Alignment for family M15A

         12        13          14          15        16        17        18        19           20                 21        22        23        24                 25     
     6789A01234567890123A456A789012AB345678901234567890123456789012345678901234567890ABC123456789012345A67ABCDEFG8A90123456789012345678901234567890123ABCDEFGHI456789012345
                           +                                                  +              #      #                 +                        # #                      +  
                           /1                                                1\                                       /2                                               2\  
   1 YALQ-DADCTPVHFTYAEL-NKC-NSDWSG--GAVSAATAKSNALKTMWKLEAMRHALGDVPITISSGFRSRACNSAVGG---SSTSRHLYGDAADLT-GS-------P--SFCRLAQQARTHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPNCGI   1
   2 YALQ-DADCTPVHFTYAEL-NKC-NSDWSG--GAVSAATAKSNALKTMWKLEAMRHALGDVPITISSGFRSRACNSAVGG---SSTSRHLYGDAADLT-GS-------P--SFCRLAQQARTHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPNCGI   2
   3 YALQ-DADCTPVHFTYAEL-NKC-NSDWSG--GAVSAATAKSNALKTMWKLEAMRHALGDVPITISSGFRSRACNSAVGG---SSTSRHLYGDAADLT-GS-------P--SFCRLAQQARTHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPNCGI   3
   4 YSLQ-DADCTPVHFTYAEL-NKC-NSDWSG--GAVSAATAKSNALKTMWKLEAMRHALGDVPLTISSGFRSRACNNAVGG---SATSRHLYGDAADLV-GS-------P--SLCRLAQQSRTHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPTCGI   4
   5 YALQ-DADCTPIHFTYGEL-NRC-NSDWSG--GAVSAATAKANALKTMWKLEAMRHALGDVPISISSGFRSYACNSAVGG---SSTSRHLYGDAADLT-GS-------P--SLCRLAQQARTHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPSCGI   5
   6 YALQ-DADCTPVHFSYSEL-NKC-NSDWSG--GAVSAATAKSNALKTMWKLEAMRHALGDVPINISSGFRSYACNNAVGG---ASNSRHLYGDAADLV-GS-------P--SFCTLARQSRVHGFSEILGPGYPGHNDHTHVAFD---------PSPYWSAPSCGM   6
   7 YALQ-DDDCTPVNFSYAEL-NNC-NSTWAG--GAVAASTARANALVSMWKLQALRHALGDVPIAISSSFRSYACNSAVGG---ASNSRHLYGDAVDLV-GS-------P--SLCRLAQQARSHGFGQILGPGYPDHNDHTHVAAV---------GG--WSAPTCGI   7
   8 YALQ-DPDCTPVSFSYAEW-NRC-NSDWSG--GAVSASTARFNALVSMWKLQAMRRAMGNAPLYLSSGFRSYSCNSAVGG---ASNSRHLYGDGIDLV-GS---------HSFCALAQQARNHGFTNILGPGYPGHNDHTHLGNT---------PSRSWSAPSCGI   8
   9 YQLQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAGTARANALVTMWKLQAMRHAMGDRPITVNGGFRSVSCNSAVGG---AANSRHMYGHAADLG-AG-------S-QGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGG---------SGRFWSAPSCGI   9
  10 YQLQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAGTARANALVTMWKLQAMRHAMGDRPITVNGGFRSVSCNSAVGG---AANSRHMYGHAADLG-AG-------S-QGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGG---------SGRFWSAPSCGI  10
  11 YQLQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAATARANALVTMWKLQAMRHAMGDRPITVNGGFRSVSCNSAVGG---AANSRHMYGHAADLG-AG-------S-QGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGG---------SGRFWSAPSCGI  11
  12 YALQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAATARANALVTMWKLQAMRHAMGDRPITVNGGFRSVSCNSAVGG---AANSRHMYGHAADLG-AG-------S-QGFCGLAQAARNHGFTEILGPGYPGHNDHTHVAGG---------SGRFWSAPSCGI  12
  13 YQLQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAATARANALVTMWKLQAMRHAMGDKPITVNGGFRSVTCNSNVGG---ASNSRHMYGHAADLG-AG-------S-QGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGG---------DGRFWSAPSCGI  13
  14 YQLQ-DDDCTPVNFTYAEL-NRC-NSDWSG--GKVSAATARANALVTMWKLQAMRHAMGDKPITVNGGFRSVTCNSNVGG---ASNSRHMYGHAADLG-AG-------S-QGFCALAQAARNHGFTEILGPGYPGHNDHTHVAGG---------DGRFWSAPSCGI  14
  15 YALQ-DDDCTPIHFSYSEL-NSC-NSTWSG--GAVSASTAKANALRTMWKLEALRHALGDQPIRVTSGFRSHACNDAVGG---ASGSRHLYGDAADLG-AG-------P-HSLCTLAKQARYHGFRGILGPGYPGHNDHTHVDHR---------GSQYWSAPTCGV  15
  16 YALQ-DSDCTPAHFSYAEL-NRC-NSTWSG--GAVSAATAKANALRTMWKLEALRHALGDQPITVTSGFRSYSCNSAVGG---ASSSRHLYGDAADLG-AG-------P-HSLCKLAQQARNHGFNGILGPGYPGHNDHTHVDHR---------GSRYWSAPSCGI  16
  17 YALQ-DNDCTPVHFSYAEL-NKC-NSTWSG--GAVSAATAKSNALRTMWKLEALRHALGDKPIRVTSGFRSKSCNSAVGG---ATNSRHLYGDSADLG-AG-------P-HSLCTLAKQARNHGFRGILGPGYPGHNDHTHVDHR---------ASRHWSAPTCGI  17
  18 YALQ-DDDCTPVNFSYGEL-NNC-NSNWSG--GAVGASTAKANALVSMWKLQAMRHALGDQPIRVTSGFRSHSCNDAVGG---APNSRHLYGDAVDLG-SG-------P-HSLCTLARQARSHGFNGILGPGYPGHSDHTHVDHR---------SSRFWSASSCGI  18
  19 YALQ-DDDCTPVHFTYPEL-NTC-NSTWAG--GAVAAGTAKANALSSMWKLEALRHALGDQSIRVTSGFRSTSCNAAVGG---ATNSRHLYGDAVDLG-SG-------P-HSLCTIAKQARNHGFNGILGPGYAGHSDHIHVNQG---------PNHFWSASGCGI  19
  20 YALQ-DDDCTPVHFTYPEL-NTC-NSTWAG--GAVAAGTAKANALSSMWKLEALRHALGDQSIRVTSGFRSTSCNAAVGG---ATNSRHLYGDAVDLG-SG-------P-HSLCTIAKQARNHGFNGILGPGYAGHSDHIHVNQG---------PNHFWSASGCGI  20
  21 YALQ-DDDCTPIHFTYPEL-NKC-NSTWAG--GAVAAGTAKANALSSMWKLEALRHALGDQPIRVTSGFRSTPCNASVGG---AANSRHLYGDAVDLG-AG-------P-HSLCTIAKQARNHGFNGILGPGYPGHSDHIHVNQG---------PSHFWSASGCGV  21
  22 YALQ-DNDCTPIHFTYPEL-NKC-NSTWAG--GKVAAGTAKANALSSMWKLEALRHALGDKSIRVTSGFRSASCNAAVGG---ASNSRHMYGDAVDLG-AS-------P-HSLCTLAKQARYHGFRGILGPGYVGHNDHVHVNQG---------PSRFWSAPSCGV  22
  23 YALQ-DNDCTPIHFTYPEL-NTC-NSTWAG--GKVAAGTARANALSSMWKLEALRHALGDRSIRVTSGFRSASCNAAVGG---ASNSRHMYGDAVDLG-AS-------P-HSLCTLAKQARYHGFRGILGPGYVGHNDHVHVNQG---------PSRFWSAPSCGI  23
  24 YALQ-DNDCTPIHFTYPEL-NKC-NSTWTG--GKVAAGTAKANALSSMWKLEALRHALGDRSIRVTSGFRSASCNAAVGG---ASNSRHMYGDAVDLG-AS-------P-HSLCTLAKQARHHGFRGILGPGYVGHNDHVHVNQG---------PSRFWSAPSCGI  24
  25 YALQ-DNDCTPAHFTYPEL-NKC-NSTWAG--GKVAAGTAKANALSSMWKLEALRHALGDQSIRVTSGFRSVSCNAAVGG---ASNSRHMYGDAVDLG-AS-------P-HSLCTLAKQARYHGFRGILGPGYVGHNDHVHVNQG---------PSRFWSAPSCGI  25
  26 YQLQ-DNDCTPAHFSYSEL-NKC-NSTWSG--GAVSASTARANALVSMWKLEALRHALGDKPVRVTSGFRSKACNDRAGG---SASSRHMYGDGVDLG-SL-------S-HSFCTIAKQARYHGFSNILGPGYPNHNDHVHVA-V---------GSTTWSAPNCGI  26
  27 YELQ-DDDCTPIHFTYAELND-C-NSDWSG--GKVSAAEAKANALRVMWSLEAMRHALGDKPITVTSGFRSVQCNNNAGG---ASDSQHLYGRSADLG-AG-------P-HSLCTLAKEARSHGFMGIFGPGYDGHDDHTHADIR---------STQAWSAPDCGV  27
  28 YALQ-DDDCTPIHFTYAELDDGCGGSGYDG--GPLSEAATRANALQTMWQLEALRHALGDQPLTVTSGFRSYSCNSSVGG---ASNSQHLYGRSADL--VG-------V-HSLCTLAKQARYHGFGGIFGPGYAGHNDHTHLDIR---------TSNSWAAPSCGI  28
  29 YSLQ-DGDNTPKHFSYAEL-NGC-NSSWAG--GTVSSTTAKYRALITMWKLEAMRHALGDKSISVSSGFRSKACNDAVGG---ASNSQHMTGSAADLV-GS---------HSLCTLAKQARYHGFGTILGPGYDGHGDHVHLDGL---------NRIYWSAPNCGV  29
  30 YDLQKDSDCTPKHFSYAELDNGCGKGGWAG--GPLSSSATRENALRTMWKLEALRRSLGDKPLYVTSGFRSIACNRQVGG---AADSQHLYGNAADLI-AK-------H-RSLCDIARSARDQGFSGIYGPGYPDHDDHTHVDSRRENNRDKVPNTRDWSAPDCGV  30
  31 YDLQKDSDCTPKHFSYAELDNGCGKGGWAG--GPLSSSATRENALRTMWKLEALRRSLGDKPLYVTSGFRSIACNRQVGG---AADSQHLYGNAADLI-AK-------H-RSLCDIARSARDQGFSGIYGPGYPDHDDHTHVDSRRENNRDKVANTRDWSAPDCGV  31
  32 YALQ-DDDCTPAHFSYSEMDDGCGRGGWSG--GPLSSAKTRDNALRAMWKLEALRRGLGDEPLRVTSGFRSEVCNRQVRG---ASNSQHLYGNAADLA-AP-------SGSSLCDVALHARDHGFSGIYGPGYPDHEDHVHVDSRRENNDDGIPNTTSWSAPDCGI  32
  33 YQLQ-DNDCTPAHFTYNELDNGCGGSGWSG--GPVSASQTKQNALRTMWKLEALRKSLGDKPLNVSSGFRSRACNNQVGG---ASDSQHLYGNAADVT-SR-------T-SSLCTVAKKARNNGFSGIYGPGYPDHDDHVHVDSRRENNSDNSSNTTSWSAPDCGI  33
  34 YQLQ-DNDCTPRHFNWAEMDDGCGRGGWTG--GPLTTAQTRQNALRTMWKLEALRKSLGDKPLIVTSGFRSSTCNSQVGG---ASNSQHLYGNAADLI-SR-------D-RSLCDVARAARNHGFSGIIGPGVSGHNTHVHVDSRRENNRDGVTNNTYWAAPDCGI  34
  35 YELQ-DADCTPIHFDHSEFNYNCGARNYEG--GKVPAATARENMRRVMWQLEALRHKLGDRPLVVTSGFRSVSCNASVGG---SSTSLHMYGQAADLG-LS-------SGPSQCQMWNGGKSAGFEELLGPGYPGHNDHVHVGNK---------ASRFWSAPNC--  35
  36 YQLQ-DADCTPIHFDHSEFNYNCGARNYNG--GKVTAATARENMRRVMWQLEAMRHKLGDRPLVVTSGFRSVSCNSSVGG---SSTSLHMYGQAADLG-LS-------SSPSQCQMWNSGKSAGFEELLGPGYPGHNDHVHVGNK---------ASRFWSAPNC--  36
  37 YQLQ-DADCTPIHFDHSEFNYNCGARNYNG--GKVTAATARENMRRVMWQLEALRHKLGDRPLVVTSGFRSVSCNSSVGG---SSTSLHMYGQAADLG-LS-------SSPTQCQMFHGSKSAGFEEILGPGYPGHNDHVHVGNK---------SSRFWSAPNC--  37
  38 YQLQ-DADCTPIHFSHSEFNYNCGARNYNG--GKVTAATARENMRRIMWQLEALRHKLGDRPLVVTSGFRSVSCNSSVGG---SSTSLHMYGQAADLG-LS-------SSPTQCQMFHGSKSAGFEEILGPGYPGHNDHVHVGNK---------ASRFWSAPNC--  38
  39 YQLQ-DSDCTPIHFSYSEFNYNCGARNFNG--GRVTAAEAKENTRRVMWQLEAMRHKLGDRPMVVTSGFRSVSCNSSVGG---SSTSLHLYGQAADLG-LS-------SSPSQCQMWNSAKSAGFEEILGPGYPGHNDHVHVGNK---------SSRFWSAPNC--  39
  40 YALQ-DADCTPIHFSHSEFNDNCGANNYYG--GKVSAGTARENIRRVMWQLEALRHKLGDRPLVVTSGFRSESCNAAVGG---SSTSLHMYGRAADLG-LA-------SGPTQCQMWSSARSAGFEEILGPGYPNHNDHVHVGNK---------STRFWRAPNC--  40
  41 YALQ-DDDCTPIHFDWSEVDDVC-YGGWPTPISGVTITQVKANLMQAMWRAEAIRHRLGDNPLRVTSAYRSKACNDAVGG---ASNSNHLYGRAMDLVPGS-------SATTMCGIARASR-QSFPQVLGPGYPDHSDHIHLGIQ---------SSVYHSASQC--  41
  42 --LE-QSDGSTVHFNFSEFTDRD-SGTFNG--GKVSAATAKENARRCMYKLEALRKKLGNKPITVNSGFRSIAHNAEIGG---ASDSMHLYGTAADL--NV-------PGVANKTVYQKAETCGFSGL--ETYN--TDHQHVDSR---------------------  42
  43 --LE-QSDGSTAHFNWSEFVDQS-SGTFNG--GKASAAQVKENARRCMYKLEALRKKLGDKPITVNSGFRSIAHNAEIGG---ASDSMHLYGTAADL--DV-------PGVATKTVYQKAETCGFSGL--ERYT--VDHQHVDSR---------------------  43
  44 --LE-QADGSTAHFDFAEFTDRV-SGTFAG--GKLSAAATKENVRRAMYKLEALRKKLGNVPITVNSGFRSIAHNAEVGG---ASDSMHLYGTAADL--DV-------PGVSNRTVYQKAETCGFSGL--ETYT--ADHQHVDSR---------------------  44
  45 -----------------------------------------------------------------SGQYNSYLQINAIAGACHSSTSWHYQGTSVDLQIKSGDSGYASSWMSTCSAAGAREN------LGPGYPGHSTHTHCA-----------------------  45
  46 -----------------------------------------------------------------------------------SSTSRHYSGYAVDFQIKA-NSPY-ESYMSMCAVSGAVEN------LGPGTPGHSTHTHCA-----------------------  46

     Active site residue:           X

     Metal binding site:            X

     Disulfide bond:                X

     Putative:              +

     Experimental:          #