$VAR1 = undef;
Summary for peptidase S01.191: complement factor D
| Names | |
|---|---|
| MEROPS Name | complement factor D |
| Other names | adipsin, C3 proactivator convertase, PoDAK peptidase (Paralichthys olivaceus) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.191 |
| Holotype | complement factor D (Homo sapiens), Uniprot accession P00746 (peptidase unit: 26-253), MERNUM MER0000130 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00299 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.46 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Activity status | human: active (Volanakis, 2004) mouse: active (Xu et al., 2001) | ||
| Physiology | Hydrolyses factor B in suitable complexes, leading to complement factor C3 cleavage. | ||
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Complement_factor_D | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| CFD | 19 | ENSG00000177649 | 1675 | DF | 134350 | |
| Mouse genetics | ||||||
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| Adn | 10:C1 | ENSMUSG00000020125 | 11537 | MGI:87931 | ||
