Sequence features for peptidase A22.002: presenilin 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0689746 Acanthisitta chloris 457 23-457 D269, D375 UNIPROT:A0A091NEJ6
MER0689746 Acanthisitta chloris 457 23-457 D269, D375 UNIPROT:A0A091NEJ6
MER0198584 Ailuropoda melanoleuca 480 55-480 D295, D398 GENBANK:XP_002925804
MER0270166 Alligator mississippiensis 458 23-458 D268, D376 GENBANK:XP_006272677
MER0319876 Anas platyrhynchos 458 23-458 D269, D376 GENBANK:XP_005022602
MER0198409 Anolis carolinensis 471 43-471 D269, D389 GENBANK:XP_003216113
MER0688229 Apaloderma vittatum 457 23-457 D269, D375 GENBANK:XP_009865246
MER0682851 Aptenodytes forsteri 458 23-458 D269, D376 GENBANK:XP_009283836
MER0685211 Aquila chrysaetos 458 23-458 D269, D376 GENBANK:XP_011583994
MER0556324 Astatotilapia burtoni 430 74-430 D259, D349 GENBANK:XP_005952410
MER0362272 Astyanax mexicanus 418 41-418 D233, D337 GENBANK:XP_007260696
MER0387787 Balaenoptera acutorostrata 448 22-448 D263, D366 GENBANK:XP_007167256
MER0681488 Balearica regulorum 458 23-458 D269, D376 GENBANK:XP_010307858
MER0680427 Bison bison 449 22-449 D264, D367 GENBANK:XP_010851179
MER0425876 Boiga irregularis 463 84-462 D269, D381 UNIPROT:A0A0B8RXQ6
MER0425876 Boiga irregularis 463 84-462 D269, D381 UNIPROT:A0A0B8RXQ6
MER0090021 Bos grunniens 461 36-461 D276, D379 UNIPROT:L8IRC1
MER0090021 Bos grunniens 461 36-461 D276, D379 UNIPROT:L8IRC1
MER0012009 Bos taurus 449 22-449 D264, D367 UNIPROT:Q9XT96
MER0012009 Bos taurus 449 22-449 D264, D367 UNIPROT:Q9XT96
MER0012009 Bos taurus 449 22-449 D264, D367 UNIPROT:Q9XT96
MER0678732 Buceros rhinoceros 459 23-459 D270, D377 GENBANK:XP_010139508
MER0201337 Callithrix jacchus 57 26-57 missing, missing UNIPROT:A6MKL6
MER0201337 Callithrix jacchus 57 26-57 missing, missing UNIPROT:A6MKL6
MER0321059 Callithrix jacchus 517 59-517 D333, D435 GENBANK:XP_003735282
MER0321066 Callithrix jacchus 567 154-567 H384, H485 GENBANK:XP_003735414
MER0582037 Calypte anna 458 23-458 D269, D376 UNIPROT:A0A091HZ52
MER0582037 Calypte anna 458 23-458 D269, D376 UNIPROT:A0A091HZ52
MER0676963 Camelus dromedarius 465 65-465 D280, D383 GENBANK:XP_010990724
MER0356702 Camelus ferus 448 22-448 D263, D366 GENBANK:XP_006188177
MER0549648 Capra hircus 449 22-449 D264, D367 GENBANK:XP_005690595
MER0675977 Cariama cristata 457 23-457 D269, D375 GENBANK:XP_009702439
MER0103422 Cavia porcellus 448 23-448 D263, D366 GENBANK:XP_003474278
MER0541950 Ceratotherium simum 448 22-448 D263, D366 GENBANK:XP_004439619
MER0587767 Cercopithecus sabaeus 414 24-414 D263, D332 GENBANK:XP_007986448
MER0587768 Cercopithecus sabaeus 448 22-448 D263, D366 GENBANK:XP_007986445
MER0672871 Chaetura pelagica 462 23-462 D269, D380 GENBANK:XP_009993083
MER0430381 Charadrius vociferus 464 84-463 D269, D376 UNIPROT:A0A099ZX04
MER0430381 Charadrius vociferus 464 84-463 D269, D376 UNIPROT:A0A099ZX04
MER0671574 Charadrius vociferus 445 23-445 D269, D368 GENBANK:XP_009880091
MER0592214 Chelonia mydas 459 24-459 D270, D378 GENBANK:XP_007071762
MER0582939 Chinchilla lanigera 448 22-448 D263, D366 GENBANK:XP_005374813
MER0577108 Chrysemys picta 459 24-459 D269, D377 GENBANK:XP_008173296
MER0575585 Chrysochloris asiatica 448 22-448 D263, D366 GENBANK:XP_006871323
MER0670435 Colius striatus 458 23-458 D269, D376 GENBANK:XP_010208932
MER0670050 Colobus angolensis 481 55-481 D296, D399 GENBANK:XP_011804354
MER0090017 Columba livia 458 88-458 D269, D376 GENBANK:EMC85171
MER0572577 Corvus brachyrhynchos 458 23-458 D269, D376 UNIPROT:A0A091EJA2
MER0572577 Corvus brachyrhynchos 458 23-458 D269, D376 UNIPROT:A0A091EJA2
MER0667903 Corvus cornix 458 23-458 D269, D376 GENBANK:XP_010391793
MER0201945 Cricetulus griseus 448 39-448 D263, D366 GENBANK:XP_003507279
MER0245673 Crotalus adamanteus 463 25-463 D269, D381 UNIPROT:J3SCX6
MER0245673 Crotalus adamanteus 463 25-463 D269, D381 UNIPROT:J3SCX6
MER0694443 Crotalus horridus 463 84-462 D269, D381 UNIPROT:T1E4N9
MER0694443 Crotalus horridus 463 84-462 D269, D381 UNIPROT:T1E4N9
MER0664789 Cuculus canorus 455 23-455 D269, D373 UNIPROT:A0A091GJT9
MER0664789 Cuculus canorus 455 23-455 D269, D373 UNIPROT:A0A091GJT9
MER0567259 Cynoglossus semilaevis 426 73-426 D255, D345 GENBANK:XP_008314567
MER0012017 Danio rerio 441 19-441 D262, D360 GENBANK:CAB71930
MER0012017 Danio rerio 441 19-441 D262, D360 GENBANK:CAB71930
MER0012017 Danio rerio 441 19-441 D262, D360 GENBANK:CAB71930
MER0012017 Danio rerio 441 19-441 D262, D360 GENBANK:CAB71930
MER0245706 Desmodus rotundus 456 31-456 D271, D374 UNIPROT:K9ISM5
MER0245706 Desmodus rotundus 456 31-456 D271, D374 UNIPROT:K9ISM5
MER0599829 Echinops telfairi 448 22-448 D263, D366 GENBANK:XP_004700025
MER0662795 Egretta garzetta 457 23-457 D269, D375 GENBANK:XP_009646477
MER0565839 Elephantulus edwardii 448 22-448 D263, D366 GENBANK:XP_006897811
MER0563325 Eptesicus fuscus 448 22-448 D263, D366 GENBANK:XP_008156220
MER0098326 Equus caballus 448 22-448 D263, D366 GENBANK:XP_001489764
MER0561881 Equus przewalskii 409 81-409 D224, D327 GENBANK:XP_008529758
MER0615577 Erinaceus europaeus 448 22-448 D263, D366 GENBANK:XP_007534579
MER0661650 Esox lucius 445 71-445 D259, D364 GENBANK:XP_010904158
MER0658175 Eurypyga helias 458 23-458 D269, D376 GENBANK:XP_010159448
MER0559890 Falco cherrug 458 23-458 D269, D376 GENBANK:XP_005434054
MER0545807 Falco peregrinus 458 23-458 D269, D376 GENBANK:XP_005241892
MER0245679 Felis catus 465 24-465 D280, D383 GENBANK:XP_003999139
MER0569396 Ficedula albicollis 458 23-458 D269, D376 UNIPROT:U3KAI4
MER0569396 Ficedula albicollis 458 23-458 D269, D376 UNIPROT:U3KAI4
MER0656676 Fukomys damarensis 466 41-466 D281, D384 GENBANK:XP_010640880
MER0654734 Fulmarus glacialis 457 23-457 D269, D375 GENBANK:XP_009575574
MER0557066 Galeopterus variegatus 378 23-378 D193, D296 GENBANK:XP_008582739
MER0021224 Gallus gallus 456 23-443 D269, D374 GENBANK:-
MER0021224 Gallus gallus 456 23-443 D269, D374 GENBANK:-
MER0653481 Gavia stellata 458 23-458 D269, D376 GENBANK:XP_009814615
MER0559548 Geospiza fortis 457 23-457 D269, D375 GENBANK:XP_005427072
MER0352377 Gorilla gorilla 448 22-448 D263, D366 GENBANK:XP_004028546
MER0653372 Haliaeetus albicilla 458 23-458 D269, D376 UNIPROT:A0A091PKF4
MER0653372 Haliaeetus albicilla 458 23-458 D269, D376 UNIPROT:A0A091PKF4
MER0652151 Haliaeetus leucocephalus 458 23-458 D269, D376 GENBANK:XP_010576043
MER0198490 Heterocephalus glaber 450 26-450 D265, D368 UNIPROT:G5AM44
MER0198490 Heterocephalus glaber 450 26-450 D265, D368 UNIPROT:G5AM44
MER0005223 Homo sapiens 448 22-448 D263, D366 GENBANK:EAW69799
MER0005223 Homo sapiens 448 22-448 D263, D366 GENBANK:EAW69799
MER0005223 Homo sapiens 448 22-448 D263, D366 GENBANK:EAW69799
MER0612008 Ictidomys tridecemlineatus 448 22-448 D263, D366 UNIPROT:I3N481
MER0612008 Ictidomys tridecemlineatus 448 22-448 D263, D366 UNIPROT:I3N481
MER0548089 Jaculus jaculus 448 22-448 D263, D366 GENBANK:XP_004653316
MER0554527 Lepisosteus oculatus 406 73-406 D260, D324 GENBANK:XP_006638781
MER0694460 Lepisosteus oculatus 447 76-446 D261, D365 GENBANK:-
MER0553382 Leptonychotes weddellii 357 29-357 D172, D275 GENBANK:XP_006751431
MER0420488 Leptosomus discolor 422 84-422 D269, D376 UNIPROT:A0A091P717
MER0420488 Leptosomus discolor 422 84-422 D269, D376 UNIPROT:A0A091P717
MER0453699 Loxodonta africana 448 84-447 D263, D366 UNIPROT:G3T011
MER0198359 Macaca fascicularis 481 57-481 D296, D399 UNIPROT:G7P3N8
MER0198359 Macaca fascicularis 481 57-481 D296, D399 UNIPROT:G7P3N8
MER0647260 Manacus vitellinus 457 23-457 D269, D375 GENBANK:XP_008933051
MER0645088 Mandrillus leucophaeus 481 55-481 D296, D399 GENBANK:XP_011831375
MER0543179 Maylandia zebra 429 75-429 D258, D348 GENBANK:XP_004576312
MER0198580 Meleagris gallopavo 456 39-456 D269, D374 UNIPROT:G1N2Q5
MER0198580 Meleagris gallopavo 456 39-456 D269, D374 UNIPROT:G1N2Q5
MER0541145 Melopsittacus undulatus 458 23-458 D269, D376 GENBANK:XP_005151916
MER0644486 Merops nubicus 458 23-458 D269, D376 UNIPROT:A0A091QQM7
MER0644486 Merops nubicus 458 23-458 D269, D376 UNIPROT:A0A091QQM7
MER0643855 Mesitornis unicolor 456 23-456 D267, D374 UNIPROT:A0A091RSJ8
MER0643855 Mesitornis unicolor 456 23-456 D267, D374 UNIPROT:A0A091RSJ8
MER0544430 Mesocricetus auratus 448 22-448 D263, D366 GENBANK:XP_005078198
MER0005230 Microcebus murinus 445 22-445 D263, D366 UNIPROT:P79801
MER0005230 Microcebus murinus 445 22-445 D263, D366 UNIPROT:P79801
MER0005230 Microcebus murinus 445 22-445 D263, D366 UNIPROT:P79801
MER0537815 Microtus ochrogaster 448 22-448 D263, D366 GENBANK:XP_005349026
MER0694513 Micrurus fulvius 461 84-460 D269, D379 UNIPROT:U3ERM3
MER0694513 Micrurus fulvius 461 84-460 D269, D379 UNIPROT:U3ERM3
MER0512824 Monodelphis domestica 456 81-455 D267, D374 UNIPROT:F7EIE5
MER0005224 Mus musculus 448 22-448 D263, D366 UNIPROT:Q61144
MER0005224 Mus musculus 448 22-448 D263, D366 UNIPROT:Q61144
MER0005224 Mus musculus 448 22-448 D263, D366 UNIPROT:Q61144
MER0198367 Mustela putorius 456 33-456 D272, D375 UNIPROT:G9KIX1
MER0198367 Mustela putorius 456 33-456 D272, D375 UNIPROT:G9KIX1
MER0571241 Myotis brandtii 484 58-484 D299, D402 GENBANK:XP_005880200
MER0245814 Myotis davidii 498 22-498 D263, D366 GENBANK:XP_006756110
MER0641773 Nannospalax galili 411 22-411 D226, D329 GENBANK:XP_008820587
MER0641775 Nannospalax galili 448 22-448 D263, D366 GENBANK:XP_008820583
MER0201179 Nematostella vectensis 151 1-99 missing, D74 GENBANK:XP_001625236
MER0632064 Neovison vison 329 1-328 D144, D247 UNIPROT:U6DA99
MER0632064 Neovison vison 329 1-328 D144, D247 UNIPROT:U6DA99
MER0638720 Nestor notabilis 458 23-458 D269, D376 UNIPROT:A0A091RY44
MER0638720 Nestor notabilis 458 23-458 D269, D376 UNIPROT:A0A091RY44
MER0636695 Nipponia nippon 458 23-458 D269, D376 UNIPROT:A0A091WVW2
MER0636695 Nipponia nippon 458 23-458 D269, D376 UNIPROT:A0A091WVW2
MER0534024 Ochotona princeps 448 22-448 D263, D366 GENBANK:XP_004578536
MER0533355 Octodon degus 448 22-448 D263, D366 GENBANK:XP_004626897
MER0530615 Odobenus rosmarus 464 22-464 D279, D382 GENBANK:XP_004393608
MER0496196 Ophiophagus hannah 435 84-434 D241, D353 UNIPROT:V8P4S9
MER0496196 Ophiophagus hannah 435 84-434 D241, D353 UNIPROT:V8P4S9
MER0694351 Opisthocomus hoazin 458 84-457 D269, D376 UNIPROT:A0A091WB94
MER0694351 Opisthocomus hoazin 458 84-457 D269, D376 UNIPROT:A0A091WB94
MER0529441 Orcinus orca 448 22-448 D263, D366 GENBANK:XP_004271021
MER0597960 Oreochromis niloticus 430 74-430 D259, D349 UNIPROT:I3JIE1
MER0597960 Oreochromis niloticus 430 74-430 D259, D349 UNIPROT:I3JIE1
MER0098099 Ornithorhynchus anatinus 461 22-461 D268, D379 GENBANK:XP_007670588
MER0527737 Orycteropus afer 448 22-448 D263, D366 GENBANK:XP_007935173
MER0198380 Oryctolagus cuniculus 448 24-448 D263, D366 GENBANK:XP_002717668
MER0111354 Oryzias latipes 421 67-421 D252, D340 GENBANK:XP_004085405
MER0321057 Otolemur garnettii 483 59-483 D298, D401 GENBANK:XP_003798871
MER0245727 Ovis aries 445 76-445 D260, D363 GENBANK:XP_004013686
MER0325279 Pan paniscus 448 22-451 D263, F369 GENBANK:XP_003814978
MER0053308 Pan troglodytes 481 57-481 D296, D399 GENBANK:XP_003949755
MER0519131 Panthera tigris 445 22-399 D280, D383 GENBANK:XP_007077018
MER0517795 Pantholops hodgsonii 449 22-449 D264, D367 GENBANK:XP_005965192
MER0525346 Papio anubis 448 22-448 D263, D366 UNIPROT:A0A096MR14
MER0525346 Papio anubis 448 22-448 D263, D366 UNIPROT:A0A096MR14
MER0633120 Pelecanus crispus 457 23-457 D269, D375 GENBANK:XP_009482728
MER0693253 Petromyzon marinus 441 61-440 D246, D359 UNIPROT:S4RRQ1
MER0632105 Phaethon lepturus 457 23-457 D269, D375 GENBANK:XP_010290080
MER0631714 Phalacrocorax carbo 458 23-458 D269, D376 UNIPROT:A0A093SZB7
MER0631714 Phalacrocorax carbo 458 23-458 D269, D376 UNIPROT:A0A093SZB7
MER0520903 Physeter catodon 448 22-448 D263, D366 GENBANK:XP_007102735
MER0693808 Picoides pubescens 459 84-458 D271, D377 UNIPROT:A0A093GI05
MER0693808 Picoides pubescens 459 84-458 D271, D377 UNIPROT:A0A093GI05
MER0694149 Podiceps cristatus 458 84-457 D269, D376 UNIPROT:A0A094NEF6
MER0694149 Podiceps cristatus 458 84-457 D269, D376 UNIPROT:A0A094NEF6
MER0523320 Poecilia formosa 424 68-424 D251, D343 GENBANK:XP_007541480
MER0514854 Poecilia reticulata 427 71-427 D254, D346 GENBANK:XP_008419395
MER0170589 Pongo abelii 448 22-448 D263, D366 UNIPROT:Q5RCN9
MER0170589 Pongo abelii 448 22-448 D263, D366 UNIPROT:Q5RCN9
MER0091808 Pongo pygmaeus 448 22-448 D263, D366 UNIPROT:Q5RCN9
MER0091808 Pongo pygmaeus 448 22-448 D263, D366 UNIPROT:Q5RCN9
MER0091808 Pongo pygmaeus 448 22-448 D263, D366 UNIPROT:Q5RCN9
MER0590479 Pterocles gutturalis 457 23-457 D269, D375 GENBANK:XP_010074607
MER0246404 Pteropus alecto 423 24-322 D252, missing UNIPROT:L5KIN7
MER0246404 Pteropus alecto 423 24-322 D252, missing UNIPROT:L5KIN7
MER0598068 Pteropus vampyrus 417 30-417 D243, D346 GENBANK:XP_011359178
MER0694366 Pygoscelis adeliae 458 84-457 D269, D376 UNIPROT:A0A093NPJ7
MER0694366 Pygoscelis adeliae 458 84-457 D269, D376 UNIPROT:A0A093NPJ7
MER0439444 Python bivittatus 464 23-464 D270, D382 GENBANK:XP_007431590
MER0005228 Rattus norvegicus 448 22-448 D263, D366 UNIPROT:O88777
MER0005228 Rattus norvegicus 448 22-448 D263, D366 UNIPROT:O88777
MER0005228 Rattus norvegicus 448 22-448 D263, D366 UNIPROT:O88777
MER0556260 Rhinopithecus roxellana 448 22-448 D263, D366 GENBANK:XP_010380221
MER0245677 Saimiri boliviensis 448 24-448 D263, D366 GENBANK:XP_003930338
MER0144016 Salmo salar 447 20-447 D261, D366 UNIPROT:B5X1U6
MER0144016 Salmo salar 447 20-447 D261, D366 UNIPROT:B5X1U6
MER0321058 Sarcophilus harrisii 456 84-456 D267, D374 UNIPROT:G3W889
MER0321058 Sarcophilus harrisii 456 84-456 D267, D374 UNIPROT:G3W889
MER0541111 Serinus canaria 457 23-457 D269, D375 GENBANK:XP_009094399
MER0597412 Sorex araneus 448 22-448 D263, D366 GENBANK:XP_004605486
MER0471655 Stegastes partitus 430 71-430 D259, D349 GENBANK:XP_008297106
MER0200038 Stenella coeruleoalba 102 1-90 D41, missing UNIPROT:Q56JJ9
MER0200038 Stenella coeruleoalba 102 1-90 D41, missing UNIPROT:Q56JJ9
MER0693064 Struthio camelus 458 84-457 D269, D376 UNIPROT:A0A093H409
MER0693064 Struthio camelus 458 84-457 D269, D376 UNIPROT:A0A093H409
MER0091783 Sus scrofa 448 22-448 D263, D366 GENBANK:ABI15722
MER0091783 Sus scrofa 448 22-448 D263, D366 GENBANK:ABI15722
MER0091783 Sus scrofa 448 22-448 D263, D366 GENBANK:ABI15722
MER0091783 Sus scrofa 448 22-448 D263, D366 GENBANK:ABI15722
MER0178622 Taeniopygia guttata 458 23-445 D269, D376 UNIPROT:H0Z1M3
MER0178622 Taeniopygia guttata 458 23-445 D269, D376 UNIPROT:H0Z1M3
MER0427340 Takifugu rubripes 422 24-421 D211, D341 UNIPROT:H2TY46
MER0647777 Takifugu rubripes 423 24-422 D211, D342 UNIPROT:H2TY45
MER0694446 Takifugu rubripes 406 4-405 D191, D325 UNIPROT:H2TY44
MER0694455 Takifugu rubripes 436 69-435 D256, D355 UNIPROT:H2TY49
MER0596134 Tarsius syrichta 447 22-447 D262, D365 GENBANK:XP_008067531
MER0369664 Tauraco erythrolophus 456 23-456 D269, D374 GENBANK:XP_009984022
MER0694515 Tetraodon nigroviridis 416 18-415 D203, D335, GENBANK:-
MER0471289 Tinamus guttatus 458 23-458 D269, D376 UNIPROT:A0A099ZAU8
MER0471289 Tinamus guttatus 458 23-458 D269, D376 UNIPROT:A0A099ZAU8
MER0483269 Trichechus manatus 448 22-448 D263, D366 GENBANK:XP_004375933
MER0598627 Tupaia chinensis 447 22-447 D263, D365 GENBANK:XP_006157310
MER0455776 Tyto alba 459 24-459 D270, D377 GENBANK:XP_009971872
MER0294654 Ursus maritimus 465 22-465 D280, D383 GENBANK:XP_008693362
MER0616922 Vicugna pacos 448 22-448 D263, D366 GENBANK:XP_006198885
MER0005229 Xenopus laevis 449 20-449 D266, D367 PIR:JC5391
MER0005229 Xenopus laevis 449 20-449 D266, D367 PIR:JC5391
MER0084683 Xenopus tropicalis 451 23-451 D268, D369 UNIPROT:F7C949
MER0457231 Xiphophorus maculatus 424 68-424 D251, D343 UNIPROT:M4A5W4
MER0457231 Xiphophorus maculatus 424 68-424 D251, D343 UNIPROT:M4A5W4
MER0445879 Zonotrichia albicollis 457 23-457 D269, D375 GENBANK:XP_005488531