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Alignment for family A24A

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Summary Holotypes Alignment Tree Genomes Literature

 

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               6              7         8         9        10        11        12          13                  14             15                                              16          17                                                                                                             18               19        20             21            22                   23        24                         25                       26        27        28 
     01234567890ABCDE1234567890123456789012345678901234567890123456789012345678901234567AB890ABCDEFGHIJ1234567890ABCD123456A7890ABCDEFGH1234ABCDEFGHIJKLMNOPQRSTUVWXYZab567AB890AB1234567890123456ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvw78901ABCD2345678ABC9012345678901234567ABCDE89012345ABCD67890123A456789ABCDEFGHIJ012345678901ABC23ABCDE456789ABCDEFGHI0123ABCDEFGHIJ4567ABCDE890123456789012345678901
                                                                                          +                                  +#                                              +                                                                                                                          +        +                      +              #                   +                                     +                                    +              +     
                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
   1 GLVIDRFPQQ---------SIIAPASHCNHCKKQLKAWDLIPIVSQLSTHSKCRYCQAKIPYWYLLLEISSAFLVVLT--------------------AYQVLSFATSCVLLTGLVLG-IYDI--------KHRE----------------------------YPL--VVW--LVLTFIALLFS-------------------------------------------------------------------------------------------------------------------SLNWLFF---FFLALAYLAEKVNL----------KIGSGDLL----YLATLALI-FPYTNL----------LWIIQISSILGLVTYFY--------------------------------------FYRK-ALPFIPFLWL-ASIPVLL------   1
   2 GLVVDRFPEQ---------SIITPASHCNVCGQKLAPRDLIPVLSQLINRLRCRFCNSKIPIRYILLELTGGCLFLAT--------------------SLGYLNINRLVLLAMGMTLS-LYDQ--------REQE----------------------------YPL--LIW--LIFHIFLLFLT-------------------------------------------------------------------------------------------------------------------SFNLLMV---AFLALGILAHFVDL----------RIGAGDFL----FLASCSTI-FHLTEV----------LLIIQIASIIGLLLFGL--------------------------------------KSKKDRLAFVPCLFCGSSILIMIQ-----   2
   3 ---------------------------------------------------------------GITLACLLGWLYFLWAFTWYFALNA---------------------LTTLCLVACALVDN--------KYRV----------------------------IPH--TLL--VIPACIGVFFAHLSCSL-------------------------------------------------------------------------------------------------------------LTYDSAP---FICFILCIIWFVFAYANHDANAAPLIGAGDIK----LLLVLSLY-MTPLSF----------LVMLVIACIGGLCHAAL---------------------------------------IRQKTFPWAPSIVFAWYMVM--------   3
   4 -------------------------------------------------------------------------------------------------IKNIILFILTNIYLIILYKAS-IRDI--------KERI----------------------------VLN--RTC--LIEYILAFLIA----------------------------------------------------------------------------------------------------------ILLKIPIKYILINSIW---LFAIMYILQLVYGLMTDEI-----GIGGGDIK----LAPAITLF--------------------------------------------------------------------------------IYPYSYIGLLIGL--------   4
   5 --------------------------------------------------------------------TLTG--------IATMLLCF------------------------LLLGLA-AMDA--------ETLT----------------------------LPD--AFT--MPGIVLGLV----------------YHAVMPA----------------SGVKE----------------------------------------------------------------RL--LETGVAALWGLL---FAFLLLLVRWVYFLLRQQE-----GLGLGDAK----LMAMIAIW-LSPALT----------AEALFLGVVAAAIFGAAW------LLLHPREGM-------------------------RAMLPLGTFLCAAALLVLFKGQPLLK   5
   6 ------------------KPVIRPLTRCEECGARVRFWKLIPVLRWLPFQNRCRTCTARLPRSEILLEILTGTLFVLFYFMAVQLRCLEVPSVRPSGEMLEWRLIYLYVLLALLVAAT-SIDF--------REYL----------------------------IPD--QIT--IPGMLIGVLGATIAGHLQIIHLWVDWNQAVPGLTGPYIPEWIKAHSHWHGLSW----------------------------------------------------------------SLTGLIVGGGLTWGL------------RLVSSVLLGQE-----ALGLGDVT----LMAMV----------------------GSFLG----------WQAILPILLLAPLCGILIGFLTRV--------------MTGKTYLPYGPYLCAATLIVLMS----WK   6
   7 --------------------------------------------------------------TAPGAEGLYGAF-----------------------------------LAALMLAIA-THDA--------RHYL----------------------------IPN--ELT--GTAFALALLRAGAFVP-----------------------------------------------------------------------------------------------------DVGLEALIWPLARAAA---VALPLLLLMVLYRRWRGRD-----GLGLGDVK----LAAVCGAW-LDLATV----------AAVIELAALLAIGAYAA-----NAALQR-------------------------RPLRATAFLPFGLFLAPAIWIGWLGETWYAN   7
   8 -----------------------------------------------------------------------------YQNDSAVGVLF------------------MTIMTGCMTLMT-LTDA--------ASCR----------------------------LPR--PFT--IMYLISGSA-------------------------------------------F----------------------------------------------------------------RLWQGDWLTGLCSAGF---WFLLLLLFRQYTSYRRKTE-----TIGLGDVF----LIAGIAIW-SPPGDI----------PWIVATAAGGALLY----------LWCNRQRRI-------------------------TRELPFGPFLCASQYAFTF-------   8
   9 ------------------------------------------------------------------------------------------------------------IMTGCMTLMT-LTDA--------ASCR----------------------------LPR--PFT--IMYLISGSA-------------------------------------------F----------------------------------------------------------------RLWQGDWLTGLCSAGF---WFLLLLLFRQYTSYRRKTE-----TIGLGDVF----LIAGIAIW-SPPGDI----------PWIVATAAGGALLY----------LWCNRQRRI-------------------------TRELPFGPFLCASQY-----------   9
  10 -----------------------------------------------------------------AVLALTATITHIIRGTDITGLCF------------------LLLMAGCMTLMT-LTDA--------ASCR----------------------------LPR--PFT--LTFLMLGVA-------------------------------------------F----------------------------------------------------------------RLWQGDAAIALACALF---WFLLLSLLRRYTSYRKGVE-----TLGLGDVF----LIAGVAMW-SSANST----------PWIIGIAATGTMVC----------MSLFPRSNT-------------------------RAAIPFGPFICASLYIFTFFPGAI--  10
  11 ------------------------------------------------------------------LLAVLSICLNGAYGVDATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLAHALLNASL---WFGMIYLLRRIFLAVKGTE-----ALGLGDVF----LIAGIAMW-TQAQHT----------PLIITAAASGAFLF----------ILIFCRRRR-------------------------QQALPFAPFLCASLYVLTLFPDS---  11
  12 ------------------------------------------------------------------LLAVLSICLNGAYGVDATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLAHALLNASL---WFGMIYLLRRIFLAVKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITAAASGAFLF----------ILIFCRRRR-------------------------QQALPFAPFLCASLYVLTLFPDS---  12
  13 ------------------------------------------------------------------LLAVLSICLNGAYGVDATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLAHALLNASL---WFGMIYLLRRIFLAVKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITAAASGAFLF----------ILIFCRRRR-------------------------QQALPFAPFLCASLYVLTLFPDSV--  13
  14 ------------------------------------------------------------------LLAVLSICLNGAYGVDATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLAHALLNASL---WFGMIYLLRRIFLAAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITAAASGAFLF----------ILIFCRRRR-------------------------QLALPFAPFLCASLYVLTLFPDS---  14
  15 ---------------------------------------------------------------------------------------------------------------------T-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLAHALLNASL---WFGMIYLLRRIFLAAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITAAASGAFLF----------ILIFCRRRR-------------------------QLALPFAPFLCASLYVLTLFPDSV--  15
  16 --------------------------------------------------------------------------------------LF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIILGAA-------------------------------------------F----------------------------------------------------------------RYSQDSLTHALLNASL---WFGMIYLLRRIFLAAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITAAASGAFLF----------ILIFCRRRC-------------------------QLALPFAPFLCASL------------  16
  17 ----------------------------------------------------------RSVVYVCCLLAIVSVSLNGAYGVEATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIVLGAA-------------------------------------------F----------------------------------------------------------------RYSLEELTYSLLNASL---WFGMTYLLRQFFITAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLLITAAASGAFLF----------ILLFCRRRR-------------------------QQALPFAPFLCASLYALTL-------  17
  18 --------------------------------------------------------------YVCCLLAIVSVSLNGAYGVEATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIVLGAA-------------------------------------------F----------------------------------------------------------------RYSLEELTYSLLNASL---WFGMTYLLRQFFITAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLLITAAASGAFLF----------ILLFCRHRH-------------------------QQALPFAPFLCASLYALTL-------  18
  19 ---------------------------------------------------------------------------------------------------------------------T-LTDI--------AVCR----------------------------LPR--IFT--LSLIVLGAA-------------------------------------------F----------------------------------------------------------------RYSLEELTYSLLNASL---WFGMTYLLRQFFITAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLLITAAASGAFLF----------ILLFCRRRR-------------------------QQALPFAPFLCASLYALTL-------  19
  20 --------------------------------------------------------------YVCCLLAIVSVSLNGAYGVEATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIVLGAA-------------------------------------------F----------------------------------------------------------------RYSLEELTYSLLNASL---WFGMTYLLRQFFITAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLLITAAASGAFLF----------ILLFCRRRR-------------------------QQALPFAPFLCASLYALTL-------  20
  21 --------------------------------------------------AVHDTRPPRPVVYVCCLLAIVSVSLNGAYGVEATGLLF------------------LSILTGLLTVMT-LTDI--------AVCR----------------------------LPR--IFT--LSLIVLGAA-------------------------------------------F----------------------------------------------------------------RYSLEELTYSLLNASL---WFGMTYLLRQFFITAKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLLITAAASGAFLF----------ILLFCRRRR-------------------------QQALPFAPFL----------------  21
  22 ------------------------------------------------------------VVFICCFLSLLSVTLNGVYGVDATGLLF------------------LSILMGLLTVMT-VTDI--------AVCR----------------------------LPR--IFT--LSLIILGTA-------------------------------------------F----------------------------------------------------------------RFSQDSLPHALLNATL---WFFAIYLLRRAFQAVKGTE-----ALGLGDVF----LIAGIAMW-TQPQHT----------PLIITIAATGAFLF----------ILFFFRCKR-------------------------KQELPFAPFLCASLYAFTLFPDSI--  22
  23 ------------------------------------------------------------------ILTTLAVLYLSLNQLSLIQSII------------------VIVFYAFLTLMA-CIDL--------LSFL----------------------------LPR--LYT--VTFIFSGLL-------------------------------------------Y----------------------------------------------------------------QTWNNNILSGLFCAML---MFFIMLFVRLYFAYKNGTE-----SFGMGDVL----LIAGTGVWFPTPEIA----------CSIVFIAVIGGIIF----------FTLGGLNKQ-------------------------KKYIPFGPFLCGGMFVYSL-------  23
  24 ------------------------------------------------------------------ILTTLAVLYLSLNQLSLIQSII------------------VIVFYAFLTLMA-CIDL--------LSFL----------------------------LPR--LYT--VTFIFSGLL-------------------------------------------Y----------------------------------------------------------------QTWNNNILSGLFCAML---MFFIMLFVRLYFAYKNGTE-----SFGMGDVL----LIAGTGVWFPTPEIA----------CSIVFIAVIGGIIF----------------------------------------------------------------------  24
  25 ------------------------------------------------------------------ILTTLAVLYLSLNQLSLIQSII------------------VIVFYAFLTLMA-CIDL--------LSFL----------------------------LPR--LYT--VTFIFSGLL-------------------------------------------Y----------------------------------------------------------------QTWNNNILSGLFCAML---MFFIMLSVRLYFAYKNGTE-----SFGMGDVL----LIAGTGVWFPTPEIA----------CSIVFIAVIGGIIF----------FTLGGLNKQ-------------------------KKYIPFGPFLCGGMFVYSL-------  25
  26 NVMIIRLPRER---------RLIGWPRCIRTGQPLRWWQLLPVIGWLLQRGRAAD-GRPLPVIYPLVEIGSALWLWRLYELYGFGPLF-----------------AYLAFVGAVLIVTGVVDW----------------------------------------LYR--WIY--TFVILGGAIIAFIWGSLVG--------------------------------------------------------------------------------------------------AGWRE----LLLGGLIGGVGFFFLYLLALILFPAKSAP------FGLGDVY----LAIFIGAA-LGLRHL----------GPALIYGVFMAGLVAAG-----ILIARR-------------------------FGRQTPEYLPYGAYLCLGVLIYVALG-----  26
  27 ----QPIPEST-----KPFNLMYPRSYCPHCSCQLRVRDNIPLLSYLYLKGRAHCCGKRISYLYLLVELACAILFMLAAWAF----------------SPGLLLIGAWIFLSMLLVLA-VIDY--------RTYL----------------------------LPD--ILT--LPLVWLGLLFNLQNGY-----------------------------------------------------------------------------------------------------VPLDQ----AVIGAIS---GYLCLWSLYWICRLVTGNE-----AIGYGDFK----LLSALGAW-MGWMTL----------PQILLLAAGSGF---IV-----TLLQRG---------RAQL----------MLNR-----PLAFGPWLALGG------------  27
  28 -------------------NLILPRSCCPHCSHQIRIRDNIPLLSYLYLKGETHCCGQRIPYHYPLIEMMCAMLFMLAAWKF----------------SLSLLLIGSWIFLSMLLVLA-IIDY--------RTYL----------------------------LPD--ILT--LPLLWLGLLFNLPEGY-----------------------------------------------------------------------------------------------------ISLEQ----AVVGAIS---GYLCLWCLYWAFRFVTGKE-----ALGYGDFK----LLAALGAW-MGWQAL----------PQIIFLAAGSGL---IV-----TLLVRY---------QTQT----------SISR-----PLAFGPWLALSAGYYFL-------  28
  29 ------EPESE-----PVFNLMIPRSHCPYCFQPLSIRDNIPLLSYLFLKGKSRCCGERIPIYYPLVEITSSVLFILAASRF----------------HPGLTLVAAWLFIAMLLVLA-VIDC--------RTAM----------------------------LPD--VLT--LSLLWLGLLFSLQGGR-----------------------------------------------------------------------------------------------------VPLEE----AVVGAVS---GYLCLWGLYWLFRFVTGRE-----GLGYGDFK----LAAALGAW-MGWQVL----------PSVLLFASVSGL---II-----TVLLRF---------VTAT----------DFTR-----PLPFGPWLALSG------------  29
  30 --------------------LMIPRSHCPYCFQPLSIRDNIPLLSYLFLKGKSRCCGERIPIYYPLVEITSSVLFILAASRF----------------HPGLTLVAAWLFIAMLLVLA-VIDC--------RTAM----------------------------LPD--VLT--LSLLWLGLLFSLQGGR-----------------------------------------------------------------------------------------------------VPLEE----AVVGAVS---GYLCLWGLYWLFRFVTGRE-----GLGYGDFK----LAAALGAW-MGWQVL----------PSVLLFASVSGL---II-----TVLLRF---------VTAT----------DFTR-----PLPFGPWLALSGVCHFL-------  30
  31 --------------------LMIPRSHCPYCFQPLSIRDNIPLLSYLFLKGKSRCCGERIPIYYPLVEITSSVLFILAASRF----------------HPGLTLVAAWLFIAMLLVLA-VIDC--------RTAM----------------------------LPD--VLT--LSLLWLGLLFSLQGGR-----------------------------------------------------------------------------------------------------VPLEE----AVVGAVS---GYLCLWGLYWLFRFVTGRE-----GLGYGDFK----LAAALGAW-MGWQVL----------PSVLLFASVSGL---II-----TVLLRF---------VTAT----------DFTR-----PLPFGPWLALSGVCHFL-------  31
  32 ------EPESE-----PVFNLMIPRSHCPYCFQPLSIRDNIPLLSYLFLKGKSRCCGERIPIYYPLVEITSSVLFILAASRF----------------HPGLTLVAAWLFIAMLLVLA-VIDC--------RTAM----------------------------LPD--VLT--LSLLWLGLLFSLQGGS-----------------------------------------------------------------------------------------------------VPLEE----AVVGAVS---GYLCLWGLYWLFRFVTGRE-----GLGYGDFK----LAAALGAW-MGWQVL----------PSVLLFASVSGL---II-----TVLLRF---------VTAT----------DFTR-----PLPFGPWLALSG------------  32
  33 ----------------SAFNLMVPRSHCPCCFHPLSIRDNIPLFSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFIAMLLVLA-VIDC--------RTAL----------------------------LPD--VLT--LSLLWLGLLFSLQGGV-----------------------------------------------------------------------------------------------------VPLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSVLLFASVSGL---II-----TVLLRF---------VTAT----------DFTR-----PLPFGPWLALSG------------  33
  34 -------PESG-----PAFNLMIPQSHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAA----------------------------------------------------------------------------------------------------------  34
  35 -------------------------------------------------------CGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  35
  36 -------PESG-----PAFNLMIPQSHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------P-----------------------------------------------------------------------------------  36
  37 ----------------------------------------IPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  37
  38 --------------------------------------DNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  38
  39 --------------------------------HPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  39
  40 -------------------------SHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  40
  41 -------PESG-----PAFNLMIPQSHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSG------------  41
  42 --------------------LMIPQSHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRF----------------PPGLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSGVCHFL-------  42
  43 ----------------------------------------------------------------------------------------------------GLTLAAAWLFISMLLVLA-VIDC--------HTAL----------------------------LPD--VLT--LPLLWLGLLFSLQRGV-----------------------------------------------------------------------------------------------------VTLEE----AVVGAVS---GYLCLWGLYWLFRFATGRE-----GLGYGDFK----LAAALGAW-MGWQAL----------PSILLFASVSGL---IV-----TVLLRI---------VTAT----------DFTR-----PLPFGPWLALSGVCHFLLM-----  43
  44 RLPLMMQQEES-----ARFNLCVPASFCPQCQRPIIWRDNIPLLSYLSLKGRARCCQAPISQRYPLTELASGLLFVLTGYLL----------------TPGLPLLGGLILLSTLLVLA-IIDG--------QTQL----------------------------LPD--RLT--LPLLWAGLLFNLNGTF-----------------------------------------------------------------------------------------------------VPLSE----AVIGAMT---GYLSLWTVYWLFRLLTGKE-----ALGYGDFK----LLAALGAW-SGWQIL----------PQTLLCASASGL---IW-----TLLQRR---------ITLQ----------SLDQ-----PLAFGPWLALAGSGLFLWTQT---  44
  45 -------------------------AAAIACA------------------------------LAPFTPIVTGALF---------------------------------LYFCFVLTLS-VIDF--------RTQL----------------------------LPD--KLT--LPLLWLGLVFNAQYGL-----------------------------------------------------------------------------------------------------IDLHD----AVYGAVA---GYGVLWCVYWGVWLVCHKE-----GLGYGDFK----LLAAAGAW-CGWQTL----------PMILLIASLGGIGYAIV-----SQLLQR---------RTIT----------T---------IAFGPWLALGSMINLG-------  45
  46 VHFRQKKYAWH-----DTVPLILCVAAAIACA------------------------------LAPFTPIVTGALF---------------------------------LYFCFVLTLS-VIDF--------RTQL----------------------------LPD--KLT--LPLLWLGLVFNAQYGL-----------------------------------------------------------------------------------------------------IDLHD----AVYGAVA---GYGVLWCVYWGVWLVCHKE-----GLGYGDFK----LLAAAGAW-CGWQTL----------PMILLIASLGGIGYAIV-----SQLLQR---------RTIT----------T---------IAFGPWLALGSMINLGYLAWISY  46
  47 -------------------------AAAIACA------------------------------LTPFTPIVTGALF---------------------------------LYFCFALTLS-VIDF--------RTQL----------------------------LPD--KLT--LPLLWLGLVFNAQSGL-----------------------------------------------------------------------------------------------------IDLHD----AVYGAVA---GYGVLWCVYWGVWLVCHKE-----GLGYGDFK----LLAAAGAW-CGWQTL----------PMILLIASLGGIGYAIV-----SQLLQR---------RTIT----------T---------IAFGPWLALGSMINLGYLAW---  47
  48 -----------------------------ACA------------------------------LAPFMPIVTGALF---------------------------------LYFCFALTLS-VIDF--------RTQL----------------------------LPD--KLT--LPLLWLGLLFNAQSGL-----------------------------------------------------------------------------------------------------VDLHD----AIYGAVA---GYGVLWCVFWGVWFVCHKE-----GLGYGDFK----LLAAAGAW-CGWQTL----------PMILLIASLGGIFYAIA-----SQLWQR---------QTIT----------T---------IAFGPWLALGSMINLTYLVW---  48
  49 ----------E-----GSGNLLFPASHCPVCKHTLAAWENIPLVSWLLLRGRCHQCGTAIPLR-----------------------------------------------------IF-LVDFSPRCFAASRPGLCQTFSRCFPYGCWRRFTAAGHDRLAAPAAPD--CLT--QPLLWAGLVLHAFDHT-----------------------------------------------------------------------------------------------------LPLRD----ALFGAVA---GYLSLWLLYWAFRLIAGRE-----GLGYGDFK----LLAALGAW-CGWQAL----------PSIELAAALSGIVGYFA----------------------------------ANNLNKNNLTISFGPYLAFAGIVVFISQQLT--  49
  50 EALGLEPEPKQ-----ATYNLVLPNSACPRCGHEIRPWENIPLVSYLALGGKCSSCKAAIGKRYPLVELATALLSGYVAWHFG--FTW----------QAGAMLLLTW----GLLAMS-LIDA--------DHQL----------------------------LPD--VLV--LPLLWLGLIANHFGLF-----------------------------------------------------------------------------------------------------ASLDD----ALFGAVF---GYLSLWSVFWLFKLVTGKE-----GMGYGDFK----LLAMLGAW-GGWQIL----------PLTILLSSLVGA---IL-----GVIMLR---------LRNA----------ESGT-----PIPFGPYLAIAGWIALLWGDQITR  50
  51 ----------------------------------------------------------------------------------------------------------LILYACLSVLLF-LWDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFSQVCNP-----------------------------------------------------------------------------------------------------DGLAD----ALWGAII---GYGTFAVIYWGYRILRHKE-----GLGYSDVK----FLAALGAW-HTWTFL----------PRLVFLAASFA-----CGAVVVGLLMRG---------KESL-----------------KNPLPFGPFLAAAGFVVGWD------  51
  52 ---------------------------------------------------------------------------------------------------MDATLPFLILYACLSVLLF-LWDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFSQVCNP-----------------------------------------------------------------------------------------------------DCLAD----ALWGAII---GYGTFAVIYWGYRILRHKE-----GLGYGDVK----FLAALGAW-HTWTFL----------PRLVFLAASFA-----CGAVVVGLLMRG---------KESL-----------------KNPLPFGPFLAAAGFVVGWDSLLAGR  52
  53 ----------------------------------------------------------------------------------------------------------LILYACLSVLLF-FWDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFYQVCYP-----------------------------------------------------------------------------------------------------DGLAD----ALWGAII---GYGTFAVIYWGYRILCHKE-----GLGYGDVK----FFAALGAW-HTWTFL----------PRLVFLAASFA-----CGAVVIGLLMRG---------KESL-----------------KNPLPFGPFLAAAGFVVGWD------  53
  54 ---------------------------------------------------------------------------------------------------------FVRLFICPT---F-LWDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFSQVCNP-----------------------------------------------------------------------------------------------------DGLAD----ALWGAII---GYGTFAVIYWGYRILRHKE-----GLGYGDVK----FLAALGAW-HTWTFL----------PRLVFLAASFA-----CGAVVVGLLMRG---------KESL-----------------KNPLPFGPFLAAAGFVVGWDSLLAGR  54
  55 ----------------------------------------------------------------------------------------------------------LILYACLSALLF-FWDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFYQVCQP-----------------------------------------------------------------------------------------------------AGLAD----ALWGAII---GYGAFAVIYWGYRILRHKE-----GLGYGDVK----FLAALGAW-HTWAFL----------PRLVFLAASFA-----CGAVVIGLLMRG---------KESL-----------------KNPLPFGPFLAAAGFVVGWD------  55
  56 ----------------------------------------------------------------------------------------------------------LILYICLSSLLF-FYDA--------KHGL----------------------------LPD--RFT--CPLLWSGLLFYQICHP-----------------------------------------------------------------------------------------------------GGLAD----ALWGAII---GYGAFAIIYWGYRILRHKE-----GLGYGDVK----FLAALGAW-HTWAFL----------PRLVFLAASFA-----CGAVVIGVLMRG---------KASL-----------------KNPLPFGPFLAA--------------  56
  57 -------------------------------------------------------------------------------------------------------------YVSLSGLLL-VHDL--------RTGL----------------------------LPD--KFT--CPLLWGGLIYHQCCKP-----------------------------------------------------------------------------------------------------AQLSD----ALWGTVA---GYGVFALFYWGYRLICRQE-----GLGFGDVK----FLAALGAW-HRWESL----------PLLVLLAAGMA-----CCLTGISCVRYG---------RQML-----------------KNPLPFGPYLAAAGFVIGWV------  57
  58 ---------------------------------------------------------------------------------------------------MLAALPFLLCYSGLTVALC-HQDL--------RHGL----------------------------LPD--RYT--CPLLWSGLLFYLCLAP-----------------------------------------------------------------------------------------------------HQLHD----AVWGAIT---GYLSLAAIYWLYRGIRGYE-----GLGYGDIK----YLAALGAW-HGWRLL----------PQLVLVASLLAGIAWAGAGLYASCGRKS---------KWGR-----------------SNPLPFGPFLAAAGFWCGWQTL----  58
  59 -----------------------------------------------------------------------------------------------------------LLYSGLSLALC-WYDL--------RYGL----------------------------LPD--RLT--CPLLWSGLFYYLYYAP-----------------------------------------------------------------------------------------------------LQLEY----AVGGAIG---GYLAFTCLYWLYRGVRGYE-----GLGYGDVK----FLAALGAW-HGWQML----------PQLVFMATVFAG----GVMLLLMILGKV---------QRSL-----------------NNPLPFGPFLAAAGFWCGW-------  59
  60 -----LPVEPK-----PKFNLATPRSQCPRCKKTLKIRHNLPLISYLTLRGRCAYCHEKISPLYPIVELLCAILSVAIVIRYQ--ISW----------QALAGLLLTW----VLIVLF-FIDL--------KTQL----------------------------LPD--AIT--LPTLWFGLSLSLFYMF-----------------------------------------------------------------------------------------------------VSPYQ----AIFGAIL---GYGLLWITAAFYQLIRKKE-----GMGRGDFK----MVSMLGAW-FGPGIV----------LNVLLLSVFLGL---IT-----SFMLLA---------LKKI----------SVKQ-----PIPFGPFIAVAGWISLLSG-----  60
  61 -EYLNLPVEPK-----PKFNLATPRSQFPRCKKTLKIRHNLPLISYLTLRGRCAYCHEKISPLYPIVELLCAILSVAIVIRYQ--ISW----------QALAG-LLTW----VLIVLF-FIDL--------KTQL----------------------------FPD--AIT--LPTLWFGLSLSLFYMF-----------------------------------------------------------------------------------------------------VSPYQ----AIFGAIL---GYGLLWITAAFYQLIRKKE-----GMGRGDFK----MVSMLGAW-FGPGIV----------LNLLLLAVFLGL---IT-----SFMLLA---------LKKI----------SVKQ-----PIPFGPFIAVAGWISLLSGPVLIH  61
  62 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------P-----------------------------------------------------------------------------------  62
  63 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VG--------------------------------------------------------------------------------------------------  63
  64 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR-------------------------------------------  64
  65 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  65
  66 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-GGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  66
  67 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  67
  68 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  68
  69 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGVVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR-------------------------------------------  69
  70 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGVVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFG-------------------  70
  71 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWXLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGVVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  71
  72 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLSAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR-------------------------------------------  72
  73 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLSAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  73
  74 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFIAFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGSLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  74
  75 -----ETPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLG---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGSW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  75
  76 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-----------------------------------------------------------------------------------------------------  76
  77 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------P-----------------------------------------------------------------------------------  77
  78 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------P-----------------------------------------------------------------------------------  78
  79 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLI-----------------------------------------------------------------------  79
  80 ----------Q-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GATT------LPFGPCLSLGG------------  80
  81 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  81
  82 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  82
  83 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  83
  84 -----EMPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  84
  85 -----------------KISLALPRSHCPHCQQTIRIRDNIPLFSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGGIATLYL------  85
  86 ----------------------------------------------------------------------------------------------------SGWGLAVMILSAWLIAAS-VIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGGIATLY-------  86
  87 -----ETPSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLFSWLMLKGRCRDCQTKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGAW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  87
  88 -----ETPSTQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-VIDL--------DNQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPFGPCLSLGG------------  88
  89 -----EMPSTQ-----SKINLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-VIDL--------DNQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGPLSL----------PNVALIAS----------------------------------------------------------------------------  89
  90 -----ETPSTQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWGLAVMILSAWLIAAS-IIDL--------DNQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIILRKE-----ALGMGDVL----LFAALGGW-VGPLSL----------PNVALIASCCGLIYAVI-----T----------------KR----------GSTT------LPF--------------------  90
  91 -------------------------SHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGPLSL----------PNVALIASCCGLIYAII-----T----------------KR----------GSTT------LPFGPCLSLGG------------  91
  92 -----EMSSAQ-----SKISLALPRSHCPHCQQTIRVRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESG-SLAVMILSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQQSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLV---GFITFYSLRWIAGIVLRKE-----ALGMGDVL----LFAALGGW-VGALSL----------PNVALIASCCGLIYAII-----T----------------KR----------GSTT------LPFGPCLSLGG------------  92
  93 -----ETPSAQ-----PKISLVLPRSYCPHCQQTIRIRDNIPLLSWLMLKGRCRDCQAKISKRYPLVELLTALAFLLASLVW----------------PESGWALAMMALSAWLIAAS-IIDL--------DHQW----------------------------LPD--VFT--QGVLWTGLIAAWAQLSP----------------------------------------------------------------------------------------------------LTLQD----AVTGVLT---GFTSFYSLRLLAEVILHKE-----ALGMGDVI----LFSGLGSW-VGVFSL----------AHVALLASCGGLIYAIV-----T----------------RK----------TSRQ------LPFGPFLSVGGLITL--------  93
  94 -----DIDSSQ-----PKISLARPRSHCPYCRQTLRVYDIIPLFSWLILKGYCRNCHEKIGLRYPLTELLTAFSFLLAWFVW----------------PANIWSVAVMILSALLIAAS-FIDI--------EHQW----------------------------LPD--VFT--QGILWTGLIVAWTQQSP----------------------------------------------------------------------------------------------------LSLHE----AVTGVLA---GFASFYSLRWGAGIVLRKE-----SLGMGDVL----LFAGLGGW-VGASSL----------PYVALIASLSGLVYAVI-----M----------------RN----------QSGL------LPFGPCLSLGG------------  94
  95 -----------------QISLARPRSHCPHCRQTLRVYDIIPLFSWLILKGYCRNCHKKIGLRYPLTELLTAFSFLLAWFVW----------------PTNIWSVAVMILSAFLIAAS-FIDI--------EHQW----------------------------LPD--VFT--QGILWTGLIVAWTQQSP----------------------------------------------------------------------------------------------------LSLHE----AVTGVLA---GFASFYSLRWGAGIVLRKE-----SLGMGDVL----LFAGLGSW-VGASSL----------PYVALIASLSGLVYAVI-----M----------------RN----------QSGL------LPFGPCLSLGGLATLYV------  95
  96 -----ETQNVP-----PGINLIRPRSHCPHCRKSIRIRDNIPLISWLILKGRCSDCHGKISLRYPLVELLTALSFLLAGIVW----------------PDSGWGVAVMILSAWLIAAS-FIDL--------EHQW----------------------------LPD--IFT--QGVLWTGLIVAWGGLSP----------------------------------------------------------------------------------------------------LPLHD----AVSGGLA---GFVSFYTLRWLAGVVLRRE-----ALGMGDVL----LFTGLGSW-TGPLLL----------PDVALVASFCALIYAIT-----T----------------GK----------YAST------VPFGPFLSLGGMVTLYTGIDV--  96
  97 -------------------NLIRPRSHCPHCRKSIRIRDNIPLISWLILKGRCSDCHGKISLRYPLVELLTALSFLLAGIVW----------------PDSGWGVAVMILSAWLIAAS-FIDL--------EHQW----------------------------LPD--IFT--QGVLWTGLIVAWGGLSP----------------------------------------------------------------------------------------------------LPLHD----AVSGGLA---GFVSFYTLRWLAGVVLRRE-----ALGMGDVL----LFTGLGSW-TGPLLL----------PDVALVASFCALIYAIT-----T----------------GK----------YAST------VPFGPFLSLGGMVTLYTGIDV--  97
  98 -------------------NLIRPRSHCPHCRKSIRIRDNIPLISWLILKGRCSDCHGKISLRYPLVELLTALSFLLAGIVW----------------PDSGWGVAVMILSAWLIAAS-FIDL--------EHQW----------------------------LPD--IFT--QGVLWTGLIVAWGGLSP----------------------------------------------------------------------------------------------------LPLHD----AVSGGLA---GFVSFYTLRWLAGVVLRRE-----ALGMGDVL----LFTGLGSW-TGPLLL----------PDVALVASFCALIYAIT-----T----------------GK----------YAST------VPFGPFLSLGGMVTLYTGIDV--  98
  99 -----ETQNGH-----PGINLIRPRSHCPHCRKSIRIRDNIPLISWLILKGRCRDCHGKISLRYPLVELLTALSFLLAGLVW----------------SDSGWAVAVMILSAWLIAAS-FIDL--------DHQW----------------------------LPD--IFT--QGVLWTGLIVAWGGPGP----------------------------------------------------------------------------------------------------LPLHD----AVSGGLA---GFVSFYTLRWLAGAVLRRE-----ALGMGDVS----LFAGLGTW-TGPLLL----------PDVALVASLCALIYAVT-----T----------------GK----------YAST------VPFGPFLSLGGMVAL--------  99
 100 -------------------SLAYPPSYCPSCGHRLGPKDLVPVLSYLALRGRCRYCQSPISPRYPLVEAITGSLFLLAALFY----------------PPSPMAFLVFAFLAFLVALA-FIDL--------DTYE----------------------------LPD--ALT--YGLLFLGLAASYFLAFPLPFRKSLDGALMAAGGLGLVAGYGGLFLRRFRERRPEVPVGPHQVHMAALLGALLGPGVGMALAFLTWALSARTGRPVVLPDRLTLPLLPVALLLAPALGLDLLE----SLKGSLVAAGGLALAGGLYWAFRPAPPEEEEEPVAMGYGDVK----LLGALGAW-LGLY-A----------FLALLLAVFLG----AA-----FGLVLR---------RQ---------------------KIPFGPYLALGGVVAFFFGEAIWK 100
 101 ------------NANEKVFNIAWPPSHCTHCGNNILKRDNIPVISWFMLRGRCRFCGSVISSRYPFVEFITGLVFSVLGTYMF-FIAD----------KNIYVISLILFLFSILLCLA-VIDF--------DHLL----------------------------LPD--SLV--YIMLWGGLLAAAFELSP----------------------------------------------------------------------------------------------------ITLKD----AVISICG---TWITLSTIVQLFIFIRKKE-----GLGAGDIK----LICALAAW-IGWYNI----------PFLLVISSIIGGVMF--------INIKRRFDCGYDGNIKNC------------------HVIPFGPAISISGFLIYLF------ 101
 102 -------------------------------------------------------------------------------------IAD----------KNIYVVSLILFLFSILLCLA-VIDF--------DHLL----------------------------LPD--SLV--YIMLWGGLLAAAFELSP----------------------------------------------------------------------------------------------------ITLKD----AVISICG---TWITLSTIVQLFIFIRKKE-----GLGAGDIK----LICALAAW-IGWYNI----------PFLLVISSIIGGVMF--------INIKRRFDCGYDGNIKNC------------------HVIPFGPAISISGFVIYLFIANGYD 102
 103 ---------------DEIFNIAWPPSHCTKCDNKILKRDNIPVISFFLLKGKCRFCGSVISSRYPLIEFITGISFSIIGLWMIVYLKQ----------EPIEVIS-VLFLFSVLLCLA-VIDL--------DHLL----------------------------LPD--CLV--FTLLWTGLLISCLELSP----------------------------------------------------------------------------------------------------VSLQD----AVIGICG---VWIILSMIVQIFILIRKKE-----GLGAGDIK----LICALTAW-IGWHNV----------PILLVFSAIIGGVMF--------INVKRRFDCGYDGSIKNC------------------HVIPFGPAISISGFVIYLF------ 103
 104 NVVIYRIPKSIMEPVHGVFNIAWPPSHCTKCDNKILKRDNIPVISWFLLKGKCRFCGSVIPTRYPVIEITTGLCFSIIGLFLFVVLKQ----------ELFTVFA-VLFLFSVLLCLS-FIDF--------DHLL----------------------------LPD--SLV--YTLLWAGLLIASFDMSS----------------------------------------------------------------------------------------------------VNLHD----AVIGICA---TWISLTLVAHIFTIIWKKD-----GLGAGDVK----LLSALAAW-IGWYNI----------PVLIVLSSIIGGVIF--------MCNKRKFEFTINNETQSC------------------HVIPFGPAISLSGFVVYLL------ 104
 105 ------------KPQDDIFNIAWPPSHCTNCKNKILKRDNIPLLSWLLLKGQCRFCGGVISSRYPIIELITGLCFSVIGLWMFDFLNQ----------QPLVVIS-VLFLFSVLLCLT-VIDL--------DHLL----------------------------LPD--SLV--FTLLWTGLLAATFEISP----------------------------------------------------------------------------------------------------VHLKD----AVIGVCG---TWLFLTVITYLFTVIRNKE-----GLGGGDVK----LISALSAW-VGWYYI----------PALLVFSSVIGFILF--------FIAKRKMEFSSDTERTLY------------------YVVPFG------------------- 105
 106 ------------KPQDDIFNIAWPPSHCTNCKNKILKRDNIPLLSWLLLKGQCRFCGGVISSRYPIIELITGLCFSVIGLWMFDFLNQ----------QPLVVIS-VLFLFSVLLCLT-VIDL--------DHLL----------------------------LPD--SLV--FTLLWTGLLAATFEISP----------------------------------------------------------------------------------------------------VHLKD----AVIGVCG---TWLFLTVITYLFTVIRNKE-----GLGGGDVK----LISALSAW-VGWYYI----------PALLVFSSVIGFILF--------FIAKRKMEFSSDTERTLY------------------YVVPFGPAISLTAF----------- 106
 107 ------------KPQDDIFNIAWPPSHCTNCKNKILKRDNIPLLSWLLLKGQCRFCGGVISSRYPIIELITGLCFSVIGLWMFDFLNQ----------QPLVVIS-VLFLFSVLLCLT-VIDL--------DHLL----------------------------LPD--SLV--FTLLWTGLLAATFEISP----------------------------------------------------------------------------------------------------VHLKD----AVIGVCG---TWLFLTVITYLFTVIRNKE-----GLGGGDVK----LISALSAW-VGWYYI----------PALLVFSSVIGFILF--------FIAKRKMEFSSDTERTLY------------------YVVPFGPAISLTAF----------- 107
 108 -------------------------------------------------------------------------------------LNQ----------QPLVVIS-VLFLFSVLLCLT-VIDL--------DHLL----------------------------LPD--SLV--FTLLWTGLLAATFEISP----------------------------------------------------------------------------------------------------VHLKD----AVIGVCG---TWLFLTVITYLFTVIRNKE-----GLGGGDVK----LISALSAW-VGWYYI----------PALLVFSSVIGFILF--------FIAKRKMEFSSDTERTLY------------------YVVPFGPAISLTAFFIYLSSIN--- 108
 109 NVVIYRIPLSLIKPQDDIFNIAWPPSHCTNCKNKILKRDNIPLLSWLLLKGQCRFCGGVISSRYPIIELITGLCFSVIGLWMFDFLNQ----------QPLVVIS-VLFLFSVLLCLT-VIDL--------DHLL----------------------------LPD--SLV--FTLLWTGLLAATFEISP----------------------------------------------------------------------------------------------------VHLKD----AVIGVCG---TWLFLTVITYLFTVIRNKE-----GLGGGDVK----LISALSAW-VGWYYI----------PALLVFSSVIGFILF--------FITKRKMEFSSDTERTLY------------------YVVPFGPAISLTAFFIYLSS----- 109
 110 NVVAYRLPEG--------LSLVHPPSRCPHCGHRLGPKENVPVVGWLWLRGKCRWCQTAISPRYPLVEAATGFLFALTCWRF----------------GWQWQTFGYWILISFLISLT-LIDW--------DTMT----------------------------LPN--SLT--KPGLVLGLLFHLLLGWQRGHWI-----------------------------------------------------------------------------------------------VPLVE----AIASAVL---GLWLFDLIRMGGSLLLGRE-----GMGDGDPK----LASMVGAW-LGWPSL----------LLTTFIACFIGSIYGGL-----KLLLGT---------LQRR------------------QGFPFGPFLAIGALISLFWGEKLIT 110
 111 NVIVYRLPAG--------LSILWPPSRCPKCLNQLKAYDNVPVFGWISLRGRCRYCKSKISVRYPVVEGVTGIIFLLIFLVF----------------QVSILTIGYWAFCSWLLALS-LIDL--------DTMT----------------------------LPN--PLT--QSGLVAGILFQMVVGYLSEGSS-----------------------------------------------------------------------------------------------VALVNHLMIAILGAVL---GLWLFDAIALLGSIAFGKT-----AMGAGDAK----LAAMMGAW-LGWKYL----------LLATFIACALGALIGSAIIMHKRILLGR---------SKLRTASGREATNEQTSTHRLGQKMPFGPFLALGSLITLFSGEAILS 111
 112 NVVIYRSTKEDLKLWDP------PHSFCPNCKRKIEWYDNIPVISYILLRGKCRHCGWRIPIRYPIVEISTGTLFLMNRVLI----------------KDPLLFVSSCVIASALIAIS-LIDL--------ETYL----------------------------IPD--YLN--FTVLIFSFVVALR--------------------------------------------------------------------------------------------------------TSFLE----HLISFLIVTIMFLILKAMY--------RD-----GLGAGDVI----LAMGIGFL-LSPVPS----------IFAILIASISGILYALIKGKGKMDIKTR---------------------------------IPFGPFLALGGYTLFLISYGMGW 112
 113 TDWPWWVAGAWAGVCLVSLGRIIP--------HKVLQRAQVPLNEWQGPGGGLEQPVPKARRIW--VPVVNAGLWASAADTANQPVFW----------GTFLWAA----LASTLLLLA-LIDW--------DTTL----------------------------LPD--WIV--LPLGLAGLLSSYAGFTR----------------------------------------------------------------------------------------------------QSLAV----SAASAVV---VLVLLGGFAWIFHRIRGVS-----GIGGGDLK----LLAALAAW-WGPDGV----------LYVVALGSVVTVVWYLVWRRFKGLSPEA--------------------------------EWPFGPALVVAALAWGL------- 113
 114 ----------------------------------------------------------------------------------------------------------LSLSMGLLCACT-VTDA--------LRTW----------------------------LPA--ELT--LPLAVTMIWHAS---------------------------------------------------------------------------------------------------------LSPWGFQNDLIWGA-----VWAAFYGGRWLFYRLQRRED----SPGSGDII----LAGVAGIA-GGPSSA------------FLIASAIAGHLAWGT--------------------------------------VRHLHEAPFGPWLCLAITVQLLF------ 114
 115 AACSYRMPRD--------ISIVFPASHCPRCQEHIAWFANVPVLGYVFCRGRCLHCHGSISPLYPLLEASLGLLFAAVTFHFL--PDI----------PQVIWYLSLVFF---LFACG-VIDAVSASQFGGGEGI----------------------------IPD--FFS--VGGLVAGLALAIWFGHFAA-----------------------------------------------------------------------------------------------------------SLAGALA---GGGILLAVYLYYRYVRQIE-----ALGLGDVK----MLAMIGAF-VGVTGV----------LYTLFLASLTGLAAAVF-----FMIYHR---------SFSL-----------------QMKIPFGPFLALGALL---------- 115
 116 ----------------------------------FGTDFSRPVLS-------------------PEVWADAAAMFWLLLGAY----------------P-----------------VC-AVDC--------KYKL----------------------------IPD--SIS--VG--------------------------------GIVAG---------------------------LLISLV-PG-----------------------------------------GVTPLQ----SLIGAVVAGGGLYLLG---WIATKVLKKD-----AMGFGDVK----LLAGYGAL-MDVTGA----------VETLLVAALLGIVVMVP-----YGMLAA---------KKAA----------KNKNSEEAGQIPFGPFLAIAAPVIYLWGSALLD 116
 117 --------------------------------------------------------------------SVDGVVY--------------------------------YFFFSALLVMS-IIDW--------YYFI----------------------------LPP--GIN--IGGLVLGILVSPFRQD-----------------------------------------------------------------------------------------------------ITPKE----SIIGAVV---GVLIPFVIYLYYVKFRKIE-----GLGFGDVI----LLGFIGSV-SGVYGV----------FSALFIGSFLGL----L-----YALPMI---------IRHK----------SMNF-----ALPFGPFLSLGAFIGIVFKEQILT 117
 118 NVCAYRLPKEE--------SVIRPGSRCPHCKSPIKWYDNIPILSFLWLRGRCRNCGGQISWRYPLVELITALLSVAVYLRF----------------GLTPAYLGFFFLVAALWVAS-LIDL--------EHQI----------------------------IPD--EIS--LIGILVGLAFSL--YNPL---------------------------------------------------------------------------------------------------TTPTD----ALLGALC---GAGGLYLLAEFYYFFTKRE-----GLGGGDLK----LLAMIGAF-LGVKSL----------IPVVFLASLVGAVIGIA-----LALWQK---------AKDK----------RTFA------IPFGPFLSLGAVVYLFFAPYL-- 118
 119 NVCIYRLPTGE--------SVVFPPSRCTSCGTRIRPWDNIPILSWLILRGSCRACRAKISARYPLVELINGLLCLALFLKF----------------GPTLTFAALFVFCSALVAIS-FIDL--------DHQI----------------------------IPD--VIS--LPGIVLGFVLSF--FLPW---------------------------------------------------------------------------------------------------LGWLN----SLIGIAA---GGGSLLLVAWLYERLTGKE-----GMGGGDIK----LLAMMGAF-LGWRAV----------PFIIFASSLVGSVIGLT-----LMMLQK---------KDSK------------LA------IPFGPFLALGALLYIFFGKAIIL 119
 120 NVLIARLPRG--------ISIAFPPSNCPKCGHRIRFYHNIPLIGFLLLKGRCRDCGEKISLKYPLVELLTGVIFLLVFLKF----------------GMSLYTLKYSVFVFLLLGAG-LTDVFTAADAEFECGI----------------------------IPD--TYT--LGGAVAGVFFSFITY-P-----------------------------------------------------------------------------------------------------GIQT----SLLGALA---GFLSLWIPAWLYKKLRRQE-----GMGGGDIK----LMMMIGAF-LGYVPV----------YFIVFGSAVIGSLVGIP-----LVILK------------KD----------KNYM------IPFGVFIAAAAVLYIFFEPRIMA 120
 121 SFSTL----------------------------------------------------------------------------------------------------KLLILFSMLLPVF-FIDL--------EHML----------------------------IPD--VIT--IPGTGVGLIISLFEGRLA---------------------------------------------------------------------------------------------------QGI--------LGSLI---FGGILLLIYVIALLILKEE-----GMGQGDIK----LGFMLGSF-LGIKLS----------LLSLFLSYFIGGLFSLL-----IILIKG---------KDLK------------------TAIPFGPFLIIGALISLFFGKTLIN 121
 122 SLFTF----------------------------------------------------------------------------------------------------KSLILISMLIPIF-FIDL--------ENML----------------------------IPD--VIS--IPGIVVGLLFSFWEGNLV---------------------------------------------------------------------------------------------------QGV--------LGSLI---FGGILLLIYVVALLILKEE-----GMGQGDIK----LGFMLGGF-LGLKLS----------LFAIFLSYLIGGIFSIL-----VIVLRS---------KNLK------------------TAIPFGPFLITGALISLFWGEVLIK 122
 123 ----------------------------------------------------------------------TPVMLLNLRYAF------------------------HLVLIESLMVAT-FIDF--------DLKI----------------------------IPD--GAT--MPAMFIGVIGSFAFGLLYLVPVWFQEPSVVRLLGIYFPEQYRSAFVVEKVPQWVNLYPHL---------------------------------------------------------HGLAV----SLVGLVV---GGGVVWAVRIIGQWTLRQE-----AMGFGDVI----LMAVIGSF-LGWQAT----------VTVFVISPLCALGVVAV-----SIFFKQ---------SRE---------------------IPFGPYLSLGALLVLLGW----- 123
 124 TVVAVRIPIGQ--------SIIAPRSYCDYCRHTLRPKELIPIISFCLQRGRCIHCKMKVPFIYTLFEVITGGAFLFFTYVIG--MDK----------ELILIWT----LLSLLIIIT-MTDL--------FYML----------------------------IPD--VILFSFACL---FVLEHIFISL----------------------------------------------------------------------------------------------------VPWWE----GLIGGGT---IFIVLYLVQILF-----PN-----GLGGGDVK----LLSLLGFI-IGAKAI----------FIVLCCASSLSLCFFGI-----GMLLKR---------ITSR------------------QPFPFGPFIALGTICYLA------- 124
 125 TVVAVRIPIGQ--------SIIAPRSYCDYCRHTLRPKELIPIISFCLQRGRCIHCKMKVPFIYTLFEVITGGAFLFFTYVIG--MDK----------ELILIWT----LLSLLIIIT-MTDL--------FYML----------------------------IPD--VILFSFACL---FVIEHIFISL----------------------------------------------------------------------------------------------------VPWWE----GLIGAGT---IFIVLYLVQILF-----PN-----GLGGGDVK----LLSLLGFI-IGAKAI----------FIVLCCASSLSLCFFGI-----GMLLKR---------ITSR------------------QPLPFGPFIALGTICYLA------- 125
 126 TVVAVRIPIGQ--------SIITPRSYCHGCHHTLSPKELIPIVSFCLQRGRCTHCKMKIPFIYTLFEVITGAVFLFFTYVIG--MEK----------ELIFIWT----LLSLLIIIT-MTDL--------FYML----------------------------IPN--IILVFFACS---FLIERIFIPL----------------------------------------------------------------------------------------------------VPWWD----SLIGGGI---ICIVLYFAQIIF-----PN-----GLGGGDVK----LLSLLGFI-VGVKAI----------LIVLCFASSLGLCFLGI-----GMLLKR---------MTAR------------------QPLPFGPFIALGMV----------- 126
 127 LVVALRVPRGE--------SIITPRSYCPHCQHRLQPKELIPILSFCMQSGRCKHCKRKIPYTYPIVELITGSLFLISVCMVG--VEQ----------ELIVICT----LFSLLVMIT-LTDL--------FYMM----------------------------IPN--AVLLSFSCI---FLIEYMISPF----------------------------------------------------------------------------------------------------IFWLD----SVLGGGI---IFCVLYILRMIY-----PN-----GLGGGDVK----LLSLLGFV-LGIKGI----------LITLCIASCSSLCFLGI-----CFLFKR---------MNIR------------------DPLPFGPFIALGTICYV-------- 127
 128 MLVAVRVPLGA--------SIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIIYVAFECITGSIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAVL---LILESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFLLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFFGI-----GIGLKR---------IEVR------------------KPIPFGPFISLGAMCYVL------- 128
 129 -------------------SIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIMYVAFECITGSIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAVL---LILESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIILFLAS---------------------------------------------------------------------------- 129
 130 MLVAMRVPLGV--------SIITPRSHCDYCKYVLRTKELIPIISFYIQRGYCTNCKRKIPIMYVTFEYITGGIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAVL---LILESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIAGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFLGI-----GIGLKR---------IEVR------------------KPIPFGPFISLGAMCYVLA------ 130
 131 MLVAMRVPLGA--------SIITPRSHCGYCKYVLRTKELIPIISFYIQRGCCTNCKRKIPIMYVAFECITGGIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAFL---LILESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIAGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFFGI-----GIGLKR---------IEVR------------------KPIPFGPFISLGAICYVLA------ 131
 132 MLVAMRVPLGA--------SIITPRSHCDYCKYVLRTKELIPIISFYIQRGCCTNCKRKIPIMYVAFECITGGIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAFL---LILESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIAGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFFGI-----GIGLKR---------IEVR------------------KPIPFGPFISLGAICYVLA------ 132
 133 MLVAMRGPLGA--------SIITPRSHCDYCKYVLRTKELIPIISFYIQRGCCTNCKRKIPIMYVAFECITGGIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAFL---LTLESVFVQL----------------------------------------------------------------------------------------------------VTWTD----SIAGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFFGI-----GIGLKR---------IEVR------------------KPLPFGPFISLGAICYVLA------ 133
 134 MLVAVRVPLGA--------SIITPRSHCYYCKYVLRPKELIPIISFYIQRGCCTNCKRKIPIIYVAFECITGSIFLLTVYMIG--IER----------ELIIILS----LFSLLLIIS-VTDY--------LYML----------------------------IPD--CILISFAVL---LILESIFVQL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFLLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGV----------FIVLFLASCFSLCFFGI-----GIVLKR---------IEVG------------------KPIPFGPFISLGAMCYVLA------ 134
 135 MLIAIRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRGIPILYVVFEFVTGTIFFLTVYMIG--VER----------ELLIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPD--RILISFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGV---ILFLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGV----------FIILFLASYFSLCFFGM-----GILLKR---------IEAS------------------KPIPFGPFISLGAICYVLI------ 135
 136 MLIAIRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTDCKRGIPILYVVFEFVTGTIFFLTVYMIG--VER----------ELLIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPD--RILISFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGV---ILFLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGV----------FIILFLASYCSLCFFGM-----GILLKR---------IEAS------------------KPIPFGPFISLGAICYVLI------ 136
 137 MLIAIRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRGIPILYVVFEFVTGTIFFLTVYMIG--VER----------ELLIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPD--RILISFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGV---ILFLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGV----------FIILFLASYCSLCFFGM-----GILLKR---------IEAS------------------KPIPFGPFISLGAICYVLI------ 137
 138 MLIAIRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRGIPILYVVFEFVTGTIFFLTVYMIG--VER----------ELLIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPD--RILISFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGV---ILFLLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGV----------FIILFLASYCSLCFFGM-----GILLKR---------IEAS------------------KPIPFGPFISLGAI----------- 138
 139 MLIAIRVPVGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRGIPILYIVFEFVTGTIFFLTVYMIG--VER----------ELLIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPD--RILISFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGV---ILILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FIILFLASYFSLCFFGM-----GILLKR---------IEAS------------------KPIPFGPFISLGAICYVLI------ 139
 140 MLIAMRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVVFELVTGMIFLLTVYMIG--VER----------ELIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGV-----GIVLKR---------MKMR------------------SQIPFGPFISLGAICYMLV------ 140
 141 MLIAMRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVVFELVTGMIFLLTVYMIG--VER----------ELIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGV-----GIVLKR---------MKMR------------------SQIPFGPFISLGAICYMLF------ 141
 142 MLIAMRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVVFELVTGMIFFLTVYMIG--VER----------ELIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGV-----GIVLKR---------MKMR------------------SQIPFGPFISLGAICYMLV------ 142
 143 MVIAMRVPLGE--------SIITPRSHCHYCKYVLKPKELIPIISFCIQRGRCKNCKRTISILYVVFELVTGMIFLLTVYMIG--MER----------EIIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LIFECIFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLHCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-AGLKGI----------FMILFLASCFSLCFFGV-----GIVLKR---------MKMR------------------SQIPFGPFISLGAI----------- 143
 144 MLIAMRVPLGE--------SIITPRSHCYYCKYVLKPKELIPIISFCIQRGRCTNCKREISILYVVFELVTGMIFLLTVYMIG--VER----------ELIIILS----LFSLLLIIS-ITDY--------IYML----------------------------IPN--RILAWFACL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDVK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGA-----GIVLKR---------MKMR------------------TPIPFGPFISLGAICYMLV------ 144
 145 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKSKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--CILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGA-----GIVLKR---------MKKR------------------SQIPFGPFISLGAICYMLV------ 145
 146 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKSKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLASCFSLCFFGA-----GIVLKR---------MKMR------------------SQIPFGPFISLGAI----------- 146
 147 MVIAMRVPLGE--------SIITPRSYCHYCKYVLKPKELIPIISFCMQRGRCTNCKRKISILYVVFELVTGMICLLTVYMIG--VER----------ELIIVLS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECAFIPL----------------------------------------------------------------------------------------------------VTWID----SIVGSCV---IFILLYCMQKIY-----PE-----GLGGGDVK----LLSLLGFI-VGLKGI----------FIVLFLASCFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAICYMLV------ 147
 148 MVIAMRVPLGE--------SIITPRSYCHYCKYVLKPKELIPIISFCMQRGRCTNCKRKISILYVVFELVTGMICLLTVYMIG--VER----------ELIIVLS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECAFIPL----------------------------------------------------------------------------------------------------VTWID----SIVGSCV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FIVLFLASCFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAI----------- 148
 149 MVIAMRVPLGE--------SIITPRSYCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISTLYVVFELITGMICLLTVYMIG--VER----------ELIIVLS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSCV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FIVLFLASCFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAICYMLV------ 149
 150 MVIAMRVPLGE--------SIITPRSYCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVVFELITGMICLLTVYMIG--LER----------ELIIVLS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECAFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSCV---IFILLYCMQKIY-----PE-----GLGGGDVK----LLSLLGFI-MGLKGI----------FMIIFLASFFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAICYMLV------ 150
 151 MVIAMRVPLGE--------SIITPRSYCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVVFELITGMICLLTVYMIG--LER----------ELIIVLS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFACL---LILECAFVPL----------------------------------------------------------------------------------------------------VTWTD----SIVGSCV---IFILLYCMQKIY-----PE-----GLGGGDVK----LLSLLGFI-MGLKGI----------FMIIFLASFFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAI----------- 151
 152 MLIAMRIPLGE--------SIIIPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVIFELVTGIIYLLTVYMIG--VER----------ELIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFSCL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWTE----SIVGSGV---IFILLYYMQKIY-----PE-----GLGGGDIK----LLSLLGFI-VGLKGI----------FMILFLSSFFSLCFFGA-----GLALKR---------IKMR------------------TQIPFGPFISLGAICYMLF------ 152
 153 -------------------SIIIPRSHCHYCKYVLKPKELIPIISFCIQRGRCTNCKRKISILYVIFELVTGIICLLTVYMIG--VER----------ELIIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILAWFSCL---LILECVFVPL----------------------------------------------------------------------------------------------------VTWTE----SIVGSGV---IFILLYCMQKIY-----PE-----GLGGGDIK----LLSLLGFI-AGLKGV----------FMILFLSSFFSLCFFGA-----GLVLKR---------MKMR------------------TQIPFGPFISLGAICYLL------- 153
 154 MVIAMRVPIGE--------SIIIPRSHCHYCKCVLKPKELIPVISFCIQRGRCTNCKEKIPIMYVVFELITGSIFLLTVYMIG--MER----------ELTIILS----LFSLLLIIS-VTDY--------IYML----------------------------IPN--RILIWFALL---LTIECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGI---IFILLYCMQKIY-----PE-----GLGGGDVK----LLSLLGFI-VGVKGI----------FMILLLASCFSLCFFGV-----GIVLKR---------IETR------------------KPIPFGPFISFGAICYVLV------ 154
 155 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIIPFCMQKGCCTNCKRKISSLYVVFEFLTGSLFVLTAYVIG--IER----------ELIPILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFAFL---ITLECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIVGSGI---IFILLYCVRRIY-----PE-----GLGGGDIK----LLSLLGFI-VGVKGI----------FIILFLASCFSLCFFGI-----GIALKR---------IEAR------------------KPIPFGPFISLGAI----------- 155
 156 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCMQKGRCTSCKRKISSLYIVFEFVTGSLFFLTVYVIG--IEQ----------ELIIILS----LISLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIAGSGI---IFILLYCMQKIY-----PA-----GLGGGDVK----LLSLLGFI-IGVKGI----------FITLFLASCFSLCFFGI-----GIALKR---------IKIR------------------TPIPFGPFISLGAICYVLV------ 156
 157 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCMQKGRCTSCKRKISSLYIVFEFVTGSLFFLTVYVIG--IEQ----------ELIIILS----LISLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFAFL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIAGSGT---IFILLYCMQKIH-----PA-----GLGGGDVK----LLSLLGFI-IGVKGI----------FITLFLASCFSLCFFGI-----GIALKR---------IKIR------------------TPIPFGPFISLGAI----------- 157
 158 MVIAMRVPVGE--------SIITPRSYCHYCKYTLKPKELIPIISFCMQKGRCTNCKRKIPSLYITFEFVTGSLFFLTVYVIG--IER----------ELIIILS----LLSLLLIIS-VTDF--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SIAGSGT---IFILLYCMQRIY-----PD-----GLGGGDVK----LLSLLGFI-IGVKGI----------FMTLFLASFFSLCIFGI-----GIALKR---------IKVR------------------TPIPFGPFISLGAICYVLV------ 158
 159 MVIAMRVPVGE--------SIITPRSYCHYCNYTLKSKELIPIISFSLQKGRCTSCKRKISSLYIIFEFVTGSLFVLTVYIIG--IER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFGLL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----GLAGSGT---IFILLYCMQRIY-----PD-----GLGGGDVK----LLSLLGFI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKL---------IKIR------------------TPIPFGPFISLGAICYVLV------ 159
 160 MVIAMRVPVGE--------SIITPRSYCYYCKYTLKPKELIPIISFCIQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYVIG--IER----------ELIITLS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQRIY-----PD-----GLGGGDVK----LLSLLGFI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------IKII------------------TPIPFGPFISLGAICYVLV------ 160
 161 MVIAMRVPVGE--------SIITPRSYCYYCKYTLKPKELIPIISFCIQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYIIG--IER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFGLL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---ILILLYCMQRIY-----PD-----GLGGGDVK----LFSLLGFI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------IKIR------------------TPIPFGPFISLGAICYVLFT----- 161
 162 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQKIY-----PD-----GLGGGDVK----LLSLLGCI-VGVKGG----------FITLFLASCFSLCFFGI-----GIALKR---------INIR------------------TPIPFGPFISLGAICYVLV------ 162
 163 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQKIY-----PD-----GLGGGDVK----LLSLLGCI-VGVKGG----------FITLFLASCFSLCSFGI-----GIALKR---------INIR------------------TPIPFGPFISLGAI----------- 163
 164 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQKIY-----PD-----GLGGGDVK----LLSLLGCI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------INIR------------------TPIPFGPFISLGAICYVLV------ 164
 165 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGRCTNCKSKISSLYIVFEFVTGSLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQKIY-----PD-----GLGGGDVK----LLSLLGCI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------INIR------------------TPIPFGPFISLGAICYVLV------ 165
 166 MVIAMRVPVGE--------SIITPRSYCHYCKYTLQPKELIPIISFCIQKGCCTNCKSKISSLYIVFEFVTGNLFFLTVYVIG--MER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQKIY-----PD-----GLGGGDVK----LLSLLGCI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------INIR------------------TPIPFGPFISLGAI----------- 166
 167 MVIAMRVPIGE--------SIITPRSYCHYCKYTLQPKELIPIISFCMQKGRCTNCKRKISSLYIVFEFVTGSLFFLTVYVIG--IER----------ELIIILS----LFSLLLIIS-VTDL--------VYML----------------------------IPN--RILIWFALL---LILECIFVPL----------------------------------------------------------------------------------------------------VTWID----SLAGSGT---IFILLYCMQRIH-----PD-----GLGGGDVK----LLSLLGFI-VGVKGV----------FITLFLASCFSLCFFGI-----GIALKR---------IKIR------------------TQMPFGPFISLGAICYMLV------ 167
 168 YTAGCRIPLHL--------SIIAPRSSCPFCRRTLTPAELIPILSFLIQKGKCKSCGHMISFMYPAAELVTACLFAAAGIRFG--TSL----------ELFPALV----FISLLIIVA-VTDL--------HFML----------------------------IPN--RILIFFLPF---LAAARLISPL----------------------------------------------------------------------------------------------------DSWYA----GLLGAAA---GFLFLAVIAAIT-----HG-----GVGGGDIK----LFAVIGFV-LGVKML----------AAAFFFSVLIGALYGAA-----AVLTGR---------LAKR------------------QPLPFAPAIAAGSILAYLYGDSIIS 168
 169 --------------------------------------------------------------------------------------SL----------ELFPAVV----FISLLIIVA-VTDI--------HFML----------------------------IPN--RILIFFLPF---LAAARLISPL----------------------------------------------------------------------------------------------------DSWYA----GLLGAAA---GFLFLAVIAAIT-----HG-----GVGGGDIK----LFAVIGFV-LGVKML----------AAAFFFSVLIGALYGAA-----AVLTGR---------LAKR------------------QPLPFAPAIAAGSILAYLYGDSIIS 169
 170 YTAGCRIPLHI--------SIITPRSACSFCRRTLTPAELIPILSFLFQIGKCKSCGHRISFMYPVAELVTACLFAAAGIRFG--PSP----------ELFPALV----FISLLIIVA-VTDI--------HFML----------------------------IPN--RILIFFVPV---LAAARLISPL----------------------------------------------------------------------------------------------------DSWYA----GLLGAAA---GFLFLALIAAIT-----HG-----GIGGGDIK----LFAVIGFV-LGVKMM----------AAAFFFSVLIGALYGAA-----AVLTGR---------LAKR------------------QPLPFAPAIAAGSILAYLYGDSIIS 170
 171 --------------------------------------------------------------MYPAAELVTACLFAAAEIRFG--SSP----------ELFPAVV----FISLLIIVA-VTDI--------HFML----------------------------IPN--RILIFFLPF---LAAARLISPL----------------------------------------------------------------------------------------------------DSWYV----SLLGAAA---GFLFLTLIAAIT-----HG-----GIGGGDIK----LFAVIGFM-LGVKML----------AAAFFFSVLIGALYGAA-----TVLTGR---------LAKR------------------QPLPFAPAIAAGSILAYLYGDSIIS 171
 172 YTAGCRIPLHI--------SIITPRSACSFCRQALTPAELIPILSFLFQKGKCKSCGQKISFMYPAAELVTACLFAAAGIRFG--LSP----------ELFPAVV----FISLLIIVA-VTDI--------HFML----------------------------IPN--RILIYFLPF---LAAARLISPL----------------------------------------------------------------------------------------------------DSWYA----GLLGAAA---GFLSLALIAAIT-----RG-----GIGGGDIK----LFAVIGFV-LGVKMM----------AAAFFFSVLIGALYGVA-----AVLTGR---------LAKR------------------EPLPFAPAIAAGSMLAYFYGESIIS 172
 173 YAAGCRIPLQI--------SIIKPRSSCSFCRNPLSYTELIPVFSFFLQKGRCKSCSQKLSLMYPAAELWTAGLFTAAYLRFG--LSG----------ELFVALL----LISLLSIIV-ASDI--------HYML----------------------------IPD--SVLMFFLPF---LIAGRMIAPL----------------------------------------------------------------------------------------------------PAWYD----SLSGAAA---GFFMLVLIAVLS-----KG-----GIGGGDIK----LFAVLGIA-LGVKML----------IAAFVLAVFIGMLYGAC-----GTLSGK---------LDRK------------------QPIPFAPAIAAGSLVSYLYGEEILA 173
 174 YTAACRIPLRI--------SVISPRSSCSFCGLPLSWGELVPVVSYVLQKGRCRNCRGKLSIMYPAAECWTACLFTAAGIHFG--FSR----------ELLVALL----FLSLLMIVT-VTDL--------QYML----------------------------IPD--KVLLFFLPL---LIVGRIFSPL----------------------------------------------------------------------------------------------------DSWYA----GFAGAVC---GFFLLIFIMFVS-----KG-----GIGAGDVK----LFGVIGLA-LGVKLV----------LIAFFLSVIIGAVYGMC-----AAAGGR---------LGKK------------------QPFPFAPAIAAGSAVSYLYGEELFS 174
 175 ---------------------------------------------------------------------------------------------------------ILIILLYILLFLVMYIDI--------NKKY----------------------------IPN--VLN--FSILVLSIF------------------------------------------------------------------------------------------------------------ICGIDKVDIFFIGASC---YTLPILIFYGYISDILKKE-----VFGFDDIK----LIIPLGGL-LYLGEINFFLQIYIFYLLVFSLATLYIIIYIVISYCRNKPVKIR------------------------------GVELAFAPYICLAFIIIYN------- 175
 176 ---------------------------------------------------------------------------------------------------------ILIILLYILLFLVMYIDI--------NKKY----------------------------IPN--ILN--FSILVLSIF------------------------------------------------------------------------------------------------------------ICGIDKINSFFIGASC---YTLPILVFYGYISDILKKE-----VFGFGDIK----LIISLGGL-LYLGEINIFLQIYVFYLLVFSLATLYIIIYIVVSYCRNKPVKIR------------------------------GVELAFAPYICLAFIIIYN------- 176
 177 ---------------------------------------------------------------------------------------------------------ILIILLYILLFLVMYIDI--------NKKY----------------------------IPN--ILN--FAILVLSIF------------------------------------------------------------------------------------------------------------IYGIDKVDIFFIGASC---YTLPILIFYGYISDILKKE-----VFGFGDIK----LIISLGGL-LYLGEINIFLQIYIFYLLVFLLATLYIIIYIVISYCRNKPLKIR------------------------------GVELAFAPYICLAFIIIYNF------ 177
 178 ---------------------------------------------------------------------------------------------------------ILIILLYFLLFLVMYIDI--------NKKY----------------------------IPN--ILN--FSILVLSIF------------------------------------------------------------------------------------------------------------ICGIDKIDSFFIGASC---YTLPILIFYGYVSDILKKE-----VFGFGDIK----LIIALGGL-LYQGEINIFLQIYIFYLLVFSLATLYIIIYIVISYCRNKSVKIR------------------------------GVELAFAPYICLAFIIIYN------- 178
 179 ---------------------------------------------------------------------------------------------------------ILIILLYILLFLIMYIDI--------NKKY----------------------------IPN--ILN--FSILVLSIF------------------------------------------------------------------------------------------------------------ICGIDKIDIFFIGASC---YTLPILIFYGYMSDILKKE-----VFGFGDIK----LIIALGGL-LYQGEINIFLQIYIFYLLVFSLATLYIIIYIVISYCRNKSVKIK------------------------------GVELAFAPYICLAFIIIYN------- 179
 180 ------------------------------------------------------------------------ALFGAATIVTLQLKPS----------APAIV------SVAMIGALSALVDA--------RTHK----------------------------LPN--AYT--ATMAI-------------GVTFGALCM------------------------------------------------------------------------------------------VFHSETPLKVILRIAL---SMAIWAVPLWILSRIPG-------GVGFGDVKIAPVLGALLGCV-G-------------------IQAAYGGLIISFV--LAGGAALWRLVVGN----------AG------------TGARIPLGPWLILGAAGGYIGWGAILQ 180
 181 -------------------------------------------------------------------------------LVT-PMNAS----------HPALIYVIAASAVALAGAVH---DA--------RTRR----------------------------IPN--KLT--GPALLAGLLLHFAFDGWRGMGMAAL----------------------------------------------------------------------------------------------------------------AALLAFVVFLVFFLAG-------GMGAGDVK----LMTAVACV-AGNHFV----------IELLVTTAIAGGVMALG--LALARGRFKQTLGNVAMLMSHHRHAGLQPHPELNVRNQQSLRLPYG----LAIAAGCIFTLAS-- 181
 182 ----------------------------------------------------------------------------------------------------------------CTIALC-ATDL--------VNRV----------------------------VPRLWVLLAAFAQSAANLIFSLITFHNVN-----------------------------------------------------------------------------------------------------------FLLRGWL---CAVTVFAIYVLTQKLCVRG-----ALGFGDVTCASMIAQALALF--GFDCI----------IYWFALVGIFGLIWILVWKICSKVCLRF---------------------FRVHLVQNEQNKIPFVPVLAASSIIAVMF------ 182
 183 --------------------------------------------------------------------------------------------------------------LICMIAVC-ATDL--------TSRI----------------------------VPRLWVLLAAFAQSAANLIFSLITFHNVN-----------------------------------------------------------------------------------------------------------FLLRGWL---CAVTVFAIYVLTQKLCVRG-----ALGFGDVTCASMIAQALALF--GFDCI----------IYWFASIGIFGLIWILVWKICSKVCLRF---------------------FRGHLVQNEQNKIPFVPVLAASSIIAVML------ 183
 184 -----------------------------------------------------------------------------------------------------------LLLFPALMAFAAASDL--------FTMT----------------------------ISN--RVSLALVAGFFALALSGGMAPY-------------------------------------------------------------------------------------------------------------EMLGHV----GAGALVLVVAFTCFAMG-------WVGGGDAK----VAASVALW-FGFAPL----------MNFLLYASLFGGALTLL-----LLQFRQ-------------------------------WPLPYG--LAGQAWLA--------- 184
 185 SFLNLCICRIP-----KNESIVYPASHCTSCQNKIKSYDLIPIMSYIILKGKCRYCGEKISINSLIVECLTGVIFLGVYLKY----------------GLTIEFIKYLFLCSFLIIIG-CIDY--------NTTD----------------------------VYF--STT--IIGIIVGIVFILINWYLN---------------------------------------------------------------------------------------------------LPIKT----YFLAAII---AG------MVISLIIVVTG-----GMGWGDVE----ICILSGMY-LGVRLT----------ILMLFLSFIIGAIIGVL-----LIVYKK---------KSRK------------------DYIAFGPSIVIATLITIYAGENIIK 185
 186 SFLNLCICRIP-----KNESIVYPASHCTSCQNKIKPYDLIPIISYIILKGKCRYCEEKISINSPIIECLTGVIFLGVYLKY----------------GLTIEFVKYLFLCSFLIIIG-CIDY--------NTTE----------------------------VYF--STT--SIGIIVGIIFILINWYLN---------------------------------------------------------------------------------------------------LPIKT----YFLGAII---AG------MVISLIIILTD-----GMGWGDVE----ICVLSSIY-LGARLT----------ILMLFLSFIIGAIVGVL-----LIIYKK---------KSRK------------------DYIAFGPSIVIATLTTIYAGENIIK 186
 187 SFLNLCICRIP-----KNESIVYPVSHCTSCQNKIKPYDLIPIISYILLKGRCRYCKEKISIVSPVIELFTGVIFLGLYLKY----------------GLTIEFIKYLFLCSFLIIIG-CIDY--------NTTD----------------------------VYF--NTT--ISGIIVGILFLLINWYLN---------------------------------------------------------------------------------------------------LPIKT----YFLGGII---AG------IAISLIVILTG-----GMGWGDVE----ICVLSGIY-IGAKLT----------ILMLFLSFIIGSIVGII-----LIIYKK---------KSRK------------------DYIAFGPSIVIATLITIYSGESIIK 187
 188 NVVALRLQKEE--------DFIRGHSHCVECQHELSWKDLIPVLSWMWLRGKCRYCGRTISSRYWMVEVMSGCIFMLMIGIWNG--------------REWMGLLDLWLLASLAIFCS-LTDL-------QEQVI----------------------------YPK--GLV------IIGLLHIVIGIS-----------------------------------------------------------------------------------------------------CLLCNIHLESVLVAGA---FYGGIYIVGYL---LWKEE-----VFGLGDCY----YLATVALW-YPVKEI----------VLIGLLSFVAGGGILGL-----LLIVKK----------------------------ERIERVAFVPFIVIAQVLAMILG----- 188



     Active site residue:           X
     Transmembrane domain:          X
     Putative:              +
     Experimental:          #

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