$VAR1 = undef;
Summary for peptidase C02.004: calpain-3
Names | |
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MEROPS Name | calpain-3 |
Other names | calpain LP74 (Rattus norvegicus), calpain-3 form Lp82, calpain-3 form Lp85, calpain p94, CANP3 g.p., CAPN3 g.p. (Homo sapiens), lens-specific calpain, Lp82, Lp85, muscle calpain, nCL-1, calpain Rt88 (Rattus norvegicus) |
Domain architecture |
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MEROPS Classification | |
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Classification | Clan CA >> Subclan (none) >> Family C2 >> Subfamily A >> C02.004 |
Holotype | calpain-3 (Homo sapiens), Uniprot accession P20807 (peptidase unit: 99-400), MERNUM MER0001446 |
History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
Activity | |||
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Catalytic type | Cysteine | ||
Peplist | Included in the Peplist with identifier PL00079 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.54 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (4 cleavages) | ||
Activity status | human: active (Guyon et al., 2003) mouse: active (Azuma et al., 2003) | ||
Knockout | In humans, naturally-occurring mutations in the gene encoding C02.004 cause limb girdle muscular dystrophy type 2A (LGMD2A) (Sorimachi et al., 1995). Transgenic mice in which the active site Cys129 was replaced by Ser showed muscular abnormalities (Tagawa et al., 2000; Kramerova et al., 2004). | ||
Pharmaceutical relevance | Possible target for gene therapy. | ||
Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Calpain-3 | |
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | -/-/l/--/-/-/- (based on 19 cleavages) |
Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Human genetics | ||||||
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Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
CAPN3 | 15q15.1 | ENSG00000092529 | 825 | CAPN3 | 114240 | |
Mouse genetics | ||||||
Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
Capn3 | 2:F1 | ENSMUSG00000027289 | 12335 | MGI:107437 |