Summary for clan SC
| Clan type peptidase | S10.005 - serine carboxypeptidase D (Triticum aestivum), MEROPS Accession MER0000416 (peptidase unit: 15-437); PDB accession 1BCS |
| History | Methods Enzymol. 244:461-486 (1994) |
| Description | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence |
| Contents of clan | Clan SC includes both endopeptidases and exopeptidases. |
| Evidence | (See Protein fold.) |
| Catalytic mechanism | The active site residues are in the order Ser, Asp, His in the sequence (see the Alignment). |
| Peptidase activity | The endopeptidases include oligopeptidases, and the exopeptidases include aminopeptidases and carboxypeptidases. Specificities are very varied (see individual family summaries). |
| Protein fold | Tertiary structures have been determined for members of several families, the first being that of wheat serine carboxypeptidase II (S10.005; Liao & Remington, 1990). Peptidases in clan SC are proteins with a core consisting of an alpha/beta/alpha sandwich, in which the beta sheet has eight strands (in the order 12435678 in which strand 2 is antiparallel to the rest). |
| Homologous non-peptidase families | The fold for members of clan SC is shared with many other enzymes, and has been called the 'alpha-beta hydrolase' fold. Other enzymes with this fold include acetylcholinesterase, haloalkane dehalogenase, dienelactone hydrolase, bromoperoxidase A2, thioesterase, triacylglycerol lipase, hydroxynitrile lyase and a variety of other esterases and lipases. Not all of these enzymes are hydrolases (for example haloalkane dehalogenase) and not all of these enzymes have Ser as the nucleophile (for example dienelactone hydrolase has Cys and haloalkane dehalogenase has Asp) (Ollis et al., 1992; Cygler et al., 1993). |
| Activation mechanism | (See family summaries.) |
|
Other databases
| PFAM | CL0028 |
|
| SCOP | 53474 |
Families
| S9 |
prolyl oligopeptidase (Sus scrofa) |
Yes |
| S10 |
carboxypeptidase Y (Saccharomyces cerevisiae) |
Yes |
| S15 |
Xaa-Pro dipeptidyl-peptidase (Lactococcus lactis) |
Yes |
| S28 |
lysosomal Pro-Xaa carboxypeptidase (Homo sapiens) |
Yes |
| S33 |
prolyl aminopeptidase (Neisseria gonorrhoeae) |
Yes |
| S37 |
PS-10 peptidase (Streptomyces lividans) |
- |
| S82 |
autocrine proliferation repressor protein A ({Dictyostelium discoideum}) (Dictyostelium discoideum) |
- |
Distribution of clan SC among Kingdoms of Organisms
