Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.046: falcipain-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Hernandez Gonzalez,J.E., Salas-Sarduy,E., Alvarez,L.H., Valiente,P.A., Arni,R.K. and Pascutti,P.G. \<br\>Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?\<br\>Curr Med Chem (2023) PubMed  Europe PubMed DOI
  2. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N. \<br\>Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials\<br\>Eur J Med Chem (2023) 252, 115299. PubMed  Europe PubMed DOI
    3. 2022
  3. Chakraborty,S., Alam,B. and Biswas,S. \<br\>New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain\<br\>Biochem Biophys Res Commun (2022) 590, 145-151. PubMed  Europe PubMed DOI
  4. Hernandez Gonzalez,J.E., Alberca,L.N., Masforrol Gonzalez,Y., Reyes Acosta,O., Talevi,A. and Salas-Sarduy,E. \<br\>Tetracycline Derivatives Inhibit Plasmodial Cysteine Protease Falcipain-2 through Binding to a Distal Allosteric Site\<br\>J Chem Inf Model (2022) 62, 159-175. PubMed  Europe PubMed DOI
    5. 2021
  5. Aratikatla,E.K., Kalamuddin,M., Rana,K.C., Datta,G., Asad,M., Sundararaman,S., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K. \<br\>Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials\<br\>Eur J Med Chem (2021) 220, 113454. PubMed  Europe PubMed DOI
    6. 2020
  6. Aratikatla,E.K., Kalamuddin,M., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K. \<br\>Enantioselective Synthesis of gamma-Phenyl-gamma-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials\<br\>ACS Omega (2020) 5, 29025-29037. PubMed  Europe PubMed DOI  PMC  EPMC  I
  7. Ettari,R., Previti,S., Di Chio,C. and Zappala,M. \<br\>Falcipain-2 and falcipain-3 inhibitors as promising antimalarial agents\<br\>Curr Med Chem (2020) PubMed  Europe PubMed DOI  V
  8. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Leite,V.B.P. and Pascutti,P.G. \<br\>Water Bridges Play a Key Role in Affinity and Selectivity for Malarial Protease Falcipain-2\<br\>J Chem Inf Model (2020) PubMed  Europe PubMed DOI  T
  9. Kumar,A., Kumar,D., Kumar,R., Singh,P., Chandra,R. and Kumari,K. \<br\>DFT and docking studies of designed conjugates of noscapines & repurposing drugs: promising inhibitors of main protease of SARS-CoV-2 and falcipan-2\<br\>J Biomol Struct Dyn (2020) 1-21. PubMed  Europe PubMed DOI
  10. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S., Pandey,K.C. and Singh,S. \<br\>Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial\<br\>J Biomol Struct Dyn (2020) 1-13. PubMed  Europe PubMed DOI
  11. Rajguru,T., Bora,D. and Modi,M.K. \<br\>Combined CADD and Virtual Screening to Identify Novel Nonpeptidic Falcipain-2 Inhibitors\<br\>Curr Comput Aided Drug Des (2020) PubMed  Europe PubMed DOI
  12. Rosenthal,P.J. \<br\>Falcipain cysteine proteases of malaria parasites: an update\<br\>Biochim Biophys Acta Proteins Proteom (2020) 1868, 140362. PubMed  Europe PubMed DOI
  13. Singh,A., Kalamuddin,M., Maqbool,M., Mohmmed,A., Malhotra,P. and Hoda,N. \<br\>Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies\<br\>Bioorg Chem (2020) 104514. PubMed  Europe PubMed DOI  I
  14. Singh,V., Hada,R.S., Uddin,A., Aneja,B., Abid,M., Pandey,K.C. and Singh,S. \<br\>Inhibition of hemoglobin degrading protease falcipain-2 as a mechanism for anti-malarial activity of triazole-amino acid hybrids\<br\>Curr Top Med Chem (2020) 20, 377-389. PubMed  Europe PubMed DOI  I
  15. Uddin,A., Singh,V., Irfan,I., Mohammad,T., Singh Hada,R., Imtaiyaz Hassan,M., Abid,M. and Singh,S. \<br\>Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease\<br\>Bioorg Chem (2020) 103, 104142. PubMed  Europe PubMed DOI
  16. Zhu,L., Shan,L., Zhu,J., Li,L., Li,S., Wang,L., Wang,J., Zhang,S., Zhou,H., Zhang,W. and Li,H. \<br\>Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2\<br\>Sci China Life Sci (2020) PubMed  Europe PubMed DOI
    17. 2019
  17. Alam,B. and Biswas,S. \<br\>Inhibition of Plasmodium falciparum cysteine protease falcipain-2 by a human cross-class inhibitor serpinB3: a mechanistic insight\<br\>Biochim Biophys Acta Proteins Proteom (2019) 1867, 854-865. PubMed  Europe PubMed DOI
  18. Alberca,L.N., Chuguransky,S.R., Alvarez,C.L., Talevi,A. and Salas-Sarduy,E. \<br\>In silico guided drug repurposing: discovery of new competitive and non-competitive inhibitors of falcipain-2\<br\>Front Chem (2019) 7, 534. PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Allangba,K.N.P.G., Keita,M., Kre N'Guessan,R., Megnassan,E., Frecer,V. and Miertus,S. \<br\>Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone-chalcone and isatin-chalcone inhibitors probing the S2 active site pocket\<br\>J Enzyme Inhib Med Chem (2019) 34, 547-561. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A. \<br\>Can cysteine protease cross-class inhibitors achieve selectivity?\<br\>J Med Chem (2019) 62, 10497-10525. PubMed  Europe PubMed DOI  I
  21. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Leite,V.B.P. \<br\>Prediction of noncompetitive inhibitor binding mode reveals promising site for allosteric modulation of falcipain-2\<br\>J Phys Chem B (2019) 123, 7327-7342. PubMed  Europe PubMed DOI  I
  22. Machin,J.M., Kantsadi,A.L. and Vakonakis,I. \<br\>The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site\<br\>Malar J (2019) 18, 388. PubMed  Europe PubMed DOI  I
  23. Musyoka,T.M., Njuguna,J.N. and Tastan Bishop,O. \<br\>Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design\<br\>Malar J (2019) 18, 159. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Pasupureddy,R., Verma,S., Pant,A., Sharma,R., Seshadri,S., Pande,V., Saxena,A.K., Dixit,R. and Pandey,K.C. \<br\>Crucial residues in falcipains that mediate hemoglobin hydrolysis\<br\>Exp Parasitol (2019) 197, 43-50. PubMed  Europe PubMed DOI
  25. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N. \<br\>Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity\<br\>Bioorg Med Chem (2019) 115155. PubMed  Europe PubMed DOI  I
  26. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J. \<br\>Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials\<br\>J Med Chem (2019) 62, 5562-5578. PubMed  Europe PubMed DOI  I
    27. 2018
  27. Aggarwal,S., Paliwal,D., Kaushik,D., Gupta,G.K. and Kumar,A. \<br\>Pyrazole Schiff base hybrids as anti-malarial agents: synthesis, in vitro screening and computational study\<br\>Comb Chem High Throughput Screen (2018) 21, 194-203. PubMed  Europe PubMed DOI  I
  28. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E. \<br\>Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery\<br\>Curr Drug Targets (2018) 19, 501-526. PubMed  Europe PubMed DOI  I
  29. Hernandez-Gonzalez,J.E., Salas-Sarduy,E., Hernandez Ramirez,L.F., Pascual,M.J., Alvarez,D.E., Pabon,A., Leite,V.B.P., Pascutti,P.G. and Valiente,P.A. \<br\>Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures\<br\>Biochim Biophys Acta Gen Subj (2018) 1862, 2911-2923. PubMed  Europe PubMed DOI  I
  30. Himangini, Pathak,D.P., Sharma,V. and Kumar,S. \<br\>Designing novel inhibitors against falcipain-2 of Plasmodium falciparum\<br\>Bioorg Med Chem Lett (2018) 28, 1566-1569. PubMed  Europe PubMed DOI  I
  31. Nizi,E., Sferrazza,A., Fabbrini,D., Nardi,V., Andreini,M., Graziani,R., Gennari,N., Bresciani,A., Paonessa,G. and Harper,S. \<br\>Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins\<br\>Bioorg Med Chem Lett (2018) 28, 1540-1544. PubMed  Europe PubMed DOI  I
  32. Pant,A., Kumar,R., Wani,N.A., Verma,S., Sharma,R., Pande,V., Saxena,A.K., Dixit,R., Rai,R. and Pandey,K.C. \<br\>Allosteric site inhibitor disrupting auto-processing of malarial cysteine proteases\<br\>Sci Rep (2018) 8, 16193. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V. \<br\>Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates\<br\>Bioorg Med Chem (2018) 26, 4624-4634. PubMed  Europe PubMed DOI  I
  34. Salawu,E.O. \<br\>In silico study reveals how E64 approaches, binds to, and inhibits falcipain-2 of Plasmodium falciparum that causes malaria in humans\<br\>Sci Rep (2018) 8, 16380. PubMed  Europe PubMed DOI  PMC  EPMC  I
  35. Siddiqui,F.A., Cabrera,M., Wang,M., Brashear,A., Kemirembe,K., Wang,Z., Miao,J., Chookajorn,T., Yang,Z., Cao,Y., Dong,G., Rosenthal,P.J. and Cui,L. \<br\>Plasmodium falciparum falcipain-2a polymorphisms in southeast Asia and their association with artemisinin resistance\<br\>J Infect Dis (2018) 218, 434-442. PubMed  Europe PubMed DOI
    36. 2017
  36. Chen,W., Huang,Z., Wang,W., Mao,F., Guan,L., Tang,Y., Jiang,H., Li,J., Huang,J., Jiang,L. and Zhu,J. \<br\>Discovery of new antimalarial agents: second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely\<br\>Bioorg Med Chem (2017) 25, 6467-6478. PubMed  Europe PubMed DOI  I
  37. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Valiente,P.A. \<br\>Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships\<br\>Proteins (2017) 85, 1666-1683. PubMed  Europe PubMed DOI  I
  38. Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M. \<br\>Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs)\<br\>J Med Chem (2017) 60, 6911-6923. PubMed  Europe PubMed DOI  I
  39. Rudrapal,M., Chetia,D. and Singh,V. \<br\>Novel series of 1,2,4-trioxane derivatives as antimalarial agents\<br\>J Enzyme Inhib Med Chem (2017) 32, 1159-1173. PubMed  Europe PubMed DOI  I
    40. 2016
  40. Bertoldo,J.B. and Terenzi,H. \<br\>Oxidation and tyrosine nitration induce structural changes and inhibits Plasmodium falciparum falcipain-2 activity in vitro\<br\>Protein Pept Lett (2016) 23, 562-572. PubMed  Europe PubMed
  41. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O. \<br\>Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs\<br\>Sci Rep (2016) 6, 23690. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O. \<br\>Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow\<br\>J Biomol Struct Dyn (2016) 34, 2084-2101. PubMed  Europe PubMed DOI  I
  43. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T. \<br\>Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites\<br\>Malar J (2016) 15, 51. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Poongavanam,V. and Kongsted,J. \<br\>Binding affinity models for falcipain inhibition based on the linear interaction energy method\<br\>J Mol Graph Model (2016) 70, 236-245. PubMed  Europe PubMed DOI  I
  45. Schmidt,I., Pradel,G., Sologub,L., Golzmann,A., Ngwa,C.J., Kucharski,A., Schirmeister,T. and Holzgrabe,U. \<br\>Bistacrine derivatives as new potent antimalarials\<br\>Bioorg Med Chem (2016) 24, 3636-3642. PubMed  Europe PubMed DOI  I
  46. Thillainayagam,M., Anbarasu,A. and Ramaiah,S. \<br\>Comparative molecular field analysis and molecular docking studies on novel aryl chalcone derivatives against an important drug target cysteine protease in Plasmodium falciparum\<br\>J Theor Biol (2016) 403, 110-128. PubMed  Europe PubMed DOI  I
    47. 2015
  47. Bertoldo,J.B., Chiaradia-Delatorre,L.D., Mascarello,A., Leal,P.C., Cordeiro,M.N., Nunes,R.J., Sarduy,E.S., Rosenthal,P.J. and Terenzi,H. \<br\>Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum\<br\>J Enzyme Inhib Med Chem (2015) 30, 299-307. PubMed  Europe PubMed DOI  I
  48. Chakka,S.K., Kalamuddin,M., Sundararaman,S., Wei,L., Mundra,S., Mahesh,R., Malhotra,P., Mohmmed,A. and Kotra,L.P. \<br\>Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents\<br\>Bioorg Med Chem (2015) 23, 2221-2240. PubMed  Europe PubMed DOI  I
  49. Marques,A.F., Gomes,P.S., Oliveira,P.L., Rosenthal,P.J., Pascutti,P.G. and Lima,L.M. \<br\>Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme\<br\>Arch Biochem Biophys (2015) 573, 92-99. PubMed  Europe PubMed DOI
  50. Omotuyi,I.O. and Hamada,T. \<br\>Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-beta-bound state\<br\>J Biomol Struct Dyn (2015) 33, 1027-1036. PubMed  Europe PubMed DOI
  51. Sharma,R.K., Younis,Y., Mugumbate,G., Njoroge,M., Gut,J., Rosenthal,P.J. and Chibale,K. \<br\>Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2\<br\>Eur J Med Chem (2015) 90C, 507-518. PubMed  Europe PubMed DOI  I
  52. Singh,A.K., Rajendran,V., Pant,A., Ghosh,P.C., Singh,N., Latha,N., Garg,S., Pandey,K.C., Singh,B.K. and Rathi,B. \<br\>Design, synthesis and biological evaluation of functionalized phthalimides: a new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite\<br\>Bioorg Med Chem (2015) 23, 1817-1827. PubMed  Europe PubMed DOI  I
    53. 2014
  53. Arafet,K., Ferrer,S., Marti,S. and Moliner,V. \<br\>Quantum mechanics/molecular mechanics studies of the mechanism of falcipain-2 inhibition by the epoxysuccinate E64\<br\>Biochemistry (2014) 53, 3336-3346. PubMed  Europe PubMed DOI  I
  54. Conrad,M.D., Bigira,V., Kapisi,J., Muhindo,M., Kamya,M.R., Havlir,D.V., Dorsey,G. and Rosenthal,P.J. \<br\>Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children\<br\>PLoS ONE (2014) 9, e105690. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J. \<br\>Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials\<br\>J Med Chem (2014) 57, 10557-10563. PubMed  Europe PubMed DOI  I
  56. Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P. \<br\>Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents\<br\>ChemMedChem (2014) 9, 1817-1825. PubMed  Europe PubMed DOI  I
  57. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J. \<br\>Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II\<br\>Fitoterapia (2014) 94, 55-61. PubMed  Europe PubMed DOI  I
  58. Omotuyi,O.I. \<br\>Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site\<br\>J Mol Model (2014) 20, 2386. PubMed  Europe PubMed DOI  I
  59. Wang,L., Zhang,S., Zhu,J., Zhu,L., Liu,X., Shan,L., Huang,J., Zhang,W. and Li,H. \<br\>Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening\<br\>Bioorg Med Chem Lett (2014) 24, 1261-1264. PubMed  Europe PubMed DOI  I
  60. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A. \<br\>Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum\<br\>Bioorg Med Chem Lett (2014) 24, 1274-1279. PubMed  Europe PubMed DOI  I
    61. 2013
  61. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P. \<br\>Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum\<br\>Proc Natl Acad Sci U S A (2013) 110, 5392-5397. PubMed  Europe PubMed DOI
  62. Cotrin,S.S., Gouvea,I.E., Melo,P.M., Bagnaresi,P., Assis,D.M., Araujo,M.S., Juliano,M.A., Gazarini,M.L., Rosenthal,P.J., Juliano,L. and Carmona,A.K. \<br\>Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity\<br\>Mol Biochem Parasitol (2013) 187, 111-116. PubMed  Europe PubMed DOI  P
  63. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R. \<br\>Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review\<br\>Expert Opin Ther Pat (2013) 23, 165-187. PubMed  Europe PubMed DOI  V  I
  64. Marques,A.F., Esser,D., Rosenthal,P.J., Kassack,M.U. and Lima,L.M. \<br\>Falcipain-2 inhibition by suramin and suramin analogues\<br\>Bioorg Med Chem (2013) 21, 3667-3673. PubMed  Europe PubMed DOI  I
  65. Mugumbate,G., Newton,A.S., Rosenthal,P.J., Gut,J., Moreira,R., Chibale,K. and Guedes,R.C. \<br\>Novel anti-Plasmodial hits identified by virtual screening of the ZINC database\<br\>J Comput Aided Mol Des (2013) 27, 859-871. PubMed  Europe PubMed DOI  I
  66. Somanadhan,B., Kotturi,S.R., Yan Leong,C., Glover,R.P., Huang,Y., Flotow,H., Buss,A.D., Lear,M.J. and Butler,M.S. \<br\>Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2\<br\>J Antibiot (Tokyo) (2013) 66, 259-264. PubMed  Europe PubMed DOI  I
  67. Tadigoppula,N., Korthikunta,V., Gupta,S., Kancharla,P., Khaliq,T., Soni,A., Srivastava,R.K., Srivastava,K., Puri,S.K., Raju,K.S., Wahajuddin, Sijwali,P.S., Kumar,V. and Mohammad,I.S. \<br\>Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents\<br\>J Med Chem (2013) 56, 31-45. PubMed  Europe PubMed DOI  I
  68. Wang,J., Li,Y., Yang,Y., Zhang,S. and Yang,L. \<br\>Profiling the structural determinants of heteroarylnitrile scaffold-based derivatives as falcipain-2 inhibitors by in silico methods\<br\>Curr Med Chem (2013) 20, 2032-2042. PubMed  Europe PubMed  I
    69. 2012
  69. Bagnaresi,P., de Barros,N.M., Assis,D.M., Melo,P.M., Fonseca,R.G., Juliano,M.A., Pesquero,J.B., Juliano,L., Rosenthal,P.J., Carmona,A.K. and Gazarini,M.L. \<br\>Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins\<br\>Malar J (2012) 11, 156. PubMed  Europe PubMed DOI
  70. Ettari,R., Micale,N., Grazioso,G., Bova,F., Schirmeister,T., Grasso,S. and Zappala,M. \<br\>Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors\<br\>ChemMedChem (2012) 7, 1594-1600. PubMed  Europe PubMed DOI  I
  71. Grazioso,G., Legnani,L., Toma,L., Ettari,R., Micale,N. and De Micheli,C. \<br\>Mechanism of falcipain-2 inhibition by alpha,beta-unsaturated benzo[1,4]diazepin-2-one methyl ester\<br\>J Comput Aided Mol Des (2012) 26, 1035-1043. PubMed  Europe PubMed DOI  I
  72. Huang,H., Lu,W., Li,X., Cong,X., Ma,H., Liu,X., Zhang,Y., Che,P., Ma,R., Li,H., Shen,X., Jiang,H., Huang,J. and Zhu,J. \<br\>Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent\<br\>Bioorg Med Chem Lett (2012) 22, 958-962. PubMed  Europe PubMed DOI  I
  73. Liu,Y., Lu,W.Q., Cui,K.Q., Luo,W., Wang,J. and Guo,C. \<br\>Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors\<br\>Arch Pharm Res (2012) 35, 1525-1531. PubMed  Europe PubMed DOI  I
  74. Mane,U.R., Li,H., Huang,J., Gupta,R.C., Nadkarni,S.S., Giridhar,R., Naik,P.P. and Yadav,M.R. \<br\>Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors\<br\>Bioorg Med Chem (2012) 20, 6296-6304. PubMed  Europe PubMed DOI  I
  75. Marco,M. and Coteron,J.M. \<br\>Falcipain inhibition as a promising antimalarial target\<br\>Curr Top Med Chem (2012) 12, 408-444. PubMed  Europe PubMed DOI  I
  76. Pandey,K.C. and Dixit,R. \<br\>Structure-function of falcipains: malarial cysteine proteases\<br\>J Trop Med (2012) 2012, 345195. PubMed  Europe PubMed DOI  I
  77. Perez,B.C., Teixeira,C., Figueiras,M., Gut,J., Rosenthal,P.J., Gomes,J.R. and Gomes,P. \<br\>Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials\<br\>Eur J Med Chem (2012) 54, 887-899. PubMed  Europe PubMed DOI  I
  78. Prasad,R., Atul, Soni,A., Puri,S.K. and Sijwali,P.S. \<br\>Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasite\<br\>PLoS ONE (2012) 7, e51619. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Sarduy,E.S., Munoz,A.C., Trejo,S.A. and Chavez Planes,M.D. \<br\>High-level expression of falcipain-2 in Escherichia coli by codon optimization and auto-induction\<br\>Protein Expr Purif (2012) 83, 59-69. PubMed  Europe PubMed DOI  E
  80. Shah,F., Gut,J., Legac,J., Shivakumar,D., Sherman,W., Rosenthal,P.J. and Avery,M.A. \<br\>Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis\<br\>J Chem Inf Model (2012) 52, 696-710. PubMed  Europe PubMed DOI  I
  81. Stolze,S.C., Deu,E., Kaschani,F., Li,N., Florea,B.I., Richau,K.H., Colby,T., Van Der Hoorn,R.A., Overkleeft,H.S., Bogyo,M. and Kaiser,M. \<br\>The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains\<br\>Chem Biol (2012) 19, 1546-1555. PubMed  Europe PubMed DOI  I
  82. Sundararaj,S., Singh,D., Saxena,A.K., Vashisht,K., Sijwali,P.S., Dixit,R. and Pandey,K.C. \<br\>The ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparum\<br\>PLoS ONE (2012) 7, e47227. PubMed  Europe PubMed DOI  PMC  EPMC
    83. 2011
  83. Ehmke,V., Heindl,C., Rottmann,M., Freymond,C., Schweizer,W.B., Brun,R., Stich,A., Schirmeister,T. and Diederich,F. \<br\>Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei\<br\>ChemMedChem (2011) 6, 273-278. PubMed  Europe PubMed DOI  I
  84. Ehmke,V., Kilchmann,F., Heindl,C., Cui,K., Huang,J., Schirmeister,T. and Diederich,F. \<br\>Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2\<br\>Medchemcomm (2011) 2, 800-804. DOI  I
  85. Ettari,R., Zappala,M., Micale,N., Grazioso,G., Giofre,S., Schirmeister,T. and Grasso,S. \<br\>Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors\<br\>Eur J Med Chem (2011) 46, 2058-2065. PubMed  Europe PubMed DOI  I
  86. Hansen,G., Heitmann,A., Witt,T., Li,H., Jiang,H., Shen,X., Heussler,V.T., Rennenberg,A. and Hilgenfeld,R. \<br\>Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium\<br\>Structure (2011) 19, 919-929. PubMed  Europe PubMed DOI  S
  87. Hansen,G., Schwarzloh,B., Rennenberg,A., Heussler,V.T. and Hilgenfeld,R. \<br\>The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis\<br\>Acta Crystallograph Sect F Struct Biol Cryst Commun (2011) 67, 1406-1410. PubMed  Europe PubMed DOI  PMC  EPMC
  88. Liu,Y., Cui,K., Lu,W., Luo,W., Wang,J., Huang,J. and Guo,C. \<br\>Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives\<br\>Molecules (2011) 16, 4527-4538. PubMed  Europe PubMed DOI  I
  89. Micale,N., Cinellu,M.A., Maiore,L., Sannella,A.R., Severini,C., Schirmeister,T., Gabbiani,C. and Messori,L. \<br\>Selected gold compounds cause pronounced inhibition of falcipain 2 and effectively block P. falciparum growth in vitro\<br\>J Inorg Biochem (2011) 105, 1576-1579. PubMed  Europe PubMed DOI  I
  90. Pandey,K.C. \<br\>Centenary celebrations article: Cysteine proteases of human malaria parasites\<br\>J Parasit Dis (2011) 35, 94-103. PubMed  Europe PubMed DOI
  91. Rizzi,L., Sundararaman,S., Cendic,K., Vaiana,N., Korde,R., Sinha,D., Mohmmed,A., Malhotra,P. and Romeo,S. \<br\>Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors\<br\>Eur J Med Chem (2011) 46, 2083-2090. PubMed  Europe PubMed DOI  I
  92. Rosenthal,P.J. \<br\>Falcipains and other cysteine proteases of malaria parasites\<br\>Adv Exp Med Biol (2011) 712, 30-48. PubMed  Europe PubMed DOI
  93. Shah,F., Mukherjee,P., Gut,J., Legac,J., Rosenthal,P.J., Tekwani,B.L. and Avery,M.A. \<br\>Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library\<br\>J Chem Inf Model (2011) 51, 852-864. PubMed  Europe PubMed DOI  I
  94. Teixeira,C., Gomes,J.R.B. and Gomes,P. \<br\>Falcipains, plasmodium falciparum cysteine proteases as key drug targets against malaria\<br\>Curr Med Chem (2011) 18, 1555-1572. PubMed  Europe PubMed DOI  T
  95. Teixeira,C., Gomes,J.R.B., Couesnon,T. and Gomes,P. \<br\>Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium falciparum cysteine proteases inhibitors\<br\>J Comput Aided Mol Des (2011) 25, 763-775. PubMed  Europe PubMed DOI  I
    96. 2010
  96. Bova,F., Ettari,R., Micale,N., Carnovale,C., Schirmeister,T., Gelhaus,C., Leippe,M., Grasso,S. and Zappala,M. \<br\>Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors\<br\>Bioorg Med Chem (2010) 18, 4928-4938. PubMed  Europe PubMed DOI  I
  97. Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T. \<br\>Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids\<br\>J Med Chem (2010) 53, 1951-1963. PubMed  Europe PubMed DOI  I
  98. Coteron,J.M., Catterick,D., Castro,J., Chaparro,M.J., Diaz,B., Fernandez,E., Ferrer,S., Gamo,F.J., Gordo,M., Gut,J., de Las Heras,L., Legac,J., Marco,M., Miguel,J., Munoz,V., Porras,E., de la Rosa,J.C., Ruiz,J.R., Sandoval,E., Ventosa,P., Rosenthal,P.J. and Fiandor,J.M. \<br\>Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series\<br\>J Med Chem (2010) 53, 6129-6152. PubMed  Europe PubMed DOI  I
  99. Ettari,R., Bova,F., Zappala,M., Grasso,S. and Micale,N. \<br\>Falcipain-2 inhibitors\<br\>Med Res Rev (2010) 30, 136-167. PubMed  Europe PubMed DOI  V  I
  100. Ettari,R., Zappala,M., Micale,N., Schirmeister,T., Gelhaus,C., Leippe,M., Evers,A. and Grasso,S. \<br\>Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain\<br\>Eur J Med Chem (2010) 45, 3228-3233. PubMed  Europe PubMed DOI  I
  101. Gibbons,P., Verissimo,E., Araujo,N.C., Barton,V., Nixon,G.L., Amewu,R.K., Chadwick,J., Stocks,P.A., Biagini,G.A., Srivastava,A., Rosenthal,P.J., Gut,J., Guedes,R.C., Moreira,R., Sharma,R., Berry,N., Cristiano,M.L., Shone,A.E., Ward,S.A. and O'Neill,P.M. \<br\>Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity\<br\>J Med Chem (2010) 53, 8202-8206. PubMed  Europe PubMed DOI  I
  102. Hans,R.H., Gut,J., Rosenthal,P.J. and Chibale,K. \<br\>Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids\<br\>Bioorg Med Chem Lett (2010) 20, 2234-2237. PubMed  Europe PubMed DOI  I
  103. Khanye,S.D., Smith,G.S., Lategan,C., Smith,P.J., Gut,J., Rosenthal,P.J. and Chibale,K. \<br\>Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity\<br\>J Inorg Biochem (2010) 104, 1079-1083. PubMed  Europe PubMed DOI  I
  104. Loser,R., Gut,J., Rosenthal,P.J., Frizler,M., Gutschow,M. and Andrews,K.T. \<br\>Antimalarial activity of azadipeptide nitriles\<br\>Bioorg Med Chem Lett (2010) 20, 252-255. PubMed  Europe PubMed DOI  I
  105. Waag,T., Gelhaus,C., Rath,J., Stich,A., Leippe,M. and Schirmeister,T. \<br\>Allicin and derivates are cysteine protease inhibitors with antiparasitic activity\<br\>Bioorg Med Chem Lett (2010) 20, 5541-5543. PubMed  Europe PubMed DOI  I
    106. 2009
  106. Dude,M.A., Kaeppler,U., Herb,M., Schiller,M., Schulz,F., Vedder,B., Heppner,S., Pradel,G., Gut,J., Rosenthal,P.J., Schirmeister,T., Leippe,M. and Gelhaus,C. \<br\>Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid\<br\>Molecules (2009) 14, 19-35. PubMed  Europe PubMed DOI  I
  107. Kerr,I.D., Lee,J.H., Pandey,K.C., Harrison,A., Sajid,M., Rosenthal,P.J. and Brinen,L.S. \<br\>Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity\<br\>J Med Chem (2009) 52, 852-857. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  108. Li,H., Huang,J., Chen,L., Liu,X., Chen,T., Zhu,J., Lu,W., Shen,X., Li,J., Hilgenfeld,R. and Jiang,H. \<br\>Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening\<br\>J Med Chem (2009) 52, 4936-4940. PubMed  Europe PubMed DOI
  109. Micale,N., Ettari,R., Schirmeister,T., Evers,A., Gelhaus,C., Leippe,M., Zappala,M. and Grasso,S. \<br\>Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors\<br\>Bioorg Med Chem (2009) 17, 6505-6511. PubMed  Europe PubMed DOI  I
  110. Pandey,K.C., Barkan,D.T., Sali,A. and Rosenthal,P.J. \<br\>Regulatory elements within the prodomain of falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum\<br\>PLoS ONE (2009) 4, e5694. PubMed  Europe PubMed DOI  PMC  EPMC
  111. Subramanian,S., Hardt,M., Choe,Y., Niles,R.K., Johansen,E.B., Legac,J., Gut,J., Kerr,I.D., Craik,C.S. and Rosenthal,P.J. \<br\>Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3\<br\>PLoS ONE (2009) 4, e5156. PubMed  Europe PubMed DOI  PMC  EPMC  P
  112. Zhu,J., Chen,T., Chen,L., Lu,W., Che,P., Huang,J., Li,H., Li,J. and Jiang,H. \<br\>2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies\<br\>Molecules (2009) 14, 494-508. PubMed  Europe PubMed DOI  I
  113. Zhu,J., Chen,T., Liu,J., Ma,R., Lu,W., Huang,J., Li,H., Li,J. and Jiang,H. \<br\>2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. Design, synthesis and biological evaluation\<br\>Molecules (2009) 14, 785-797. PubMed  Europe PubMed DOI  I
    114. 2008
  114. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E. \<br\>Plasmodium food vacuole plasmepsins are activated by falcipains\<br\>J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
  115. Ettari,R., Nizi,E., Di Francesco,M.E., Dude,M.A., Pradel,G., Vicik,R., Schirmeister,T., Micale,N., Grasso,S. and Zappala,M. \<br\>Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors\<br\>J Med Chem (2008) 51, 988-996. PubMed  Europe PubMed DOI  I
  116. Korde,R., Bhardwaj,A., Singh,R., Srivastava,A., Chauhan,V.S., Bhatnagar,R.K. and Malhotra,P. \<br\>A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development\<br\>J Med Chem (2008) 51, 3116-3123. PubMed  Europe PubMed DOI  I
  117. Verissimo,E., Berry,N., Gibbons,P., Cristiano,M.L., Rosenthal,P.J., Gut,J., Ward,S.A. and O'Neill,P.M. \<br\>Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors\<br\>Bioorg Med Chem Lett (2008) 18, 4210-4214. PubMed  Europe PubMed DOI  I
    118. 2007
  118. Armstrong,C.M. and Goldberg,D.E. \<br\>An FKBP destabilization domain modulates protein levels in Plasmodium falciparum\<br\>Nat Methods (2007) 4, 1007-1009. PubMed  Europe PubMed DOI
  119. Chipeleme,A., Gut,J., Rosenthal,P.J. and Chibale,K. \<br\>Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum\<br\>Bioorg Med Chem (2007) 15, 273-282. PubMed  Europe PubMed DOI  I
  120. Dasaradhi,P.V., Korde,R., Thompson,J.K., Tanwar,C., Nag,T.C., Chauhan,V.S., Cowman,A.F., Mohmmed,A. and Malhotra,P. \<br\>Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum\<br\>Mol Biochem Parasitol (2007) 156, 12-23. PubMed  Europe PubMed DOI
  121. Schulz,F., Gelhaus,C., Degel,B., Vicik,R., Heppner,S., Breuning,A., Leippe,M., Gut,J., Rosenthal,P.J. and Schirmeister,T. \<br\>Screening of protease inhibitors as antiplasmodial agents. Part I: aziridines and epoxides\<br\>ChemMedChem (2007) 2, 1214-1224. PubMed  Europe PubMed DOI  I
  122. Singh,A., Walker,K.J., Sijwali,P.S., Lau,A.L. and Rosenthal,P.J. \<br\>A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2\<br\>Protein Eng Des Sel (2007) 20, 171-177. PubMed  Europe PubMed DOI
  123. Subramanian,S., Sijwali,P.S. and Rosenthal,P.J. \<br\>Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole\<br\>J Biol Chem (2007) 282, 24961-24969. PubMed  Europe PubMed DOI
    124. 2006
  124. [YEAR:15-6-2006]Hogg,T., Nagarajan,K., Herzberg,S., Chen,L., Shen,X., Jiang,H., Wecke,M., Blohmke,C., Hilgenfeld,R. and Schmidt,C.L. \<br\>Structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum\<br\>J Biol Chem (15-6-2006) 281, 25425-25437. PubMed  Europe PubMed DOI  T
  125. [YEAR:2-4-2006]Jeong,J.J., Kumar,A., Hanada,T., Seo,P.S., Li,X., Hanspal,M. and Chishti,A.H. \<br\>Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2B\<br\>Blood Cells Mol Dis (2-4-2006) 36, 429-435. PubMed  Europe PubMed DOI
  126. [YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E. \<br\>Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems\<br\>Proc Natl Acad Sci U S A (6-6-2006) 103, 8840-8845. PubMed  Europe PubMed DOI  PMC  EPMC
  127. [YEAR:1-6-2006]Micale,N., Kozikowski,A.P., Ettari,R., Grasso,S., Zappala,M., Jeong,J.J., Kumar,A., Hanspal,M. and Chishti,A.H. \<br\>Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents\<br\>J Med Chem (1-6-2006) 49, 3064-3067. PubMed  Europe PubMed DOI  I
  128. [YEAR:15-6-2006]Ramjee,M.K., Flinn,N.S., Pemberton,T.P., Quibell,M., Wang,Y. and Watts,J.P. \<br\>Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery\<br\>Biochem J (15-6-2006) 399, 47-57. PubMed  Europe PubMed DOI  P
  129. [YEAR:20-7-2006]Sijwali,P.S., Koo,J., Singh,N. and Rosenthal,P.J. \<br\>Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum\<br\>Mol Biochem Parasitol (20-7-2006) 150, 96-106. PubMed  Europe PubMed DOI  K
  130. [YEAR:6-12-2006]Singh,N., Sijwali,P.S., Pandey,K.C. and Rosenthal,P.J. \<br\>Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'\<br\>Exp Parasitol (6-12-2006) 112, 187-192. PubMed  Europe PubMed DOI
  131. [YEAR:1-8-2006]Wang,S.X., Pandey,K.C., Somoza,J.R., Sijwali,P.S., Kortemme,T., Brinen,L.S., Fletterick,R.J., Rosenthal,P.J. and McKerrow,J.H. \<br\>Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease\<br\>Proc Natl Acad Sci U S A (1-8-2006) 103, 11503-11508. PubMed  Europe PubMed DOI  PMC  EPMC  S
    132. 2005
  132. [YEAR:11-7-2005]Chan,C., Goh,L.L. and Sim,T.S. \<br\>Differences in biochemical properties of the plasmodial falcipain-2 and berghepain-2 orthologues: implications for in vivo screens of inhibitors\<br\>FEMS Microbiol Lett (11-7-2005) 249, 315-321. PubMed  Europe PubMed DOI
  133. Dahl,E.L. and Rosenthal,P.J. \<br\>Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum\<br\>Mol Biochem Parasitol (2005) 139, 205-212. PubMed  Europe PubMed DOI
  134. [YEAR:12-9-2005]Dasaradhi,P.V., Mohmmed,A., Kumar,A., Hossain,M.J., Bhatnagar,R.K., Chauhan,V.S. and Malhotra,P. \<br\>A role of falcipain-2, principal cysteine proteases of Plasmodium falciparum in merozoite egression\<br\>Biochem Biophys Res Commun (12-9-2005) 336, 1062-1068. PubMed  Europe PubMed DOI
  135. Florent,I., Lecaille,F., Montagne,J.J., Gauthier,F., Schrevel,J. and Lalmanach,G. \<br\>Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe\<br\>Biol Chem (2005) 386, 401-406. PubMed  Europe PubMed DOI
  136. [YEAR:8-8-2005]Goh,L.L. and Sim,T.S. \<br\>Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum\<br\>Biochem Biophys Res Commun (8-8-2005) 335, 762-770. PubMed  Europe PubMed DOI
  137. [YEAR:28-6-2005]Pandey,K.C., Wang,S.X., Sijwali,P.S., Lau,A.L., McKerrow,J.H. and Rosenthal,P.J. \<br\>The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif\<br\>Proc Natl Acad Sci U S A (28-6-2005) 102, 9138-9143. PubMed  Europe PubMed DOI  PMC  EPMC
    138. 2004
  138. Desai,P.V. and Avery,M.A. \<br\>Structural characterization of vivapain-2 and vivapain-3, cysteine proteases from Plasmodium vivax: comparative protein modeling and docking studies\<br\>J Biomol Struct Dyn (2004) 21, 781-790. PubMed  Europe PubMed DOI
  139. Desai,P.V., Patny,A., Sabnis,Y., Tekwani,B., Gut,J., Rosenthal,P., Srivastava,A. and Avery,M. \<br\>Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database\<br\>J Med Chem (2004) 47, 6609-6615. PubMed  Europe PubMed DOI  I
  140. [YEAR:15-10-2004]Goh,L.L. and Sim,T.S. \<br\>Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design\<br\>Biochem Biophys Res Commun (15-10-2004) 323, 565-572. PubMed  Europe PubMed DOI
  141. [YEAR:23-4-2004]Kumar,A., Dasaradhi,P.V., Chauhan,V.S. and Malhotra,P. \<br\>Exploring the role of putative active site amino acids and pro-region motif of recombinant falcipain-2: a principal hemoglobinase of Plasmodium falciparum\<br\>Biochem Biophys Res Commun (23-4-2004) 317, 38-45. PubMed  Europe PubMed DOI
  142. [YEAR:15-9-2004]Na,B.K., Kim,T.S., Rosenthal,P.J., Lee,J.K. and Kong,Y. \<br\>Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors\<br\>Parasitol Res (15-9-2004) 94, 312-317. PubMed  Europe PubMed DOI  I
  143. [YEAR:20-11-2004]Na,B.K., Shenai,B.R., Sijwali,P.S., Choe,Y., Pandey,K.C., Singh,A., Craik,C.S. and Rosenthal,P.J. \<br\>Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax\<br\>Biochem J (20-11-2004) 378, 529-538. PubMed  Europe PubMed DOI  PMC  EPMC
  144. [YEAR:18-11-2004]Pandey,K.C., Sijwali,P.S., Singh,A., Na,B.K. and Rosenthal,P.J. \<br\>Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2\<br\>J Biol Chem (18-11-2004) 279, 3484-3491. PubMed  Europe PubMed DOI
  145. Rosenthal,P.J. \<br\>Falcipains\<br\>[ISSN:0-12-079610-4] (2004) 2, 1157-1160.  V
  146. [YEAR:30-3-2004]Sijwali,P.S. and Rosenthal,P.J. \<br\>Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum\<br\>Proc Natl Acad Sci U S A (30-3-2004) 101, 4384-4389. PubMed  Europe PubMed DOI  PMC  EPMC
    147. 2003
  147. [YEAR:15-5-2003]Batra,S., Sabnis,Y.A., Rosenthal,P.J. and Avery,M.A. \<br\>Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines\<br\>Bioorg Med Chem (15-5-2003) 11, 2293-2299. PubMed  Europe PubMed DOI  I
  148. [YEAR:20-10-2003]Chiyanzu,I., Hansell,E., Gut,J., Rosenthal,P.J., McKerrow,J.H. and Chibale,K. \<br\>Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain\<br\>Bioorg Med Chem Lett (20-10-2003) 13, 3527-3530. PubMed  Europe PubMed DOI  I
  149. [YEAR:8-8-2003]Dhawan,S., Dua,M., Chishti,A.H. and Hanspal,M. \<br\>Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cells\<br\>J Biol Chem (8-8-2003) 278, 30180-30186. PubMed  Europe PubMed DOI
  150. Goh,L.L., Loke,P., Singh,M. and Sim,T.S. \<br\>Soluble expression of a functionally active Plasmodium falciparum falcipain-2 fused to maltose-binding protein in Escherichia coli\<br\>Protein Expr Purif (2003) 32, 194-201. PubMed  Europe PubMed DOI  E
  151. Lee,B.J., Singh,A., Chiang,P., Kemp,S.J., Goldman,E.A., Weinhouse,M.I., Vlasuk,G.P. and Rosenthal,P.J. \<br\>Antimalarial activities of novel synthetic cysteine protease inhibitors\<br\>Antimicrobial Agents Chemother (2003) 47, 3810-3814. PubMed  Europe PubMed DOI  PMC  EPMC  I
  152. Shenai,B.R., Lee,B.J., Alvarez-Hernandez,A., Chong,P.Y., Emal,C.D., Neitz,R.J., Roush,W.R. and Rosenthal,P.J. \<br\>Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones\<br\>Antimicrobial Agents Chemother (2003) 47, 154-160. PubMed  Europe PubMed DOI  PMC  EPMC  I
  153. [YEAR:15-8-2003]Sweeney,D., Raymer,M.L. and Lockwood,T.D. \<br\>Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents\<br\>Biochem Pharmacol (15-8-2003) 66, 663-677. PubMed  Europe PubMed DOI
    154. 2002
  154. [YEAR:1-8-2002]Hanspal,M., Dua,M., Takakuwa,Y., Chishti,A.H. and Mizuno,A. \<br\>Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development\<br\>Blood (1-8-2002) 100, 1048-1054. PubMed  Europe PubMed DOI
  155. Malhotra,P., Dasaradhi,P.V., Kumar,A., Mohmmed,A., Agrawal,N., Bhatnagar,R.K. and Chauhan,V.S. \<br\>Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum\<br\>Mol Microbiol (2002) 45, 1245-1254. PubMed  Europe PubMed DOI
  156. Rosenthal,P.J., Sijwali,P.S., Singh,A. and Shenai,B.R. \<br\>Cysteine proteases of malaria parasites: targets for chemotherapy\<br\>Curr Pharm Des (2002) 8, 1659-1672. PubMed  Europe PubMed DOI
  157. Sabnis,Y., Rosenthal,P.J., Desai,P. and Avery,M.A. \<br\>Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors\<br\>J Biomol Struct Dyn (2002) 19, 765-774. PubMed  Europe PubMed DOI  I
  158. [YEAR:26-4-2002]Sijwali,P.S., Shenai,B.R. and Rosenthal,P.J. \<br\>Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain\<br\>J Biol Chem (26-4-2002) 277, 14910-14915. PubMed  Europe PubMed DOI
    159. 2001
  159. Dua,M., Raphael,P., Sijwali,P.S., Rosenthal,P.J. and Hanspal,M. \<br\>Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1\<br\>Mol Biochem Parasitol (2001) 116, 95-99. PubMed  Europe PubMed DOI
  160. Joachimiak,M.P., Chang,C., Rosenthal,P.J. and Cohen,F.E. \<br\>The impact of whole genome sequence data on drug discovery - a malaria case study\<br\>Mol Med (2001) 7, 698-710. PubMed  Europe PubMed  PMC  EPMC
  161. Sijwali,P.S., Brinen,L.S. and Rosenthal,P.J. \<br\>Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2\<br\>Protein Expr Purif (2001) 22, 128-134. PubMed  Europe PubMed DOI  E
  162. Singh,A. and Rosenthal,P.J. \<br\>Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum\<br\>Antimicrobial Agents Chemother (2001) 45, 949-951. PubMed  Europe PubMed DOI  PMC  EPMC  I
    163. 2000
  163. [YEAR:7-9-2000]Hanspal,M. \<br\>cDNA cloning of a novel cysteine protease of Plasmodium falciparum\<br\>Biochim Biophys Acta (7-9-2000) 1493, 242-245. PubMed  Europe PubMed DOI
  164. [YEAR:15-9-2000]Shenai,B.R., Sijwali,P.S., Singh,A. and Rosenthal,P.J. \<br\>Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum\<br\>J Biol Chem (15-9-2000) 275, 29000-29010. PubMed  Europe PubMed DOI
    165. 1999
  165. Olson,J.E., Lee,G.K., Semenov,A. and Rosenthal,P.J. \<br\>Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors\<br\>Bioorg Med Chem (1999) 7, 633-638. PubMed  Europe PubMed DOI  I
    166. 1997
  166. Rosenthal,P.J. \<br\>Cysteine proteases of malaria parasites, including a haemoglobinase of Plasmodium falciparum (falcipain)\<br\>Expert Opin Ther Targets (1997) 1, 39-42. DOI
    167. 1993
  167. Rosenthal,P.J., Lee,G.K. and Smith,R.E. \<br\>Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria\<br\>J Clin Invest (1993) 91, 1052-1056. PubMed  Europe PubMed DOI  PMC  EPMC
    168. 1987
  168. [YEAR:1-9-1987]Rosenthal,P.J., Kim,K., McKerrow,J.H. and Leech,J.H. \<br\>Identification of three stage-specific proteinases of Plasmodium falciparum\<br\>J Exp Med (1-9-1987) 166, 816-821. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2023 EBI
Terms of use