shows a 12-stranded beta barrel domain unlike that of any other peptidase (Tajima et al., 2010). |
| Catalytic mechanism | (see family N4) |
| Peptidase activity | (see family N4) |
Families
| N4 |
Tsh-associated self-cleaving domain ({Escherichia coli}) and similar (Escherichia coli) |
Yes |
Distribution of clan ND among Kingdoms of Organisms
