$VAR1 = undef;

Summary for peptidase A22.002: presenilin 2

Names
MEROPS Name	presenilin 2
Other names	PS2, PSEN2 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan AD >> Subclan (none) >> Family A22 >> Subfamily A >> A22.002
Holotype	presenilin 2 (Homo sapiens), Uniprot accession P49810 (peptidase unit: 22-448), MERNUM MER0005223
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Aspartic
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Kimberly et al., 2002) mouse: active (Esler et al., 2002)
Structure	Catalytic residues in presenilin-1 were investigated by by Wrigley et al. (2004).
Knockout	Conditional double knockout mice lacking presenilin 1 and presenilin 2 show impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration (Saura et al., 2004).
Pharmaceutical relevance	Presenilin 2 is apparently a component of an Alzheimer"s gamma-secretase that, although less active than the presenilin 1-dependent secretase, may nevertheless make presenilin 2 a drug target (Lai et al., 2003).
Pathways	KEGG	Alzheimer's disease
	KEGG	Notch signaling pathway
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Presenilin_2