Alignment for family M10A
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
890123456789A012ABCDEFGHIJ3456ABCDEFGHIJKLMNOPQRSTUVWXYZabc78AB9A01AB2AB34A5AB67ABCDEFGH89012345678901234ABC5678ABCDEF90123ABCDEFGH45A6A7ABCDE89012345ABCDEFGHIJKLMNOPQRSTUVWXYZ6AB78A9ABC0ABCDE1AB2A3ABCDE4A5ABC678ABCDEFGHI90ABCD1234567ABCD89ABCD01234ABCDEFGHI5678A90A123A4ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUV567ABCD89ABCDEFGHIJK01ABC23456789012345A678ABC9A0123456ABCD7ABCDEFG8ABCD90AB12ABCD3ABCDEFGHIJKLMNO456ABC7890123456789ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklm0ABCDEFGHIJKLMNOPQR1ABCDEFGHIJKLMNOPQ2A34ABC5678A901ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzABCDEFGHIJKLM23456
+ ## # #
1 RNRRYTLQGTTW-KKN----------ELTW-----------------------------KL--L-NN--N--ND-G-LTR--------GEIETTLHKAFSMWEAV---TNLK------FRQLQ-IN-----EN-KKA-----DIEIKFAQ--------------------------G--YH-D---D--------PYS-----F-D---GFG---------GT----LAHAFYP----HTNEG--LSGD---------VHFD-DA-EKF-TIESPE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------RS---LLWVAVHEIGHSIG-LEH---S-NVKEALM----F-------P----WY--RV----Q-------------DVRNI---QLSDDDVLGIQSI---------------------------------------Y------------------G-----------------SKKSIMLPSTVTPTKNMKNS--------------------------------------------------------------------------------------------------------------------- 1
2 RNRRYTLQGTTW-KKN----------ELTW-----------------------------KL--L-NN--N--ND-G-LTR--------GEIETTLHKAFSMWEAV---TNLK------FRQLQ-IN-----EN-KKA-----DIEIKFAQ--------------------------G--YH-D---D--------PYS-----F-D---GFG---------GT----LAHAFYP----HTNEG--LSGD---------VHFD-DA-EKF-TIESPE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------RS---LLWVAVHEIGHSIG-LEH---S-NVKEALM----F-------P----WY--RV----Q-------------DVRDI---QLSDDDVLGIQSI---------------------------------------Y------------------G-----------------SKKSIMLPSTVTPTKKMKNS--------------------------------------------------------------------------------------------------------------------- 2
3 RNRRYTLQGTTW-KKN----------VFFF-----------------------------CF--L-FI--N--ND-V-YIR--------GEIETTLHKAFSMWEAV---TNLK------FRQLQ-IN-----EN-KKA-----DIEIKFAQ--------------------------G--YH-D---D--------PYS-----F-D---GFG---------GT----LAHAFYP----HTNEG--LSGD---------VHFD-DA-EKF-TIESPE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------RS---LLWVAVHEIGHSIG-LEH---S-NVKEALM----F-------P----WY--RV----Q-------------DVRNI---QLSDDDVLGIQSI---------------------------------------Y------------------G-----------------SKKSIMLPSTVTPTKKMKNS--------------------------------------------------------------------------------------------------------------------- 3
4 RKRRYALQGSAW-KKT----------NLTW-----------------------------KL--L-ND--N--ND-G-LTR--------DQVEDVLIEAFTKWEKV---SSLN------FKKLD-LQ-----SS-EKV-----DIEVKFVQ--------------------------N--YH-Q---D--------PYV-----F-D---GLG---------GT----LAHAFYP----HTNEG--LSGD---------VHFD-DA-EMF-TIGSST-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------RN---LLWVAVHEIGHSIG-LEH---S-NVKDAIM----F-------P----YY--RG----N-------------KGNDF---LLTDDDILGVQTL---------------------------------------Y------------------G-----------------SRKKM------------------------------------------------------------------------------------------------------------------------------------ 4
5 --------------------------NITW-----------------------------KL--I-ND--N--ND-G-LSR--------NQVENVIQKAVSRWEAV---TNLN------FRKIE-IN-----SK-EVA-----DIEVSFGI--------------------------R--YH-R---D--------AYP-----F-D---GPG---------GV----LAHGFYP----STNEG--ISGD---------LHFD-DD-EVF-TIGTSE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------RN---LLWVAVHEIGHCIG-LEH---S-NIRESIM----Y-------P----WY--KG----Y-------------MGEDF---PLTQDDIYGIQTL---------------------------------------Y------------------G-----------------SKK-------------------------------------------------------------------------------------------------------------------------------------- 5
6 RIRRYTPQGSKW-KKL----------DLTW-----------------------------KL--L-ND--N--ND-N-LSR--------SQVEDTLQQAFARWEAV---TNLR------FHKLE-KS-----SD-EYA-----DIDVSFVY--------------------------R--FQ-QQERD--------PTL-----F-Y---GAG---------NV----LAHGYYP----NTNKG--ISGD---------LHFY-DE-TEF-TLGTTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------IN---LLWVAVHEIGHCIG-LEH---S-SVENSIM----Y-------P----QY--KG----Y-------------MGENF---TLSKDDILGIQSI---------------------------------------Y------------------G-----------------SK--------------------------------------------------------------------------------------------------------------------------------------- 6
7 ------------------------------------------------------------------------------------------IDKTIKDAFHKWEAV---SRLK------FTE----R-----SN-GIA-----DIKIKFTR--------------------------S--NH-G------------D-PYP---F-D---GPG---------GT----LAHAFYP-------GTHDLSGD---------IHFD-DD-ELF-TL-NTMEG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KD---LSWVVLHELGHSLG-LEH---S-HEKGAIM----Y-------P----WY-----------------ERHD--GREI---VLHEDDIEGIQFL---------------------------------------Y------------------GKSK------------------------------------------------------------------------------------------------------------------------------------------------------- 7
8 RPKRYVTQGGKW-HKK----------LLTF-----------------------------QI--L-NY------SND-LSK--------NQIDKTIKDAFHKWEAV---SRLK------FTE----R-----SN-GIA-----DIKIKFTR--------------------------S--NH-G------------D-PYP---F-D---GPG---------GT----LAHAFYP-------GTHDLSGD---------IHFD-DD-ELF-TL-NTMEG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KD---LSWVVLHELGHSLG-LEH---S-HEKGAIM----Y-------P----WY-----------------ERHD--GREI---VLHEDDIEGIQFL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 8
9 RKRKYLLQGTKW-FKQ----------NLTW-----------------------------AV--E-ND------NNDGISR--------TDVRNIMRRSFEKWAAV---TNLK------FIELE-KR-----PV-NSA-----DIRVSFEI--------------------------K--KH-G------------D-PYA---F-D---GEG---------GT----LAHAFYP------LENTGLAGD---------CHFD-DD-EVF-TI-AANPSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQ-----------KS---LLWVAVHELGHSIG-LEH---S-DVRGAIM----Y-------P----WY-----------------TGFK--GQDF---DLTFDDISGIQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 9
10 ---------------S----------NITW-----------------------------KL--L-ND--N--ND-G-LSR--------KEVETLLEKAFQKWEAI---ADLT------FNKLS-FT-----SK-EQA-----DIDIKFVQ--------------------------G--DH-G---D--------AFS-----F-R---LFR---------YD----LAHAFYP----LNNQG--ISGD---------VHFN-DI-FNF-NVKEKN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------VN---LFWAAIHEIGHSLG-LHH---S-SFQGSLM----Y-------P----TY--LG----N-------------KEQNI---QLHEDDILGIQSM---------------------------------------Y------------------G-----------------SKRKPILPSKKT----------------------------------------------------------------------------------------------------------------------------- 10
11 LNYSFFPNTYPS-DGS----------I---------------------------------------------------SR--------TDIEKGITAAMCLWEMN---SNVR------FTGNL-GP-----GV-SSA-----DVTISFGR--------------------------R--DH-G---D--------PYP-----F-D---GKG---------KT----LAHAFYP----E-------SGK---------LHFD-LD-EPW-FLSMNNNNQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-----------KD---IFTVAAHELGHTLG-LAH---S-EVRGSLM----A-------P----YYLFTT------------------SFENY---LLPRDDTLGIQSM---------------------------------------Y------------------GR--------------------------------------------------------------------------------------------------------------------------------------------------------- 11
12 ----------------------------------------------------------------------------------------------ITAAMCLWEMN---SNVR------FTGNL-GP-----GV-SSA-----DVTISFGR--------------------------R--DH-G---D--------PYP-----F-D---GKG---------KT----LAHAFYP----E-------SGK---------LHFD-LD-EPW-FLSMNNNNQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RK-----------KD---IFTVAAHELGHTLG-LAH---S-EVRGSLM----A-------P----YYLFTT------------------SFENY---LLPRDDTLGIQSM---------------------------------------Y------------------GRRIGSVALNDRNSACYQLRSLYGAETAGSTQTNRPVPPPTTTTATTTT---------------------------------------------------------------------------------------------------------- 12
13 RGKRYAIGPSKW-ENK----------QLSF-----------------------------RI--L-SY-----SPDLPAAD--------QR--DALIRAFRVWMDV---TQLS------FHE---EQQGS-------A-----DIMVTFGR--------------------------H--YH-G---D--------PYP-----F-D---GPG---------MV----LAHAFFP----GEER----GGD---------VHFD-ED-EQW---TVHSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------VN---LFAVAAHEIGHSLG-LKH---S-NVPGSLM----Y-------P----WYQG--------------------YTPDF---HLHTDDIAGIQYL---------------------------------------Y------------------GYKEVPYDPYSP----------------------------------------------------------------------------------------------------------------------------------------------- 13
14 RKKRYVLAPSKW-NHK----------DLTY-----------------------------RI--E-NY--T--PD-L--PW--------QEVRRVLADAFKVWSDV---TDLT------FTEVM--------HT-S-A-----DIMIKFAS--------------------------K--YH-K---D-----G--Y-P-----F-D---GKG---------LI----LAHAFFP----GK----DKGGD---------THFD-ED-EKW-TINSNE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------VD---LFMVAAHEFGHALG-LSH---S-NEPKALM----Y-------P----WY--QG----Y-------------IP-NF---QLPYDDTVGIQVI---------------------------------------Y------------------G-----------------GKGPYATLPPRERTTP------------------------------------------------------------------------------------------------------------------------- 14
15 RKKRYALVGYYW-QKK----------NLTY-----------------------------RI--V-RT--T--PQ-L--SP--------YVVHDAIRRAFNVWSDV---TPLT------FTEMF--------HG-E-A-----DIMIDFLW--------------------------G--FH-G---D--------GNP-----F-D---GPG---------NT----LAHAFFP----GP----RRGGD---------THFD-EE-EKW-TMTK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------AN---LFQVATHEFGHALG-LGH---S-SEHNTIM----G-------P----FY--------R-------------YRDPL---QLTEDDIRGIQQL---------------------------------------Y------------------G-----------------APEEKARPKQPLTPV-------------------------------------------------------------------------------------------------------------------------- 15
16 -------GNYRW-NKE----------TLTY-----------------------------RI--V-NFPTMRKASSV--SE--------VQVRHDVRMAFKLWSDV---TPLV------FIEVH-DDTVEV------------DIELKFGSRV------------------------HTSVY-G---D----------PA----F-D---GEG---------GT----LAHAFTPNSGWG-----KTNGD---------VHFD-DD-EHF-THKIY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------VN---LFYTTAHEIGHALG-LDH---S-DQRNSLM----W-------PWDKGYI------------------------PNF---RLPLDDKLGIQVV---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 16
17 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-G---D----------PA----F-D---GEG---------GT----LAHAFTPNSGWG-----KTNGD---------VHFD-DD-EHF-THKIY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------VN---LFYTTAHEIGHALG-LDH---S-DQRNSLM----W-------PWDKGYI------------------------PNF---RLPLDDKLGIQVV---------------------------------------Y------------------GGNTKNKTTSASSSNSAAPIQDQDGQELLEDGPTPQVQTYTNWPTISNNHYSEGKNPFQVSTDPPPTTPGTTTQPPILIPPYCNTTLDAVADIRGNL---------------------------------------------------------- 17
18 -----------W-GRT----------TITF-----------------------------TF--D-NY--T--PD-L--PM--------NQVRREVLRGLKVWSDV---TPLK------FQELR-YG-----MG-E-P-----DIHIQFAA--------------------------QE--H-N---D-----E--Y-P-----F-D---GQG---------GT----LAHAFYP----G-P---GLGGD---------AHFD-ED-EQF-TA--GTS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TN---LFFVAAHELGHSLG-LGH---S-DVSGSLM----A-------P----YY--Q-----G-------------FQPNF---RLHEDDMMAIQEI---------------------------------------Y------------------G---------------------------------------------PNPNPPVP----------------------------------------------------------------------------------------------------- 18
19 ----------KW-ETH----------SLTF-----------------------------RILNSANRLRG------------------PESDDAIRRAFKVWEEV---TPLK------FTEV---------QGNGRA-----DIYLTFGS--------------------------G--DH-G---D--------QFP-----F-D---GPG---------FT----LAHAFPPQSGWGE-----MDGD---------VHFD-DA-ETY-TVSSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------TN---LFQVAAHEIGHSLG-LGH---S-TDSRALM----A-------P----FY--------------------AGYIPDF---QLPYDDQQGIQRL---------------------------------------Y------------------GSKRPSVGTTTKKPPQPGPNPKPEPGPNPGPTTHAPDTRCKK----------------------------------------------------------------------------------------------------------------- 19
20 RMRRFAHTGGKW-ETH----------SLTF-----------------------------RILNSANRLRG------------------SESDDAIRRAFKVWEEV---TPLK------FTEV---------QGNGRA-----DIYLTFGS--------------------------G--DH-G---D--------QFP-----F-D---GPG---------FT----LAHAFPPQSGWGE-----MDGD---------VHFD-DA-ETY-TVSSY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------TN---LFQVAAHEIGHSLG-LGH---S-TDSRALM----A-------P----FY--------------------AGYIPDF---QLPYDDQQGIQRL---------------------------------------Y------------------GSKRPSVGTTTKKPPQPGPNPK------------------------------------------------------------------------------------------------------------------------------------- 20
21 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 21
22 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 22
23 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 23
24 RRKRYALTGQKW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSDLENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKIPPPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 24
25 RRKRYALTGQKW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKIPPPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 25
26 ------------------------------------------------------------------------------------------------------------------------------ELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 26
27 RRKRYALTGQKW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKIPPPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 27
28 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------AETRKAIRRAFDVWQNV---TPLT------FEEVP-YIELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKISPPTKPLPTVP------------------------------------------------------------------------------------------------------------------------- 28
29 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------AETRKAIRRAFDVWQNV---TPLT------FEEVP-YIELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKISPPTKPLPTVP------------------------------------------------------------------------------------------------------------------------- 29
30 ----------KW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRKAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPSDDLQGIQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 30
31 RRKRYALTGQKW-QHK----------HIAY-----------------------------SI--K-NV--T--PK-V--GD--------AETRKAIRRAFDVWQNV---TPLT------FEEVP-YIELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDRIPPPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 31
32 RRKRYALTGQKW-QHK----------HITY-----------------------------SI--K-NV--T--PK-V--GD--------PETRRAIRRAFDVWQNV---TPLT------FEEVP-YSELENGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------RSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------ETDNF---KLPNDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKIPPPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 32
33 ----------KW-LHR----------HITY-----------------------------SI--K-NF--T--PK-V--GA--------EETHNAIRRAFDVWQNV---TPLR------FEAVP-YSELERSKK--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPTAIM----A-------P----FY--QY----M-------------DTENF---RLPHDDLQGIQKI---------------------------------------Y------------------G-----------------PPDKLPQPTRP------------------------------------------------------------------------------------------------------------------------------ 33
34 ----------KW-QRE----------HISY-----------------------------SI--K-NV--T--PK-V--GN--------QETHDAIRRAFDVWQGV---TPLR------FEAVP-FRDLDSGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHDGERT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------ND---LFLVAVHELGHALG-LEH---S-SDPTAIM----A-------P----FY--QY----M-------------DTESF---KLPHDDLQGIQKI---------------------------------------Y------------------G-----------------PPNKNPQP--------------------------------------------------------------------------------------------------------------------------------- 34
35 RKKRYALTGQKW-QRE----------HISY-----------------------------SI--K-NV--T--PK-V--GN--------QETHDAIRRAFDVWQGV---TPLR------FEAVP-FRDLDSGKR--DV-----DITIIFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNPNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-SDPTAIM----A-------P----FY--QY----M-------------DTESF---KLPHDDLQGIQKI---------------------------------------Y------------------G-----------------PPNKNPQPTRLLTT--------------------------------------------------------------------------------------------------------------------------- 35
36 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 36
37 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 37
38 RHKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTL-------------------------------------------------------------------------------------------------------------------------- 38
39 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 39
40 RNKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPG------------------------------------------------------------------------------------------ 40
41 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 41
42 RNKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTL-------------------------------------------------------------------------------------------------------------------------- 42
43 RNKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTL-------------------------------------------------------------------------------------------------------------------------- 43
44 RNKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTL-------------------------------------------------------------------------------------------------------------------------- 44
45 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-SDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 45
46 ----------KW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-SDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 46
47 RNKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-SDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRPLPTL-------------------------------------------------------------------------------------------------------------------------- 47
48 ----------KW-RQK----------HITY-----------------------------SV--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQRV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNSNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G-----------------PPAEPLEPTRP------------------------------------------------------------------------------------------------------------------------------ 48
49 RKKRYALTGQKW-RQK----------HITY-----------------------------SV--H-NY--T--PK-V--GE--------LDTRRAIRQAFDVWQRV---TPLT------FEEVP-YHEIKNDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNSNHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 49
50 RHKRYALTGQKW-RQK----------HITY-----------------------------SI--H-NY--T--PK-V--GE--------LDTRKAIRQAFDVWQKV---TPLT------FEEVP-YHEIKSDRK--EA-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGIG----GD---------THFD-SD-EPW-TLGNANHD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPQDDLQGIQKI---------------------------------------Y------------------GVWRIHSPSERKHERQPRPPRPPLGDRPATPGA-------------------------------------------------------------------------------------------------------------------------- 50
51 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ND---LFLVAVHELGHALG-LEH---S-SDPSAIM----A-------P----FY--QY----M-------------ETHNF---KLPLDDLQGIQKI---------------------------------------Y------------------A---------------------MLEPTRPLPTF-------------------------------------------------------------------------------------------------------------------------- 51
52 ----------KW-DKT----------HITF-----------------------------SI--Q-NY--T--PK-I--GE--------YNSYEAIRRAFRVWEKV---TPLT------FDEIP-FHEVKYGRR-KEP-----DIMIFFAS--------------------------G--FH-G---D--------SSP-----F-D---GEG---------GF----LAHAYFP----GPGMG----GD---------THFD-SD-EPW-TIGSQNLQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LEH---S-NNPLAIM----A-------P----FY--QW----M-------------DTENF---ELPEDDLRGVQQI---------------------------------------Y------------------G-----------------PPSS--SPTQALPTVTPR----------------------------------------------------------------------------------------------------------------------- 52
53 RRKRYAIQGLKW-QHN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------YATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SESGSPTKMPPQPRTTS----------------------------------------------------------------------------------------------------------------------------- 53
54 RRKRYAIQGLKW-QHN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------YATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SESGSPTKMPPQPRTTS----------------------------------------------------------------------------------------------------------------------------- 54
55 RRKRYAIQGLKW-QHN----------EITF-----------------------------CI--Q-NY--T--PN-V--GE--------YATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SKSGSPTKMPPQPRTTS----------------------------------------------------------------------------------------------------------------------------- 55
56 ----------KW-QHN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------HATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SESGFPTKMPPQ---------------------------------------------------------------------------------------------------------------------------------- 56
57 RRKRYAIQGLKW-QHN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------YATYEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-SDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------GESGFPTKMPPQPRTTS----------------------------------------------------------------------------------------------------------------------------- 57
58 RRKRYAIQGLKW-QHN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------YATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMILFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVQNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----S-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SKSGSPTKMPPQPRTTS----------------------------------------------------------------------------------------------------------------------------- 58
59 ----------------------------TM-----------------------------NI--Q-NY--T--PK-V--GE--------YATFEAIRKAFRVWESA---TPLR------FREVP-YAYIREGHE-KQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPNIG----GD---------THFD-SA-EPW-TVRNEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPDDDRRGIQQL---------------------------------------Y------------------G------------SESGSPTKMPPQ---------------------------------------------------------------------------------------------------------------------------------- 59
60 ----------KW-SHY----------DLTF-----------------------------CI--Q-NY--T--PK-V--GE--------HATFSAIRRAFNVWQSV---TPLR------FREVS-YSLVREGHE-PQA-----DIMIFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GPHIG----GD---------THFD-AA-EPW-TSRNDDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---IFLVAVHELGHALG-LEH---S-NDPSAIM----A-------P----FY--QW----M-------------DTENF---ELPEDDRRGIQQL---------------------------------------Y------------------G------------SEMGHPSKPPPVPR-------------------------------------------------------------------------------------------------------------------------------- 60
61 RKKRYVAQGSKW-DKR----------EVTF-----------------------------SI--Q-NY--T--PK-V--GE--------RATHEAIKKAFRVWEAV---TPLK------FREIP-YSQINGKVE-KFA-----DIMLFFAE--------------------------G--FH-G---D--------STP-----F-D---GEG---------GF----LAHAYFP----GHGIG----GD---------THFD-EA-EPW-TTGNVDKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---VFLVAVHELGHALG-LEH---S-GDPSAIM----A-------P----FY--QW----M-------------DTENF---VLPEDDRRGIQQI---------------------------------------Y------------------G------------AGSEDKPQ-PPAPRPPT----------------------------------------------------------------------------------------------------------------------------- 61
62 ----------KW-DKN----------EITF-----------------------------CI--Q-NY--T--PK-V--GE--------YETFEAIRKAFKVWESV---TPLR------FREIS-YSDIRDKVV-DFA-----DIMLFFAD--------------------------G--FH-G---D--------ASP-----F-D---GEG---------GF----LAHAYFP----GNGIG----GD---------THFD-AA-EPW-TIGNKDLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---VFLVAVHELGHALG-MEH---S-NDPSAIM----A-------P----FY--QW----M-------------ETDHF---VLPDDDRKGIQKL---------------------------------------Y------------------G------------PGSGGHPRTPVTPETP------------------------------------------------------------------------------------------------------------------------------ 62
63 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFD-AA-EPW-TIGNKDLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---VFLVAVHELGHALG-MEH---S-NDPSAIM----A-------P----FY--QW----M-------------ETDHF---VLPDDDRKGIQKL---------------------------------------Y--------------------------------GSGGHPRTPVTPETPHH---------------------------------------------------------------------------------------------------------------------------- 63
64 ----------KW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDTF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTRP------------------------------------------------------------------------------------------------------------------------------ 64
65 RRKRYALTGRKW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDTF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTRPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPAQPRA----------------------------------------------------------------------------------- 65
66 RRKRYALTGRKW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDTF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTRPLP---------------------------------------------------------------------------------------------------------------------------- 66
67 RRKRYALTGRKW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDTF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 67
68 ----------KW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DIDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTQP------------------------------------------------------------------------------------------------------------------------------ 68
69 RRKRYALTGRKW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DIDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTQPLPTV-------------------------------------------------------------------------------------------------------------------------- 69
70 ----------KW-SSH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFQVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQP--------------------------------------------------------------------------------------------------------------------------------- 70
71 ----------KW-SSH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFQVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPD-------------------------------------------------------------------------------------------------------------------------------------- 71
72 RRRRYALTGRKW-SSH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSLEAVRRAFQVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTRLLPTV-------------------------------------------------------------------------------------------------------------------------- 72
73 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NN---LFLVAVHELGHALG-LEH---S-SNPNAIM----A-------P----FY--QW----K-------------DVDNF---KLPEDDLRGIQQL---------------------------------------Y------------------G-----------------A---------------------------------------------------------------------------------------------------------------------------------------- 73
74 RRKRYALTGRKW-NNH----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YHSMEAVRRAFRVWEQA---TPLV------FQEVP-YEDIRLRRQ-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GTG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NN---LFLVAVHELGHALG-LEH---S-SNPNAIM----A-------P----FY--QW----K-------------DVDNF---KLPEDDLRGIQQL---------------------------------------Y------------------G-----------------TPDGQPQPTQPLPTV-------------------------------------------------------------------------------------------------------------------------- 74
75 RRKRYTLTGKAW-NNY----------HLTF-----------------------------SI--Q-NY--T--EK-L--GW--------YNSMEAVRRAFQVWEQV---TPLV------FQEVS-YDDIRLRRR-AEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GVG---------GF----LAHAYFP----GPGLG----GD---------THFD-AD-EPW-TFSSTDLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------IS---LFLVAVHELGHALG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTDNF---QLPEDDLRGIQQL---------------------------------------Y------------------G-----------------SPDGKPQPTRPLPTV-------------------------------------------------------------------------------------------------------------------------- 75
76 ----------RW-SQS----------HLTF-----------------------------SI--Q-NY--T--EK-L--GR--------YHSYEAIRQAFRVWERA---TPLA------FQEVP-YEDIRQKRK-KEA-----DIMVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GVG---------GF----LAHAYFP----GPGMG----GD---------THFD-SD-EPW-TLENTDVS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NN---LFLVAVHELGHSLG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTENF---QLPEDDLKGIQQL---------------------------------------Y------------------G-----------------TADGHPQPTKPLPTVTPR----------------------------------------------------------------------------------------------------------------------- 76
77 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FD-SD-EPW-TLENTDVS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NN---LFLVAVHELGHSLG-LEH---S-SNPSAIM----A-------P----FY--QW----M-------------DTENF---QLPEDDLKGIQQL---------------------------------------Y------------------G-----------------TADGHPQPTKPLPTV-------------------------------------------------------------------------------------------------------------------------- 77
78 ----------RW-TQS----------QLTF-----------------------------SI--Q-NH--T--EK-L--GR--------SASQEAIRRAFRVWEEA---TPLS------FREVS-FSGT-------EA-----DLVVLFAS--------------------------G--FH-G---D--------SSP-----F-D---GAG---------GF----LAHAFFP----GPGMG----GD---------AHFD-LD-EPW-TLENVDGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------NN---LFLVAVHELGHSLG-LEH---S-SHPSAIM----A-------P----FY--QW----M-------------DTQAF---RLPDDDLRGIQQL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 78
79 RRKRFALTGHKW-NQN----------NLTY-----------------------------SI--Q-NH--S--PK-V--GQ--------QQTYEAIRKAFRVWEKV---TPLQ------FEEVP-YHKIKNGSE--GP-----DIILLFAS--------------------------G--YH-G---D--------MSL-----F-D---GEG---------GS----LAHAFFP----GPGMG----GD---------THFD-TD-EPW-TLNQQEGS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------VD---LFLVAVHELGHALG-LEH---S-NNPSAIM----A-------P----FY--QW----M-------------DTESF---ALADDDINGIHQI---------------------------------------Y------------------G-----------------SPETVTTQAAPT----------------------------------------------------------------------------------------------------------------------------- 79
80 -----VTVGSPW-QKN----------LITY-----------------------------SI--N-NF--T--PK-L--GQ--------KLTHEAIDDAFRVWGSF---VPLQ------FKKVD-ASQ--------NP-----DIVTFFAE--------------------------G--FH-N---D--------NTN-----F-D---GVG---------GY----LAHAFYP----GSGIG----GD---------THFD-GA-EPW-TLHQGPNR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LQH---S-PDVKAIM----A-------P----VY--KY----H-------------DTENF---QLPQDDILGIQSL---------------------------------------Y------------------G----------------ARYSGTERPIVPTTSK-------------------------------------------------------------------------------------------------------------------------- 80
81 RKKRYVTVGSPW-QKN----------LITY-----------------------------SI--N-NF--T--PK-L--GQ--------KLTHEAIDDAFRVWGSF---VPLQ------FKKVD-ASQ--------NP-----DIVTFFAE--------------------------G--FH-N---D--------NTN-----F-D---GVG---------GY----LAHAFYP----GSGIG----GD---------THFD-GA-EPW-TLHQGPNR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LQH---S-PDVKAIM----A-------P----VY--KY----H-------------DTENF---QLPQDDILGIQSL---------------------------------------Y---------------------------------------GEPQPIVPTTSKPT------------------------------------------------------------------------------------------------------------------------ 81
82 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ND---LFLVAVHELGHALG-LQH---S-PDVKAIM----A-------P----VY--KY----H-------------DTENF---QLPQDDILGIQSL---------------------------------------Y------------------G----------------EPQKPTRRP--------------------------------------------------------------------------------------------------------------------------------- 82
83 RRRRYALLGSKW-TIR----------DITY-----------------------------RV--T-GY--T--QK-L--SQ--------TDIDNDIKIAFDMWSEN---ANLK------FSQVP--------SD-TDA-----HITMFFAP--------------------------G--DH-G---D--------RDP-----F-D---GPA---------GT----LAHALPP----------IAGGE---------THFD-DD-ETW-TVRTFSGDSFSVMFIQMSKLSYLCKD----------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------IN---LLQVAAHEFGHALG-LGH---S-DVEEALM----A-------P----FY--RG------------------YKENF---QLHDDDIQGIQIL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 83
84 ----------KW-DHT----------DLTY-----------------------------NF--K-NF--S--PD-L--KE--------GEQKDAIAKALDLWAQV---TPLT------FTLVA--------PD-DEA-----DIVIQFLS--------------------------G--DH-G---D-----G--S-P-----F-D---GNG---------GT----LGHAFFP-------GD-GIGGD---------THFD-EA-EVF-NI--V------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPG-EFTTA-----------VD---MMTVAAHEFGHALG-LGH---S-NIQDALM----A-------P----FY--R-------------------YSSEL---QLHVDDISGIQKL---------------------------------------Y------------------G-----------------VPSTVAPTPDEMTTEAQNATTQGQETTTQGEQLTTAFVDDTTLGDTTTTVSTPRRPETTTTLATTPAPTASTTPEPTTTAAPEPTTTTNAPEPPTTKAPEPPTTTAAEPTTTKAPEATTTTTAEPTTTQPATTTAGP 84
85 ----------------------------------------------------------------------------------------------MAKAAKLWSDV---TPLT------ISQV---D-----AT-TPA-----DIDVYFAE--------------------------G--NH-G------------D-GFN---F-D---GIG---------GT----LAHGFYPPPAWEDQNVPTLAGD---------IHFD-LT-EMF-VA-NSNRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---ILQTAVHELGHSLG-LMH---S-HNKNAVM----A-------P----VY-----------------RRYN---PDL---QLHQDDVDGIQLL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 85
86 --YLIGDEKMKW-TKK----------QLTW-----------------------------QI--Q-SY-----PSHS-LSR--------VRAHAVFQHTFNLWSRV---VNLD------FMEEKDYYKP--------A-----DIVIQFGA--------------------------G--KH-G---D--------SIP-----F-D---GAG---------GV----LAHAYYP----TPDNVYSFSGD---------AHFD-DD-EIWNDGPHKTH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RN---LISVAAHELGHSLG-LGH---S-SVPTAIM----Y-------P----YYTR--------------------TWEKV---KLDPDDIAGIQQI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 86
87 ----------KW-TKK----------QLTW-----------------------------QI--Q-SY-----PSHS-LSR--------VRAHAVFQHTFNLWSRV---VNLD------FMEEKDYYKP--------A-----DIVIQFGA--------------------------G--KH-G---D--------SIP-----F-D---GAG---------GV----LAHAYYP----TPDNVYSFSGD---------AHFD-DD-EIWNDGPHKTH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RN---LISVAAHELGHSLG-LGH---S-SVPTAIM----Y-------P----YYTR--------------------TWEKV---KLDPDDIAGIQQI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 87
88 -EYSLFPDSPKW-TSN----------VVTY-----------------------------RV--V-SH--P--RE-L--SL--------VIVNQLVAKALKMWSEE---IPLH------FKRVS--------WG-T-A-----DIMIGFAR--------------------------G--AH-G---D-----P--Y-P-----F-D---GPG---------NT----LAHAFSP----GP----GLGGD---------AHFD-ED-ERW-TD--GSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-----------IN---FLFAATHEFGHSLG-LGH---S-SDPSAVM----Y-------P----TY--RD----G-------------DPKNF---KLSRDDIKGIQKL---------------------------------------Y------------------G-----------------ERSDSR----------------------------------------------------------------------------------------------------------------------------------- 88
89 -EYSLFPNSPKW-TSK----------VVTY-----------------------------RI--V-SY--T--RD-L--PH--------ITVDRLVSKALNMWGKE---IPLH------FRKVV--------WG-T-A-----DIMIGFAR--------------------------G--AH-G---D-----S--Y-P-----F-D---GPG---------NT----LAHAFAP----GT----GLGGD---------AHFD-ED-ERW-TD--GSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------IN---FLYAATHELGHSLG-MGH---S-SDPNAVM----Y-------P----TY--GN----G-------------DPQNF---KLSQDDIKGIQKL---------------------------------------Y------------------G-----------------KRSNSRKK--------------------------------------------------------------------------------------------------------------------------------- 89
90 AEFSLFPNHPKW-TSK----------VVTY-----------------------------RI--M-SY--T--SD-L--PH--------ITVNQLVAKAFKIWSEA---IPLT------FKRLR--------WG-T-A-----DIMIGFAR--------------------------R--AH-G---D-----P--Y-P-----F-D---GPG---------AT----LAHAFAP----GP----GLGGD---------AHFD-ED-ERW-TD--GIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-----------VN---FLYVATHELGHSLG-LSH---S-SDPNAVM----Y-------P----TY--SK----E-------------DSKNF---KLSQDDINGIQLL---------------------------------------Y------------------G-----------------KRND------------------------------------------------------------------------------------------------------------------------------------- 90
91 AEFSLFPNHPKW-TSK----------VVTY-----------------------------RI--M-SY--T--SD-L--PH--------ITVNQLVAKAFKIWSEA---IPLT------FKRLR--------WG-T-A-----DIMIGFAR--------------------------R--AH-G---D-----P--Y-P-----F-D---GPG---------AT----LAHAFAP----GP----GLGGD---------AHFD-ED-ERW-TD--GIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-----------VN---FLYVATHELGHSLG-LSH---S-SDPNAVM----Y-------P----TY--SK----E-------------DSKNF---KLSQDDINGIQLL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 91
92 AHFSLFPNRPKW-TSE----------VITY-----------------------------RI--A-SY--T--PD-L--PR--------FRVNQLVAKALAMWSKE---IPLS------FRRVP--------RG-T-A-----DIMIGFAR--------------------------G--AH-G---D-----Y--Y-P-----F-D---GPG---------NI----LAHAFAP----GP----DLGGD---------AHFD-ED-ERW-TD--GSR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-----------IN---FLIAATHELGHSLG-LGH---S-SDPDAVM----Y-------P----TY--SI----R-------------DSKSF---KLSQDDIEGIQKL---------------------------------------Y------------------V-----------------LQDNPQQ---------------------------------------------------------------------------------------------------------------------------------- 92
93 AHFSLFPNRPKW-TSE----------VITY-----------------------------RI--A-SY--T--PD-L--PR--------FRVNQLVAKALAMWSKE---IPLS------FRRVP--------RG-T-A-----DIMIGFAR--------------------------G--AH-G---D-----Y--Y-P-----F-D---GPG---------NI----LAHAFAP----GP----DLGGD---------AHFD-ED-ERW-TD--GSR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-----------IN---FLIAATHELGHSLG-LGH---S-SDPDAVM----Y-------P----TY--SI----R-------------DSKSF---KLSQDDIEGIQKL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 93
94 GEDLPSRNRPKW-ISK----------VVTY-----------------------------RI--I-SY--T--RD-L--PR--------VTVDHLVAKALNMWSKE---IPLS------FRRVV--------LG-I-P-----DIVIGFAR--------------------------G--AH-G---D-----F--Y-P-----F-D---GPG---------GT----LAHAYEP----GP----GLGGD---------AHFD-ED-ERW-AD--GRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------IN---FLAVATHELGHSLG-LRH---S-SDPDSVM----Y-------P----TY--GA----R-------------DSENF---KLSPGDIREIQEL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 94
95 -----SRNRPKW-ISK----------VVTY-----------------------------RI--I-SY--T--RD-L--PR--------VTVDHLVAKALNMWSKE---IPLS------FRRVV--------LG-I-P-----DIVIGFAR--------------------------G--AH-G---D-----F--Y-P-----F-D---GPG---------GT----LAHAYEP----GP----GLGGD---------AHFD-ED-ERW-AD--GRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------IN---FLAVATHELGHSLG-LRH---S-SDPDSVM----Y-------P----TY--GA----R-------------DSENF---KLSPGDIREIQEL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 95
96 AEYSLMPNSPKW-HSR----------IVTY-----------------------------RI--V-SY--T--SD-L--PR--------IVVDQIVKKALRMWSMQ---IPLN------FKRVS--------WG-T-A-----DIIIGFAR--------------------------R--DH-G---D-----S--F-P-----F-D---GPG---------NT----LGHAFAP----GP----GLGGD---------AHFD-KD-EYW-TD--GED-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------VN---FLFAATHEFGHSLG-LSH---S-SVPGTVM----Y-------P----TY--QR----D-------------YSEDF---SLTKDDIAGIQKL---------------------------------------Y------------------G-----------------KRNTL------------------------------------------------------------------------------------------------------------------------------------ 96
97 ----------RW-KKN----------IITY-----------------------------GV--G-RY-----TNDL--PV--------NAVDDLISSALDVWAKA---SPLT------FLRSYS----------HQA-----DIMVEFVG--------------------------K--EH-G---D--------FFP-----F-D---GPD---------GT----LAHAFGP--------GEGIGGD---------VHFD-EA-EVW-T-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------YNGFNLYVVAAHEFGHALG-LKH---S-QLPESVM----Y-------P----TYKRR-------------------KTHNL----LSSEDIININTL---------------------------------------Y------------------GPRDKRPYPS------------------------------------------------------------------------------------------------------------------------------------------------- 97
98 ----------RW-KKN----------DLTY-----------------------------RI--W-NY--T--PD-L--SP--------SQVREAIRRGFQVWSDV---TPLR------FRET---T-----SS-N-A-----DINIQFSR--------------------------FD--H-R---D-----G--Y-P-----F-D---GRG---------GT----LAHAFYP----E-------DGR---------THFD-DD-EQW-TD--GMY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------TN---LFIVTAHEIGHALG-LAH---S-SYPGALM----A-------P----FY--Q-----G-------------YDPDF---KLPVDDTRGIQQL---------------------------------------Y------------------G-----------------MPDVSRPQPPVRPDPPRPEPPVRPEPPRPNPPKPKPEVPDTCSSDFGAISMDGL-----------------TYAFKDKYMWRINDYGVERGYPKPTRDLWPKLPRGIQAAAYSRWSSRMYFFK-------------- 98
99 NYQTFYGSP-RW-NKK----------YLTY-----------------------------KI--V-NY--T--PD-L--PR--------EYVDDAIRRALMVWSNV---TPLR------FKRVT--------SG-Q-A-----DIMIKFAR--------------------------R--AH-G---D-----G--Y-P-----F-D---GRG---------GT----LAHAFQP----GE----GLGGD---------AHFD-DD-ERW-S--KYN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------VN---LFLVAAHEFGHSLG-LAH---S-NVRGALM----Y-------P----LY--SY----V-------------NPETF---TLHWDDRRGIQKL---------------------------------------Y------------------G-----------------R---------------------------------------------------------------------------------------------------------------------------------------- 99
100 -----------W-NKH----------NLTY-----------------------------RI--K-NY--T--AD-L--PQ--------AEVDNAVEQALKLWSDV---TPLT------FRRVK--------TK---A-----DIEISFEQ--------------------------H--DH-G---D-----D--A-P-----L-D---GPG---------GT----LAHAFFP----GR----GIGGD---------LHFD-DS-ETW-TVRSFKG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFIVAAHEFGHSLG-LDH---S-KVKGSLM----Y-------P----WY--Q-----G-------------YTPDF---KLHRDDVERIQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 100
101 ----------KW-NKR----------KLTY-----------------------------RI--K-NY--T--PD-L--PE--------EEVDDAVRRGLQVWSNV---TPLV------FEKTS--------AY---S-----DIEMSFEK--------------------------Y--GH-G---D-----E--D-P-----L-D---GPG---------GT----LAHAFFP----GP----GIGGD---------VHFD-DS-ETW-TVRSFRGGLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFIVAAHELGHSLG-LDH---S-DVRGSLM----F-------P----IY--Q-----G-------------YTPNF---KLHKDDIKRIQNL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 101
102 SEYTTFEGSPKW-KKN----------SLTY-----------------------------RI--I-NT--T--SD-L--PQ--------DKVESILAEAIKVWSDV---TPLK------FTKTT-----------DTA-----DIDIYFAR--------------------------D--EH-G---D--------NYP-----F-D---GVG---------GT----LAHAFAP----GK----GLAGD---------AHFD-DD-EYW-TEDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TS---LFIVAAHEFGHSLG-LGH---S-KSHGALM----Y-------P----TY--------S-----------YKKQKNY---KLPTDDVKGIQKL---------------------------------------Y------------------------------------VKSDEKIS--------------------------------------------------------------------------------------------------------------------------------- 102
103 ----------RW-RKH----------DITY-----------------------------RI--L-NH--T--PD-L--PR--------ADVERELKKALDTWSEY---TPLR------FRRLT--------GS-TRS-----DIEISFAA--------------------------F--GH-G---D-----G--N-S-----F-D---GAG---------GT----LAHAYGP----GNG----IGGD---------SHFD-ES-ETW-TI--N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGS-SRPRG-----------ID---LHQVAAHEFGHALG-LGH---S-QVNTALM----A-------P----FY--R-------------------YQADF---RLHGDDIRGIQRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 103
104 -----TQLGSRW-QKN----------DLTY-----------------------------RI--N-NF--T--PD-L--PR--------DQVVDAIARAFDVWAQV---TPLT------FRRVS--------GP---A-----DIEIRFAA--------------------------G--SH-G---D-----G--N-S-----F-D---SRG---------GV----LAHAYQP----GGG----IGGD---------AHFD-ES-EIW-QI--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPNIASLSG-----------TD---LFSVAAHEFGHSLG-LGH---S-QVNSALM----A-------P----FY--R-------------------YQRSL---RLDRDDISGIQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 104
105 --GEFRLTGRKW-DKT----------HLTY-----------------------------RL--I-NT--S--PQ-L--DR--------AEVEDAIYRAFRIWEQV---TPLR------FSRTS--------GT-S-------DIEISFVQ--------------------------F--SH-G---D-----G--N-P-----F-D---GRG---------GT----LAHAYFP----GT----GIGGD---------AHFD-ES-EQW-TVRTARG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFIVAAHEFGHSLG-LEH---S-QVLGALM----Y-------P----FY--Q-----G-------------YVEDF---QLDYDDILGIQTI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 105
106 GEYNVFPRTLKW-SKM----------NLTY-----------------------------RI--V-NY--T--PD-L--TH--------SEVEKAFRKAFKVWSDV---TPLN------FTRIH--------NG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GKSHF---MLPDDDVQGIQSL---------------------------------------Y------------------G-----------------PGDE---DP-Y-SKH---------------------------------------------------------------------------------------------------------------------PKTPD 106
107 GEYNVFPRTLKW-PKM----------NLTY-----------------------------RI--V-NY--T--PD-L--TH--------SEVEKAFKKAFKVWSDV---TPLN------FTRLY--------NG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GKSHF---VLPDDDVQGIQYL---------------------------------------Y------------------G-----------------PGDE---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTPD 107
108 ---------------------------------------------------------------------------------------------AFKKAFKVWSDV---TPLN------FTRLH--------DG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GKSHF---MLPDDDVQGIQSL---------------------------------------Y------------------G-----------------PGDE---DP-N-PRH---------------------------------------------------------------------------------------------------------------------P---- 108
109 GEYNVFPRTLKW-SKM----------NLTY-----------------------------RI--V-NY--T--PD-M--TH--------SEVEKAFKKAFKVWSDV---TPLN------FTRLH--------DG-I-A-----DIMISFGI--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GKSHF---MLPDDDVQGIQSL---------------------------------------Y------------------G-----------------PGDE---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTPD 109
110 GEYNVFPRTLKW-SKT----------NLTY-----------------------------RI--V-NY--T--PD-L--TH--------PEVEKAFKKALKVWSDV---TPLN------FTRLH--------DG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GQSHF---MLPDDDVQGIQSL---------------------------------------Y------------------G-----------------PGDE---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTPD 110
111 ----------KW-SKT----------NLTY-----------------------------RI--V-NY--T--PD-L--TH--------PEVEKAFKKALKVWSDV---TPLN------FTRLH--------DG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STS----KG-----------YN---LFLVAAHEFGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GQSHF---MLPDDDVQGIQSL---------------------------------------Y------------------G-----------------PGDE---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTP- 111
112 GEYNVFPRTLKW-SQT----------NLTY-----------------------------RI--V-NY--T--PD-M--SH--------SEVEKAFRKAFKVWSDV---TPLN------FTRIY--------DG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----NYGGD---------AHFD-DD-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSS----KG-----------YN---LFIVAAHELGHSLG-LDH---S-KDPGALM----F-------P----IY--TY----T-------------GKSHF---MLPDDDVQGIQFL---------------------------------------Y------------------G-----------------PGDE---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTPE 112
113 ----------KW-SNT----------NLTY-----------------------------RI--M-SY--T--SD-L--RR--------AEVERAFKRAFKVWSDV---TPLN------FTRIR--------SG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--Y-P-----F-D---GPS---------GL----LAHAFPP----GP----DYGGD---------AHFD-DD-ETW-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDS----RG-----------YN---LFLVAAHEFGHSLG-LEH---S-RDPGALM----F-------P----IY--TY----T-------------GKSGF---VLPDDDVQGIQEL---------------------------------------Y------------------G-----------------AGDR---DP-N-PKH---------------------------------------------------------------------------------------------------------------------PKTPE 113
114 AEYNHFPRDLKW-KTT----------NVTF-----------------------------RI--L-NY--T--PD-L--KK--------KVVDRAVRKALNVWSKV---TPLR------FTKTF--------DG-T-A-----DIMISFGT--------------------------K--EH-G---D-----F--N-P-----F-D---GPE---------GL----LAHAYPP----GI----GIGGD---------THFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDY----HA-----------FN---LFLVAAHEFGHALG-MAH---S-SDPGSLM----Y-------P----VY--SY----A---------------KGF---PLSEDDIEGIQSL---------------------------------------Y------------------G-----------------E---------N-PDHEKFKPK---------------------------------------------------------------------------------------------------------------PIAP- 114
115 --YSTFPGDYKW-KKH----------QLTY-----------------------------RI--E-NY--T--LD-M--SV--------AEVDDSISRALKVWSDV---TPLR------FTRIY--------SG-T-A-----DIMIFFAT--------------------------G--DH-G---D-----G--Y-P-----F-D---GPN---------GF----LAHAYPP----YE----GVGGD---------AHFD-DD-ETFSY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RST----QY-----------YT---LFSVAAHEFGHSLG-LGH---S-RDPGALM----Y-------P----TY--VY----R-------------DMDRF---ILPRDDVNGIQSL---------------------------------------Y------------------G-----------------PNTDVNTDDSK-PTP---------------------------------------------------------------------------------------------------------------------PVTP- 115
116 --YSTFAGDYKW-KKH----------QLTY-----------------------------RI--E-NY--T--PD-M--SV--------AEVDDSISKALKVWADV---TPLR------FTRIY--------SG-T-A-----DIMISFAT--------------------------G--DH-R---D-----G--Y-P-----F-D---GPN---------GF----LAHAFPP----FE----GIGGD---------AHFD-DD-ETFSY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSP----QY-----------YN---LFLVAAHEFGHSLG-LEH---S-QDPGALM----Y-------P----TY--VY----R-------------DVDRF---VLPRDDVNGIQSL---------------------------------------Y------------------G-----------------PNTDVNTDDSK-PTP---------------------------------------------------------------------------------------------------------------------PVTP- 116
117 ------------------------------------------------------------------------PD-L--DP--------ETVDDAFARAFQVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GVGGD---------SHFD-DD-ELW-TL--GEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGSKHESCTSAGRSDGKMWCATTANYDDDRKWGF-CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KNF---RLSHDDIKGIQEL---------------------------------------YGASPDI------------D-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------PTLGP 117
118 ANYNFFPRKPKW-DKN----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARAFQVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GVGGD---------SHFD-DD-ELW-TL--GEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGSKHESCTSAGRSDGKMWCATTANYDDDRKWGF-CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KNF---RLSHDDIKGIQEL---------------------------------------YGASPDI------------D-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------PTLGP 118
119 ANYNFFPRKPKW-DKN----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARAFQVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GT----GVGGD---------SHFD-DD-ELW-T-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KNF---RLSQDDIKGIQEL---------------------------------------YGASPDI------------D-----------------LGTG--------PT----------------------------------------------------------------------------------------------------------------------PTL-- 119
120 -NYNFFPRKPKW-DKN----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------QTVDDAFARAFQVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GVGGD---------SHFD-DD-ELR-TL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KNF---RLSHDDIQGIQEL---------------------------------------YGASPDI------------D-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------PTLGP 120
121 ANYNFFPRKPKW-DKN----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARAFQVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GVGGD---------SHFD-DD-ELW-TL--GEGQVVRVKYGNADGEY---------------------------------------------------------------------------------------------------------------------------------------------------------------PD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-EDPGALM----A-------P----IY--TY----T---------------KNF---RLSQDDIKGIQEL---------------------------------------YGASPDA------------G-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------PTL-- 121
122 -NYNFFPRKPKW-EKT----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARAFRVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GVGGD---------SHFD-DD-ELW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KHF---RLSHDDIKGIQEL---------------------------------------YGGSP--------------D-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------PTLGP 122
123 ANYNFFPRKPKW-DKN----------QITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARALKVWSDV---TPLR------FSRIH--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GT----GVGGD---------SHFD-DD-ELW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-QDPGALM----A-------P----IY--TY----T---------------KNF---RLSHDDIKGIQEL---------------------------------------YGPSPDADT----------D-----------------TGTG--------PT----------------------------------------------------------------------------------------------------------------------P---- 123
124 ANYNFFPRKPKW-EKN----------HITY-----------------------------RI--I-GY--T--PD-L--DP--------ETVDDAFARAFKVWSDV---TPLR------FNRIN--------DG-E-A-----DIMINFGR--------------------------W--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GIGGD---------SHFD-DD-ELW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-EDPGALM----A-------P----IY--TY----T---------------KNF---RLSQDDIKGIQEL---------------------------------------YEVSPDVEP----------G-----------------PGPG--------PG----------------------------------------------------------------------------------------------------------------------P---- 124
125 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNYD-ED-RKW-G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-CPD----QG-----------YS---LFLVAAHEFGHAMG-LEH---S-EDPGALM----A-------P----IY--TY----T---------------KYF---RLSQDDVQGIQEL---------------------------------------YGGSTDV-------------------------------GPG--------PS----------------------------------------------------------------------------------------------------------------------PTLGP 125
126 ANYNFFHRKPKW-GQK----------NVTY-----------------------------RI--L-GH--T--PD-L--DE--------DTIDDAFYRAFKVWSDV---TPLK------FTRIM--------DG-E-A-----DIMINFGR--------------------------N--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAP----GP----GIGGD---------SHFD-DD-EQW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHALG-LEH---S-DDPGALM----A-------P----IY--TF----T---------------KTL---RLSDDDVKGIQEL---------------------------------------YGEPTDKPL----------A-----------------THT-------------------------------------------------------------------------------------------------------------------------------------- 126
127 GKFQTFEGDLKW-HHH----------NITY-----------------------------WI--Q-NY--S--ED-L--PR--------DVIDDAFARAFAAWSAV---TPLT------FTRVY--------GL-E-A-----DIVIQFGV--------------------------R--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFPP----GP----GIQGD---------AHFD-DE-ELW-SL--GKGVVVPTYFGNAGGAACHFPFTFEGRSYSACTTDGRSDDMLWCSTTADYDTDRRFGFCPSERLYTQDGNGEGKPCVFPFTFEGHSYSACTTEGRSDGYRWCATTANYDQDKLYGFCPTRADSTVTGGNSAGELCVFPFIFLGKEYSTCTREGRGDGHLWCATTSNFDRDKKWGFCPD----QG-----------YS---LFLVAAHEFGHALG-LDH---S-SVPEALM----Y-------P----MY--SF----T---------------EGP---PLHEDDVKGIQHL---------------------------------------Y------------------G-----------------PRPE--------PE----------------------------------------------------------------------------------------------------------------------PRPPT 127
128 GRFQTFEGDLKW-HHH----------NITY-----------------------------WI--Q-NY--S--ED-L--PR--------AVIDDAFARAFALWSAV---TPLT------FTRVY--------SR-D-A-----DIVIQFGV--------------------------A--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFPP----GP----GIQGD---------AHFD-DD-ELW-S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAAHEFGHALG-LDH---S-SVPEALM----Y-------P----MY--RF----T---------------EGP---PLHKDDVNGIRHL---------------------------------------Y------------------G-----------------PRPE--------PE----------------------------------------------------------------------------------------------------------------------PRPP- 128
129 GRFQTFEGELKW-HHH----------NITY-----------------------------WI--Q-NY--S--ED-L--PR--------AVIDDAFARAFALWSAV---TPLT------FTRVY--------GP-E-A-----DIVIQFGV--------------------------R--EH-G---D-----G--Y-P-----F-D---GKN---------GL----LAHAFPP----GK----GIQGD---------AHFD-DE-ELW-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHALG-LDH---T-SVPEALM----Y-------P----MY--RF----T---------------EEH---PLHRDDVQGIQHL---------------------------------------Y------------------G-----------------PRPE--------PE----------------------------------------------------------------------------------------------------------------------PRPP- 129
130 --FQTFEGDLKW-HHR----------DITY-----------------------------WI--Q-NY--S--GD-L--PR--------DVIDDAFARAFAVWSEV---TPLT------FTRVN--------GP-Q-A-----DIVIQFGV--------------------------R--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFPP----GP----GIQGD---------AHFD-DE-ELW-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHALG-LDH---S-SVPAALM----Y-------P----MY--SF----T---------------EEP---PLHEDDVNGIQYL---------------------------------------Y------------------G-----------------PRPK--------PE----------------------------------------------------------------------------------------------------------------------PQPP- 130
131 GKFQTFEGDLKW-HHN----------DITY-----------------------------WI--Q-NY--S--ED-L--PR--------DVIDDAFARAFAVWSAV---TPLT------FTRVY--------GP-E-A-----DIIIQFGV--------------------------R--EH-G---D-----G--Y-P-----F-D---GKN---------GL----LAHAFPP----GP----GIQGD---------AHFD-DE-ELW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHALG-LDH---S-SVPEALM----Y-------P----MY--SF----T---------------EGP---PLHEDDVRGIQHL---------------------------------------YGEVGGRDGGRVPTTLEGEG-----------------PRPE--------PE----------------------------------------------------------------------------------------------------------------------PQPP- 131
132 GRFQTFKG-LKW-DHH----------NITY-----------------------------WI--Q-NY--S--ED-L--PR--------DMIDDAFARAFAVWGEV---APLT------FTRVY--------GP-E-A-----DIVIQFGV--------------------------A--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFPP----GA----GVQGD---------AHFD-DD-ELW-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----QG-----------YS---LFLVAAHEFGHALG-LDH---S-SVPEALM----Y-------P----LY--SY----L---------------EGF---PLNKDDIDGIQYL---------------------------------------Y------------------G-----------------RGSK--------PD----------------------------------------------------------------------------------------------------------------------PRPPA 132
133 GGFLTFEGELKW-DHM----------DLTY-----------------------------RV--M-NY--S--PD-L--DR--------AVIDDAFRRAFKVWSDV---TPLT------FTQIY--------SG-E-A-----DIMIMFGS--------------------------Q--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFPP----GS----GIQGD---------AHFD-DD-EFW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----RG-----------YS---IFLVAAHEFGHSLG-LDH---S-SVREALM----Y-------P----MY--SY----V---------------QDF---QLHEDDVQGIQYL---------------------------------------Y------------------G-----------------RGSG--------PE----------------------------------------------------------------------------------------------------------------------PTPPA 133
134 RNYKTFDGDLKW-DHT----------DVTY-----------------------------RI--L-NY--S--PD-M--EA--------SLIDDAFARAFKVWSDV---TPLT------FTRLF--------DG-I-A-----DIMISFGK--------------------------L--DH-G---D-----P--Y-P-----F-D---GKD---------GL----LAHAYPP----GE----GTQGD---------AHFD-DD-EYW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPD----RG-----------YS---LFLVAAHEFGHALG-LDH---S-NIKDALM----Y-------P----MY--KY----V---------------EGF---PLHRDDIDGIQYL---------------------------------------Y------------------G-----------------PRTG--------PE----------------------------------------------------------------------------------------------------------------------PTAPQ 134
135 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RI--S-KY--T--PS-M--AA--------ADVDKAVEMALQAWGSA---VPLT------FVRVT--------SG-E-A-----DIMISFES--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GMN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-TDPSALM----Y-------P----TY--KY----Q-------------HPYGF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRKTFPGKPTV-------------------------------------------------------------------------------------------------------------------------PHAP- 135
136 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RI--S-KY--T--SS-M--SP--------AEVDKAVEMALQAWGSA---VPLS------FIRVN--------SG-E-A-----DIMISFET--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GMN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-TDPSALM----Y-------P----TY--KY----Q-------------HPYGF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRKTLLGKPTV-------------------------------------------------------------------------------------------------------------------------PHAPP 136
137 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RI--S-KY--T--TS-M--TP--------ADVNKAVEMALQAWSSA---VPLN------FVRVD--------SG-E-A-----DIMISFET--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GTN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-TDPSALM----Y-------P----TY--KY----Q-------------NPYGF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRRAFLGKPTM-------------------------------------------------------------------------------------------------------------------------PHAPP 137
138 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RI--S-KY--T--PS-M--SS--------VEVDKAVEMALQAWSSA---VPLS------FVRIN--------SG-E-A-----DIMISFEN--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GTN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-TDPSALM----Y-------P----TY--KY----K-------------NPYGF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRKVFLGKPTL-------------------------------------------------------------------------------------------------------------------------PHAPH 138
139 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RI--S-KY--T--PS-M--TP--------AEVDRAMEMALRAWSSA---VPLN------FVRIN--------AG-E-A-----DIMISFET--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GTN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-TDPSALM----F-------P----TY--KY----Q-------------NPYGF---RLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRRAFSGKPTA-------------------------------------------------------------------------------------------------------------------------PHGPP 139
140 ANYRLFPGEPKW-KKN----------ILTY-----------------------------RI--S-KY--T--PS-M--SP--------TEVDKAIQMALHAWSTA---VPLN------FVRIN--------SG-E-A-----DIMISFET--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GTN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LGH---S-TDPSALM----Y-------P----TY--KY----Q-------------NPYRF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------PRKIFPGKPTM-------------------------------------------------------------------------------------------------------------------------PHIPP 140
141 ANYRLFPGEPKW-KKN----------TLTY-----------------------------RV--K-KY--T--PS-L--SH--------AEVDKAVEMGLKAWSAA---APLN------FVKTT--------SG-E-A-----DIMISFEN--------------------------G--DH-G---D-----S--Y-P-----F-D---GPR---------GT----LAHAFAP----GE----GLGGD---------THFD-NA-EKW-TM--GMN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFTVAAHEFGHALG-LAH---S-ADPSALM----Y-------P----TY--KY----Q-------------HPFGF---HLPKDDVKGIQAL---------------------------------------Y------------------G-----------------SRLTGSRAPQV-------------------------------------------------------------------------------------------------------------------------PHLP- 141
142 --FSFYPGRPKW-KSN----------IITY-----------------------------RI--A-RF-----TPDL--RP--------EEVENSLHLALKIWSDA---APLK------FV-QI-KE-----G---RA-----DITFSFNS--------------------------K--AH-G---D--------FFP-----F-D---GPG---------GV----LAHAFEP----GE----GLGGD---------VHFD-DD-EIW-TVGRG----R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------YN---LFTVAAHELGHSLG-LSH---S-KDPTALM----Y-------P----KYKFIN------------------A-ATY---KLPRDDTLGIQAL---------------------------------------Y------------------GKKTRQQELVIP----------------------------------------------------------------------------------------------------------------------------------------------- 142
143 ENFSFYPGRPKW-KSN----------IITY-----------------------------RI--A-RF-----TPDL--RP--------EEVENSLHLALKIWSDA---APLK------FV-QI-KE-----G---RA-----DITFSFNS--------------------------K--AH-G---D--------FFP-----F-D---GPG---------GV----LAHAFEP----GE----GLGGD---------VHFD-DD-EIW-TVGRG----R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------YN---LFTVAAHELGHSLG-LSH---S-KDPTALM----Y-------P----KYKFIN------------------A-ATY---KLPRDDTLGIQAL---------------------------------------Y------------------GES-------------------------------------------------------------------------------------------------------------------------------------------------------- 143
144 --FSFYPGRPKW-KSN----------IITY-----------------------------RI--A-RF-----TPDL--RP--------EEVENSLHLALKIWSDA---APLK------FV-QI-KE-----G---RA-----DITFSFNS--------------------------K--AH-G---D--------FFP-----F-D---GPG---------GV----LAHAFEP----GE----GLGGD---------VHFD-DD-EIW-TVGRG----R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------YN---LFTVAAHELGHSLG-LSH---S-KDPTALM----Y-------P----KYKFIN------------------A-ATY---KLPRDDTLGIQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 144
145 -----------W-DHT----------HLTY-----------------------------RI--E-NY--T--PD-L--PR--------AEVDSAIEKAFQLWSNV---SPLT------FTKVF--------EG-Q-A-----DIMISFVW--------------------------G--DH-R---D-----N--S-P-----F-D---GPN---------GN----LAHAFQP----GP----NLGGD---------IHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNF----RN-----------YN---LYRVAAHELGHSLG-LSH---S-TDIGALM----Y-------P----NY--MY----S---------------GNV---QLSQDDINGIQAI---------------------------------------Y------------------G-----------------E---------------------------------------------------------------------------------------------------------------------------------------- 145
146 AQYVLTDGS-QW-DHT----------HLTY-----------------------------RI--E-NY--T--PD-L--PR--------AEVDSAIEKAFQLWSNV---SPLT------FTKVF--------EG-Q-A-----DIMISFVW--------------------------G--DH-R---D-----N--S-P-----F-D---GPN---------GN----LAHAFQP----GP----NLGGD---------IHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNF----RN-----------YN---LYRVAAHELGHSLG-LSH---S-TDIGALM----Y-------P----NY--MY----S---------------GNV---QLSQDDINGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPVQ-PTG---------------------------------------------------------------------------------------------------------------------PQTPQ 146
147 APYVLTEGNPRW-EHT----------DLTYRS---------------------------RI--E-NY--T--PD-L--PR--------AEVDRAIEKAFQLWSDV---SPLT------FTKVS--------EG-Q-A-----DIMLSFVW--------------------------G--DH-Y---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GP----NLGGD---------VHFD-ED-ERW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDF----RD-----------FN---LYRVAAHELGHSLG-LSH---S-TDIGALM----Y-------P----NY--IY----S---------------GDV---QLSQDDIDGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPIP-PTG---------------------------------------------------------------------------------------------------------------------PQTPQ 147
148 APYVLTEGNPRW-EHT----------DLTY-----------------------------RI--E-NY--T--PD-L--PR--------AEVDRAIEKAFQLWSDV---SPLT------FTKVS--------EG-Q-A-----DIMLSFVW--------------------------G--DH-Y---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GP----NLGGD---------VHFD-ED-ERW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDF----RD-----------FN---LYRVAAHELGHSLG-LSH---S-TDIGALM----Y-------P----NY--IY----S---------------GDV---QLSQDDIDGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPI------------------------------------------------------------------------------------------------------------------------------- 148
149 AEFVLTEGNPRW-ENT----------HLTY-----------------------------RI--E-NY--T--PD-L--PR--------ADVDQAIEKAFQLWSNV---SPLT------FTKVS--------EG-Q-A-----DIMISFVR--------------------------G--DH-R---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GP----RIGGD---------AHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNF----RN-----------YN---LYRVAAHEFGHSLG-LSH---S-TDIGALM----Y-------P----NY--FF----T---------------GDV---QLSQDDINGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPIQ-PIG---------------------------------------------------------------------------------------------------------------------PQTPE 149
150 AQFVLTEGNPRW-EQT----------HLTY-----------------------------RI--E-NY--T--PD-L--PR--------ADVDHAIEKAFQLWSNV---TPLT------FTKVS--------EG-Q-A-----DIMISFVR--------------------------G--DH-R---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GP----GIGGD---------AHFD-ED-ERW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNF----RE-----------YN---LHRVAAHELGHSLG-LSH---S-TDIGALM----Y-------P----SY--TF----S---------------GDV---QLAQDDIDGIQAI---------------------------------------Y------------------G-----------------R-SQ---NPVQ-PIG---------------------------------------------------------------------------------------------------------------------PQTPK 150
151 APFVLTPGNPRW-ENT----------NLTY-----------------------------RI--E-NY--T--PD-L--SR--------ADVDQAIEKAFQLWSNV---TPLT------FTKVS--------EG-Q-A-----DIMISFVR--------------------------G--DH-R---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GA----GIGGD---------AHFD-DD-EWW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNF----QD-----------YN---LYRVAAHEFGHSLG-LAH---S-TDIGALM----Y-------P----SY--TF----S---------------GDV---QLSQDDIDGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPTQ-PVG---------------------------------------------------------------------------------------------------------------------PQTPE 151
152 APFVLTPGKSCW-ENT----------NLTY-----------------------------RI--E-NY--T--PD-L--SR--------ADVDQAIEKAFQLWSNV---TPLT------FTKVS--------EG-Q-A-----DIMISFVR--------------------------G--DH-R---D-----N--S-P-----F-D---GPG---------GN----LAHAFQP----GA----GIGGD---------AHFD-DD-EWW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNF----QD-----------YN---LYRVAAHEFGHSLG-LAH---S-TDIGALM----Y-------P----SY--TF----S---------------GDV---QLSQDDIDGIQAI---------------------------------------Y------------------G-----------------P-SQ---NPTQ-PVG---------------------------------------------------------------------------------------------------------------------PQTPE 152
153 -----------------------------------------------------------RV--E-NY--T--PD-L--SR--------ADIEQAVEKAFQLWSSA---SPLS------FTKVS--------EG-Q-V-----DIMISFVW--------------------------G--DH-C---D-----N--S-P-----F-H---GPG---------GI----FAHAFQP----GI----GI-GD---------VHLD-EE-EIW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVL----NN-----------YN---LYWVLAHELGHSFG-LSH---S-TNIGALM----Y-------P----NY--IY----T---------------GEV---YLSQDDISGIQAI---------------------------------------Y------------------G-----------------P-SN---KPQL-VPV---------------------------------------------------------------------------------------------------------------------PQIPQ 153
154 APYVLTEGNPRW-EHT----------DLTY-----------------------------RI--E-NY--T--PD-L--PR--------AEVDRAIEKAFQLWSDV---SPLT------FTKVS--------EG-Q-A-----DIMLSFGE--------------------------V--NH-G---D-----K--S-D-----F-G---RIR---------SP----FAHVFPP----GR----GMGGG---------VHFD-EE-KTW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDF----RN-----------YN---LYYVAAHELGHSLG-LLH---S-DDIGSLM----F-------P----RY--IY----Y---------------GDA---LLSLKDIDAIQAI---------------------------------------Y------------------G-----------------P-SK---NPIQ-P---------------------------------------------------------------------------------------------------------------------------- 154
155 GDFMLTPGNPKW-KQT----------NLTY-----------------------------RI--I-KY--T--PQ-L--SE--------ANVETAIQKAFQVWSNV---SPLT------FTKVS--------QG-E-V-----DIRISFVQ--------------------------G--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GQ----GIGGD---------VHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENS----SN-----------YN---LFLVAAHEVGHSLG-LSH---S-TDPGALM----Y-------P----NY--VF----H-------------DPSTY---TLPQDDINGIQTI---------------------------------------Y------------------G-----------------P-SS---NPVQ-PTG---------------------------------------------------------------------------------------------------------------------PSTP- 155
156 GDFLLTPGSPKW-THT----------NLTY-----------------------------WI--I-NH--T--PQ-L--SR--------AEVKTAIEKAFHVWSVA---SPLT------FTEIL--------QG-E-A-----DINIAFVS--------------------------R--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GQ----GIGGD---------AHFD-SE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDS----KN-----------YN---LFLVAAHEFGHSLG-LSH---S-TDPGALM----Y-------P----NY--AY----R-------------EPSTY---SLPQDDINGIQTI---------------------------------------Y------------------G-----------------P-SD---NPIQ-PTG---------------------------------------------------------------------------------------------------------------------PST-- 156
157 --FMLTPGNPKW-ERT----------NLTY-----------------------------RI--R-NY--T--PQ-L--SE--------AEVERAIKDAFELWSVA---SPLI------FTRIS--------QG-E-A-----DINIAFYQ--------------------------R--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GQ----GIGGD---------AHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTS----AN-----------YN---LFLVAAHEFGHSLG-LAH---S-SDPGALM----Y-------P----NY--AF----R-------------ETSNY---SLPQDDIDGIQAI---------------------------------------Y------------------G-----------------L-SS---NPIQ-PTG---------------------------------------------------------------------------------------------------------------------PSTPK 157
158 GGFMLTPGNPKW-ERT----------NLTY-----------------------------RI--R-NY--T--PQ-L--SE--------AEVERAIKDAFELWSVA---SPLI------FTRIS--------QG-E-A-----DINIAFYQ--------------------------R--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GQ----GIGGD---------AHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTS----AN-----------YN---LFLVAAHEFGHSLG-LAH---S-SDPGALM----Y-------P----NY--AF----R-------------ETSNY---SLPQDDIDGIQAI---------------------------------------Y------------------G-----------------L-SS---NPIQ-PTG---------------------------------------------------------------------------------------------------------------------PST-- 158
159 --FMVTPGNPRW-KHT----------NLTY-----------------------------RI--L-KY--T--TQ-L--SQ--------TKVETVISTAFQVWANA---SSLT------FTKIS--------QG-E-A-----DINIAFYE--------------------------G--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GP----GIGGD---------AHFD-EQ-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNF----EN-----------YN---LFLVAAHEFGHSLG-LSH---S-TDPVALM----Y-------P----IY--AF----R-------------EPSTY---TLPQDDINGIQAI---------------------------------------Y------------------G-----------------P-SS---NPVQ-PTG---------------------------------------------------------------------------------------------------------------------PSTP- 159
160 -EFMITPGNPKW-ERN----------NLTY-----------------------------RI--I-NY--T--PHLL--LR--------ADVERAFERAFEEWSIA---SSLK------FKKIS--------QG-E-A-----DIRIAFYQ--------------------------G--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GP----GIGGD---------AHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNR----TN-----------YN---LLIVAAHEFGHSLG-LAH---S-TNPAALM----Y-------P----TY--AF----R-------------DPSTY---LLSQDDINGIQAI---------------------------------------Y------------------G-----------------P-SN---DPIQ-PTG---------------------------------------------------------------------------------------------------------------------STAP- 160
161 GEFMITPGNPKW-ERN----------NLTY-----------------------------RI--I-NY--T--PHLL--LR--------ADVERAFERAFEEWSIA---SSLK------FKKIS--------QG-E-A-----DIRIAFYQ--------------------------G--DH-G---D-----N--S-P-----F-D---GPN---------GI----LAHAFQP----GP----GIGGD---------AHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNR----TN-----------YN---LLIVAAHEFGHSLG-LAH---S-TNPAALM----Y-------P----TY--AF----R-------------DPSTY---LLSQDDINGIQAI---------------------------------------Y------------------G-----------------P-SN---DPIQ-PTG---------------------------------------------------------------------------------------------------------------------STAP- 161
162 GSFMRTPGNPKW-EKT----------KLTY-----------------------------RI--V-NY--T--PN-L--TE--------MDVEAIIEEAFKVWSKV---SPLT------FNRTL--------DE-E-A-----DIQISFAQ--------------------------R--DH-G---D-----N--S-P-----F-D---GPD---------GI----LAHAFQP----GP----GIGGD---------VHFD-AE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTS----EN-----------YN---LFPVAAHEFGHSLG-LAH---S-SDPGALM----Y-------P----NY--AF----I-------------DPSSY---SLHQDDINGIQAI---------------------------------------Y------------------G-----------------P-SS---NPVQ-PTG---------------------------------------------------------------------------------------------------------------------PTT-- 162
163 --FLLTDGNPKW-KKN----------NITY-----------------------------RI--V-NF--T--PD-M--HP--------SDVDKAIEKAFEVWSKA---SPLT------FKRLY--------DG-I-A-----DIMMSFQI--------------------------G--DH-R---D-----N--S-P-----F-D---GPN---------GV----LAHAFQP----GD----NIGGD---------VHFG-KS-EYC-F----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y----VFSG-----------YS---LFLVAAHELGHSLG-LSH---S-NDPGALM----Y-------P----TY--SY----T-------------APNLF---RLPQDDINGIQAI---------------------------------------Y------------------G-----------------K-AN---NQVQ-PTG---------------------------------------------------------------------------------------------------------------------PTTP- 163
164 --FLLTDGNPKW-KKN----------NITY-----------------------------RI--V-NF--T--PD-M--HP--------SDVDKAIEKAFEVWSKA---SPLT------FKRLY--------DG-I-A-----DIMMSFQI--------------------------G--DH-R---D-----N--S-P-----F-D---GPN---------GV----LAHAFQP----GD----NIGGD---------VHFG----XXC-N----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FRPSEIHEC-----------YS---LFLVAAHELGHSLG-LSH---S-NDPGALM----Y-------P----TY--SY----T-------------APNLF---RLPQDDINGIQAI---------------------------------------Y------------------G-----------------K-AN---NQVQ-PTG---------------------------------------------------------------------------------------------------------------------PTTP- 164
165 --FVLTDGNPKW-KKN----------NITY-----------------------------RI--V-NY--T--PD-M--HP--------SDVDKAIEKAFEVWSKA---SPLT------FKRLY--------DG-I-A-----DIMMSFEI--------------------------R--DH-G---D-----N--S-P-----F-D---GPN---------NY----LAHAFSP----GD----NIGGD---------VHFD-ED-ELW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKGS---RG-----------YN---LFLVAAHELGHSLG-LFH---S-TDPGALM----Y-------S----EY--SY----T-------------APNLF---QLPQDDINGIQAI---------------------------------------Y------------------G-----------------K-AN---SKVQ-PTG---------------------------------------------------------------------------------------------------------------------PTTP- 165
166 --YVFTPGNPKW-KKN----------NLTY-----------------------------RI--V-NY--T--TK-M--RQ--------TDVDEAIQKALKVWSSV---TPLT------FQKTE--------DK-I-A-----DIMISFAY--------------------------R--DH-N---D-----N--S-P-----F-D---GPN---------GL----LAHAFQP----GE----GLGGD---------VHLD-EE-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----RG-----------YN---LFIVVAHELGHSLG-LSH---S-NDPGALM----Y-------P----NY--AY----T-------------DPKEF---LLPQDDIDGIQAI---------------------------------------Y------------------G-----------------Q-SD---DAVQ-PTG---------------------------------------------------------------------------------------------------------------------PT--- 166
167 GQYSTVAKSSAW-QKK----------DLTY-----------------------------RI--L-NF--T--PD-L--PQ--------ADVETAIQRAFKVWSDV---TPLT------FTRIY--------NE-V-S-----DIEISFTA--------------------------G--DH-K---D-----N--S-P-----F-D---GSG---------GI----LAHAFQP----GN----GIGGD---------AHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTS----EI-----------YN---LFLVAAHEFGHSLG-LSH---S-TDQGALM----Y-------P----TY--SN----T-------------DPKTF---QLPQDDINAIQYL---------------------------------------Y------------------G-----------------K-SS---NPVQ-PTG---------------------------------------------------------------------------------------------------------------------PSTPS 167
168 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVAIHEFGHTWG-LDHPDEADQNVVAIM-----------------------------------------NSKISDVDRVQQDDIDGIVAI---------------------------------------Y------------------GSAD------------------------------------------------------------------------------------------------------------------------------------------------------- 168
169 -EFRTLAGRPVW-KKR----------FLTY-----------------------------RI--N-SY--T--PD-M--KP--------ADVDYAIQKAFQVWSDV---TPLK------FRKI---------HS-GEA-----DIMIGFAS--------------------------G--AH-G---D--------FNP-----F-D---GRG---------GI----IAHAFGP----GPGIG----GD---------THFD-EA-ETW-TANYR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLVAVHELGHSLG-LGH---S-SDPKAIM----F-------P----TY--HY----V-------------DPNTF---RLSSDDVRGIQSL---------------------------------------Y------------------G-----------------GPERRQPPSHP------------------------------------------------------------------------------------------------------------------------------ 169
170 -EFRTLAGRPVW-KKR----------FLTY-----------------------------RI--N-SY--T--PD-M--KP--------ADVDYAIQKAFQVWSDV---TPLK------FRKI---------HS-GEA-----DIMIGFAS--------------------------G--AH-G---D--------FNP-----F-D---GRG---------GI----IAHAFGP----GPGIG----GD---------THFD-EA-ETW-TANYR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLVAVHELGHSLG-LGH---S-SDPKAIM----F-------P----TY--HY----V-------------DPNTF---RLSSDDVRGIQSL---------------------------------------Y------------------G-----------------GPERRQPPSHP------------------------------------------------------------------------------------------------------------------------------ 170
171 -HFSTMQGRPVW-KKH----------LITY-----------------------------RI--N-NY--T--PD-M--QP--------ADVDYAIHKAFEVWSNV---TPLK------FRKV---------NS-GEA-----DIMILFAS--------------------------R--AH-G---D--------FSP-----F-D---GRG---------GV----IAHAFGP----GPQIG----GD---------MHFD-EA-EIW-TKTYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLVAVHELGHSLG-LGH---S-SDPKAIM----F-------P----TY--SY----V-------------NPNTF---HLSADDIHGIQSL---------------------------------------Y------------------G-----------------GPEKHQFSSNTDGTE-------------------------------------------------------------------------------------------------------------------------- 171
172 YDFRVMQGRPVW-KKH----------FITY-----------------------------RI--K-NY--T--PD-M--KP--------EDVDYAIQKAFQVWSDV---TPLK------FRKI---------NT-GEA-----DIMIQFAH--------------------------G--AH-G---D--------YSP-----F-D---GRN---------GI----LAHAFGP----GPGIG----GD---------THFD-EA-EIW-TKSYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLVAVHELGHSLG-LGH---S-HDPKAIM----F-------P----TY--SY----I-------------DLSTF---RLSADDIRGIQSL---------------------------------------Y------------------G-----------------APEKPRPSSKPDSTDP------------------------------------------------------------------------------------------------------------------------- 172
173 HHFREMPGGPVW-RKH----------YITY-----------------------------RI--N-NY--T--PD-M--NR--------EDVDYAIRKAFQVWSNV---TPLK------FSKI---------NT-GMA-----DILVVFAR--------------------------G--AH-G---D--------FHA-----F-D---GKG---------GI----LAHAFGP----GSGIG----GD---------AHFD-ED-EFW-TTHSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLTAVHEIGHSLG-LGH---S-SDPKAVM----F-------P----TY--KY----V-------------DINTF---RLSADDIRGIQSL---------------------------------------Y------------------G-----------------DPKENQRLPNPDNSEP------------------------------------------------------------------------------------------------------------------------- 173
174 QHLRAVPQRSRW-MKR----------YLTY-----------------------------RI--Y-NY--T--PD-M--KR--------EDVDYIFQKAFQVWSDV---TPLR------FRKL---------HK-DEA-----DIMILFAF--------------------------G--AH-G---D--------FNY-----F-D---GKG---------GT----LAHAFYP----GPGIQ----GD---------AHFD-EA-ETW-TKSFQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------TN---LFLVAVHELGHSLG-LQH---S-NNPKSIM----Y-------P----TY--RY----L-------------NPSTF---RLSADDIRNIQSL---------------------------------------Y------------------G-----------------APVKPPSLTKPSSPPS------------------------------------------------------------------------------------------------------------------------- 174
175 -NFQVFPGRPAW-KKR----------LITY-----------------------------RI--N-NY--T--PD-L--KP--------EDVDDAFQKAFQVWSDV---TPLK------FRKV---------HD-NEA-----DIMIRFAF--------------------------R--EH-G---D--------AYS-----F-D---GPW---------GI----LAHAFAP----GAGLG----GD---------AHFD-EA-ETW-TKGHK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------PN---LFLVAVHEIGHSLG-LDH---S-SDTRAIM----F-------P----SY--RD----V-------------DYRRF---RLSTDDIRGIQSL---------------------------------------Y------------------G-----------------RPDKHQVPSNPDNTNP------------------------------------------------------------------------------------------------------------------------- 175
176 ------RGPAKW-GKN----------VLTY-----------------------------RI--N-NY--T--PD-M--HP--------AKVHEVIAKAFKVWSDV---TPLQ------FRYTR--------RP-A-------DIEISFAY--------------------------G--DH-R---D-----G--N-P-----F-D---GRG---------GT----LAHAFFP----AP----NLGGD---------AHFD-ES-EYW-S-EFGKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AN---LFIVAVHEFGHSLG-LEH---S-NVRGAVM----Y-------S----IY--TF----T-------------NPNTF---RLSYDDVQRIQRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 176
177 -------------------------------------------------------------------------------Q--------ADVDEAIAKAFQLWSSV---TPLR------FIRLY--------SG-D-A-----DIMISFAS--------------------------G--FH-G---D-----F--Y-S-----F-D---GPG---------GT----LAHAYPP----NT----GIGGD---------AHFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTTY--SG-----------YN---LFLVAAHELGHSLG-LGH---S-NVFGALM----Y-------P----IY--MA----K-------------DTRNY---RLHQDDISGIQAL---------------------------------------Y------------------G-----------------PPR----EFPAFPTKAFPPQE---------------------------------------------------------------------------------------------------------------P---- 177
178 --YSTFPRNPKW-KKE----------DVTY-----------------------------RI--L-NY--T--PD-M--LQ--------ADVDEAIAKAFQLWSSV---TPLR------FIRLY--------SG-D-A-----DIMISFAS--------------------------G--FH-G---D-----F--Y-S-----F-D---GPG---------GT----LAHAYPP----NT----GIGGD---------AHFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTTY--SG-----------YN---LFLVAAHELGHSLG-LGH---S-NVFGALM----Y-------P----IY--MA----K-------------DTRNY---RLHQDDISGIQAL---------------------------------------Y------------------G-----------------PPR----EFPAFPTKAFPPQE---------------------------------------------------------------------------------------------------------------P---- 178
179 AGFSTFAGEPKW-AKQ----------VLTY-----------------------------RI--L-NY--T--PD-L--RP--------ADVNAAIKKAFSIWSSV---TPLK------FIKRD--------RG-D-A-----DIMISFAT--------------------------G--GH-N---D-----F--I-P-----F-D---GPG---------GS----VAHAYAP----GK----DFGGD---------AHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KST----EG-----------AN---LFYVAAHEFGHSLG-LFH---S-KEPNALM----Y-------P----IY--RK----F-------------DPSVF---PLHQDDINGIQSL---------------------------------------Y------------------G-----------------PS----------------------------------------------------------------------------------------------------------------------------------PN--- 179
180 --FSTFAGEPKW-AKQ----------VLTY-----------------------------RI--L-NY--T--PD-L--RP--------ADVNAAIKKAFSIWSSV---TPLK------FIKRD--------RG-D-A-----DIMISFAT--------------------------G--GH-N---D-----F--I-P-----F-D---GPG---------GS----VAHAYAP----GK----DFGGD---------AHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KST----EG-----------AN---LFYVAAHEFGHSLG-LFH---S-KEPNALM----Y-------P----IY--RK----F-------------DPSVF---PLHQDDINGIQSL---------------------------------------Y------------------G-----------------PS----------------------------------------------------------------------------------------------------------------------------------PNTSN 180
181 --FSTFAGEPKW-AKQ----------VLTY-----------------------------RI--L-NY--T--PD-L--RP--------ADVNAAIKKAFSIWSSV---TPLK------FIKRD--------RG-D-A-----DIMISFAT--------------------------G--GH-N---D-----F--I-P-----F-D---GPG---------GS----VAHAYAP----GK----DFGGD---------AHFD-ED-ETW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KST----EG-----------AN---LFYVAAHEFGHSLG-LFH---S-KEPNALM----Y-------P----IY--RK----F-------------DPSVF---PLHQDDINGIQSL---------------------------------------Y------------------G-----------------PS----------------------------------------------------------------------------------------------------------------------------------PNTSN 181
182 GQFAFFSGQPKW-GKK----------DLTY-----------------------------RI--L-NY--T--PD-M--EI--------QDVDKDIERAFKVWSRV---SPLT------FTRVL--------QG-D-A-----DILISFGS--------------------------R--DH-G---D-----F--N-P-----F-D---GPG---------GT----VAHAYAP----SS----GIGGD---------AHFD-ED-ENW-S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGL----EG-----------SN---LFFVAAHEFGHSLG-LYH---S-NDPNAVM----F-------P----VY--RQ----P-------------ELGQQ---ILAQDDIQGIQHL---------------------------------------Y------------------G-----------------PST----NPPQDPKEDDEPNNDKDQALLFKGNQFWAVRGEYRVPGYPKRIQSLGFPKDVKKIDAAFYNANEKRTYFFSSDKYWRYDEVTQTLEKKPRRIRDDFPGIDGKIDAVFQHNGLLYFFRGTNQYEFDPNTSR 182
183 GDFTTFPGMPKW-RKT----------HLTY-----------------------------RI--M-NY--T--PD-L--PR--------DAVDSAIEKALNVWKEV---TPLT------FSRTD--------EG-E-A-----DIKISFAV--------------------------R--DH-G---D-----F--N-P-----F-D---GPG---------NV----LGHAYPP----GP----GIYGD---------AHFD-DD-EQW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDT----SG-----------TN---LFLVAAHELGHSLG-LFH---S-ADPSALM----Y-------P----VY--NVL---A-------------DLARF---HLSQDDVNGIQSL---------------------------------------Y------------------G-----------------GPPS---DSSNDPVV---------------------------------------------------------------------------------------------------------------------PTES- 183
184 -QFTTFPGLPKW-RKT----------HLTY-----------------------------RI--V-NY--T--PD-L--PR--------EAVDSAFEKALKAWEEV---TPLT------FSKIY--------EG-E-A-----DVMIFFAV--------------------------R--DH-G---D-----F--I-P-----F-D---GPG---------NI----LGHAYAP----GP----GINGD---------AHFD-DD-EQW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDT----SG-----------TN---LFLVAAHELGHSLG-LYH---S-ADPTALM----Y-------P----VY--NPR---T-------------DLTRF---RLAQDDVNGIQSL---------------------------------------Y------------------G-----------------PPPM---SSPDGPAG---------------------------------------------------------------------------------------------------------------------P---- 184
185 GHFSSFPGMPKW-RKT----------HLTY-----------------------------RI--V-NY--T--PD-L--PR--------DAVDSAIEKALKVWEEV---TPLT------FSRLY--------EG-E-A-----DIMISFAV--------------------------K--EH-G---D-----F--Y-S-----F-D---GPG---------HS----LAHAYPP----GP----GLYGD---------IHFD-DD-EKW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDA----SG-----------TN---LFLVAAHELGHSLG-LFH---S-ANTEALM----Y-------P----LY--NSF---T-------------ELAQF---RLSQDDVNGIQSL---------------------------------------Y------------------G-----------------PPP----ASTEEPLV---------------------------------------------------------------------------------------------------------------------PTKS- 185
186 GHFRTFPGIPKW-RKT----------HLTY-----------------------------RI--V-NY--T--PD-L--PK--------DAVDSAVEKALKVWEEV---TPLT------FSRLY--------EG-E-A-----DIMISFAV--------------------------R--EH-G---D-----F--Y-P-----F-D---GPG---------NV----LAHAYAP----GP----GINGD---------AHFD-DD-EQW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDT----TG-----------TN---LFLVAAHEIGHSLG-LFH---S-ANTEALM----Y-------P----LY--HSL---T-------------DLTRF---RLSQDDINGIQSL---------------------------------------Y------------------G-----------------PPP----DSPETPLV---------------------------------------------------------------------------------------------------------------------PTEP- 186
187 -------------------------------------------------------------------------------------------------------------------------IY--------EG-E-A-----DIMIIFAV--------------------------R--EH-G---D-----F--L-P-----F-D---GPG---------KV----LAHAYPP----GS----GFYGD---------AHFD-DD-EQW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDT----SG-----------IN---LFLVAAHELGHSLG-LQH---S-TEREALM----Y-------P----VY--DPR---T-------------DLTRF---RLSQDDVXGIQFL---------------------------------------Y------------------G-----------------SPP----VSPNDPVV---------------------------------------------------------------------------------------------------------------------P---- 187
188 GHFTTFPGMPKW-SKT----------HLTY-----------------------------RI--V-NY--T--QD-L--PR--------DAVDSDVEKALKIWEEV---TPLT------FSRIY--------EG-E-A-----DIMITFAV--------------------------R--EH-G---D-----F--F-P-----F-D---GPG---------KV----LAHAYPP----GP----GMNGD---------AHFD-DD-EHW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDA----SG-----------IN---FLLVAAHELGHSLG-LYH---S-TNTEALM----Y-------P----LY--NTL---K-------------GPARV---RLSQDDVTGIQSL---------------------------------------Y------------------G-----------------PPP----ASPDSPVE---------------------------------------------------------------------------------------------------------------------PSEP- 188
189 GGFSTFPGSPKW-RKS----------HITY-----------------------------RI--V-NY--T--PD-L--PR--------QSVDSAIEKALKVWEEV---TPLT------FSRIS--------EG-E-A-----DIMISFAV--------------------------G--EH-G---D-----F--Y-P-----F-D---GPG---------QS----LAHAYPP----GP----GFYGD---------VHFD-DD-EKW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAP----SG-----------TN---LFLVAAHELGHSLG-LFH---S-DKKESLM----Y-------P----VY--RFS---T-------------SPANF---HLSQDDIEGIQSL---------------------------------------Y------------------G-----------------AGP----SS-DATVV---------------------------------------------------------------------------------------------------------------------PVLS- 189
190 GGFSTFPGSPKW-RKS----------HITY-----------------------------RI--V-NY--T--PD-L--PR--------QSVDSAIEKALKVWEEV---TPLT------FSRIS--------EG-E-A-----DIMISFAV--------------------------G--EH-G---D-----F--V-P-----F-D---GPG---------TV----LAHAYAP----GP----GINGD---------AHFD-DD-ERW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDV----TG-----------TN---LFLVAAHELGHSLG-LYH---S-AKAEALM----Y-------P----VY--KSS---T-------------DLSRF---HLSQDDVDGIQSL---------------------------------------Y------------------G-----------------TPT----ASPDVLVV---------------------------------------------------------------------------------------------------------------------PTKS- 190
191 --YGYTLP--GW-KKY----------NLTY-----------------------------RI--V-NY--T--PD-M--AR--------ADVDEAIQKGLEVWSKV---TPLI------FTKIS--------KG-I-A-----DIMIAFKT--------------------------R--VH-G---------S--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----VG-----------FS---LFLVAAHEFGHSLG-LSH---S-SDQTALM----F-------P----NY--VS----L-------------DPSKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------P-PK---VPEK-PKG---------------------------------------------------------------------------------------------------------------------PTLPH 191
192 GQYGFTLP--GW-KKH----------NLTY-----------------------------RI--V-NY--T--PD-M--AR--------ADVDEAIQKGLEVWSKV---TPLI------FTKIS--------KG-I-A-----DIMIAFKT--------------------------R--VH-G---------S--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----VG-----------FS---LFLVAAHEFGHSLG-LSH---S-SDQTALM----F-------P----NY--VS----L-------------DPSKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------P-PK---VPEK-PKG---------------------------------------------------------------------------------------------------------------------PTLPH 192
193 GQYGYTLP--GW-KKY----------NLTY-----------------------------RI--M-NY--T--PD-M--AR--------ADVDEAIQKGLEVWSKV---TPLM------FTKIS--------KG-I-A-----DIMIAFRT--------------------------R--VH-G---------R--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----VG-----------FN---LFLVAAHEFGHSLG-LSH---S-NDPTALM----F-------P----NY--VS----L-------------DPSKY---PLSQDDISGIQSI---------------------------------------Y------------------G-----------------DLPE---TPTK-PKE---------------------------------------------------------------------------------------------------------------------PTVPH 193
194 -------P--GW-RKY----------NLTY-----------------------------RI--I-NY--T--PD-M--AR--------AAVDEAIQEGLEVWSKV---TPLK------FTKIS--------KG-I-A-----DIMIAFRT--------------------------R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPRKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------GLPK---EPAK-PKE---------------------------------------------------------------------------------------------------------------------PTIP- 194
195 -------P--GW-RKY----------NLTY-----------------------------RI--I-NY--T--PD-M--AR--------AAVDEAIQEGLEVWSKV---TPLK------FTKIS--------KG-I-A-----DIMIAFRT--------------------------R--VH-G---------R--C-PRY---F-D---GPL---------GV----LGHAFPP----GP----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----AG-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPRKY---PLSQDDINGIQSI---------------------------------------Y------------------------------------GLPK---EPAK-PKE---------------------------------------------------------------------------------------------------------------------PTIP- 195
196 GQYGYTLP--GW-RKY----------NLTY-----------------------------RI--I-NY--T--PD-M--AR--------AAVDEAIQEGLEVWSKV---TPLK------FTKIS--------KG-I-A-----DIMIAFRT--------------------------R--VH-G---------R--C-PRY---F-D---GPL---------GV----LGHAFPP----GP----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----AG-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPRKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------GLPK---EPAK-PKE---------------------------------------------------------------------------------------------------------------------PTIPH 196
197 ---GYTLP--GW-RRH----------NLTY-----------------------------RI--V-NY--T--PD-M--SR--------ADVDEAIRNGLEVWSRV---TPLT------FTKTS--------RG-I-A-----DIMIAFRT--------------------------R--VH-G---------R--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----AG-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPNKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------SLPK---ASAK-PKG---------------------------------------------------------------------------------------------------------------------PTVPH 197
198 -------P--GW-RRH----------NLTY-----------------------------RI--V-NY--T--PD-M--SR--------ADVDEAIRNGLEVWSRV---TPLT------FTKTS--------RG-I-A-----DIMIAFRT--------------------------R--VH-G---------R--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ENW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----AG-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPNKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------SLPK---ASAK-PKG---------------------------------------------------------------------------------------------------------------------PTVP- 198
199 GQYGYTLP--GW-RKY----------NLTY-----------------------------RI--V-NY--T--PD-M--AR--------VDVDKAIQNGLEVWSGV---TPLT------FTKIS--------KG-I-A-----DIMIAFRT--------------------------R--VH-G---------W--C-PRY---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-EDW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----AG-----------FN---LFLVAAHEFGHALG-LSH---S-NDQTALM----F-------P----NY--VS----L-------------DPNKY---PLSQDDINGIQSI---------------------------------------Y------------------G-----------------SLPT---ASAK-PKE---------------------------------------------------------------------------------------------------------------------STILH 199
200 GQYGYTLP--GW-RKY----------SLTY-----------------------------RI--M-NY--T--PD-M--TP--------ADVDEAIQKALQVWSKV---TPLT------FTRIS--------KG-V-A-----DIMIAFRTGGKACSEGSDFFEDHRELTYLPINCLS--VH-G---------W--C-PRH---F-D---GPL---------GV----LGHAFPP----GL----GLGGD---------THFD-ED-ETWIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDG----EG-----------FN---LFLVAAHEFGHSLG-LSH---S-NDQTALM----F-------P----NY--IS----L-------------DPSKY---PLSQDDIDGIQSI---------------------------------------Y------------------G-----------------SPPK---VTTK-PSG---------------------------------------------------------------------------------------------------------------------NSEPH 200
201 GLYGVTLP--GW-KKN----------NLTY-----------------------------RI--V-NY--T--PD-L--SK--------EVVDKAIQKAFKARSTV---TPLI------FARIQ--------EG-I-A-----DIMVAFGT--------------------------K--AH-G---------H--C-PRY---F-D---GPL---------GV----LAHAFPP----GS----GFGGD---------VHFD-ED-EDW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGS----DG-----------FN---LFLVAAHEVGHALG-LSH---P-NDQRAFM----F-------P----NY--AY----I-------------SPSEF---PLSPDDISGIQSI---------------------------------------Y------------------G-----------------SATK---TPGKRPTV---------------------------------------------------------------------------------------------------------------------PTSPN 201
202 DVGQYVLASPGWKKNKLTYRIVNYTPDMRQ----------------------------------------------------------ADVATAIQKAFEVWSAV---TPLT------FRRVH-----------------------------------------------------------KERADITIEFATRVHGRCPRHF-D---GPL---------GV----LGHAFPP--------NNPFRGN---------IHFD-ED-ESW-T------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FN---LWLVAAHEIGHALG-LAH---S-DDPRALM----Y-------P----NY----------------------KPIDPEDFLLSQDDIEGIQAI------YGPSLNPPKSPVKPTQPYENMNDQVFFFKDNHFWMISGFQMQPGYPKTIGNFGFPQNI--KKIDAALFDRNTGKTYFFIGAHYWRYDENRQSMDAEYPRKIEDDFPAIGQQVDAAFQHNGLFYFFHGSKQWEFDPNEKRVIRAMESNSWLNC------------------------------------------------------- 202
203 ITHNN----PRW-TKT----------HLTY-----------------------------SI--L-NY--T--P-YL--SK--------AVVEDAIARAFRVWSDV---TPLT------FQRVF--------EE-E-G-----DIVLSFHR--------------------------G--DH-G---D--------LYT-----F-D---GSK---------YH----FAHAFLPG-----L---GLGGN---------VHYD-LD-QKW-T-DNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ED-----------FN---LFYVTAHELGHSLG-LSH---S-NDEEALM----F-------P----SY--------------------TWSNKDF---VLNQDDINRIQAL---------------------------------------Y------------------GPSPNPIQLTDATL-DPCNSGL------------------------------------------------------------------------------------------------------------------------------------- 203
204 ITHNN----PRW-TKT----------HLTY-----------------------------SI--L-NY--T--P-YL--PK--------AVVEDAIARAFRVWSDV---TPLT------FQRVF--------EE-E-G-----DIVLSFHR--------------------------G--DH-G---D--------NNP-----F-D---GPN---------YK----LAHTFQPG-----P---GLGGD---------VHYD-LD-ETW-T-NSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN-----------FN---LFYVTAHELGHSLG-LTH---S-SDIGALM----F-------P----SY--------------------TWYTEDF---VLNQDDINRIQDL---------------------------------------Y------------------GPSPNPIQPTGATTPHPCNGDL------------------------------------------------------------------------------------------------------------------------------------- 204
205 ARFGHFEGKPRW-KQS----------VVTY-----------------------------RI--T-EY-----STQL--SQ--------REVDSTIAKAFQLYSDV---IPVD------FK-QI-FS-----G---TA-----DIMILFKG--------------------------G--HH-G---D--------FYP-----F-D---GPN---------GV----LAHANSP----GP----EQGGD---------THFD-DD-EKW-SLSSH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-----------IN---LLLVAAHEFGHALG-LDH---S-RDSSALM----Y-------P----TYRYVS------------------T-NAY---TLPRDDRLGVQAL---------------------------------------Y------------------GVRASTNKPEPKPEPKPNPQPAPS----------------------------------------------------------------------------------------------------------------------------------- 205
206 ARFGHFEGKPRW-KQS----------VVTY-----------------------------RI--T-EY-----TTQL--SQ--------REVDSTIAKAFQLYSDV---IPVD------FK-QI-FS-----G---TA-----DIMILFKG--------------------------G--HH-G---D--------FYP-----F-D---GPN---------GV----LAHANSP----GP----EQGGD---------THFD-DD-EKW-SLSSH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-----------IN---LLLVAAHEFGHALG-LDH---S-RDSSALM----Y-------P----TYRYVS------------------T-NGY---TLPRDDRLGVQAL---------------------------------------Y------------------GVRASTNKPEPKPEPKPNPQPAPSP---------------------------------------------------------------------------------------------------------------------------------- 206
207 --FATFAMSPKW-GVK----------DLTY-----------------------------SI--Q-NY--T--QK-M--EP--------ADIDDAIERAWKMWSEV---TPLT------FTRVY--------NG-S-A-----DIRISFVT--------------------------G--NH-G---D-----I--R-P-----F-Q---KGD---------NQ----LAHAFSP----------AFGGE---------VHFN-DD-IVW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDL----AG-----------IN---FFIVAAHEFGHSLG-LYH---S-SVLKALM----F-------A----LY--PT----T-------------DPKTL---RLHKDDIKGIQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 207
208 --FATFAMSPKW-GVK----------DLTY-----------------------------SI--Q-NY--T--QK-M--EP--------ADIDDAIERAWKMWSEV---TPLT------FTRVY--------NG-S-A-----DIRISFVT--------------------------G--NH-G---D-----I--R-P-----F-Q---KGD---------NQ----LAHAFSP----------AFGGE---------VHFN-DD-IVW-T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDL----AG-----------IN---FFIVAAHEFGHSLG-LYH---S-SVLKALM----F-------A----LY--PT----T-------------DPKTL---RLHKDDIKGIQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 208
209 --------SPKW-EKK----------DLTY-----------------------------SI--Q-NY--T--PD-M--ER--------ADVDNAIERAWKMWSDV---TPLT------FTRVY--------DG-S-A-----DIEISFAS--------------------------G--NH-G---D-----Y--I-P-----F-D---GQG---------GQ----LAHAYSP----------AYGGN---------AHFD-ED-ETW-M----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSS----TG-----------IN---LFIVAAHEFGHSLG-LYH---S-RELDALM----F-------P----TY--QF----G-------------DPQTL---KLHRDDIEGIQHL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 209
210 ----------KW-DRT----------NLTY-----------------------------KF--V-NF--T--PD-L--AI--------VEQKKTIEQAFAAWSDV---TPLS------FTEVF--------DG-R-P-----DILLEFSS--------------------------G--VH-S---D-----GKNA-A-----F-D---GPG---------GV----LAHAYYP----QF-------GD---------AHFD-DD-EYF-TVRTSDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VN---LLFTAAHEFGHSLG-LAH---S-SVSDALM----Y-------P----FY--Q-----G-------------YNPDF---ALTEDDIRGIQAI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 210
211 ----------KW-EKN----------DLTY-----------------------------KI--L-NY--T--PD-L--AE--------ADTSETIRLAFDIWQAV---TPLT------FTEI---Y-----DG-T-P-----DINILFAR--------------------------GY--H-G---D-----G--G-P-----F-D---GPG---------GT----LAHAYFP----G-G---GLGGD---------AHFD-DD-ETF-TI--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------TN---LLQVAAHEFGHSLG-LGH---S-SVYGALM----A-------P----YY--Q-----G-------------YAPDY---VLPEDDKRGIQAL---------------------------------------Y------------------G--------------------------------SAP------------SGPVEPEMPE------------------------------------------------------------------------------------------------- 211
212 ----------KW-KKT----------DLTF-----------------------------RF--L-GY--T--YD-M--DK--------QQQRAAIYEAFKRWSDV---TPLT------FKEVT--------SD-E-A-----DIYIEFAT--------------------------R--IH-S---D-----GPLA-A-----F-D---GPG---------GT----LAHAYFP----EH-------GD---------MHFD-DD-EYF-TRFSKDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IN---LDGTALHELGHSLG-LSH---S-NNKQAVM----Y-------P----IYRKY-----E-------------YYPNL---QLSQDDIMGIQAL---------------------------------------Y------------------G-----------------QYSSNYWWLTCSFTQAGACLVILWAMQKTTMHRKKTVMVTMVVVVVTAVTDGHGGGRGGGGGGGIMPDLPPSDPGAPDLCTSNFDAVLTDTNEDTFAIKGKYIWKLDGG-GIADGYPKKLYAEFYGIPSNINAGFTS 212
213 ----------KW-GKT----------DLTF-----------------------------RF--L-SY--T--SD-M--TD--------SEQRDAIYRSFKHWSDV---TPLT------FTEVS--------NG-E-A-----DILIEFAT--------------------------G--VH-S---D-----GPGA-A-----F-D---GPG---------GT----LAHAYFP----ED-------GD---------MHFD-DD-EYF-TVNSDHG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IN---LDFTATHELGHSLG-LSH---S-GDQNAIM----Y-------P----FY--L-----G-------------YVPDL---QLKQDDIIGIQTL---------------------------------------Y------------------G-----------------SNEAD------------------------------------------VITDG-----------------TPVDPGAPDVCTSDFDAVLTDYDKNTLVIKGLYLWKLHGNDGVVSGYPRRLKEEFPGLPGNINTGFTS 213
214 ----------KW-SKT----------DLTY-----------------------------KF--Y-SY--T--NQ-L--TH--------GQVRSAIYRAFQLWADV---SPLT------FTEV---A-----SG-D-A-----DINIEFAR--------------------------WT--H-S---D-----GYAA-S-----F-D---GPG---------GT----LAHAYFP----E-------NGD---------AHFD-DD-ETF-TV--YSD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TN---LFIVAAHEFGHSLG-LGH---S-NTQGALM----Y-------P----WY--Q-----G-------------YVPDY---QLPQDDIMGIQYL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 214
215 -----------W-KKV----------NITY-----------------------------HF--K-NF--S--PD-L--TE--------AQIRDAVSRAFQLWADV---TTLT------FRETS--------DP-KAA-----DIVIRFAT--------------------------G--VH-G---D-----GAFA-A-----F-D---GPG---------GT----LAHAFFP----EN-------GD---------LHFD-DD-ETF-SVGSEQD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LFIVAAHEIGHSLG-LEH---S-SDMGALM----Y-------P----WY--L-----G-------------YQHDY---ALSQDDIDGIQQI---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 215
216 -----------W-KKV----------NITY-----------------------------HF--K-NF--S--PD-L--TE--------AQIRDAVSRAFQLWADV---TTLT------FRETS--------DP-KAA-----DIVIRFAT--------------------------G--VH-G---D-----GAFA-A-----F-D---GPG---------GT----LAHAFFP----EN-------GD---------LHFD-DD-ETF-SVGSEQD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LFIVAAHEIGHSLG-LEH---S-SDMGALM----Y-------P----WY--L-----G-------------YQHDY---ALSQDDIDGIQQI---------------------------------------Y------------------G-----------------KPALKRKEMEMGAAPT-----------------------------------------------------NPPNPNLPD----------------------------------------------------------- 216
217 -----------W-KKV----------NITY-----------------------------HF--K-NF--S--PD-L--TE--------AQIRDAVSRAFQLWADV---TTLT------FRETS--------DP-KAA-----DIVIRFAT--------------------------G--VH-G---D-----GAFA-A-----F-D---GPG---------GT----LAHAFFP----EN-------GD---------LHFD-DD-ETF-SVGSEQD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LFIVAAHEIGHSLG-LEH---S-SDMGALM----Y-------P----WY--L-----G-------------YQHDY---ALSQDDIDGIQQI---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 217
218 ---------------------------------------------------------------L-NF--T--PD-L--TE--------AEVVDSFERAFKVWSDV---TPLT------FRRV---F-----DV-P-G-----DIHIQFSE--------------------------YD--H-G---D-----G--V-A-----F-D---GLG---------GT----LAHAYFP----G-G---SIGGD---------AHFD-DS-EIF-SVFLSDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DK-----------TD---LFMVAAHEFGHSLG-LGH---S-SDIHALM----A-------P----FY--V-----G-------------YDPGF---SLGYDDLHGIQSI---------------------------------------Y------------------G-----------------I-------------NSSPRPGDRFIPLRPQPSPPDPEVERCSKSFNAVAFIRNE-----LFLFK------------------------------------------------------------------------- 218
219 ----------KW-DHQ----------EITY-----------------------------RI--L-NF--T--PD-L--TE--------AEVVDSFERAFKVWSDV---TPLT------FRRV---F-----DV-P-G-----DIHIQFSE--------------------------YD--H-G---D-----G--V-A-----F-D---GLG---------GT----LAHAYFP----G-G---SIGGD---------AHFD-DS-EIF-SVFLSDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DK-----------TD---LFMVAAHEFGHSLG-LGH---S-SDIHALM----A-------P----FY--V-----G-------------YDPGF---SLGYDDLHGIQSI---------------------------------------Y------------------G-----------------I-------------NSSPRPGDRFIPLRPQPSPPDPEVERCSKSFNAVAFIRNE-----LFLFKGKNFWRMREQGKPLEGYPVEMGQFWHGLPPKVDASYERHDGKIVFLK-------------------------- 219
220 -------QGNKW-NKN----------NLTY-----------------------------KF--V-KF--T--SD-L--SK--------DDIRSAIAKAFSLWSEV---TPLT------FKEVT---------T-GNA-----DILISFVT--------------------------G--EH-G---D-----N--N-P-----F-D---GSG---------NV----LAHAYFP----PPNSG-SLAGD---------AHFD-DG-ETW-SI--S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SP----ASG-----------ID---LITVAAHEFGHSLG-LSH---S-NVRGSLM----F-------P----SY--S--------------------GILR---SLHQDDISGIQSI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 220
221 -------QGNKW-NKN----------NLTY-----------------------------KF--V-KF--T--SD-L--SK--------DEVRSAIAKAFSLWSEV---TPLT------FEEVT---------T-DNA-----DILISFVT--------------------------G--EH-G---D-----N--N-P-----F-D---GNG---------NV----LAHAYFP----PPNSG-SLAGD---------AHFD-DG-ETW-SI--S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----TSG-----------ID---LITVAAHEFGHSLG-LSH---S-KVRGSLM----F-------P----SY--S--------------------GILR---SLHQDDISGIQSI---------------------------------------Y------------------G-------------------------------------------------------------------------------------------------------------------------SRE------------------------------ 221
222 -------QGNRW-NKN----------DLTY-----------------------------KF--V-NF--T--SD-L--TE--------EEIRSGIATAFGLWSQV---TPLT------FTEVT---------S-NNA-----DILISFVT--------------------------G--DH-G---D-----G--D-P-----F-D---GAG---------NV----LAHAYYP----PPNGG-EIAGD---------AHFD-DS-ETW-SM--N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP----PSG-----------FD---LISVAAHEFGHSLG-LDH---S-TVPGALM----F-------S----SY--S--------------------GPQR---ALHEDDIAGIQSI---------------------------------------Y------------------G-------------------------------------------------------------------------------------------------------------------------HA------------------------------- 222
223 -------QGNKW-DKT----------SLTY-----------------------------RF--V-NF--T--AD-L--SE--------AEVRNAIAAALGLWSAV---TPLI------FTEVT--------GD-NNA-----DILIRFAT--------------------------G--DH-G---D-----G--K-P-----F-D---GVG---------NT----LAHAFYP----PPNGG-DIAGD---------THFD-DD-ETW-SV--N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LP----PSG-----------ID---LVTVAAHEFGHSLG-LDH---S-NVVGSLM----N-------A----SY--S--------------------GAQR---FLHEDDIKGIQSI---------------------------------------Y------------------G-------------------------------------------------------------------------------------------------------------------------ANRDPVSVDAP---------------------- 223
224 ----------RW-TKN----------NLTY-----------------------------HI--K-SF-----TPDL--SR--------LQTRNAIRRAFQLWANV---SPLS------FNE----------SSNATA-----DIVIDFVT---------------------------RYEH-N---D--------AYPMELKQF-D---GPG---------GY----LAHASYP-----------PHGI---------VHFD-ED-ETY-TVMTL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------VD---LAIVAAHEFGHVLG-LGH---S-SNSHAVM----S-------P----IY--------------------NGFVEDF---NLHQDDIDGIQYL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 224
225 ----------RW-TKN----------NLTY-----------------------------HI--K-SF-----TPDL--SR--------LQTRNAIRRAFQLWANV---SPLS------FNE----------SSNATA-----DIVIDFVT---------------------------RYEH-N---D--------AYPMELKQF-D---GPG---------GY----LAHASYP-----------PHGI---------VHFD-ED-ETY-TVMTL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------VD---LAIVAAHEFGHVLG-LGH---S-SNSHAVM----S-------P----IY--------------------NGFVEDF---NLHQDDIDGIQYL---------------------------------------Y------------------GKTVSYLMHLSLPLHCYPDVDLTLTKLEIGTSDIENLPACDSPWDAATYYAPGDVVYAFKGQFVWAINDQGVVEGYPTKTNNVFSEAPSNVHSVVSAGSRTYMFK-------------------------------------------------- 225
226 ----------KW-PYT----------DLTY-----------------------------RL--D-GT--T--PD-L--PA--------ALVNQIMALALKAWSDV---SSLT------FAQVA--------AD-QPA-----DILIDFFE--------------------------A--DH-G---D-----G--N-P-----F-D---GPG---------AV----LAHAYFP----NPN---PIAGD---------AHFD-DA-ETY-TD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPQ-----G-----------IN---LFQVAAHEFGHSLG-LGH---S-TIDAALM----A-------P----FY--Q-----G-------------YVPDF---ELHPDDVAGIQAH---------------------------------------Y------------------D-----------------TH--------------------------------------------------------------------------------------------------------------------------------------- 226
227 RKKRFTLSQLKW-PYT----------DLTY-----------------------------RL--D-GT--T--PD-L--PA--------ALVNQIMALALKAWSDV---SSLT------FAQVA--------AD-QPA-----DILIDFFE--------------------------A--DH-G---D-----G--N-P-----F-D---GPG---------AV----LAHAYFP----NPN---PIAGD---------AHFD-DA-ETY-TD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPQ-----G-----------IN---LFQVAAHEFGHSLG-LGH---S-TIDAALM----A-------P----FY--Q-----G-------------YVPDF---ELHPDDVAGIQAH---------------------------------------Y------------------G-----------------QNTNQ------------------------------------------------------------------------------------------------------------------------------------ 227
228 RARRYALSDVKW-FKT----------DLTW-----------------------------RL--E-NT--T--PD-L--RR--------SSVREIIARALKHWSDA---SQLT------FREVQ--------SG-D-A-----DLLMKFTS--------------------------R--DH-G---D--------GNP-----F-D---GSG---------KV----LAHAFFP----TSERRYSIAGD---------AHFD-EA-ETY-TDN---SY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------TN---LFQVAVHEFGHSLG-LGH---S-NNPDAIM----A-------A----IY--R-----G-------------YVPNA---ELREDDIAGIQAL---------------------------------------Y------------------G-----------------ANS-------------------------------------------------------------------------------------------------------------------------------------- 228
229 MRRKRYALGPRW-RQT----------DLTW-----------------------------NI--L-ED--S--DD-L--PR--------EQVESIMARAFKAWSDV---STLT------FRKVT--------TN-EP------DIKIIFAA--------------------------G--EH-G---D-----G--I-EAR---F-D---GGG---------GV----LAHAYFP----TSN---SLGGD---------AHFD-EG-ERF-TE--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TST-----G-----------IN---LFQVAAHEFGHSLG-LRH---S-DIEDALM----F-------P----YY--R-----G-------------YVPNF---QLHRDDIAGIQAH---------------------------------------Y------------------G-----------------EGNGQPEEPDTPSTPLDNCM--------------------------------------------------------------------------------------------------------------------- 229
230 ---------PRW-RQT----------DLTW-----------------------------NI--L-ED--S--DD-L--PR--------AQVESIMARAFKAWSDV---STLT------FSKVT--------TN-EP------DIKIIFAA--------------------------G--EH-G---D-----G--I-EAR---F-D---GGG---------GV----LAHAYFP----TSN---SIGGD---------AHFD-EG-ERF-TE--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TST-----G-----------IN---LFQVAAHEFGHSLG-LRH---S-DIEDALM----F-------P----YY--R-----G-------------YVPNF---QLHRDDIAGIQAH---------------------------------------Y------------------G-----------------EGNGQPEEPDTPSTP-------------------------------------------------------------------------------------------------------------------------- 230
231 -------------------------------------------------------------------------------------------------------------------------VT--------TN-EP------DIKIIFAL--------------------------G--DH-G---D-----G--I-EAR---F-D---GPG---------GV----LAHAYFP----TSN---SIGGD---------AHFD-EG-EMF-TE--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TST-----GNLKISLLGHQRIN---LXQVAAHEFGHSLG-LRH---S-DIEDALM----F-------P----YY--R-----G-------------YVPNF---QLHRDDIDGIQAH---------------------------------------Y------------------G-----------------EGNGQPEEPDTPSTP-------------------------------------------------------------------------------------------------------------------------- 231
232 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TST-----G-----------IN---LXQVAAHEFGHSLG-LRH---S-DIEDALM----F-------P----YY--R-----G-------------YVPNF---QLHRDDIDGIQAH---------------------------------------Y------------------G-----------------E---------------------------------------------------------------------------------------------------------------------------------------- 232
233 ----------------------------------------------------------------------------------------------MARAFKAWSDV---SSLT------FRKVT--------TN-EP------DIKIIFAL--------------------------G--DH-G---D-----G--F-EAR---F-D---GPG---------GV----LAHAYFP----SSS---SLGGD---------AHFD-EG-EMF-TE--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSR-----G-----------VN---LFQVAAHEFGHSLG-LEH---S-DVEDALM----F-------P----YY--R-----G-------------YVPNF---QLHRDDIAGIQAQ---------------------------------------Y------------------G-----------------E---------------------------------------------------------------------------------------------------------------------------------------- 233
234 ---------PRW-PKT----------DLTW-----------------------------NV--L-QE--G--AP-T--LGGVWEKEGVHGGGTDIGRVQAW-SDV---STLT------FRKVT--------TN-EP------DIKIIFAA--------------------------N--EH-G---D-----G--F-NAR---F-D---GSG---------GV----LAHAYFP----TSN---LIGGD---------AHFD-ED-ETY-TD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSS-----G-----------IN---LFQVAAHEFGHSLG-LRH---S-DVQDALM----Y-------P----YY--R-----G-------------YVANF---QLHRDDIAGIQAQ---------------------------------------Y------------------G-----------------EGNGQPEEPDTPSTP-------------------------------------------------------------------------------------------------------------------------- 234
235 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--EH-G---D-----G--F-NAR---F-D---GSG---------GV----LAHAYFP----TSN---LIGGD---------AHFD-ED-ETY-TD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSS-----G-----------IN---LFQVAAHEFGHSLG-LRH---S-DVQDALM----Y-------P----YY--R-----G-------------YVANF---QLHRDDIAGIQAQ---------------------------------------Y------------------G-----------------EGNGQPEEPDTPSTPLDNCMPQISWATRTRDGSAYFANETHV----------------------------------------------------------------------------------------------- 235
236 ------------------------------------------------------------------------------------RRG-H---------RHWKGDV---STLT------FRKVT--------TN-EP------DIKIIFAA--------------------------N--EH-G---D-----G--F-NAR---F-D---GSG---------GV----LAHAYFP----TSN---LIGGD---------AHFD-ED-ETY-TD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSS-----G-----------IN---LFQVAAHEFGHSLG-LRH---S-DVQDALM----Y-------P----YY--R-----G-------------YVANF---QLHRDDIAGIQAQ---------------------------------------Y------------------G-----------------EGNG------------------------------------------------------------------------------------------------------------------------------------- 236
237 ------------------------------------------------------------------------------AR--------IKIRPVASLVLSKWADV---SRLT------FTLVT--------SG-D-A-----DILISFAA--------------------------G--SH-G---D----------DGP---F-D---GPG---------GV----LAHAYYP----SSN-A--IGGD---------AHFD-ED-EDY-TD--A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSR-----G-----------IN---LEWVAVHEFGHSLG-LGH---S-QIEGAVM----Y-------P----YY--T-----G-------------YIPNF---QLNSDDIAGIQAH---------------------------------------Y------------------G-----------------EN--------------------------------------------------------------------------------------------------------------------------------------- 237
238 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------IN---LEWVAVHEFGHSLG-LGH---S-QIEGAVM----Y-------P----YY--T-----G-------------YVPKF---QLTSDDIAGIQAH---------------------------------------Y------------------G-----------------ENVGEPEDTPSTPEDTSST---------------------------------------------------------------------------------------------------------------------- 238
239 MRKKRYALGSRW-SKT----------ELTY-----------------------------RI--I-NR--T--PD-L--PA--------NEVDRIITESIEKWADA---SGLT------FTLVK--------SG-N-A-----DILISFAP--------------------------G--SH-G---D----------DNP---F-D---GPG---------GV----LAHAYYP----SSN-A--IGGD---------AHFD-ED-ERY-TD--A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFS-----G-----------TN---LEWVAVHEFGHSLG-LGH---S-QIEGAVM----Y-------P----YY--T-----G-------------YVPNF---QLNSDDIAGIQAH---------------------------------------Y------------------G-----------------ENVGEPENTPSTPVDK------------------------------------------------------------------------------------------------------------------------- 239
240 -RKKRYALGSRW-SKT----------ELTY-----------------------------RI--I-NR--T--PD-L--PA--------NEVDRIITESIEKWADA---SGLT------FTLVK--------SG-N-A-----DILISFAP--------------------------G--SH-G---D----------DNP---F-D---GPG---------GV----LAHAYYP----SSN-A--IGGD---------AHFD-ED-ERY-TD--A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFS-----G-----------IN---LEWVAVHEFGHSLG-LGH---S-QIEGAVM----Y-------P----FY--T-----G-------------YVPKF---QLNSDDIAGIQAH---------------------------------------Y------------------G-----------------ENVGEPENTPSTP---------------------------------------------------------------------------------------------------------------------------- 240
241 ----------RW-EKT----------DLTW-----------------------------RI--D-GS--R--PT-P--DLEA------DHVKRIMKNALQFWDDA---SALT------FREET--------GG-DA------DIQISFAV--------------------------G--EH-G---D-----T--Y-D-----F-D---GPG---------GT----LAHAFYP----TSPPV-SIAGD---------AHFD-DS-ETF-SD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAA-----G-----------TN---LLQVAIHEFGHSLG-LQH---S-DVNDAIM----Y-------P----YY--R-----G-------------YIPDI---TLDRDDIAGIQAL---------------------------------------Y------------------D-----------------TH--------------------------------------------------------------------------------------------------------------------------------------- 241
242 RKKRYVLANSRW-EKT----------DLTW-----------------------------RI--D-GS--R--PT-P--DLEA------DHVKRIMKNALQFWDDA---SALT------FREET--------GG-DA------DIQISFAV--------------------------G--EH-G---D-----T--Y-D-----F-D---GPG---------GT----LAHAFYP----TSPPV-SIAGD---------AHFD-DS-ETF-SD--G------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAA-----G-----------TN---LLQVAIHEFGHSLG-LQH---S-DVNDAIM----Y-------P----YY--R-----G-------------YIPDI---TLDRDDIAGIQAL---------------------------------------Y------------------G-----------------ENTDDPEQPST------------------------------------------------------------------------------------------------------------------------------ 242
243 --LPYVTGGIAWPRNV----------AVTY-----------------------------SF--G-TL-----TNDL--NQ--------NAIKNEIRRAFQVWDDV---SGLT------FREVV--------DS-SSV-----DIRIKFGS--------------------------Y--EH-G---D--------GI--S---F-D---GQG---------GV----LAHAFLP-----------RNGD---------AHFD-DS-ETW-TIGTNFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFQVAAHEFGHSLG-LYH---S-DVQAALM----Y-------P----YY--------------------RGYNPNF---NLDRDDIAGITSL---------------------------------------Y------------------G-----------------RNTG-TTTTTRRPTITRTTTRRTTTRRTTTRRTTTQPTTTQTTTIRPPTSPTPPR---------------------------------------------------------------------------------- 243
244 DILPYVTGGIAWPRNV----------AVTY-----------------------------SF--G-TL-----TNDL--NQ--------NAIKNEIRRAFQVWDDV---SGLT------FREVV--------DS-SSV-----DIRIKFGS--------------------------Y--EH-G---D--------GI--S---F-D---GQG---------GV----LAHAFLP-----------RNGD---------AHFD-DS-ETW-TIGTNFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFQVAAHEFGHSLG-LYH---S-DVQAALM----Y-------P----YY--------------------RGYNPNF---NLDRDDIAGITSL---------------------------------------Y------------------G-----------------RNTG-TTTTTRRPTITRTTT--------------------------------------------------------------------------------------------------------------------- 244
245 DILPYVTGGIAWPRNV----------AVTY-----------------------------SF--G-TL-----SNDL--SQ--------TAIKNELRRAFQVWDDV---SSLT------FREVV--------DS-SSV-----DIRIKFGS--------------------------Y--EH-G---D--------GI--S---F-D---GQG---------GV----LAHAFLP-----------RNGD---------AHFD-DS-ERW-TIGTNSG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFQVAAHEFGHSLG-LYH---S-DVQSALM----Y-------P----YY--------------------RGYNPNF---NLDRDDIAGITSL---------------------------------------Y------------------G-----------------RNTGSTTTTTRRPTITRTTT--------------------------------------------------------------------------------------------------------------------- 245
246 --------------------------AVTY-----------------------------SF--G-TL-----TNDL--NQ--------NAIKNELRRAFQVWVDV---SGLT------FREVV--------DS-SSV-----DIRIKFGS--------------------------Y--EH-G---D--------GI--S---F-D---GQG---------GV----LAHAFLP-----------RNGD---------AHFD-DS-ESW-TIGTNFG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LFQVAAHEFGHSLG-LYH---S-DVQSALM----Y-------P----YY--------------------RGYNPNF---NLDRDDIAGITSL---------------------------------------Y------------------G-----------------SKSY-DS---------------------------------------------------------------------------------------------------------------------------------- 246
247 ----------KW-QKN----------KLTY-----------------------------KI--T-KY--TGSPF-L--SQ--------SDVDREIEKAFKLWSDV---TPLR------FEQVP--------AY-MAA-----DIDISFPE--------------------------PYIPH-A---D-----G--FRYSI---F-D---GPG---------KT----LAHAFYP----YTY-G-DVKGD---------AHFD-DG-EQW-TA--N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYT-----G-----------IN---LWLVAAHEFGHSLG-LGH---T-NVNGALM----F-------P----YH--Q-----G-------------YNPNF---QLHDDDVAGIQFL---------------------------------------Y------------------G-----------------E---------------------------------------------------------------------------------------------------------------------------------------- 247
248 ----------QW-DKT----------DLTY-----------------------------DI--I-QY--T--PD-L--PQ--------SKVDSEIAKAFKLWSDV---TALT------FSRVH--------GD-DTA-----DIKISFPA--------------------------PFIPH-E---D-----G--YWKTT---F-D---GPG---------KV----LAHAFFP----SNY-G-DIKGD---------AHFD-DG-ENW-TA--D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TYE-----G-----------TN---LWLVAAHEFGHSLG-LAH---S-DVIGSLM----Y-------P----YY--S-----G-------------YKPNF---QLTSDDIAGMQSL---------------------------------------Y------------------G-----------------AKVPEPDITTTAPK--------------------------------------------------------------------------------------------------------------------------- 248
249 ---------PKW-RKT----------DLTW-----------------------------KI--T-KY-----TRQL--DQ--------SKTRREIIRALRHWSDV---TPLT------FREVA--------GE-S-------DITISFET--------------------------R--NH-G---D--------GVSNS---F-D---GRG---------RV----LAHAFFP-----------SNGD---------VHFD-DD-ENW-GFGDEVGNTK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---FFTVAVHEFGHTMG-LFH---S-DVQGALM----Y-------P----YY--------------------SGYNASF---TLHDDDVKGMQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 249
250 ----------KW-PKT----------EVSW-----------------------------KV--I-GYTRT--NP-L--SQ--------SQHRRAFINAFNKWSSV---SPLR------FREV---A-----SG-D-A-----DIIIDFKR--------------------------YD--H-G---D-----G--S-P-----F-D---GRS---------GT----LAHAFFP----GTS---AISGD---------THFD-DD-EKW-TM--GTS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TN---LEIVAAHEFGHALG-LSH---S-STPEALM----A-------P----YY--Q-----G-------------YDPNY---KLHNDDIRGIQSL---------------------------------------Y------------------A-----------------R---------------------------------------------------------------------------------------------------------------------------------------- 250
251 ----------KW-KKQ----------ALTW-----------------------------KA--H-NY--S--PD-L--DS--------GSQRRAFHKAFQYWSDV---TPLT------FAET---G-----AS-E-A-----DIDIQFAR--------------------------GQ--H-S---D-----GPGN-A-----F-D---GPG---------GT----LAHAFFP----E-------NGD---------THFD-ED-EDW-TQ--NTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TG-----------TN---LEIVAAHEFGHALG-LGH---S-NVRGALM----A-------P----YY--Q-----G-------------YDPNF---SLHDDDVRAIQSL---------------------------------------Y------------------G-----------------S-------------NQPAAPTLTTTRKPSTRRTPRPGSPTTTPRPGKKPDSCTA-----KFDVIFQAHDYGIYAFKAQWIWRLNDWAVDEGYPKLSRKVYQNPPLNIGAAVYSWKTRYTYFFK-------------- 251
252 -RKKRYAIQHGW-SKR----------KLTW-----------------------------AI--K-NY--T--PD-V--AK--------ATTIRVLTTAFQVWGDV---ARLD------FNPT---R-----FP-K-A-----DIIVQFAR--------------------------GN--H-G---D-----G--Y-A-----F-D---GPG---------GT----LAHAYFP----G-D---GIGGD---------VHFD-ED-ETF-SD--RTR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TN---LFIVAAHEIGHSLG-LAH---S-EVSKSLM----A-------P----YY--Q-----G-------------FQPRF---TLNTDDVRGIQSL---------------------------------------Y------------------G-----------------A--------------------RANAPNRPN-RPGGPVIPDNGP---------------------------------------------------------------------------------------------- 252
253 -----------------------------------------------------------KI--K-NY--T--PD-M--QR--------ATTTRVLVTSFQVWSDV---AMLE------FQQT---K-----FP-R-A-----DILVQFAR--------------------------GN--H-G---D-----G--Y-A-----F-D---GQG---------GT----LAHAYFP----G-D---GIGGD---------VHFD-ED-ESF-TD--ETM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R------------TN---LFIVAAHEIGHSLG-LAH---S-DVSSSLM----A-------P----YY--Q-----G-------------YQSSF---SLHTDDIKGIRSL---------------------------------------Y------------------G-----------------A--------------------RNQPPNRPRPPPGKPTIPNKGPKDRSICNARINTVAYGTIAGQPTPT--------------------------------------------------------------------- 253
254 RKRYALEGSRWA-DPE----------RLTW-----------------------------KL--S-RG--T--ND-M--SS--------AELKSEIQRAFDVWAEY---SSIE------ASET---S------S-N-P-----DINVAFYT--------------------------GN--H-G---D-----G--Y-P-----F-D---GRG---------TT----LAHAFFP----------RWGGD---------VHFD-DD-ETF-TR--NSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------TN---FFQVAAHEIGHSLG-LMH---S-SDQSSLM----A-------A----YY--R-----G-------------YQRNF---KLGNDDIRGIQNL---------------------------------------Y------------------P-----------------Q--------------------KS------------------------------------------------------------------------------------------------------------------ 254
255 -----------------------------------------------------------------------------------------------------------------------------------------------INVAFYT--------------------------GD--H-G---D-----G--H-P-----F-D---GRG---------AS----LAHAFFP----------RWGGD---------LHFD-DD-ETF-TI--NSD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------TN---FLQVAAHEIGHSLG-LRH---S-SDQSSVM----N-------A----FY--R-----G-------------YQRDF---KLASGDIRGIQSL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 255
256 ----------RW-SNT----------KLKY-----------------------------YI--E-NR--T--PD-M--TA--------AQVDDSIQRAFDVWANY---TTLR------FRQTR--N-----PS-E-A-----NFKISFGA--------------------------GS--H-G---D-----P--Y-A-----F-D---GKG---------GT----LAHAFFP----S-------DGR---------AHFD-EA-EHY-TY--KGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------VN---LFIVAAHEFGHALG-LGH---S-SVPNSLM----A-------P----FY--Q-----G-------------YTANF---QLHDDDIAGIQQL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 256
257 ----------RW-SNT----------KLKY-----------------------------YI--E-NR--T--PD-M--TA--------AQVDDSIQRAFDVWANY---TTLR------FRQTR--N-----PS-E-A-----NFKISFGA--------------------------GS--H-G---D-----P--Y-A-----F-D---GKG---------GT----LAHAFFP----S-------DGR---------AHFD-EA-EHY-TY--KGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------VN---LFIVAAHEFGHALG-LGH---S-SVPNSLM----A-------P----FY--Q-----G-------------YTANF---QLHDDDIAGIQQL---------------------------------------Y------------------G-----------------K------KVDVDAKKKRPT----------KPPTARPTAPTTTARPRPADAMNVCGKNISFDCMFFDQQKQSVFALKGKYFWKINDYGVVDGYPKKIYQYWKGLPGNIQAAAYSRITRRTYFFK-------------- 257
258 --KRYNVEGDRW-SNT----------KLKY-----------------------------YI--E-NR--T--PD-M--TA--------AQVDDSIQRAFDVWANY---TTLR------FRQTR--N-----PS-E-A-----NFKISFGA--------------------------GS--H-G---D-----P--Y-A-----F-D---GKG---------GT----LAHAFFP----S-------DGR---------AHFD-EA-EHY-TY--KGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------VN---LFIVAAHEFGHALG-LGH---S-SVPNSLM----A-------P----FY--Q-----G-------------YTANF---QLHDDDIAGIQQL---------------------------------------Y------------------G-----------------NLLITSKKVDVDAKKKRPT----------KPPTARPTAPTT------------------------------------------------------------------------------------------------ 258
259 ----------RW-SNT----------KLKY-----------------------------YI--E-NR--T--PD-M--TA--------AQVDDSIQRAFDVWANY---TTLR------FRQTR--N-----PS-E-A-----NFKISFGA--------------------------GS--H-G---D-----P--Y-A-----F-D---GKG---------GT----LAHAFFP----S-------DGR---------AHFD-EA-EHY-TY--KGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG-----------VN---LFIVAAHEFGHALG-LGH---S-SVPNSLM----A-------P----FY--Q-----G-------------YTANF---QLHDDDIAGIQQL---------------------------------------Y------------------G-----------------N---------------------------------------------------------------------------------------------------------------------------------------- 259
260 ----------RW-SNT----------KLKY-----------------------------YI--E-NR--T--PD-M--TA--------AQVDDSIQSAFNVWANY---STLT------FRQVG--S-----AE-E-A-----DLSIKFVS--------------------------GTLNH-G---D-----N--A-P-----F-D---GEG---------GT----LAHAFFP----S-------DGR---------AHFD-EA-EHY-TY--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------VN---LFIVAAHEFGHALG-LGH---S-SVPNSLM----A-------P----FY--Q-----G-------------YTANF---QLHDDDIAGIQQL---------------------------------------Y------------------G-----------------NLLITS-KIDVDAKKKRPT----------KPPTARPTAPTTTARPRPADAMNVY------------QQKQSVFALKGKYFWKINDYGVVDGYPKKIYQYWKGLPGNIQAAAYSRITRRTYFFK-------------- 260
261 ---------SKW-SKN----------VLTY-----------------------------KI--I-NH--T--PD-L--GP--------AETARIIQEAFNKWSQV---TPLI------FTRGY--------GA-T-------DMTVDF----------------------------GNLRH-S------------SCGYD---F-D---GPG---------GV----LAHAFFP-----------TDGR---------THFD-ED-EHF-TDKTT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------TN---LLWVAAHEFGHALG-LEH---S-TVQGSLM----Y-------P----YY--QG------------------YKEPF---VLHQNDISRIQQL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 261
262 -------KGNRW-TKN----------ELTY-----------------------------GI--R-KY--T--PD-L--EK--------SVVDREIAKAFQLWEEV---TPLT------FTFVE--------TG-N-V-----DIEISFES--------------------------G--AH-S---D-----S--RNHDA---F-H---GPG---------TT----YAHAAFP----PS-------GD---------THFN-DA-ETW-TI--SS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------IN---LFQVATHEFGHALG-LAH---F-ESKTDVM----F-------A----YY--------D-------------YRLNF---KLEPNDINRIQQL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 262
263 ----------RW-AKD----------DLTY-----------------------------GI--R-KY--T--LD-L--EK--------SVVDREIAKAFRLWEEV---TPLT------FTFVE--------TG-N-V-----DIEISFES--------------------------G--AH-S---D-----S--RNHDA---F-D---GPG---------KT----LAHAFFP----QS------GGD---------AHFD-EA-ETW-TI--SS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------AN---LFQVATHEFGHALG-LEH---S-ESKTAVM----Y-------S----FY--------D-------------YRPDF---KLETDDINRIQQL---------------------------------------Y------------------G-----------------AKIN------------------------------------------------------------------------------------------------------------------------------------- 263
264 -------KGNRW-TKD----------ELTY-----------------------------GI--S-KY--T--PD-L--EK--------SIVDREIAKAFQLWEEV---TPLT------FTFVE--------TG-N-V-----DIEIRFQY--------------------------G--GH-S---D-----S--KDDPT---F-E---GPG---------GI----LGYAFFP----KS-------GD---------TYFD-EA-ETW-TT--NS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------TN---LFQVATHEFGHSLG-LEH---S-ESKMAVM----Y-------S----LY--------D-------------YRPDF---KLETDDINRIQEL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 264
265 -----------W-PKK----------QLTY-----------------------------KI--K-KY--T--PD-M--SP--------SDVDREIARAFQMWADV---TDLA------FVHVN-NQ-----SA-D-V-----DIDILFAT--------------------------G--EH-G---S-----C--P-S-----FND---GPG---------GT----LAHATYP----------IYGGD---------AHFD-EG-ETW-TL--DSV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------TN---LFQVATHEFGHSLG-LEH---T-HVTTAVM----Y-------P----FY--------G-------------YSPDF---KLDKDDIEGIQEL---------------------------------------Y------------------G-----------------KNQ-------------------------------------------------------------------------------------------------------------------------------------- 265
266 -------QKRHW-PKK----------QLTY-----------------------------KI--K-KY--T--ED-M--PK--------SDVDREIARAFQMWADV---TDLA------FVHVK-NQ-----SA-D-V-----DIDILFVSGEHN----------------------G--EH-G---S-----C--N-R-----F-D---GLG---------HT----LAHAAGP----------IDGGD---------THFD-EG-ETW-TL--DSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TN---LFQLATHEFGHSLG-LGH---TRHVKMAVM----Y-------P----YY--------E-------------YQPDF---KLDKDDIEGIQVV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 266
267 RKRRYAIQGSRW-RKH----------DLTY-----------------------------RI--S-AY--T--QD-L--PA--------FEVESAVEKAFQVWARH---TPLT------FTRIY--------WG-R-P-----DLDVKFSV--------------------------G--EH-G---D-----G--N-P-----F-D---GSG---------GE----LAHAFFP----------QYGGD---------AHFD-DG-ETW-TV--RTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GG-----------TD---LFIVAAHEFGHSLG-LGH---S-DVRGSLM----A-------P----FY--Q-----G-------------YTPAF---TLPPDDVEGIQNL---------------------------------------Y----------------------------------------DRPSPHP------------------------------------------------------------------------------------------------------------------------------ 267
268 RRRRYALQGSTW-PKR----------DLTW-----------------------------SLADA-DY--T--PD-L--GK--------GDVDEAITRAFQLWQDQ---TPLT------FTRV------------S-PPT-QADIFIKFAP--------------------------I--EH-G---D-----G--A-P-----F-D---GPG---------GT----LAHAFFP----------QFGGD---------AHFD-ES-EQW-TV--KTA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------TN---LLQVAAHEFGHSLG-LSH---S-EISDALM----A-------P----FY--R-----G-------------YEPDF---VLHSDDIAGIQML---------------------------------------Y------------------G-----------------MPDMERPTPRPDAGMTPNPNPNP------------------------------------------------------------------------------------------------------------------ 268
269 RSKRYALQGSRW-KVK----------DLTY-----------------------------RI--S-KY--P--RR-L--ER--------TAVDKEIAKAFGVWSEY---TDLR------FTPKK--------TG-A-V-----HIDIRFEE--------------------------N--EH-G---D-----G--D-P-----F-D---GPG---------GT----LAHAYFP----------VYGGD---------AHFD-DA-EQW-TI--DKP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------TN---LFQVAAHEFGHSLG-LSH---S-DVRSALM----A-------P----FY--R-----G-------------YDPVF---RLDSDDIQGIQTL---------------------------------------Y------------------G-----------------TKTRNPGGGAGATPTRTPRPK-------------------------------------------------------------------------------------------------------------------- 269
270 RSKRYALQGSRW-RVK----------NLTY-----------------------------KI--S-KY--P--KR-L--KR--------VDVDAEIGRAFAVWSED---TDLT------FTRKT--------SG-P-V-----HIEIKFVE--------------------------S--EH-G---D-----G--D-A-----F-D---GQG---------GT----LAHAFFP----------VFGGD---------AHFD-DA-ELW-TI--GSP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------TN---LFQVAAHEFGHSLG-LSH---S-DQSSALM----A-------P----FY--R-----G-------------FEPVF---KLDEDDKAAIQSL---------------------------------------Y------------------G-----------------RKT-NQLRPTNVYPATTQRPY-------------------------------------------------------------------------------------------------------------------- 270
271 ----------RW-RVK----------QLTY-----------------------------SI--T-KY--P--SA-L--KT--------TDVDRELAKAFQVWEDV---TELT------FVHLR--------TG-K-V-----HIEIRFES--------------------------G--EH-G---D-----G--D-A-----F-D---GTG---------GT----LAHAYFP----------IYGGD---------AHFD-ES-ETW-TI--NSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------TN---LFQVAAHEFGHSLG-LSH---S-DVRSALM----A-------P----FY--R-----G-------------YEPSF---KLDNDDSQNVAT------------------------------------------------------------------------------TTETSSRPLPPGRATTPR---------------------------------------------------------------------------------------------------------------------- 271
272 RRRRYALHGSKW-SAK----------DLTF-----------------------------RI--S-KY-----SDQM--PK--------EEVEREIQRAFDEWGKV---TPLT------FTQV----------T-GKP-----DIDIRFEK--------------------------R--WH-G---D----------NNP---F-D---GEG---------KT----LAHAYFP----------RYGGD---------AHFD-DD-EKW-TINIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------IN---FFQVAVHEIGHSLG-LAH---S-DDYKALM----A-------P----FY--------------------KGYSRDF---RLDTDDIEAIQTL---------------------------------------Y------------------G-----------------TPASRRKP--------------------------------------------------------------------------------------------------------------------------------- 272
273 -----------W-QKT----------DLTY-----------------------------RI--A-QY-----PGENHLLH--------SEVDEAIARAFQIWEEA---TLLT---------FT-AI-----D--TVA-----DIEIKFAR--------------------------G--DH-G------------D-DTP---F-D---GSG---------HT----LAHAFSP------GEG--IHGD---------VHFD-DA-ELW-TV----DSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-----------TN---LFMVALHEFGHSLG-LNH---S-DNTDSVM----Y-------P----WY-----------------PGYPGSS--F---RLPAVDVMAIQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 273
274 ----------KW-GRV----------DLTY-----------------------------RI--N-SY-----PGENRLLA--------GEVDETIARAFQVWADV---TPLT---------FR-PV-----P--KKP-----DIDIEFAR--------------------------G--KH-G------------NCRLH---F-D---GSG---------NT----LAHAYFP------GEG--LLGD---------VHFD-AA-ERW-TI----QSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TN---LFIVAVHELGHSLG-LDH---A-DHRDAVM----F-------P----WY-----------------PGYLGSSYLY---QLPAVDVTAIQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 274
275 ---------------------------------------------------------------------------------------------------------------------------------------------ADIVISFFS--------------------------G--DH-G---D-----G--Y-P-----F-D---GND---------VTDVTDVAHAFVP----FDLSN-PIAGD---------VHFN-DA-INW-AD--DST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------FE---LNFLILHELGHSLG-LSH---S-QDISSLM----Y-------P----FY--DFNSLGS-------------LEP-------QPDDIAGIQAL---------------------------------------Y------------------G-----------------VKCGAPLDGTNTESVLIDEGSPGVVYNY------------------------------------------------------------------------------------------------------------- 275
276 ---------------------------------------------------------------------------------------------------------------------------------------------ADIVISFFS--------------------------G--DH-G---D-----G--Y-P-----F-D---GND---------VTDVTDVAHAFVP----FDLSN-PIAGD---------VHFN-DA-INW-AD--DST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------FE---LNFLILHELGHSLG-LSH---S-QDISSLM----Y-------P----FY--DFNSLGS-------------LEP-------QPDDIAGIQAL---------------------------------------Y------------------V-----------------CKT----QGYRTVAV---EPLYGVSNRYSEPRN-------------------------------------------------------------------------------------------------------- 276
277 -----------------------------------------------------------------------------------------------------WSDV---SALT------F-EYT-ADPAN-------A-----DIAISFVS--------------------------G--DH-G---D--------GLP-----F-D---GTD---------------LAHAFLP----VDLL-GPIAGD---------VHLN-DA-IHW--GTVSFD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG----------------FLFVILHELGHSLG-LSH---S-QDTNSLM----Y-------A----YYN---------------------EQP------LQLDDIAGIRAL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 277
278 ------PLDVRW-HKT----------DLSY-----------------------------RI--S-YY-----TADL--TR--------EEVDTAIADAFSVWESV---SSLR------FIRTFGHP----------------DIDLSFVY--------------------------G--EHFG---D--------AEP-----F-D---GPS--------SGTGGGNLAHAFPP------DIESELRGD---------VHFD-DA-EKW-TMDKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------IN---LFQLAVHEIGHSLG-LSH---S-RQHNSVM----Y-------P----YY--------------------LGLRRHF---RLHRDDIRDIQQL---------------------------------------Y------------------GPPR------------------------------------------------------------------------------------------------------------------------------------------------------- 278
279 RRRRYVVQGSRW-PLR----------SLKW-----------------------------KL--NDDY--K--DIKL--RK--------KDVLDAMMRAFKVWSDV---ANIN------FERVW--------NG-T-P-----DIDIRFAS--------------------------G--RH-G---D--------GNP-----F-D---GPG---------RT----LAHAYFPQ----------YGGN---------IHFA-AS-ESW-TFRNY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------TN---LFYVAAHEVGHSLG-LSH---S-RDQRALM----G-------P----FY--------------------RGYVPNF---VLPQDDINGIRYL---------------------------------------Y------------------GEISFQLSAPLNVHPRPHDPRP------------------------------------------------------------------------------------------------------------------------------------- 279
280 -RYDIADGRYKW-DSS----------QITY-----------------------------SL--V-NF-----PTRGGIKL--------SDLRNTIKRAFEVWSDV---TPLV------FTELH-GH-----EV-NQA-----MVRIAFMK--------------------------G--RH-S------------H-DLEHPIF-D---GPN---------GD----LAHAFSPKSGWGE-----VNGD---------IHFD-DD-DVF-TLGNNDRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YN---FFQTAAHEIGHALG-LDH---S-NDPEALM----W-------P----HY-----------------HFMR----DF---ELPDDDIRGVQAL---------------------------------------Y------------------G-------PN------PNP---------------------------------------------------------------------------------------------------------------------------------------- 280
281 -------------------------------------------------------------------------------------------------------DV---TPLV------FTELH-GH-----EV-NQA-----MVRIAFMK--------------------------G--RH-S------------H-DLEHPIF-D---GPN---------GD----LAHAFSPKSGWGE-----VNGD---------IHFD-DD-DVF-TLGNNDRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YN---FFQTAAHEIGHALG-LDH---S-NDPEALM----W-------P----HY-----------------HFMR----DF---ELPDDDIRGVQAL---------------------------------------Y------------------GTKTSPRVPNVRIDQGPRPKSTLVRQPSKKSYCTS------------------------------------------------------------------------------------------------------------------------ 281
282 RRYDIADGRYKW-DSS----------QITY-----------------------------SL--V-NF-----PTRGGIKL--------SDLRNTIKRAFEVWSDV---TPLV------FTELH-GH-----EV-NQA-----MVRIAFMK--------------------------G--RH-S------------H-DLEHPIF-D---GPN---------GD----LAHAFSPKSGWGE-----VNGD---------IHFD-DD-DVF-TLGNNDRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YN---FFQTAAHEIGHALG-LDH---S-NDPEALM----W-------P----HY-----------------HFMR----DF---ELPDDDIRGVQAL---------------------------------------Y------------------GTKTSPRVPNVRIDQGPRPK--------------------------------------------------------------------------------------------------------------------------------------- 282
283 ----------RW-TNK----------TLTY-----------------------------KI--S-KF-----SSKM--SS--------ARVKTAFRQAWQLWAQA---APLK------FR----RK-----RR-SDA-----DIVISFNN--------------------------K--DH-N---D--------GSP-----F-D---GEG---------GI----LAHAFSP----GP----GIGGD---------VHFD-DE-ETW-TTNGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------YN---LLPVAVHEFGHALG-LSH---S-SDPGAIM----F-------P----AYNFGL------------------H-SVL---QLSYQDVKDIKEM---------------------------------------Y------------------GERSTSPDLLPPKTP-------------------------------------------------------------------------------------------------------------------------------------------- 283
284 ----------RW-TNK----------TLTY-----------------------------KI--S-KF-----SSKM--SS--------ARVKTAFRQAWQLWAQA---APLK------FR----RK-----RR-SDA-----DIVISFNN--------------------------K--DH-N---D--------GSP-----F-D---GEG---------GI----LAHAFSP----GP----GIGGD---------VHFD-DE-ETW-TTNGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------YN---LLPVAVHEFGHALG-LSH---S-SDPGAIM----F-------P----AYNFGL------------------H-SVL---QLSYQDVKDIKEM---------------------------------------Y------------------GERSTSPDLLPPKTP-------------------------------------------------------------------------------------------------------------------------------------------- 284
285 LALTSGSSQFKW-SKT----------RLTY-----------------------------SI--E-SW-----SSDL--SK--------DDVRRAISEAYGLWSKV---TPLE------FSEVP--------AG-STS-----DIKIRFGV--------------------------R--NH-N---D--------PWP-----F-D---GEG---------GV----LAHATMP-----------ESGM---------FHFD-DD-ENW-TYKDARKIHNNEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LLAVAIHEGGHTLG-LEH---S-RDENAIM----A-------P----FY-----------------QKTTDSSGNYVYPNLKSDDISAIQAI---------------------------------------Y------------------GAGSGRSSSGSDFGGSSGGGS-------------------------------------------------------------------------------------------------------------------------------------- 285
286 -------GSSMW-DKH----------TLTY-----------------------------RI--I-NY-----PRDI--NP--------STVKNIMQNAVSIWSNV---TPLI------FQQV---------KS-QDA-----DIKISFWD--------------------------L----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------FN---LFLVAIHELGHSLG-LLH---S-KSLNSIM----Y-------P----RYVNR-------------------DPRTF---HLDGDDIKRIQQL---------------------------------------Y------------------GERCSSEMP-------------------------------------------------------------------------------------------------------------------------------------------------- 286
287 -------GSSMW-DKH----------TLTY-----------------------------RI--I-NY-----PRDI--NP--------STVKNIMQNAVSIWSNV---TPLI------FQQV---------KS-QDA-----DIKISFWD--------------------------L--AH-G---D--------CWP-----F-D---GPG---------GV----LGHAFLP----NS----RAPGV---------IHFD-RG-EHW-STSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------FN---LFLVAIHELGHSLG-LLH---S-KSLNSIM----Y-------P----RYVNR-------------------DPRTF---HLDGDDIKRIQQL---------------------------------------Y------------------GERCSSEMP-------------------------------------------------------------------------------------------------------------------------------------------------- 287
288 AKDSTFPGSSMW-DKH----------TLTY-----------------------------RI--I-NY-----PRDI--NP--------STVKNIMQNAVSIWSNV---TPLI------FQQV---------KS-QDA-----DIKISFWD--------------------------L--AH-G---D--------CWP-----F-D---GPG---------GV----LGHAFLP----NS----RAPGV---------IHFD-RG-EHW-STSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------FN---LFLVAIHELGHSLG-LLH---S-KSLNSIM----Y-------P----RYVNR-------------------DPRTF---HLDGDDIKRIQQL---------------------------------------Y------------------GERCSSEM--------------------------------------------------------------------------------------------------------------------------------------------------- 288
289 -------GSSKW-NKH----------TLTY-----------------------------RI--I-NY-----PREM--KR--------DTVKDIILDALSIWSNV---TSLI------FQEA---------KS-QDA-----DITLSFWD--------------------------L--AH-G---D--------DWP-----F-D---GPG---------GI----LGHAFLP----DS----DAPGV---------IHFD-KG-EHW-SNSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------FN---LFLVAIHELGHSLG-LRH---S-GSQNSIM----Y-------P----SYVYH-------------------DPRTF---HLGVDDIQRIQQL---------------------------------------Y------------------GMC-------------------------------------------------------------------------------------------------------------------------------------------------------- 289
290 ANSSVFPGSSKW-NKH----------TLTY-----------------------------RI--I-NY-----PREM--KR--------DTVKDIILDALSIWSNV---TSLI------FQEA---------KS-QDA-----DITLSFWD--------------------------L--AH-G---D--------DWP-----F-D---GPG---------GI----LGHAFLP----DS----DAPGV---------IHFD-KG-EHW-SNSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------FN---LFLVAIHELGHSLG-LRH---S-GSQNSIM----Y-------P----SYVYH-------------------DPRTF---HLGVDDIQRIQQL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 290
291 ----ISPGRCKW-NKH----------TLTY-----------------------------RI--I-NY-----PHDM--KP--------SAVKDSIYNAVSIWSNV---TPLI------FQQV---------QN-GDA-----DIKVSFWQ--------------------------W--AH-E---D--------GWP-----F-D---GPG---------GI----LGHAFLP----NS----GNPGV---------VHFD-KN-EHW-SASD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TG-----------YN---LFLVATHEIGHSLG-LQH---S-GNQSSIM----Y-------P----TYWYH-------------------DPRTF---QLSADDIQRIQHL---------------------------------------Y------------------GE--------------------------------------------------------------------------------------------------------------------------------------------------------- 291
292 SDTSISPGRCKW-NKH----------TLTY-----------------------------RI--I-NY-----PHDM--KP--------SAVKDSIYNAVSIWSNV---TPLI------FQQV---------QN-GDA-----DIKVSFWQ--------------------------W--AH-E---D--------GWP-----F-D---GPG---------GI----LGHAFLP----NS----GNPGV---------VHFD-KN-EHW-SASD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TG-----------YN---LFLVATHEIGHSLG-LQH---S-GNQSSIM----Y-------P----TYWYH-------------------DPRTF---QLSADDIQRIQHL---------------------------------------Y------------------GEKCSSDIP-------------------------------------------------------------------------------------------------------------------------------------------------- 292
293 ----------RW-SKK----------HISY-----------------------------RI--D-NY--P--TS-VWIPR--------RRVQDSIARALQMWGDV---TPLD------FRMLD-DWDI---DD-EDA-----DIYVSFSK--------------------------Y--RH-G---D--------PYP-----F-D---GPD---------GT----IAHAYLP----NGQFG-NLDGD---------VHFD-DS-EFF-SYDGDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------YN---LFKVAAHELGHSLG-LEH---S-HTMGSIM----V-------P----DY--AG----F-----------KGDDNEF---KLGDDDIRAIQVL---------------------------------------Y------------------GSLQ------------------------------------------------------------------------------------------------------------------------------------------------------- 293
294 RQKRYALAGDRW-SKK----------HISY-----------------------------RI--D-NY--P--TS-VWIPR--------RRVQDSIARALQMWGDV---TPLD------FRMLD-DWDI---DD-EDA-----DIYVSFSK--------------------------Y--RH-G---D--------PYP-----F-D---GPD---------GT----IAHAYLP----NGQFG-NLDGD---------VHFD-DS-EFF-SYDGDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------YN---LFKVAAHELGHSLG-LEH---S-HTMGSIM----V-------P----DY--AG----F-----------KGDDNEF---KLGDDDIRAIQVL---------------------------------------Y------------------GHMLWTYKGKTLLPGYPRSVR-------------------------------------------------------------------------------------------------------------------------------------- 294
295 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YN---LFKVAAHELGHSLG-LEH---S-HTMGSIM----V-------P----DY--AG----F-----------KGDDNEF---KLGDDDIRAIQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 295
296 ----------RW-SKK----------HISY-----------------------------RI--D-NY--P--TS-VWIPR--------RRVQDSIARALQMWGDV---TPLD------FRMLD-DWDI---DD-EDA-----DIYVSFSK--------------------------Y--RH-G---D--------PYP-----F-D---GPD---------GT----IAHAYLP----NGQFG-NLDGD---------VHFD-DS-EFF-SYDGDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------YN---LFKVAAHELGHSLG-LEH---S-HTMGSIM----V-------P----DY--AG----F-----------KGDDNEF---KLGDDDIRAIQVL---------------------------------------Y------------------GHMLWTYKGKTLLPGYPRSVRSRNMPGHVDAALHFRAYNKTYFFRGPYVWRYDEKREYVDAGFPTLTKEVFPGIQTPLDAAFQFTDKNHYF---------------------------------------------------------------- 296
297 RKKRYALQGSKW-DHK----------HLTY-----------------------------KF--I-NH--S--PD-L--PA--------SQVETEIRAAFQWWEDN---SSLR------FSKVA--------KS-QRA-----DIEILFSA--------------------------G--AH-G---D-----G--D-P-----F-D---GPG---------QT----LAHAYFP----------GSGGN---------AHFD-EA-ERW-SI--SSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGK----------VN---LRIVAAHEFGHSLG-LSH---S-DVSEALM----A-------P----FY--N--------------------PRSS---GLHSDDIQAIQRL---------------------------------------Y------------------G-----------------KSMVKPDIVTPKPTVPTTTRRTTTPRT-------------------------------------------------------------------------------------------------------------- 297
298 RKKRYALQGSKW-DHK----------HLTY-----------------------------KF--I-NH--S--PD-L--PA--------SQVETEIRAAFQWWEDN---SSLR------FSKVA--------KS-QRA-----DIEILFSA--------------------------G--AH-G---D-----G--D-P-----F-D---GPG---------QT----LAHAYFP----------GSGGN---------AHFD-EA-ERW-SI--SSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGK----------VN---LRIVAAHEFGHSLG-LSH---S-DVSEALM----A-------P----FY--N--------------------PRSS---GLHSDDIQAIQRL---------------------------------------Y------------------G-----------------KSMVKPDIVTPKPTVPTTTRRTTTP---------------------------------------------------------------------------------------------------------------- 298
299 RKKRYALKGGKW-DHK----------QLTY-----------------------------KF--I-NY--P--TK-L--SV--------SQSESEIRTAFQWWEDN---SSLR------FSKVT--------KG-EHA-----DIEIMFAV--------------------------G--DH-G---D-----W--D-S-----F-D---GPG---------HT----LAHAYFP----------VFGGN---------VHFD-EA-EPW-SI--SSA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------VK---LGTVAAHEFGHSLG-LSH---S-DVTTALM----A-------P----FY--S--------------------PNTK---GLHSDDIQAVQEL---------------------------------------Y------------------G-----------------KSLEKTDT--------------------------------------------------------------------------------------------------------------------------------- 299
300 -----------W-GKS----------VITY-----------------------------RLKQP-SQ-----RMSL------------SQQKAVFARAFATWEEH---TRLW------FVAVDDE------DE-QKA-----NIDIVFAA--------------------------G--DH-E---DGE--------P-----F-D---GKG---------NI----LAHAFFP----------RYGGD---------VHFD-ED-ELW-SAN---KT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------VD---LYAVAVHEIGHSLG-LKH---S-SNHLSIM----A-------P----FY----------------------KQYTGAVMHLHQDDISAVKRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 300
301 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHAFFP----------RYGGD---------VHFD-ED-ELW-SAN---KT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------VD---LYAVAVHEIGHSLG-LKH---S-SNHLSIM----A-------P----FY----------------------KQYTGAVMHLHQDDISAVKRL---------------------------------------Y------------------GAPVKIRKKASEHHIWR------------------------------------------------------------------------------------------------------------------------------------------ 301
302 -----------W-GKS----------IITY-----------------------------RLKQP-SQ-----RMSL------------SQQREVFAKAFA---EH---TRLW------FVAVNDD------DP-QKA-----NIDIVFAA--------------------------G--DH-E---DGE--------P-----F-D---GKG---------NI----LAHAFFP----------RYGGD---------VHFD-ED-EMW-SAN---KS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------VD---LYAVAVHEIGHSLG-LKH---S-ANHLSIM----A-------P----FY----------------------KQYTGNVMHLHQDDIQAVKRL---------------------------------------Y------------------GSPVKIR---------------------------------------------------------------------------------------------------------------------------------------------------- 302
303 ----------GW-NKR----------RITY-----------------------------FL--A-NW-----SPKI-GDE--------ETTIQQLERAFKVWSDY---AHLK------FVQ---VPTPD-------A-----DITILFGR--------------------------G--YH-G---D--------RYP-----F-D---GVG---------YT----LAHAYYP----YEFD--NFGGD---------VHFD-ED-EPWAVNPDEGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------ID---FFTVATHELGHSLG-LAH---S-PVPGSVM----F-------P----YYKG--------------------SQPNL---QLDYDDILAMYQL---------------------------------------Y------------------ISRQ------------------------------------------------------------------------------------------------------------------------------------------------------- 303
304 GVVDVMQHDQSL-RHR----------RI-----------------------------------A-NW-----SSKV-G-E--------DAVAKFMAKAFGEWSKY---SKLR------FVR---VYDPS-------A-----DIIVGFGS--------------------------G--HH-G---D--------NYP-----F-D---GPG---------NV----LAHAFYP----YEMN--AYGGD---------VHFD-ED-ENWKENSTHLS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------VD---FYSVAIHELGHSLG-LAH---S-PVYSSLM----F-------P----YYKGI-------------------AQGT-----LDYDDILAMYQL---------------------------------------Y------------------IQNPHITDEPDWMYTTEASTTVDEYGT-------------------------------------------------------------------------------------------------------------------------------- 304
305 -----------W-RKK----------NLTY-----------------------------RI--Y-NY--T--PD-M--GK--------SATQTAIRTAFKYWSDV---TPLS------FTEIH--------FG-T-A-----DIRISFHK--------------------------R---------D--------GCPSP---F-D---GPG---------HV----LAHAEAP----PS-------GI---------VHFD-ED-EFW-TEGKY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YG-----------SN---LRIVAAHEIGHALG-LGH---S-QYSSALM----A-------A----HY--TG------------------YQVNF---RLHIDDIRGIQAI---------------------------------------Y-------------------------------------GK-------------------------------------------------------------------------------------------------------------------------------------- 305
306 -----------W-RKK----------NLTY-----------------------------RI--Y-NY--T--PD-M--GK--------SATQTAIRTAFKYWSDV---TPLS------FTEIH--------FG-T-A-----DIRISFHK--------------------------R---------D--------GCPSP---F-D---GPG---------HV----LAHAEAP----PS-------GI---------VHFD-ED-EFW-TEGKY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YG-----------SN---LRIVAAHEIGHALG-LGH---S-QYSSALM----A-------A----HY--TG------------------YQVNF---RLHIDDIRGIQAI---------------------------------------Y-------------------------------------GKRVSSTTTADDIYDVTYPTMMAPFPRGDVLDPCNAKLDAIMLGPWRKTYAFSGDYVWTVTDTGHNSPVKINLLWKGLPGNLNAAVYSSRTNKTYFFK-------------------------------------- 306
307 ---------------------------------------------------------------------------------------------AIRTAFKYWSDV---TPLS------FTEIH--------FG-T-A-----DIRISFHK--------------------------R---------D--------GCPSP---F-D---GPG---------HV----LAHAEAP----PS-------GI---------VHFD-ED-EFW-TEGKY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YG-----------SN---LRIVAAHEIGHALG-LGH---S-QYSSALM----A-------A----HY--TG------------------YQVNF---RLHIDDIRGIQAL---------------------------------------Y------------------------------------ICKRVSSTTTADDIYDVTYPTMMAPFPRGDVLDPCNAKLDAIMLGPWRKTYAFSGDYVWTVT--------------------------------------------------------------------------- 307
308 ----------RW-RKR----------HLTY-----------------------------RL--Y-SH--S--ED-M--GA--------AATRTAIKTAFKYWSDV---TRLT------FQEVR--------TG-R-A-----DIRLAF--------------------------------H-G---SSPWGCS--R-P-----F-D---GPG---------HV----LAHADIP----------EL-GT---------VHFD-SA-EHW-TE--GTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEIGHALG-LGH---S-RHPTALM----A-------P----SY--S-----G-------------YRPRF---RLHHDDIEGIQAL---------------------------------------Y------------------G-----------------KK--------------------------------------------------------------------------------------------------------------------------------------- 308
309 ----------RW-RKK----------HLTF-----------------------------RI--F-NL--P--ST-L--PP--------DTARAALLQAFQYWSSA---APLT------FREVQ--------AG-W-A-----DIRLSF--------------------------------H-G---RQSPYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHELGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KK--------------------------------------------------------------------------------------------------------------------------------------- 309
310 QKTLKYLLLGRW-RKK----------HLTF-----------------------------RI--F-NL--P--ST-L--PP--------DTARAALLQAFQYWSSA---APLT------FREVQ--------AG-W-A-----DIRLSF--------------------------------H-G---RQSPYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHELGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPETEEEEEEME--LPAIPHMPTEP-------------------------------------------------------------------------------------------------------------- 310
311 ---LKYLLLGRW-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PP--------HTARAALLQAFQYWSNV---APLT------FREVQ--------AG-W-A-----DIRLSF--------------------------------H-G---RQSPYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHELGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPETEDEEEEME--LPTVPHVPTEPS------------------------------------------------------------------------------------------------------------- 311
312 ----------RW-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PP--------HTARAALLQAFQYWSNV---APLT------FREVQ--------AG-W-A-----DIRLSF--------------------------------H-G---RQSPYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHELGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KK--------------------------------------------------------------------------------------------------------------------------------------- 312
313 -----------W-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PS--------STARAALLQAFQYWSNV---APLT------FREVK--------AG-W-A-----DIRLSF--------------------------------H-G---RHSLYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEIGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPYF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KK--------------------------------------------------------------------------------------------------------------------------------------- 313
314 -----------W-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PS--------STARAALLQAFQYWSNV---APLT------FREVK--------AG-W-A-----DIRLSF--------------------------------H-G---RHSLYCS--N-S-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEIGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPYF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPEIEEEEEEEDTALPTIPLVPTEPSPMPDPCSSDLDAVMLGPRGKTYAFKGNYVWTVTDSGLGPLFQVSALWEGLPGNLDAAVYSPRTQWIHFFK--------------------------------------- 314
315 QRTLKYLLLGRW-RKK----------HLKF-----------------------------RI--L-NL--P--ST-L--PA--------HTAREALLQAFQYWSDV---TPLT------FQEVH--------AG-W-A-----DIRLSF--------------------------------H-G---RQSLYCS--K-D-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-ELW-TE--RTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHELGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPGIGDEEEEME--TSTVPQVPTEP-------------------------------------------------------------------------------------------------------------- 315
316 ----------RW-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PP--------HTARAALRQAFQDWSNV---APLT------FQEVQ--------AG-A-A-----DIRLSF--------------------------------H-G---RQSSYCS--N-T-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-EFW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEVGHALG-LGH---S-RYSQALM----A-------P----VY--E-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPV------------------------------------------------------------------------------------------------------------------------------------ 316
317 ----------RW-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PP--------HTARAALRQAFQDWSNV---APLT------FQEVQ--------AG-A-A-----DIRLSF--------------------------------H-G---RQSSYCS--N-T-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-EFW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEVGHALG-LGH---S-RYSQALM----A-------P----VY--E-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPV------------------------------------------------------------------------------------------------------------------------------------ 317
318 QKTLKYLLLGRW-RKK----------HLTF-----------------------------RI--L-NL--P--ST-L--PP--------HTARAALRQAFQDWSNV---APLT------FQEVQ--------AG-A-A-----DIRLSF--------------------------------H-G---RQSSYCS--N-T-----F-D---GPG---------RV----LAHADIP----------EL-GS---------VHFD-ED-EFW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------VN---LRIIAAHEVGHALG-LGH---S-RYSQALM----A-------P----VY--E-----G-------------YRPHF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KKSPVIRDEEEEET-ELPTVPPVPTEP-------------------------------------------------------------------------------------------------------------- 318
319 QKSLKYLLLGHW-RKK----------NLTF-----------------------------RI--F-NV--P--ST-L--SL--------PRVRAALHQAFKYWSSV---APLT------FREVK--------AG-W-A-----DIRLSF--------------------------------H-G---RQSLYCS--N-T-----F-D---GPG---------KV----LAHADIP----------EL-GS---------IHFD-KD-ELW-TE--GTY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------VN---LRIIAAHEVGHALG-LGH---S-RYTQALM----A-------P----VY--A-----G-------------YQPFF---KLHPDDVAGIQAL---------------------------------------Y------------------G-----------------KRSPETRDEEEETE--MLTVSPVTAKPG------------------------------------------------------------------------------------------------------------- 319
320 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAVHELGHTLG-LGH---S-DVPDAIM----I-------P----TY--L-------------------YRPFF---KLHPDDVAGIQRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 320
321 MRHKRWAIFQRW-PKN----------DLTY-----------------------------RI--S-TY--T--T-KL--PV--------DIVDDAVSRAFKLWSDV---ANIT------FTKIT--------SG-K-A-----DIDISFHR--------------------------G--DH-G---D--------SRP-----F-D---GSG---------LV----LGHAFPPGLITSRP---DLIGS---------IHLD-EE-ENW-TANSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------KN---LWLTVGHEIGHAIG-LSH---S-RVLPALM----Y-------P----WY--------------------PSYNPSF---TLDRDDIEGVQFL---------------------------------------Y------------------GESVSTCHRLCIRAP-------------------------------------------------------------------------------------------------------------------------------------------- 321
322 ----------KW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQDL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 322
323 ----------KW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQDL---------------------------------------Y------------------G-----------------KPQ-------------------------------------------------------------------------------------------------------------------------------------- 323
324 ------KQGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LSH---S-PAPRALM----A-------P----YY--------------------KKLGRDA---LLSWDDVLAVQSL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 324
325 ------KQGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LSH---S-PAPRALM----A-------P----YY--------------------KKLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------KPQG------------------------------------------------------------------------------------------------------------------------------------- 325
326 RKKRFAKQGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LSH---S-PAPRALM----A-------P----YY--------------------KKLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------KPQGGSVAIQLPGKLFTDFEAWDPH---------------------------------------------------------------------------------------------------------------- 326
327 ------KQGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PEHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 327
328 -------QGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PEHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 328
329 -------QGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PEHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 329
330 -------QGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PEHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 330
331 -KKRFAKQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------KP--------------------------------------------------------------------------------------------------------------------------------------- 331
332 RKKRFAKQGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PEHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-QD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------KPLGGSVAVQLPGKLFTDFETWDSYS--------------------------------------------------------------------------------------------------------------- 332
333 RKKRFAKPGNKW-YKQ----------HLSY-----------------------------RL--V-NW-----PERL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLANA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-GD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-PAPRALM----A-------P----YY--------------------KKLGRDA---LLSWDDVLAVQSL---------------------------------------Y------------------G-----------------KPLGRSVATQLPGKVFTDFEAWDPHN--------------------------------------------------------------------------------------------------------------- 333
334 ----------KW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LGHAFLP----------R-RGE---------AHFD-GD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVGLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQGL---------------------------------------Y------------------G-----------------KPQG------------------------------------------------------------------------------------------------------------------------------------- 334
335 RKKRFAKQGSKW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LGHAFLP----------R-RGE---------AHFD-GD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVGLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YY--------------------KRLGRDA---LLSWDDVLAVQGL---------------------------------------Y------------------G-----------------KPQGGSVAIQLPGKLFTDFEAWDPH---------------------------------------------------------------------------------------------------------------- 335
336 --------GSKW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YYPKKPTQIAAISWMYITGHEGKPQGGSV---AIQLPGKLFTDFE---------------------------------------A------------------W-----------------DPHRTQGRRPEIQGPKYCHASFDAITVDGQQRLYVFQGSHFWEVT-------------------------------------------------------------------------------------------- 336
337 ----------KW-YKQ----------HLSY-----------------------------RL--V-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-VPA-----DIRLTFFQ--------------------------G--DH-N---D--------GLGNA---F-D---GPG---------GA----LAHAFLP----------R-RGE---------AHFD-RD-ERW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LAH---S-PAPRALM----A-------P----YY--------------------KPKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 337
338 -------QGNKW-YKR----------HLSY-----------------------------RL--L-NW-----PQHL--PE--------PAVRGAVRAAFQLWSNV---SALE------FWEAP--------AT-GPA-----DIRLAFFQ--------------------------G--DH-N---D--------GLSNA---F-D---GPG---------GA----LAHAFLP----------R-RGK---------RTST-ET-SAW-SLSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RG-----------RN---LFVVLAHEIGHTLG-LTH---S-AAPRALM----A-------P----YY--------------------KRLAATR---ALSWDDVLAVQSL---------------------------------------Y------------------G-----------------KPQ-------------------------------------------------------------------------------------------------------------------------------------- 338
339 EQEATAEPGSKW-HKR----------HLTY-----------------------------RM--V-NW-----PPYL--PQ--------HEVRLAVRAAFELWSNV---SSLV------FWEA---------RD-GPA-----DIRLTFFH--------------------------G--DH-N---D--------GLNNA---F-D---GPG---------GA----LAHAFFP----------R-RGE---------AHFD-SA-ERW-SLHSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------RN---LFVVVAHEVGHTLG-LEH---S-PTKSALM----S-------P----YY--------------------KKLGKDF---VLNWDDILAIQNL---------------------------------------Y------------------G-----------------KPS-KGLAIQLPGRV-------------------------------------------------------------------------------------------------------------------------- 339
340 ----------KW-HKR----------HLTY-----------------------------RM--V-NW-----PPYL--PQ--------HEVRLAVRAAFELWSNV---SSLV------FWEA---------RD-GPA-----DIRLTFFH--------------------------G--DH-N---D--------GLNNA---F-D---GPG---------GA----LAHAFFP----------R-RGE---------AHFD-SA-ERW-SLHSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------RN---LFVVVAHEVGHTLG-LEH---S-PTKSALM----S-------P----YY--------------------KKLGKDF---VLNWDDILAIQNL---------------------------------------Y------------------G-----------------KPS-K------------------------------------------------------------------------------------------------------------------------------------ 340
341 ----AHPAGSKW-HKR----------HLTY-----------------------------RM--V-NW-----PPYL--PQ--------HEVRLAVRAAFELWSNV---SSLV------FWEA---------RD-GPA-----DIRLTFFH--------------------------G--DH-N---D--------GLNNA---F-D---GPG---------GA----LAHAFFP----------R-RGE---------AHFD-SA-ERW-SLHSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------RN---LFVVVAHEVGHTLG-LEH---S-PTKSALM----S-------P----YY--------------------KKLGKDF---VLNWDDILAIQNL---------------------------------------Y------------------G-----------------KPS-KGLAIQLPGRVFTHFQDW------------------------------------------------------------------------------------------------------------------- 341
342 ----------KW-QKK----------QLSY-----------------------------RI--L-NW-----PRSL--ST--------SQVHLAVSAAFQLWSNA---SGLQ------FLEL---------HQ-GPA-----DIRLAFYD--------------------------G--EH-N---D--------GAGNA---F-D---GPG---------GA----LAHAFFP----------F-RGE---------AHFD-MS-ERW-TLSGY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------HN---LFLVTAHEIGHTLG-LVH---S-PVRHALM----S-------P----YY--------------------KKISSNA---VLSWDDITAVQQL---------------------------------------Y------------------G-----------------K---------------------------------------------------------------------------------------------------------------------------------------- 342
343 ----------KW-QKK----------QLSY-----------------------------RI--L-NW-----PRSL--ST--------SQVHLAVSAAFQLWSNA---SGLQ------FLEL---------HQ-GPA-----DIRLAFYD--------------------------G--EH-N---D--------GAGNA---F-D---GPG---------GA----LAHAFFP----------F-RGE---------AHFD-MS-ERW-TLSGY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------HN---LFLVTAHEIGHTLG-LVH---S-PVRHALM----S-------P----YY--------------------KKISSNA---VLSWDDITAVQQL---------------------------------------Y------------------G-----------------KPPGDTVQQLVGR---------------------------------------------------------------------------------------------------------------------------- 343
344 ----------KW-TKT----------HLTY-----------------------------YI--V-NNASS-----L--PY--------EDVKAILNRAVQVWAEV---SPLT------FEEKR--------DG-W-A-----DLYIYFAR--------------------------G--EH-T---D--------GPENA---F-D---GPG---------GI----LGHAFFP----TS-------GH---------AHFD-DE-EKW-TNEGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------KN---LFMVAAHEFGHTLG-LAH---S-NVEESLM----S-------P----YY--QD------------------YKTDF---KMPYDDVMAIQQL---------------------------------------Y------------------GNA-------------------------------------------------------------------------------------------------------------------------------------------------------- 344
345 VKFRFINYY----------------------------------------------------------------SGI--GV--------EEQRRAIYRAFLRW---------SNYTPLSFVEVN--------DNT--A-----DIAISFAS--------------------------G--SH-G---D--------NRP-----F-D---GPG---------GV----LGHAYPPP-----------HGQ---------VHFD-AD-DKFSIFP-------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KG-----------IS---FDTVAAHEIGHSLG-MRH---S-KDEGALM----H-------P----FY--IA------------------YDPDF---VLATDDIKGIHSL---------------------------------------YG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 345
346 ----YVLQGSKW-NKT----------TLKY-----------------------------YI--Y-NS-----S-SH-LTT--------TERENAIRSAFALWSDK---STLS------FIQ---VYNPN------QA-----DIKIKWEK--------------------------G--NH-G---D--------GYP-----F-D---GNT---------GI----LAHAFYP----PPAG-GNYAGH---------LHFD-DD-ENW---SING------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------ID---LITVAAHEIGHLLG-IEH---S-NVSSALM----Y-------P----YYTGI-------------------KRQ------LDNDDCLAVWDL---------------------------------------Y------------------GYPFSISGPSSVCD---QATYTVEN---------------------------------------------------------------------------------------------------------------------------------- 346
347 ---RFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-H-A-----DIMIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------QPR--------------------------------------------------------------------------------------------------------------------------- 347
348 RQKRFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-R-A-----DIMIDFAR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------RPQ--MAPTSPA-----------PTLSSQ------------------------------------------------------------------------------------------------- 348
349 ---RFVLSGGRW-DKT----------DLTYSHQRAVPSKAQAPPPPP------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-R-A-----DIMIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHTLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------QPR--TAPTSRP-----------PAVGPQA------------------------------------------------------------------------------------------------ 349
350 -----------------------------------------------------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-R-A-----DIMIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHTLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------QPR--TAPTSRP-----------PAVGPQ------------------------------------------------------------------------------------------------- 350
351 ---RFVLSGGRW-EKT----------ELTY-----------------------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-H-A-----DITIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------RPR--------------------------------------------------------------------------------------------------------------------------- 351
352 RQKRFVLSGGRW-EKT----------ELTY-----------------------------RI--L-RFP----WQ-L--VR--------EQVRQTVAEALQVWSEV---TPLT------FTEVH--------EG-H-A-----DITIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQHL---------------------------------------Y------------------G----------------------------RPR--PAPTSRP-----------PALGPQ------------------------------------------------------------------------------------------------- 352
353 ---RFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--LR--------EQVRQTVAEALQVWSDV---TPLT------FTEVH--------EG-R-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQQL---------------------------------------Y------------------G----------------------------RPQ--------------------------------------------------------------------------------------------------------------------------- 353
354 RQKRFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--LR--------EQVRQTVAEALQVWSDV---TPLT------FTEVH--------EG-R-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQQL---------------------------------------Y------------------G----------------------------RPQ--LAPTSRP-----------PDLGPGTGADTNEIAPLEPDAPP-------------------------------------------------------------------------------- 354
355 RQKRFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--LR--------EQVRQTVAEALQVWSDV---TPLT------FTEVH--------EG-R-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------P----FY--------T-----------F--RYPL---SLSPDDRRGIQQL---------------------------------------Y------------------G----------------------------RPQ--LAPTSRP-----------PDLGP-------------------------------------------------------------------------------------------------- 355
356 RQKRFVLSGGRW-EKT----------DLTY-----------------------------RI--L-RFP----WQ-L--VQ--------EQVRQTMAEALKVWSDV---TPLT------FTEVH--------EG-R-A-----DIMIDFAR--------------------------Y--WH-G---D--------DLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGDD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QG-----------TD---LLQVAAHEFGHVLG-LQH---T-TAAKALM----S-------A----FY--------T-----------F--RYPL---SLSPDDCRGVQHL---------------------------------------Y------------------G----------------------------QPW--PTVTSRT-----------PALGPQ------------------------------------------------------------------------------------------------- 356
357 ------------------------------------------------------------I--I-RFP----WQ-L--VK--------SKVRRTIEEALKVWSDV---TPLT------FTEVQ--------EG-R-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------TD---LLQVAAHEFGHVLG-LQH---T-TVSKSLM----S-------P----FY--------I-----------F--RYPL---SLSEDDKQGIQYL---------------------------------------Y------------------G----------------------------KPKLDPDPTPTQ-----------PAELPQPDLETNEITNTEAVQPDACETAFDAAATIRGELFFFTSRYVW------------------------------------------------------- 357
358 RQKRFVLSGGRW-DKT----------DLTY-----------------------------KI--I-RFP----WQ-L--VK--------SKVRRTIEEALKVWSDV---TPLT------FTEVQ--------EG-R-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----KT----HREGD---------VHFD-YD-ETW-TIGNN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------TD---LLQVAAHEFGHVLG-LQH---T-TVSKSLM----S-------P----FY--------I-----------F--RYPL---SLSEDDKQGIQYL---------------------------------------Y------------------G----------------------------KPKLDPDPTPTQ-----------PAEL--------------------------------------------------------------------------------------------------- 358
359 RQKRYVLFGGRW-PKT----------DLTY-----------------------------KI--Q-RFP----WQ-M--RE--------DKVRRIFQEALKVWSDV---TPLT------FTEVI--------NQ-E-A-----DIVIDFTR--------------------------Y--WH-G---D--------NLP-----F-D---GPG---------GI----LAHAFFP----RT----HREGD---------IHFD-YD-ESW-TVGNE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LG-----------TD---LLQVAAHEFGHVLG-LQH---S-LVPGAIM----S-------P----FY--------S-----------F--SYPL---KLSEDDKKGIQYL---------------------------------------Y------------------G-----------------P-------PVRAPPQIPAETNDI-----------PSAFPPDACHTD------------------------------------------------------------------------------------------- 359
360 RRKRFDLFPGRW-DKT----------DLTY-----------------------------KI--I-QSP----RQ-M--NL--------ERVRYVIREALRAWSDE---TPLN------FTEVL--------SG-R-A-----DIMFDFYR--------------------------Y--SH-G---D--------YLN-----F-D---GPG---------GI----LAHAFFP----RT----YREGE---------IHFD-MD-ESW-TLGNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-----------TD---LLQVATHEIGHVLG-LQH---S-KVPGAVM----A-------P----FY--------T-----------F--SNPV---RLSEDDKRGIQAL---------------------------------------Y------------------G-----------------SK--RSDETVKAAERRPTFTERNEIDATFFPPVHPNPSHPD------------------------------------------------------------------------------------------------ 360
361 RRKRFDLFPGRW-DKT----------DLTY-----------------------------KI--I-QSP----RQ-M--NL--------ERVRYVIREALRAWSDE---TPLN------FTEVL--------SG-R-A-----DIMFDFYR--------------------------Y--SH-G---D--------YLN-----F-D---GPG---------GI----LAHAFFP----RT----YREGE---------IHFD-MD-ESW-TLGNS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-----------TD---LLQVATHEIGHVLG-LQH---S-KVPGAVM----A-------P----FY--------T-----------F--SNPV---RLSEDDKRGIQAL---------------------------------------Y------------------G-----------------SK--RSDETVKAAERRPTFTERNEIDATFFPPVHPNPSHPDACQTN------------------------------------------------------------------------------------------- 361
362 -----------W-DKT----------DLTY-----------------------------KF--V-SYGDPTVLS-L--SE--------SDIRYAVERAFAVWAEV---APLT------FTEVW--------YG-D-A-----DINIDFRR--------------------------F--YH-G---D--------NFP-----F-D---GAG---------GV----LAHAFFP----GE----GIGGD---------THFD-ED-EPW-SVGTG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TG-----------VD---IFVTASHEFGHALG-LHH---S-SFPGSLM----S-------P----YY--------N-----------YYDMDTF---TLPDDDRQGIQTL---------------------------------------Y------------------G-----------------RRHYRNQDPDEAPRTSIPENPTPPIVITENPNVVPGANPP-------------ISPQQCQPVFDAIADLRGELFFFHNEYFWRKRAGDGDMSGPWRIHSFWEGIPDDVRKIDAVYERLTDGRIFFF----------- 362
363 -----------W-PSK----------RITYGF---------------------------RM-----Y--T--DD-M--ST--------LQQQDAVARALDVWSKN---TPLV------FTQQW--------QK-D-V-----DIMISFPR--------------------------G--YH-N---D--------GYP-----F-D---GPG---------HT----LAHAFYP----GRD---YVDGD---------VHFD-GD-EKW-TYMSQE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------TS---LFMVAVHEFGHALG-LGH---S-TSKGSVM----L-------P----FY--QG------------------YKEGI---SLSSDDIQAIYTL---------------------------------------Y------------------G-----------------SEK-------------------------------------------------------------------------------------------------------------------------------------- 363
364 ----------RW-DKT----------DITW-----------------------------SM--Q-DFPPPSVSPAL--NP--------GLVRLILGNALRVWSEN---TPLR------FHYSP-DE-----PS-PQT-----DITVTFTS--------------------------G--YH-E---D--------GYP-----F-D---GKG---------GA----LAHAFFP----GKG---DLAGD---------THFD-AE-ESW-TYGDWSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D------------SD---LFTVAVHEFGHALG-LFH---S-SSSDSIM----K-------P----YY--FS----P-----------VGEMNSY---SLTAVDRLGIQAL---------------------------------------Y------------------G-----------------KQHNLKPPPSVAAP--------------------------------------------------------------------------------------------------------------------------- 364
365 ----------RW-TKS----------DITW-----------------------------SV--Q-NY--PSVHKRL--TP--------TQVDPIISYALKAWSDV---TNLN------FYGAS-SS-----EK-DRA-----DIRISFAR--------------------------S--LH-D---D--------GYP-----F-D---GKG---------GT----LAHAFFP----GES---DVAGD---------THFD-DD-EIW-TY--LDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------TD---LFAVAVHEFGHALG-LSH---S-SSSPSIM----K-------P----YY--QG----S-----------VGDVGSY---ILPDDDREAIQSL---------------------------------------Y------------------G------------------RKISSPTPSPNKP--------------------------------------------------------------------------------------------------------------------------- 365
366 -----TQAVTKW-NKR----------NLSW-----------------------------RV--R-TF--PKES-HL--GH--------DTVRALMYYALKVWSDI---TPLN------FHEVA-GN---------NA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EYW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LTH---I-SAIESIM----R-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 366
367 ----------KW-NKR----------NLSW-----------------------------RV--R-TF--PKES-HL--GH--------DTVRALMYYALKVWSDI---TPLN------FHEVA-GN---------NA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EYW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LTH---I-SAIESIM----R-------P----YY--QG----P-----------VGDPLKY---DLPYEDKVRIWQL---------------------------------------Y------------------G-----------------VRESVS----------------------------------------------------------------------------------------------------------------------------------- 367
368 RRKRHTQAVTKW-NKR----------NLSW-----------------------------RV--R-TF--PKES-HL--GH--------DTVRALMYYALKVWSDI---TPLN------FHEVA-GN---------NA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EYW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LTH---I-SAIESIM----R-------P----YY--QG----P-----------VGDPLKY---DLPYEDKVRIWQL---------------------------------------Y------------------G-----------------VRESVSPTAKPEGSKTEDHPLLPELP--------------------------------------------------------------------------------------------------------------- 368
369 ----------KW-NKR----------NLSW-----------------------------RV--R-TF--PKES-HL--GH--------DTVRALMYYALKVWSDI---TPLN------FHEVA-GN---------NA-----DIQIDFSK--------------------------T--DH-N---D--------GYP-----F-D---GPG---------GM----VAHAFSP----GEH---HAAGD---------THFD-DD-ESW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LTH---V-SAIESIM----R-------P----YY--QG----P-----------VGDPLKY---DLPYEDKVRIWQL---------------------------------------Y------------------G-----------------VRESVSLTAKPEISK-------------------------------------------------------------------------------------------------------------------------- 369
370 ----------KW-NKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GH--------DTVRALMYYALKVWSDI---APLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GHH---HTAGD---------THFD-DD-EAW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LSH---V-AAAHSIM----R-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 370
371 RRRRQAPAPTKW-NKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GH--------DTVRALMYYALKVWSDI---APLN------FHEVA-GS---------TA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GHH---HTAGD---------THFD-DD-EAW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LSH---V-AAAHSIM----R-------P----YY--QG----P-----------VGDPLRY---GLPYEDKVRVWQL---------------------------------------Y------------------G-----------------VRESVSPTAQ-----PEEPPLLPEPP--------------------------------------------------------------------------------------------------------------- 371
372 RRKRALAPQNKW-NKR----------HLSW-----------------------------RV--R-TF--PKESTSL--GR--------DTVRALMYYALKVWSDI---APLN------FHEVA-GN---------EA-----DIQIDFTK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GER---FTAGD---------THFD-DD-EAW-TFRAPDS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LAH---T-SAIESIM----R-------P----YY--QG----P-----------VGDPLKY---NLAYEDKVRVWQL---------------------------------------Y------------------G-----------------VRDSVSHTLKPDDPSQTAEPP-------------------------------------------------------------------------------------------------------------------- 372
373 ----------RW-SKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------RYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EAW-TFRSADA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFTVAVHEFGHAIG-LSH---V-AATRSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 373
374 RRRRQAPAPTRW-SKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------RYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EAW-TFRSADA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFTVAVHEFGHAIG-LSH---V-AATRSIM----Q-------P----YY--QG----P-----------VGDPLRY---GLPYEDRVRIWQL---------------------------------------Y------------------G-----------------VRESVSPTAQPDTPEPEEPPALPE----------------------------------------------------------------------------------------------------------------- 374
375 RRRRQAPAPTRW-SKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------RYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EAW-TFRSADA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFTVAVHEFGHAIG-LSH---V-AATRSIM----Q-------P----YY--QG----P-----------VGDPLRY---GLPYEDRVRIWQL---------------------------------------Y------------------G-----------------VRESVSPTAQPDTPEPEEPPALPEPP--------------------------------------------------------------------------------------------------------------- 375
376 RRRRQAPALTKW-NKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFST--------------------------A--DH-N---D--------RYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EAW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LSH---V-AATRSIM----Q-------P----YY--QG----P-----------VGDPLRY---GLPYEDRVRVWQL---------------------------------------Y------------------G-----------------VRESVSPTAQPDTPESEEPPLLPEPP--------------------------------------------------------------------------------------------------------------- 376
377 RRKRQTPPPTKW-SKR----------NLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMYYALKVWSDI---TPLN------FHEVA-GN---------AA-----DIQIDFSK--------------------------A--DH-N---D--------GYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------THFD-DD-EPW-TFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------MD---LFAVAVHEFGHAIG-LSH---V-AAPSSIM----Q-------P----YY--QG----P-----------VGDPLRY---GLPYEDRVRVWQL---------------------------------------Y------------------G-----------------VRESVSPTAQLDTPEPEEPPLLPEPP--------------------------------------------------------------------------------------------------------------- 377
378 -----------W-HKR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GP--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------AHFD-DD-ESW-AFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AATSSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 378
379 --------------------------------------------------------------------------PL--GP--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------AHFD-DD-ESW-AFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AATSSIM----Q-------P----YY--QG----P-----------VGDPLHY---RLPYEDRVRIWQL---------------------------------------Y------------------G-----------------VRESVSPTAQPDTPEPKEPPLLPEPPNNRSSTLPRKDVPHRCSTDFDAVAQIRGEA--------------------------------------------------------------------------------- 379
380 RRRRQAPAPTTW-HKR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GP--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GT----VAHAFFP----GDH---HTAGD---------AHFD-DD-ESW-AFRSSDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AATSSIM----Q-------P----YY--QG----P-----------VGDPLHY---RLPYEDRVRIWQL---------------------------------------Y------------------G-----------------VRESVSPTAQPDTPEPKEPPLLPEPP--------------------------------------------------------------------------------------------------------------- 380
381 -----------W-NRR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GA----VAHAFLP----GDQ---LSAGD---------AHFD-DD-ESW-AFRSPDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AAASSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 381
382 -----------W-NRR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GA----VAHAFLP----GDQ---LSAGD---------AHFD-DD-ESW-AFRSPDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AAASSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 382
383 -----------W-NRR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GA----VAHAFLP----GDQ---LSAGD---------AHFD-DD-ESW-AFRSPDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AAASSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 383
384 -----------W-NRR----------SLSW-----------------------------RV--R-TF--PRDS-PL--GR--------DTVRALMHYALKVWSDI---TPLN------FHEVA-GS---------AA-----DIQIDFSK--------------------------A--DH-N---D--------AYP-----F-D---GPG---------GA----VAHAFLP----GDQ---LSAGD---------AHFD-DD-ESW-AFRSPDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HD-----------MD---LFAVAVHEFGHAIG-LSH---V-AAASSIM----Q-------P----YY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 384
385 -----------W-TKR----------NISW-----------------------------RV--K-TY--PRES-HL--SR--------ETMRTLMYYALKVWSEA---TPLN------FHEVA-AT---------LR-----TXLVEVPR--------------------------L--DH-H---D--------GYP-----F-D---XPG---------GM----VAHAFFP----GDP---QRAGN---------VHFD-SS-EEW-TFRSPDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-----------TD---LFAVAVHEFGHSLG-LTH---S-PSKHSIM----R-------P----YY--QG----P-----------VGDPLQY---QLHVDDCMEIQNL---------------------------------------Y------------------G-----------------SRILHS-TEKPE----------------------------------------------------------------------------------------------------------------------------- 385
386 -----------W-KKR----------TLTW-----------------------------RV--N-SF--PQGS-GL--SQ--------ETVRTLMHHALTTWGAE---SDLR------FQEVG-SQ-----GP-TEP-----DILIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPDSIM----R-------P----FY--QG----P-----------VGNPAEY---RLSQDDREGLQQL---------------------------------------Y------------------G------------------RAPQTP---------------------------------------------------------------------------------------------------------------------------------- 386
387 RRRRYALSGSVW-KKR----------TLTW-----------------------------RV--N-SF--PQGS-GL--SQ--------ETVRTLMHHALTTWGAE---SDLR------FQEVG-SQ-----GP-TEP-----DILIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPDSIM----R-------P----FY--QG----P-----------VGNPAEY---RLSQDDREGLQQL---------------------------------------Y------------------G------------------RAPQTPYDKPTRKPLAPPPPPPALP--------------------------------------------------------------------------------------------------------------- 387
388 RRRRYALSGSMW-RKR----------TLTW-----------------------------RV--R-SF--PQSS-AL--TQ--------ETVRTLMHHALTTWGA----------------------------P-TEP-----DILIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TYGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPHEY---RLSDDDREGLQQL---------------------------------------Y------------------G------------------KVPQTPYDKPTRKPLAPPPPPPALP--------------------------------------------------------------------------------------------------------------- 388
389 -----------W-KKR----------TLTW-----------------------------RV--Q-SF--PQSS-AL--SQ--------ETVRTLMHHALTAWGAV---SGLS------FQEVG-SQ-----GP-SEP-----DILIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SVPDSIM----R-------P----FY--QG----P-----------VGDPTKY---RLSQDDREGLEQL---------------------------------------Y------------------G------------------KAPQTP---------------------------------------------------------------------------------------------------------------------------------- 389
390 RRRRYALSGSVW-KKR----------TLTW-----------------------------RV--Q-SF--PQSS-AL--SQ--------ETVRTLMHHALTAWGAV---SGLS------FQEVG-SQ-----GP-SEP-----DILIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SVPDSIM----R-------P----FY--QG----P-----------VGDPTKY---RLSQDDREGLEQL---------------------------------------Y------------------G------------------KAPQTPYDKPTRRPLAPPPPPPALP--------------------------------------------------------------------------------------------------------------- 390
391 -----------W-KKR----------TLTW-----------------------------RV--H-SF--PQSS-AL--SQ--------EMVRTLMHHALTTWGVE---SGLK------FQEVG-FQ-----SP-TEP-----DIVIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---SISGD---------THFD-DE-EIW-TYGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPDSIM----R-------P----FY--QG----P-----------VGDPHKY---RLSQDDREGLQQL---------------------------------------Y------------------G------------------KVPQTP---------------------------------------------------------------------------------------------------------------------------------- 391
392 -----------W-KKR----------TLTW-----------------------------RV--H-SF--PQSS-AL--SQ--------EMVRTLMHHALTTWGVE---SGLK------FQEVG-FQ-----SP-TEP-----DIVIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---SISGD---------THFD-DE-EIW-TYGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPDSIM----R-------P----FY--QG----P-----------VGDPHKY---RLSQDDREGLQQL---------------------------------------Y------------------G------------------KVPQ------------------------------------------------------------------------------------------------------------------------------------ 392
393 -----------W-KKR----------TLTW-----------------------------RV--H-SF--PQSS-AL--SQ--------EMVRTLMHHALTTWGVE---SGLK------FQEVG-FQ-----SP-TEP-----DIVIDFAR--------------------------A--YH-Q---D--------SYP-----F-D---GQG---------GT----LAHAFFP----GEH---SISGD---------THFD-DE-EIW-TYGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPDSIM----R-------P----FY--QG----P-----------VGDPHKY---RLSQDDREGLQQL---------------------------------------Y------------------G------------------KVPQTP---------------------------------------------------------------------------------------------------------------------------------- 393
394 -----------W-KKR----------TLTW-----------------------------RV--R-SF--PQSS-QL--SQ--------ETVRVLMSYALMAWGME---SGLT------FHEVD-SP-----QG-QEP-----DILIDFAR--------------------------A--FH-Q---D--------SYP-----F-D---GLG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPDKY---RLSQDDRDGLQQL---------------------------------------Y------------------G------------------KAPQTP---------------------------------------------------------------------------------------------------------------------------------- 394
395 RRRRYALSGSVW-KKR----------TLTW-----------------------------RV--R-SF--PQSS-QL--SQ--------ETVRVLMSYALMAWGME---SGLT------FHEVD-SP-----QG-QEP-----DILIDFAR--------------------------A--FH-Q---D--------SYP-----F-D---GLG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSKDG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPDKY---RLSQDDRDGLQQL---------------------------------------Y------------------G------------------KAPQTPYDKPTRKPLAPPPQPPASPT-------------------------------------------------------------------------------------------------------------- 395
396 ---------------------------------------------------------------------------------------------------------------------------------------EP-----DIIIHFAR--------------------------A--YH-Q---D--------SYP-----F-D---GSG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSTDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-----------ID---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPATY---RLPQDDRDGLQQL---------------------------------------Y------------------G------------------RVSQNP---------------------------------------------------------------------------------------------------------------------------------- 396
397 -----------W-KKR----------TLTW-----------------------------SI--R-SF--SQKS-QL--SP--------QIVRTLLSYALAVWATE---SGLT------FQEVN-SQ------Y-QEP-----DIIIHFAR--------------------------A--YH-Q---D--------SYP-----F-D---GSG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSTDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-----------ID---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPATY---RLPQDDRDGLQQL---------------------------------------Y------------------G------------------RVSQNP---------------------------------------------------------------------------------------------------------------------------------- 397
398 RRRRYSLSGSVW-KKR----------TLTW-----------------------------SI--R-SF--SQKS-QL--SP--------QIVRTLLSYALAVWATE---SGLT------FQEVN-SQ------Y-QEP-----DIIIHFAR--------------------------A--YH-Q---D--------SYP-----F-D---GSG---------GT----LAHAFFP----GEH---PISGD---------THFD-DE-ETW-TFGSTDD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-----------ID---LFAVAVHEFGHALG-LGH---S-SAPNSIM----R-------P----FY--QG----P-----------VGDPATY---RLPQDDRDGLQQL---------------------------------------Y------------------G------------------RVSQNPNARPTRKPLVPPPQPPAMPP-------------------------------------------------------------------------------------------------------------- 398
399 -----------W-KKT----------DLTW-----------------------------HI--R-SF--PRSS-YL--SR--------DHVRKLISEAFRAWSKS---SALT------FRELP-SD---------QA-----DILVDFTQ--------------------------S--YH-Q---D--------SYP-----F-D---GPG---------GT----LAHAFFP----GEH---PVSGD---------THFD-DE-ETW-IYNPENT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-----------TD---LFAVAVHEFGHALG-LAH---S-SAKESIM----I-------P----YY--QG----P-----------VGQAHLY---QLPLDDVMGIEQL---------------------------------------Y------------------D------------------RC-------------------------------------------------------------------------------------------------------------------------------------- 399
400 -----------W-TRR----------NINW-----------------------------RL--R-SY--PVSS-KL--SR--------ETIRSLVFYALRVWADP---TLLE------FHEVR-GP-----E---GA-----DLQIDFLH--------------------------G--PH-G---D--------GYP-----F-D---GAG---------GS----VGHAFFP----SDP---NRAGG---------VHLD-AE-EDW-AFRQPAT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFTVLVHELGHALG-LTH---S-SARRSVM----R-------P----YY--QG----P-----------LGDPLHF---SLGYQDLQHITAL---------------------------------------Y------------------G-----------------QRGNDI----------------------------------------------------------------------------------------------------------------------------------- 400
401 -----------W-TRR----------NINW-----------------------------RL--R-SY--PVSS-KL--SR--------ETIRSLVFYALRVWADP---TLLE------FHEVR-GP-----E---GA-----DLQIDFLH--------------------------G--PH-G---D--------GYP-----F-D---GAG---------GS----VGHAFFP----SDP---NRAGG---------VHLD-AE-EDW-AFRQPAT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFTVLVHELGHALG-LTH---S-SARRSVM----R-------P----YY--QG----P-----------LGDPLHF---SLGYQDLQHITAL---------------------------------------Y------------------G-----------------QRGNDIPT--------------------------------------------------------------------------------------------------------------------------------- 401
402 -----------W-TRR----------NINW-----------------------------RL--R-SY--PVSS-KL--SR--------ETIRSLVFYALRVWADP---TLLE------FHEVR-GP-----E---GA-----DLQIDFLH--------------------------G--PH-G---D--------GYP-----F-D---GAG---------GS----VGHAFFP----SDP---NRAGG---------VHLD-AE-EDW-AFRQPAT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TD---LFTVLVHELGHALG-LTH---S-SARRSVM----R-------P----YY--QG----P-----------LGDPLHF---SLGYQDLQHITAL---------------------------------------Y------------------G-----------------QRGNDIPT--------------------------------------------------------------------------------------------------------------------------------- 402
403 ----HSL-----------------------------------------------------V--N-QT--M--SE-L--DA--------GQVRRILHEALGLWAQH---ANIN------FREVY--------ST-D-A-----DIQVMFAR--------------------------K--FH-G---D--------GYN-----F-D---GPG---------KI----LAHAFYP----GT----GIGGD---------AHFD-AD-EKW-LLNEPLDA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------TR---LFDVAVHEFGHSLG-LGH---S-SQQDAIM----F-------PWHHISY--R-----G-----------KDTIP--------EDDRLGIQSI---------------------------------------Y------------------G-----------------PRKKIYGKNPERHTPSTTTT--------------------------------------------------------------------------------------------------------------------- 403
404 -----------------IALYNLKCTSLLQ-----------------------------QLHNC-HMVNRSMPDA-------------SKVERMVQTALDVWANH---SKLT------FREVY----------SDQA-----DIQILFAR--------------------------R--AH-G---D--------GYK-----F-D---GPG---------QV----LAHAFYP----GE----GRGGD---------AHFD-AD-ETW-NFDGESDDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------TN---FLNVALHELGHSLG-LAH---S-AIPDAVM----F-------P----WY--QNNEVAG---------------------NLPDDDRYGIQQL---------------------------------------Y------------------GTKEKTWGPYKPQTTTTTT---------------------------------------------------------------------------------------------------------------------------------------- 404
405 -----------W-HYT----------NLTW-----------------------------SL--R-KGAKS--RD-M--DS--------GQIRYQVHRALNLWQEA---SRLT------FTEV---------NH-EDA-----DIRVSFHS--------------------------G--FH-N---D--------GYP-----F-D---GKG---------TL----LAHAFFP----GT----GIGGD---------AHFD-DE-EPWVADEATQNSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LS---FFAVAAHEFGHSLG-LSH---S-SVQGAIM----F-------P----YY--QS------------------VDGSF---SLHSDDITGIQAI---------------------------------------Y------------------GSRNEGRVTNPALRPSTTTTPSPRITGKPEIPTKPTQPTKKPVHPPKPHPRPPHGGRKPSTCDTTY----------------------------------------------------------------------------------------- 405
406 -------GEPRW-PRNRR--------DLTY-----------------------------AF--DPRN-----A--LT-----------EEVKSVFSRAFTRWEEV---TPLT------FTRVE-------------RFS-TSDISIGFYS--------------------------G--EH-G---D--------GEP-----F-D---GPM---------RT----LAHAFSP-----------PTGH---------FHLD-GE-ENW-IVS-G----EGGDGFISVSEA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-SVEGSIM----Y-------P------------------------TIRTGRRKVD---LTTDDVEGVQYL---------------------------------------Y------------------GANPN------------------------------------------------------------------------------------------------------------------------------------------------------ 406
407 KHYSFFPGEPRW-PRNRR--------DLTY-----------------------------AF--DPRN-----A--LT-----------EEVKSVFSRAFTRWEEV---TPLT------FTRVE-------------RFS-TSDISIGFYS--------------------------G--EH-G---D--------GEP-----F-D---GPM---------RT----LAHAFSP-----------PTGH---------FHLD-GE-ENW-IVS-G----EGGDGFISVSEA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-SVEGSIM----Y-------P------------------------TIRTGRRKVD---LTTDDVEGVQYL---------------------------------------Y------------------GANPNFNGSRSPPPSTQQRDT-------------------------------------------------------------------------------------------------------------------------------------- 407
408 KRYTLFPGEPRW-PRNRR--------DLTY-----------------------------AF--DPKN-----P--LT-----------EEVKSVFSRAFGRWSDV---TALN------FTLSE-------------SFS-TSDITIGFYT--------------------------G--DH-G---D--------GEP-----F-D---GVL---------GT----LAHAFSP-----------PSGK---------FHLD-AD-ENW-VVS-G----D-LDSFLSVTAA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-SVEESIM----Y-------P------------------------TITTGKRKVD---LTNDDVEGIQYL---------------------------------------Y------------------GANPNFNGTTSPPSTTKHQRD-------------------------------------------------------------------------------------------------------------------------------------- 408
409 EKYSFFPGKPRW-PKRKR--------DLTY-----------------------------AF--APQN-----N--LT-----------DEVKRVFSRAFTRWAEV---TPLN------FTRSE-------------SIL-RADIVIGFFS--------------------------G--EH-G---D--------GEP-----F-D---GAM---------GT----LAHASSP-----------PTGM---------LHLD-GD-EDW-LISNG----EISRRILPVTTV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-SVEDAIM----F-------P------------------------AISGGDRKVE---LAKDDIEGIQHL---------------------------------------Y------------------GGNPNGDGGGSKPSRESQSTG-------------------------------------------------------------------------------------------------------------------------------------- 409
410 -------GGPSW-PPFRR--------ELRY-----------------------------AI--TASS-----A--ISIDK--------AALSGVFERAFARWAAA---TTLR------FAEAE-------------SAA-DADITIGFYA--------------------------G--AH-G---D--------GEA-----F-D---GPL---------GT----LAHAFSP-----------TDGR---------FHLD-AA-EAW-AVS-GSGGDDSSGG--PGSAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-SVQGAIM----Y-------P------------------------TIRTGTRKVE---LRQDDVEGIQSL---------------------------------------Y------------------GSNPDFKGGVAPTSPS------------------------------------------------------------------------------------------------------------------------------------------- 410
411 -------GSPSW-PRSKK--------SLKY-----------------------------AI--TATS-----A--TTIDR--------ATLSQVFARAFARWSEA---TTLN------FTETT-------------DAAGDADITIGFHG--------------------------G--EH-G---D--------GEA-----F-D---GPL---------GT----LAHAFSP-----------TDGR---------FHLD-AA-EAW-VAG-G----DVSRA--KADDA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHLLG-LGH---S-AVEGAIM----Y-------P------------------------TITSRTRKVD---LASDDVVGIQSL---------------------------------------Y------------------GGNPNFK-GVTPSTP-------------------------------------------------------------------------------------------------------------------------------------------- 411
412 SEFS-------------------------------------------------------------------------------------------------------------------------------------YN-TADVKVGFFS--------------------------G--DH-G---D--------GEP-----F-D---GPL---------GV----LAHAFSP-----------PSGQ---------LHLD-AA-ERW-TVHL-------DDQEDSS--A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVATHEIGHVLG-LAH---S-SAPDAVM----Y-------P------------------------SLKPGTRKVE---LTADDVRGVQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 412
413 SEFS-------------------------------------------------------------------------------------------------------------------------------------YN-TADVKVGFFS--------------------------G--DH-G---D--------GEP-----F-D---GPL---------GV----LAHAFSP-----------PSGQ---------LHLD-AA-ERW-TVHL-------DDQEDSS--A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVATHEIGHVLG-LAH---S-SAPDAVM----Y-------P------------------------SLKPGTRKVE---LTADDVRGVQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 413
414 SRFSFFKGQPRW-ARPQSESESDPAIVLTY-----------------------------AA--SPTA-----T-VGYLPP--------DAVRAVLQRAFTRWARV---IPVS------FVETD-------------DYD-AADIKVGFYE--------------------------G--SH-G---D--------GVP-----F-D---GPL---------GV----LGHAFSP-----------KNGR---------LHLD-AS-ERW-AVDFG------GEMETSS--A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID---LESVVTHEIGHVLG-LGH---S-TSQEAVM----Y-------P------------------------SIKPLQRKAD---LTIDDVEGVQLL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 414
415 --FPFFPGSPRW-GPDKR--------VLSY-----------------------------AF--SPDH-----EVLSEISL--------AELSTVVGRAFKRWADV---IPIT------FTESS-------------DYS-SADIKVGFYS--------------------------G--DH-G---D--------GHP-----F-D---GPL---------GT----LAHSFSP-----------PDGR---------FHLD-AA-ESW-TVDLS------SD---SAATA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID---LESIATHEIGHLLG-LGH---T-TEKAAVM----Y-------P------------------------SIAPRTRKVD---LVLDDVDGVQYV---------------------------------------Y------------------GANPNYNASAVLAQNETS----------------------------------------------------------------------------------------------------------------------------------------- 415
416 -KYVYFPGRPRW-TRDVPL-------KLTY-----------------------------AF--SQEN-----L-TPYLAP--------TDIRRVFRRAFGEWASV---IPVS------FIETE-------------DYV-IADIKIGFFN--------------------------G--DH-G---D--------GEP-----F-D---GVL---------GV----LAHTFSP-----------ENGR---------LHLD-KA-ETW-AVDFD---------EEKSSVA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHVLG-LGH---S-SVKDAAM----Y-------P------------------------TLKPRSKKVN---LNMDDVVGVQSL---------------------------------------Y------------------GTNPN------------------------------------------------------------------------------------------------------------------------------------------------------ 416
417 KKYVYFPGRPRW-TRDVPL-------KLTY-----------------------------AF--SQEN-----L-TPYLAP--------TDI-RVFRRAFGEWASV---IPVS------FIETE-------------DYV-IADIKIGFFN--------------------------G--DH-G---D--------GEP-----F-D---GVL---------GV----LAHTFSP-----------ENGR---------LHLD-KA-ETW-AVDFD---------EEKSSVA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVAVHEIGHVLG-LGH---S-SVKDAAM----Y-------P------------------------TLKPRSKKVN---LNMDDVVGVQSL---------------------------------------Y------------------GTNPNFTLNSLLASETSTNLA-------------------------------------------------------------------------------------------------------------------------------------- 417
418 AHYTYFNGKPKW-NRD----------TLTY-----------------------------AI--SKTH-----K-LDYLTS--------EDVKTVFRRAFSQWSSV---IPVS------FEEVD-------------DFT-TADLKIGFYA--------------------------G--DH-G---D--------GLP-----F-D---GVL---------GT----LAHAFAP-----------ENGR---------LHLD-AA-ETW-IVD--------DDLKGSSEVA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD---LESVATHEIGHLLG-LGH---S-SQESAVM----Y-------P------------------------SLRPRTKKVD---LTVDDVAGVLKL---------------------------------------Y------------------GPNPKLRLDSLTQSEDSIKNG-------------------------------------------------------------------------------------------------------------------------------------- 418
419 SDYTFFKDMPRW-QAGTT--------QLTY-----------------------------AF--SPEP-----R-----LD--------DTFKSAIARAFSKWTPV---VNIA------FQETT-------------SYE-TANIKILFAS--------------------------K--NH-G---D--------PYP-----F-D---GPG---------GI----LGHAFAP-----------TDGR---------CHFD-AD-EYW-VAS-G------DVTKSPVTSA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FD---LESVAVHEIGHLLG-LGH---S-SDLRAIM----Y-------P------------------------SIPPRTRKVN---LAQDDIDGIRKL---------------------------------------Y------------------GINP------------------------------------------------------------------------------------------------------------------------------------------------------- 419
420 ----------------------------------------------------------------------------------------------MHRAFNEWSAV---SSVD------FRE---I-PPDVISR-IPP-----DIHIAFEK--------------------------G--EH-S---D--------GFS-----F-D---GQD---------GV----VAHAFYP----RD-------GR---------LHFD-AE-EQW---SLNSP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------VN---LFQTAVHEIGHLLG-LEH---S-VDTRAAM----FAAKRPYDP----AFT------------------------------LGDDDVRAIRSL-------------------------------------------------------------FPQKDPDPVADSFSKNSGTKESQEFKDIVVMSKKVLK------------------------------------------------------------------------------------------------------------------- 420
421 REKRYVIRAKRW-KKH----------TLTW-----------------------------QL--Q-TQ-----NLLD-PDV--------FIVRNTMHRAFNEWSTV---SSVD------FRE---I-PPDLVTK-QPP-----DIYIAFEK--------------------------G--EH-S---D--------GFP-----F-D---GQD---------GV----VAHAFYP----RD-------GR---------LHFD-AE-EQW---SLNSV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EG-----------VN---LFQTAVHEIGHLLG-LEH---S-MDVRAAM----FAAKRPYDP----AFT------------------------------LGDDDVRAIRSL-------------------------------------------------------------FPINETD-------ANSGSEENSE--DPVTTVKPISK------------------------------------------------------------------------------------------------------------------- 421
422 -----------W-PTK----------TLTY-----------------------------KF--E-NT------GADLPAK--------T-VKDTVRKAFNMWSSV---TPLT------FTEVT-ER-----R----G-----HINIGFYS--------------------------G--TH-G------------D-GGD---F-F---GPG---------GT----LAHAFYP-----------QNGN---------LHFD-EN-ENW-VV-N-QRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LLEIAVHEIGHAIG-IQH---S-SIRGTIM----F-------P----TY-----------------FGYR---SNL---QLHDDDIKAVQAL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 422
423 -----------W-TKT----------TLTY-----------------------------SFRNK--------CEDLS--D--------GAVRQTIREAFKVWSDV---THLA------FTETS-----------GKG-----DITIGFHH--------------------------N--SH-G---D--------NSP-----F-D---GPG---------RV----LAHAYFP-----------PEGR---------LCFD-EG-ERW-VIKT--------------TG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LFEIAVHEIGHILG-LEH---S-NIQGTIM----Y-------P----SY--------------------SGYRPNL---QLHYDDRRRIQQM---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 423
424 ----------RW-YDL----------NLTY-----------------------------RI--V-EL-----HDNMPLGR--------QVIGDVVRDAMQMWMDV---TSLI------LCEVV-DQNID-------A-----DIHIRHVL--------------------------G--EH-G---D--------GIS-----F-D---GPG---------GI----LGHAFLP----T-------HGE---------IHFD-AA-ENW---TVGIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------ID---YVQVVVHEIGHALG-LTH---S-GVEGSIM----Y-------P----FYQ---------------------FRPKV---ELQDDDIQGIQLL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 424
425 DVLSFSLGWFRW-YDL----------NLTY-----------------------------RI--V-EL-----HDNMPLGR--------QVIGDVVRDAMQMWMDV---TSLI------LCEVV-DQNID-------A-----DIHIRHVL--------------------------G--EH-G---D--------GIS-----F-D---GPG---------GI----LGHAFLP----T-------HGE---------IHFD-AA-ENW---TVGIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------ID---YVQVVVHEIGHALG-LTH---S-GVEGSIM----Y-------P----FYQ---------------------FRPKV---ELQDDDIQGIQLL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 425
426 AEFNTFPNRDRW-TSN----------TVTY-----------------------------KI--T-GY--T--PD-M--SP--------CRVRNTFKRAFRVWEEA---TALN------FVESQ--------TD-D-A-----DMIIYFGY--------------------------Q--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAA----GTH---SLAGD---------AHFD-EG-EFW-TL--GDGRVADTYYGNADGAPCHFPFMFQNVEYTTCTTAGRSDGMEWCATTRNFDEDQQFGFCPHEALFTYGGNADGDPCTFPFNFLGETYNTCTYDGRSDGYRWCATTSSFDTDKKWGFCPDRARGTEGGNANGASCVFPFIFNGNSYSDCTTIGRSDYKKWCSTTDNYDTDGKYGF-CQE----SG-----------YS---LFLVAAHEFGHTIG-LDH---S-NSQGALM----Y-------P----MY--QK----F---------------TNF---RLPQDDVNGARDL---------------------------------------YPAARTTPLQPLVLEKCGGD-----------------LSVT--------EG----------------------------------------------------------------------------------------------------------------------GTDSG 426
427 -EFNTFPNRDRW-TSN----------TVTY-----------------------------KI--T-GY--T--PD-M--SP--------CRVRNTFKRAFRVWEEA---TALN------FVESQ--------TD-D-A-----DMIIYFGY--------------------------Q--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAA----GTH---SLAGD---------AHFD-EG-EFW-TL--GD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----SG-----------YS---LFLVAAHEFGHTIG-LDH---S-NSQGALM----Y-------P----MY--QK----F---------------TNF---RLPQDDVNGARDL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 427
428 AEFNTFPNRDRW-TSN----------TVTY-----------------------------KI--T-GY--T--PD-M--SP--------CRVRNTFKRAFRVWEEA---TALN------FVESQ--------TD-D-A-----DMIIYFGY--------------------------Q--EH-G---D-----G--Y-P-----F-D---GKD---------GL----LAHAFAA----GTH---SLAGD---------AHFD-EG-EFW-TL--GDGRVADTYYGNADGAPCHFPFMFQNVEYTTCTTAGRSDGMEWCATTRNFDEDQQFGFCPHEALFTYGGNADGDPCTFPFNFLGETYNTCTYDGRSDGYRWCATTSSFDTDKKWGFCPDRARGTEGGNANGASCVFPFIFNGNSYSDCTTIGRSDYKKWCSTTDNYDTDGKYGF-CQE----SG-----------YS---LFLVAAHEFGHTIG-LDH---S-NSQGALM----Y-------P----MY--QK----F---------------TNF---RLPQDDVNGARDL---------------------------------------YPAARTTPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------- 428
429 -----------------------------------------------------------------------------------------------RKALRTWSRY---SNLR------FKYTR-----------KRP-----DIRILFAR--------------------------Y--EH-G---DGD------YNA-----F-D---GQG---------RT----IGHAFRP----------KNGG----------THFD-DD-ELW-SVSTNLST----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GE-----------IH---LPTAALHEIGHAIG-LEH---V-SDYSSVM----S-------A----YF----------------------T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 429
430 -RYTLTPEKLKW-DNF----------KMTY-----------------------------KL--L-SF-----PRNL-LNA--------TDTRRGISKAFSMWSDV---SPFS------FREVP--------SD-QEA-----DIKIGFYS--------------------------V--NH-T---DCLHSHLHHC-------F-D---GIT---------GE----LAHAFFP-----------QTGE---------IHFD-DD-EYW-ILGNMRFSWNKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHVLG-LMH---S-QNPKALM----H-------L----------------------------NATLTGRKLITQDEVWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 430
431 --YTLTPEKLKW-DNF----------KMTY-----------------------------KL--L-SF-----PRNL-LNA--------TDTRRGISKAFSMWSDV---SPFS------FREVP--------SD-QEA-----DIKIGFYS--------------------------V--NH-T---DCLHSHLHHC-------F-D---GIT---------GE----LAHAFFP-----------QTGE---------IHFD-DD-EYW-ILGNMRFSWNKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHVLG-LMH---S-QNPKALM----H-------L----------------------------NATLTGRKLITQDEVWGLHRL---------------------------------------Y------------------GCLDRFFICPSWARK-------------------------------------------------------------------------------------------------------------------------------------------- 431
432 KRYTLTPEKLKW-DNF----------KMTY-----------------------------KL--L-SF-----PRNL-LNA--------TDTRRGISKAFSMWSDV---SPFS------FREVP--------SD-QEA-----DIKIGFYS--------------------------V--NH-T---DCLHSHLHHC-------F-D---GIT---------GE----LAHAFFP-----------QTGE---------IHFD-DD-EYW-ILGNMRFSWNKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHVLG-LMH---S-QNPKALM----H-------L----------------------------NATLTGRKLITQDEVWGLHRL---------------------------------------Y------------------GCLDRFFICPSWARKGYCDSKRKLMQK-------------------------------------------------------------------------------------------------------------------------------- 432
433 KRYTITPGHLKW-DHF----------NLTY-----------------------------KI--L-SF-----PRNL-INA--------RDTRKGLAAAFRMWSEV---SPFS------FREVP--------RH-VPS-----DLKIGFYS--------------------------I--NH-T---DCLESLIHHC-------F-D---GTT---------GE----LAHAFFP-----------PNGE---------IHFD-DH-EYW-ILGNTRFSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QNPNALM----H-------I----------------------------NATLTGKKTISQDEVWGIHRL---------------------------------------Y------------------GCKDRLFMCPLWARKGFCEKREKLMKK-------------------------------------------------------------------------------------------------------------------------------- 433
434 --YTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------SETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------I--NH-T---DCLVSAMHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 434
435 -----------W-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------SETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------I--NH-T---DCLVSAMHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 435
436 -RYTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------RETRRALAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------I--NH-T---DCLVSALHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 436
437 RRYTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------RETRRALAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------I--NH-T---DCLVSALHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 437
438 -RYTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------SETRRGLATAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------V--NH-T---DCLVSALHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKTLSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 438
439 -RYTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------SETRRGLATAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------V--NH-T---DCLVSALHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKTLSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 439
440 RRYTLTPARLRW-DHF----------NLTY-----------------------------RI--L-SF-----PRNL-LSP--------SETRRGLATAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------V--NH-T---DCLVSALHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKTLSQDELWGLHRL---------------------------------------Y------------------GCLDRLFVCTSWARRGFCDTRRRLMKR-------------------------------------------------------------------------------------------------------------------------------- 440
441 --YTLTPARLRW-EHF----------NLTY-----------------------------KI--L-SF-----PRNL-LSP--------SETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------V--NH-T---DCLVSPLHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 441
442 RRYTLTPARLRW-EHF----------NLTY-----------------------------KI--L-SF-----PRNL-LSP--------SETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-QPS-----DLRIGFYP--------------------------V--NH-T---DCLVSPLHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TD---LVHVAAHEIGHALG-LMH---S-QHGRALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 442
443 -RYTLTPARLRW-DHF----------NLTYRCHLDQRGGWSGHNSDTNTDSNITAALHHRV--L-SF-----PRNL-LSP--------EETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-RPS-----DLKIGFYP--------------------------V--NH-T---DCLVSAVHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LVHVAAHEIGHALG-LMH---S-QQDQALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 443
444 RRYTLTPARLRW-DHF----------NLTY-----------------------------RV--L-SF-----PRNL-LSP--------EETRRGLAAAFRMWSDV---SPFS------FREVA--------PE-RPS-----DLKIGFYP--------------------------V--NH-T---DCLVSAVHHC-------F-D---GPT---------GE----LAHAFFP-----------PHGG---------IHFD-DS-EYW-VLGPTRYSWKKGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---LVHVAAHEIGHALG-LMH---S-QQDQALM----H-------L----------------------------NATLRGWKALSQDELWGLHRL---------------------------------------Y------------------GCLDRIFVCASWARKGFCDVRQRLMKR-------------------------------------------------------------------------------------------------------------------------------- 444
445 ------PLGYKW-DHV----------NLTY-----------------------------KI--V-QF-----P-ST-LNK--------GDTERAIASAFRMWSDV---SPLS------FRRLA--------PT-QQA-----DITIGFYT--------------------------F--NH-T---DCWFSPLHPC-------F-D---GLN---------GE----LAHAFLP-----------PRGE---------IHFD-NH-EFW-IFGRSRFSWKQGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ND---LVQVAAHEIGHALG-LWH---S-RDVRALM----H-------P----------------------------NATYSRTWQIGQDDIWAIQRL---------------------------------------Y------------------GC--------------------------------------------------------------------------------------------------------------------------------------------------------- 445
446 KRYAINPLGYRW-EHF----------NVSY-----------------------------KI--T-KF-----P-NT-LNK--------DDTRKAISIAFTKWSDV---SPLT------FTEIT--------NTSKSA-----DITIGFYT--------------------------Y--NH-T---DCWRSPLHPC-------F-D---GLN---------GE----LAHAFLP-----------PRGE---------IHFD-NH-EFW-ILGKSRFSWKQGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ND---LVQVAAHEIGHALG-LWH---S-QDPNALM----H-------P----------------------------NATYTGQRNIAQDDIWGIQRL---------------------------------------Y------------------GCMDKKRVCDPWARLGFCERRRSFMKKNCPQ---------------------------------------------------------------------------------------------------------------------------- 446
447 KRYAINPLGYRW-EHF----------NVSY-----------------------------KI--T-KF-----P-NT-LNK--------DDTRKAISIAFTKWSDV---SPLT------FTEIT--------NTSKSA-----DITIGFYT--------------------------Y--NH-T---DCWRSPLHPC-------F-D---GLN---------GE----LAHAFLP-----------PRGE---------IHFD-NH-EFW-ILGKSRFSWKQGVWL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ND---LVQVAAHEIGHALG-LWH---S-QDPNALM----H-------P----------------------------NATYTGQRNIAQDDIWGIQRL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 447
448 ----------KW-DKL----------NLHY-----------------------------AI--GNVT-----S---DVSR--------ESAVQAIKNAFNSWENV---SPFT------FTEVS-------------LNE-NLDILIEWTE--------------------------T--VS-G---D---------HN-----M-R---G-----------GV----VAHSDFP-----------LGCSVMSNSLPLPIHFD-TE-HSW-CIG-------------AFVDQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FD---IESIAVHEIGHILG-LAH---S-NVHGSIM----Y-------S------------------------NVSSNYIKRT---LTQDDILGIQSL---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 448
449 ----------KW-DKR----------DLTY-----------------------------EY--L-SY-----TNDV--SK--------DDQRNAISRAFKRWSDV---TPLT------FTEVT--------DGGA-------DISLDFVV--------------------------G--DH-G---D--------GDANA---F-N---RKG---------EV----MAHAYPP-----------GNGD---------IHFN-DL-ENF-AVDSGTA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------ID---LEWVATHEIGHSLG-LGH---S-EYHKSVM----H-------S----KY--------------------PGYISNL---QLTRDDVNGIQAI---------------------------------------Y------------------GKNKYYVPMFPSHSSQAPDICKCSFDAIITANVYKDTYVIKKRHIWKLNEHGVVDTYPRKLSETYNYLPGNIDTGFTSYWSNRTYFFR------------------------------------------------------------------- 449
450 FKRFFIHKQMFWRNRN----------NITY-----------------------------------SVFIDTVPPTI--NV--------TTIKQETRFAFGVWEEA---I--SHKGVVRFCEVG--------DNVSGA-----DIKIVFAR--------------------------G--EH-G---D--------KFS-----F-D---GAG---------GV----LGHAFCPPRMGVKNAHYPSEGE---------VHLD-SD-EWWLTQD---QAPTD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-----------TY---YLPVVTHEIGHALG-LYH---S-SVRNSIM----Y-------Q----LY----------------------NSDHL---QLDKDDLNGLEQL---------------------------------------YIDNEYYKNATNKTIKTTDGTDSLTTTY-------------------------------------------------------------------------------------------------------------------------------------------------- 450
451 TKRFAIDQHLAW-DHD----------NITW-----------------------------------SLFTQILPVNV--SR--------NRVVQELTDAFMLWQKT---TTWRNESIIYFSQLL--------DNTTEA-----NIKISFAR--------------------------S--NH-N---D--------SHP-----F-D---GKG---------GV----LAHTFFPP-----------TGI---------IHFD-AA-EDWRLLDDDHKIP-E-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG-----------IS---LYLVAAHEIGHALG-LHH---T-SVRDAIM----Y-------W----YY----------------------NNEKT---GLHQDDANGMSQL---------------------------------------YADNPFRVTTTERSTTTTTTIPTTTTRR-------------------------------------------------------------------------------------------------------------------------------------------------- 451
452 ---APRGDTRAF-AKR----------TLTW-----------------------------RLLGEGAS-----GQ---LSV--------DEQRHILRLAFRMWSEV---TPLD------FRED------------LAAPGAAVDIKLGFG----------------------------RGRHLGCPRV----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PS--SDAG-----------IS---LLKVAVHEIGHVLG-LPH---T-YRTGSIM----R-------P----NY-----------------TP---QEPAF---ELDWSDRKAIQKL---------------------------------------Y-----------------EGSCEGSFDTAFDWIRK------------------------------------------------------------------------------------------------------------------------------------------- 452
453 ---------------------------LTW-----------------------------RLLGEGAS-----GQ---LSV--------DEQRHILRLAFRMWSEV---TPLD------FRED------------LAAPGAAVDIKLGFG----------------------------RGRHLGCPRV----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PS--SDAG-----------IS---LLKVAVHEIGHVLG-LPH---T-YRTGSIM----R-------P----NY-----------------TP---QEPAF---ELDWSDRKAIQKL---------------------------------------Y------------------GSCE------------------------------------------------------------------------------------------------------------------------------------------------------- 453
454 -GYPDGGAAQAF-SKR----------TLSW-----------------------------RLLGEALS-----SQ---LSV--------ADQRRIVALAFRMWSEV---TPLD------FRED------------LAAPGAAVDIKLGFG----------------------------RGRHLGCPRA----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PT--SDTG-----------IS---LLKVAVHEIGHVLG-LPH---T-YRTGSIM----Q-------P----NY-----------------IP---QEPAF---ELDWSDRKAIQKL---------------------------------------Y------------------GSCEGSFDTAFDWIRKERNQYGEVMVR-------------------------------------------------------------------------------------------------------------------------------- 454
455 -----------------------------W-----------------------------RLLGEGVS-----SQ---LAL--------DEQRYIFRLAFRMWSEV---MPLD------FQED------------LTAPGATVDIKLGFG----------------------------RGRHLGCPWV----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PT--SDSG-----------LS---LLKVAVHEIGHVLG-LPH---T-YRTGSIM----Q-------P----NY-----------------TP---QEPVF---ELDWSDRKAIQKL---------------------------------------Y------------------GSCEGSFDTVFDWIRKERNQYGEVMVR-------------------------------------------------------------------------------------------------------------------------------- 455
456 --------------------------------------------------------------------------------------------------------------LD------YKA-------------LEARTLPVSVFPGQG-----------------------------GRHLGCPWV----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PT--SDSG-----------LS---LLKVAVHEIGHVLG-LPH---T-YRTGSIM----Q-------P----NY-----------------TP---QEPVF---ELDWSDRKAIQKL---------------------------------------Y------------------GSCEGSFDTVFDWIRKERNQYGEVMVR-------------------------------------------------------------------------------------------------------------------------------- 456
457 ------GAPRAF-AKR----------TLSW-----------------------------RLLREGAS-----GQ---LAE--------AEQRRILRLAFRMWSEV---MPLH------FRED------------LAAPGAAVDIKLAFG----------------------------RGRHLGCPRV----------------F-D---GSG-------------QEFAHAWRL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------PT--SDSG-----------IS---LLKVAVHEIGHVLG-LPH---T-YRAGSIM----Q-------P----NY-----------------VP---QEPVF---ELDWSDRKAIQKL---------------------------------------Y------------------GSCEGSFDTAFDWIRKERNQHGAVRMR-------------------------------------------------------------------------------------------------------------------------------- 457
458 -DASDTGASRAF-SKK----------TLTW-----------------------------RLVGDAYS-----SQ---LSG--------DEQRYIFRLAFRMWSEV---TPLD------FRED------------RTAPGTMVDIKLGFG----------------------------RGRHLGCPRV----------------F-D---GSG-------------QEFAHAWRL-------------GE---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TP----------------LS--SDTG-----------IS---LLKVAVHEIGHVLG-LPH---T-YRVGSIM----Q-------P----NY-----------------IP---QEPAF---ELDWADRKAIQRL---------------------------------------Y------------------GSCKGSFDTVFDWIRKERNQYGEVRVR-------------------------------------------------------------------------------------------------------------------------------- 458
459 ----------AF-SKS----------VLKW-----------------------------RLIGEGYS-----SQ---LSI--------QEQKYIFRLAFRMWSEI---SPLQ------FIED------------LHSPLENIDIRLGFG----------------------------TGRHLGCSQR----------------F-D---GAG-------------REFAHAWFL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TV----------------PN--TGSG-----------IS---LLKVAVHEIGHVLG-LPH---I-YRPGSIM----Q-------P----SY-----------------LP---QDAGF---EIDWMDRKSIQRL---------------------------------------Y------------------GVCTGRFSTVFDWIRKEQTPYGEVVVR-------------------------------------------------------------------------------------------------------------------------------- 459
460 -EALQKSTGKVF-TKK----------LLKW-----------------------------RMIGEGYS-----NQ---LSI--------NEQRYVFRLAFRMWSEV---MPLD------FEED------------NTSPLSQIDIKLGFG----------------------------RGRHLGCSRA----------------F-D---GSG-------------QEFAHAWFL-------------GD---------IHFD-DD-EHF-------------------------------------------------------------------------------------------------------------------------------------------------------------------TA----------------PS--SEHG-----------IS---LLKVAAHEIGHVLG-LSH---I-HRVGSIM----Q-------P----NY-----------------IP---QDSGF---ELDLSDRRAIQNL---------------------------------------Y------------------GSCEGPFDTAFDWIYKEKNQYGELVVR-------------------------------------------------------------------------------------------------------------------------------- 460
461 --GEPVWDGQKF-TKD----------YIRW-----------------------------RMLRDGFS-----TR---IPV--------EEQRASLRLAFRMWSEV---IPII------FEED------------VSGDINRVDIEIAFG----------------------------RGSHQNCGRK----------------F-D---GHG-------------GEIAHSWSG-------------RN---------VHFD-DE-EDY-------------------------------------------------------------------------------------------------------------------------------------------------------------------KS----------------IDTISKDG-----------IY---LLRVAVHEIGHVLG-LAH---T-DKSYSIMYAIYH-------Q----NV-----------------VP---Q-AGF---ELGWEDRKSVQKI---------------------------------------Y------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------- 461
462 AEYIANGWGLAF-PRR----------TITW-----------------------------RLVREWPS-----SRNQFMTS--------NEVWFTVKLAFRMWSEI---LPRN------FLED------------NVSPVSQVDVLIGFG----------------------------INQHNRCPVS----------------F-----GQG----------PLIQEYAHAWAL-----------PKAE---------IHFN-DE-QPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------VP----------------SS--ASYP-----------IS---LLKVAIHEIGHTLG-LSH---N-DNRLSIM----N-------P----YY-----------------KPFQGSKNMD---ELSTSDRNSIKAI---------------------------------------Y------------------GECEIPFDVAFDWLRQERSPDGVFRWKY------------------------------------------------------------------------------------------------------------------------------- 462
463 ----------------------------------------------------------------------------FMTS--------NEVWFTVKLAFRMWSEI---LPRN------FLED------------NVSPVSQVDVLIGFG----------------------------INQHNRCPVS----------------F-----GQG----------PLIQEYAHAWAL-----------PKAE---------IHFN-DE-QPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------VP----------------SS--ASYP-----------IS---LLKVAIHEIGHTLG-LSH---N-DNRLSIM----N-------P----YY-----------------KPFQGSKNMD---ELSTSDRNSIKAI---------------------------------------Y------------------GEC-------------------------------------------------------------------------------------------------------------------------------------------------------- 463
464 ----------AF-PRR----------TITW-----------------------------RLVREWPS-----SRNQFMTS--------NEVWFTVKLAFRMWSEI---LPRN------FLED------------NVSPVSQVDVLIGFG----------------------------INQHNRCPVS----------------F-----GQG----------PLIQEYAHAWAL-----------PKAE---------IHFN-DE-QPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------VPVSWIPATVSGGAPQTRSS--ASYP-----------IS---LLKVAIHEIGHTLG-LSH---N-DNRLSIM----N-------P----YY-----------------KPFQGSKNMD---ELSTSDRNSIKAI---------------------------------------Y------------------GECEIPFDVAFDWLRQERSPDG------------------------------------------------------------------------------------------------------------------------------------- 464
465 --TDEGRSNVRF-EQQ----------EVCW-----------------------------RLLDTGIS-----HR---IPA--------QDQEIFLELSFRRFSEV---CPIK------FKQC------------TTRPFSDVDILIAFG----------------------------REDHQNCDKP----------------F-D---GNG-------------GELAHSWIA-------------GN---------IHFD-DA-ENY-------------------------------------------------------------------------------------------------------------------------------------------------------------------KS-----------LQDWQAKEGSPMG-----------IS---LLKVAVHEIGHVLG-LFH---V-NNENSIM----Y-------P----IY-----------------HN---MKDNF---EISRDDRRAVQQL---------------------------------------Y------------------GVCKGRFDIVMDWVRKK------------------------------------------------------------------------------------------------------------------------------------------ 465
466 --EERRKKRGIF-VNN----------YVTW-----------------------------RLLGEGYS-----SQ---LDA--------DLQLAVIQQAFRMWSEV---IPPL------FRPD------------HVSHIEEVDVNLAFG----------------------------RVRHLGCPNE----------------F-Q---E---------------QEYAHAFDE------------AAE---------VHIN-DQIQPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------N--RPDG-----------IS---LLKVAVHEIGHILG-LGH---H-EWANSVM----Q-------P----NY-----------------AP---QPYNF---EIGAEDRRAVQELGYASGLREFPCRHSAGVQDLSGYPDMLDRWILPHRRLTHH-----------------RGKCEERFDTVFDWVRPNRDENG------------------------------------------------------------------------------------------------------------------------------------- 466
467 ------RHTISLINKP----------VLVW-----------------------------RL----GQDEAGYEPTRGLSF--------QERREVIYTAFRIFDEV---LPID------FIE----------SVSGQGDVNDVDILITFNG--------------------------AGIPH--------------STCQVVFYFYD---------------NA----ISHSWTL--------TQGSTGE---------IHFN-GE-FTFLKLGQMANMNQYHPFGPRGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VH---LLSVAVHEIGHVLG-LPHVDES--ERISVMNHVYH------------GW----------------------TMSDSSSGELSREDRDAIQDL---------------------------------------Y------------------GECQVQIDTAFDFIH-------------------------------------------------------------------------------------------------------------------------------------------- 467
468 ---------------------------ITW-----------------------------RV--LDDY-----PSQYI-----------SDTSSIFTAAFRRWAEV---TPLT------FREQ------------TSGDVLNVDIYIAFAN--------------------------S-----NDLSD----------------FGDHRWSSG---------QLALSDVASSH--------------------------IFFN-DN-KLW-TDRSDQD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YN---LQSVATHEIGHFLG-LGH---S-TNVSSIM----Y-------P----IY--------------------RSFDGKV---TIDSETKTAVQDI---------------------------------------Y------------------GTCNNSLDTVFDWMRL------------------------------------------------------------------------------------------------------------------------------------------- 468
469 ------------------------------------------------------------------------------------------VRRTVQESFAKWAIA---L----ENLMEFEEIL--------DD-QEA-----NIRVFFAK--------------------------K--NH-S---C--------YEE-----F-D---GKG---------GV----VAHSMYPP-----------FGV---------LHLD-GD-EQWYATDENEEMD-Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RV-----------ID---LRMVLIHEIGHTLG-LRH---S-RRKASVM----R-------K----HYEKPK------------------NPHKI---RLSKYDVRAIREL---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 469
470 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-D---GKG---------GV----VAHSMYPP-----------YGV---------LHLD-GD-EEWHTRRWEEDGEAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KY-----------ID---LRLVLIHEIGHTLG-LRH---S-RRKTSVM----R-------K----HY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 470
471 ---------------------------------------------------------------Q-VL-----NASYRASL--------N---------LSQLSNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IANTITHEIGHTLG-LDH---S-QLPTDVM-----------------H----------------------D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 471
472 ----------KM-SQS----------EMTW-----------------------------TL--NDHK-----PDGKYLHL--------VNVLDLIEFGLNVWAKV---TNIK------FKRIQ-----------HRDFF-QADIYFSFHT--------------------------G--DH-G---D--------GNS-----F-D---GPG---------GS----LAHAINK-----------E------------IHFD-KS-EPW-QYNLK-----YSTLMKRPANA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PD---FVYTVIHEVGHVLG-LSH---S-RKLTSVM----H-------E------------------------TIQIPFSKDDPYVLDDEDITKIKAD---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 472
473 RFTGPSTITLKW-YIS----------EYTN-----------------------------DI--D-RM----------------------ETRRVVKKAFELWSSQ---SYIKHEKKVALNFVE-AA-----SK-EDS-----DINILWAE--------------------------G--SH-G------------D-EYP---F-D---GANGKIEGNKKENV----LAHTFFP------GYAFPLNGD---------IHFD-DA-ETW-EVDVDEVGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------NRKRFFPYVLAHEIGHALG-LDH---S-QKSDALM----H-------P----YY-----------------KNVP--IHEI---QLDVDDKCGVIWN---------------------------------------Y------------------GGSSNFCLYVWLMSQIIEAHNSSAQNS-------------------------------------------------------------------------------------------------------------------------------- 473
474 --SGQS-VTLKW-YIS----------DYTS-----------------------------DI--D-RL----------------------ETRKVVEKAFKLWSSQ---SYIKNEKKVTLTFQE-AS-----SK-DEA-----DINILWAE--------------------------G--NH-G------------D-EHD---F-D---GANGKIEGNKKENV----LAHTFFP------GYARPLNGD---------IHFD-DA-EDW-EIDVDQV-G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HG-----------SNKRFFPYVLAHEIGHALG-LDH---S-QKADALM----H-------P----YY-----------------KNVP--INEI---QLDIDDKCGVIWN---------------------------------------Y------------------GGASDFCLYVWLMSQIVEAHNSSAQNN-------------------------------------------------------------------------------------------------------------------------------- 474
475 --------YYTW-------------------------------------------------------------------------------QQAIKTAIADWQEF---FPLT------IVENT-----------TEA-----DITIFYRE-----------------------------------------------PPLPRIV-DPETGLV---------SFGRARTAQANYE--------------------------------FYW-TDTSPPQLRHRMAIAIKPGLAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LS---LQGTARHELGHALGIWGH---SDHKEDAL-----YPAQTADVP------------------------------------AISPRDLRTLYRL---------------------------------------Y------------QQPTRLGWS-------------------------------------------------------------------------------------------------------------------------------------------------------- 475
476 ----------------------------------------------------------------------------------------------VLRGITAWNPS---SKIQ------FTKES--------SLPGGA-----NVKIEYVD-----------------------------RYNG---DTYGI------------F-R---GSG---------NV-----------------------------------TLF-----KKWRVE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDSARRKETAVHEVGHALG-LGHTQKS-NDSISVM----R------------QYEFNYKDYPQ------------------------SDDWAGINA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 476
477 ----------------------------------------------------------------------------------------------VLRGITAWNPS---SKIQ------FTKES--------SLPGGA-----NVKIEYVD-----------------------------RYNG---DTYGI------------F-R---GSG---------NV-----------------------------------TLF-----KKWRVE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDSARRKETAVHEVGHALG-LGHTQKS-NDSISVM----R------------QYEFNYKDYPQ------------------------SDDWAGINA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 477
478 --------TPIW----------------------------------------------------------------------------------------------------------FSQTT--------NR-PDS-----DIDIMFSN-----------------------------------------------------F-----GNTGWYGSTEWYRSSTKLNSWSGTP------------TGNWSWSKINMNDYYY-ADMQKYD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---TERVVSHEIGHAMG-LAH---N-DISTSVM---RIRWPQVLAP--------------------------------------SKADLDEITRM---------------------------------------Y----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 478
479 -----------W-TKK----------SLTY-----------------------------KIVNTPKT----------LSE--------ARIRSAAHEAFAQWTRA---SGFK------FVE---------------STGQTPDITITF-------------------------------------------------------Y-D---VPQ----------SNLRIAGSASKP-----------LNSH---------IILD-KN-QEW-------------------------------------------------------------------------------------------------------------------------------------------------------------------AY-----------------KSQAPMG-----------IS---LYHTLLHEIGHVLG-LPH---T-FYRGSIMHPIFK-------P----VL-----------------LP---FGTLD---IVPNVDRLAIRKI---------------------------------------Y------------------GLSS------------------------------------------------------------------------------------------------------------------------------------------------------- 479
480 -----------W-TKK----------SLTY-----------------------------KVVNTPNT----------LSQ--------AQIRSAAHEAFEQWTRA---SGFK------FVE---------------TTGATPDITITF-------------------------------------------------------Y-D---VPQ----------SNLRIAGSASKP-----------VNSH---------IILD-KN-QEW-------------------------------------------------------------------------------------------------------------------------------------------------------------------AY-----------------KSQAPMG-----------IS---LYHTLLHEIGHILG-LPH---T-FYRGSIMHPIFK-------P----VL-----------------LP---HGTVD---TVPNVDRLAIRKI---------------------------------------Y------------------GLSS------------------------------------------------------------------------------------------------------------------------------------------------------- 480
481 ----------------------------------------------------------------------------------------PEIQQKVKEHAMEWTKH---ANIH------FDFIQ--------DGNA-------EIRISF-------------------------------KHKG---SWSYVGTDCLNPNLSQN--D---------------AT----MNYGWFT--------------------------LDTKD-EEY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SR------TVLHEFGHALG-LHH---E---------------------------------------------------------QMRPD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 481
482 ----------KW-TDK----------VITY-----------------------------GC--K-SA-----GTSTRISL--------DDLRRTMHQAASQWSEL---ADVE---------IL-ES-----SV-EKP-----NIQISAGR--------------------------S--SH-Y------------PCNVR---F-D-----S---------QT----LAHAFFP------P-----HGQ---------IHIN-DN-VHF-VMTNFTERI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GG-----------NS---LYSVVAHEMGHALG-FSH---S-PDSDSVM----F-------A----Y----------------------DTPREW---KFTPMDKYRMEMY---------------------------------------Y------------------GTKKNPTKP-------------------------------------------------------------------------------------------------------------------------------------------------- 482
483 RGKRYAPPQFKW-KEK----------IITY-----------------------------GC--K-AV-----GTSTRISL--------DDLRRTMHQAASQWSEL---ADVE---------IV-ES-----SV-KNP-----MMVISAGR--------------------------E--NH-Y------------PCTVR---F-D-----T---------KT----LAHAFFP------T-----NGQ---------IHIN-DR-VQF-AMTNYTERM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GA-----------NS---LYSVVAHEMGHALG-FSH---S-PDIDSVM----F-------A----Y----------------------DTPRKW---KFTSMDKYNMRSY---------------------------------------Y------------------GAKASKKENEEEERKTENEDKRRKTEK-------------------------------------------------------------------------------------------------------------------------------- 483
484 -------------TKR----------NLTY-----------------------------CI--STSF-----GEKY------------DTVVAAMHDAAKAWSDA---SDVR------FIHSSWLDPLCNENT---T-----DVI----------------------------------------------------------F-D--VRPV---------DVNGQYLARAFFP-------RYERLQRN---------VLID-KS-----ALNLSPGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT---LTGILRHELGHTLS-FRH---E-QT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 484
485 ---------------------------------------------------------------------------IDTQD--------ETFRSAYQEAIRTWNQT---GAFT------FQIVN--------DK-SQA-----NIV-------------------------------------ATEMN------------------D---------------GT----VSAA----------------GEAESQTNLLTKRFT-NV-----TVRLNRYYLLNSQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------YG-----------YSYERIVNTAEHELGHAIG-LEH-----NEEKSVMQSAGS------------FY------------------------------GIQAVDVQAVKEL---------------------------------------YQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 485
486 --------------------------PLRV-----------------------------FIRDG---------ESLSAWN--------PDFLPAVRDAFDTWAQAGLPLRFT------FVIDS-----------ASA-----DVHVRF-------------------------------------------------------V-D---GFA---------NG----IS------------------GR---------TVWSRDA-NYW-LVASDIQLAVLHAGGTTVTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQ---MRAIALHEVGHLIG-LDH---T-VGTEDIM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 486
Active site residue: X
Metal binding site: X
Carbohydrate attachment site: X
Putative: +
Experimental: #
