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Literature for peptidase C01.074: CPB peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A. \<br\>Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases\<br\>Bioorg Chem (2020) 101, 104039. PubMed  Europe PubMed DOI  I
  2. Fonseca Lameiro,R.D., Shamim,A., Rosini,F., Cendron,R., Jatai Batista,P.H. and Montanari,C.A. \<br\>Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds\<br\>Future Med Chem (2020) PubMed  Europe PubMed DOI
  3. Ghosh,S., Verma,A., Kumar,V., Pradhan,D., Selvapandiyan,A., Salotra,P. and Singh,R. \<br\>Genomic and Transcriptomic Analysis for Identification of Genes and Interlinked Pathways Mediating Artemisinin Resistance in Leishmania donovani\<br\>Genes (Basel) (2020) 11, PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Matos,T.K.B., Batista,P.H.J., Dos Reis Rocho,F., De Vita,D., Pearce,N., Kellam,B., Montanari,C.A. and Leitao,A. \<br\>Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB\<br\>Bioorg Med Chem Lett (2020) 30, 127439. PubMed  Europe PubMed DOI  I
  5. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A. \<br\>Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor\<br\>Bioorg Med Chem (2020) 28, 115743. PubMed  Europe PubMed DOI  I
    6. 2019
  6. Bivona,A.E., Czentner,L., Sanchez Alberti,A., Cerny,N., Cardoso Landaburu,A.C., Nevot,C., Estevez,O., Marco,J.D., Basombrio,M.A., Malchiodi,E.L. and Cazorla,S.I. \<br\>The recombinant cysteine proteinase B (CPB) from Leishmania braziliensis and its domains: promising antigens for serodiagnosis of cutaneous and visceral leishmaniasis in dogs\<br\>J Clin Microbiol (2019) PubMed  Europe PubMed DOI
    7. 2018
  7. De Luca,L., Ferro,S., Buemi,M.R., Monforte,A.M., Gitto,R., Schirmeister,T., Maes,L., Rescifina,A. and Micale,N. \<br\>Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8DeltaCTE inhibitors as potential therapeutics for leishmaniasis\<br\>Chem Biol Drug Des (2018) 92, 1585-1596. PubMed  Europe PubMed DOI  I
  8. Fey,P., Chartomatsidou,R., Kiefer,W., Mottram,J.C., Kersten,C. and Schirmeister,T. \<br\>New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8\<br\>Eur J Med Chem (2018) 156, 587-597. PubMed  Europe PubMed DOI  I
    9. 2017
  9. Beyzay,F., Zavaran Hosseini,A. and Soudi,S. \<br\>Alpha alumina nanoparticle conjugation to cysteine peptidase A and B: an efficient method for autophagy induction\<br\>Avicenna J Med Biotechnol (2017) 9, 71-81. PubMed  Europe PubMed  PMC  EPMC
    10. 2016
  10. Casgrain,P.A., Martel,C., McMaster,W.R., Mottram,J.C., Olivier,M. and Descoteaux,A. \<br\>Cysteine peptidase B regulates Leishmania mexicana virulence through the modulation of GP63 expression\<br\>PLoS Pathog (2016) 12, e1005658. PubMed  Europe PubMed DOI
  11. Santos,D.A., de Souza Costa,M.G., Alves,C.R. and Caffarena,E.R. \<br\>Structural and dynamic insights into the C-terminal extension of cysteine proteinase B from Leishmania amazonensis\<br\>J Mol Graph Model (2016) 70, 30-39. PubMed  Europe PubMed DOI
  12. Scala,A., Micale,N., Piperno,A., Rescifina,A., Schirmeister,T., Kesselring,J. and Grassi,G. \<br\>Targeting of the Leishmania mexicana cysteine protease CPB2.8DCTE by decorated fused benzo[b] thiophene scaffold\<br\>RSC Adv (2016) 6, 30628-30635. DOI  I
    13. 2015
  13. De Sousa,L.R., Wu,H., Nebo,L., Fernandes,J.B., da Silva,M.F., Kiefer,W., Schirmeister,T. and Vieira,P.C. \<br\>Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana\<br\>Exp Parasitol (2015) 156, 42-48. PubMed  Europe PubMed DOI  I
  14. Gontijo,V.S., Espuri,P.F., Alves,R.B., de Camargos,L.F., Santos,F.V., de Souza Judice,W.A., Marques,M.J. and Freitas,R.P. \<br\>Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines\<br\>Eur J Med Chem (2015) 101, 24-33. PubMed  Europe PubMed DOI  I
  15. Shahbazi,M., Zahedifard,F., Taheri,T., Taslimi,Y., Jamshidi,S., Shirian,S., Mahdavi,N., Hassankhani,M., Daneshbod,Y., Zarkesh-Esfahani,S.H., Papadopoulou,B. and Rafati,S. \<br\>Evaluation of live recombinant nonpathogenic Leishmania tarentolae expressing cysteine proteinase and A2 Genes as a candidate vaccine against experimental canine visceral leishmaniasis\<br\>PLoS ONE (2015) 10, e0132794. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2013
  16. Chaouch,M., Fathallah-Mili,A., Driss,M., Lahmadi,R., Ayari,C., Guizani,I., Ben Said,M. and Benabderrazak,S. \<br\>Identification of Tunisian Leishmania spp. by PCR amplification of cysteine proteinase B (cpb) genes and phylogenetic analysis\<br\>Acta Trop (2013) 125, 357-365. PubMed  Europe PubMed DOI
  17. Judice,W.A., Manfredi,M.A., Souza,G.P., Sansevero,T.M., Almeida,P.C., Shida,C.S., Gesteira,T.F., Juliano,L., Westrop,G.D., Sanderson,S.J., Coombs,G.H. and Tersariol,I.L. \<br\>Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-like rCPB2.8\<br\>PLoS ONE (2013) 8, e80153. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Schroder,J., Noack,S., Marhofer,R.J., Mottram,J.C., Coombs,G.H. and Selzer,P.M. \<br\>Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB\<br\>PLoS ONE (2013) 8, e77460. PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Unciti-Broceta,J.D., Maceira,J., Morales,S., Garcia-Perez,A., Munoz-Torres,M.E. and Garcia-Salcedo,J.A. \<br\>Nicotinamide inhibits the lysosomal cathepsin B-like protease and kills African trypanosomes\<br\>J Biol Chem (2013) 288, 10548-10557. PubMed  Europe PubMed DOI  I
    20. 2012
  20. Myburgh,E., Coombs,G.H. and Mottram,J.C. \<br\>Leishmania CPA, CPB and CPC cysteine proteases\<br\>[ISSN:978-0-12-407743-0] (2012) 3, 1923-1928. DOI
  21. Rana,S., Dikhit,M.R., Rani,M., Moharana,K.C., Sahoo,G.C. and Das,P. \<br\>CPDB: cysteine protease annotation database in Leishmania species\<br\>Integr Biol (Camb) (2012) 4, 1351-1357. PubMed  Europe PubMed DOI
    22. 2011
  22. Caffrey,C.R., Lima,A.P. and Steverding,D. \<br\>Cysteine peptidases of kinetoplastid parasites\<br\>Adv Exp Med Biol (2011) 712, 84-99. PubMed  Europe PubMed DOI  V
  23. Doroud,D., Zahedifard,F., Vatanara,A., Najafabadi,A.R., Taslimi,Y., Vahabpour,R., Torkashvand,F., Vaziri,B. and Rafati,S. \<br\>Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection\<br\>J Control Release (2011) 153, 154-162. PubMed  Europe PubMed DOI
    24. 2010
  24. Steert,K., Berg,M., Mottram,J.C., Westrop,G.D., Coombs,G.H., Cos,P., Maes,L., Joossens,J., Van der Veken,P., Haemers,A. and Augustyns,K. \<br\>alpha-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB\<br\>ChemMedChem (2010) 5, 1734-1748. PubMed  Europe PubMed DOI  I
    25. 2009
  25. Caffrey,C.R. and Steverding,D. \<br\>Kinetoplastid papain-like cysteine peptidases\<br\>Mol Biochem Parasitol (2009) 167, 12-19. PubMed  Europe PubMed DOI  I
  26. Rebello,K.M., Cortes,L.M., Pereira,B.A., Pascarelli,B.M., Corte-Real,S., Finkelstein,L.C., Pinho,R.T., D'Avila-Levy,C.M. and Alves,C.R. \<br\>Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis\<br\>Parasitol Res (2009) 106, 95-104. PubMed  Europe PubMed DOI
  27. Saffari,B. and Mohabatkar,H. \<br\>Computational analysis of cysteine proteases (Clan CA, Family C1) of Leishmania major to find potential epitopic regions\<br\>Genomics Proteomics Bioinformatics (2009) 7, 87-95. PubMed  Europe PubMed DOI
    28. 2008
  28. Lanfranco,M.F., Loayza-Muro,R., Clark,D., Nunez,R., Zavaleta,A.I., Jimenez,M., Meldal,M., Coombs,G.H., Mottram,J.C., Izidoro,M., Juliano,M.A., Juliano,L. and Arevalo,J. \<br\>Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis\<br\>Mol Biochem Parasitol (2008) 161, 91-100. PubMed  Europe PubMed DOI
  29. Marin-Villa,M., Vargas-Inc, Chaves,S.P., Tempone,A.J., Dutra,J.M., Soares,M.J., Ueda-Nakamura,T., Mendonca,S.C., Rossi-Bergmann,B., Soong,L. and Traub-Cseko,Y.M. \<br\>The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: a putative function in macrophage infection\<br\>Mol Biochem Parasitol (2008) 162, 52-59. PubMed  Europe PubMed DOI
    30. 2007
  30. Kuru,T., Jirata,D., Genetu,A., Barr,S., Mengistu,Y., Aseffa,A. and Gedamu,L. \<br\>Leishmania aethiopica: identification and characterization of cathepsin L-like cysteine protease genes\<br\>Exp Parasitol (2007) 115, 283-290. PubMed  Europe PubMed DOI
    31. 2006
  31. [YEAR:27-6-2006]Williams,R.A., Tetley,L., Mottram,J.C. and Coombs,G.H. \<br\>Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana\<br\>Mol Microbiol (27-6-2006) 61, 655-674. PubMed  Europe PubMed DOI  T
    32. 2005
  32. Judice,W.A., Mottram,J.C., Coombs,G.H., Juliano,M.A. and Juliano,L. \<br\>Specific negative charges in cysteine protease isoforms of Leishmania mexicana are highly influential on the substrate binding and hydrolysis\<br\>Mol Biochem Parasitol (2005) 144, 36-43. PubMed  Europe PubMed DOI  P
  33. [YEAR:3-2-2005]Mundodi,V., Kucknoor,A.S. and Gedamu,L. \<br\>Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibition\<br\>BMC Mol Biol (3-2-2005) 6, 3. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2004
  34. [YEAR:1-9-2004]Cameron,P., McGachy,A., Anderson,M., Paul,A., Coombs,G.H., Mottram,J.C., Alexander,J. and Plevin,R. \<br\>Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway\<br\>J Immunol (1-9-2004) 173, 3297-3304. PubMed  Europe PubMed
  35. Judice,W.A., Puzer,L., Cotrin,S.S., Carmona,A.K., Coombs,G.H., Juliano,L. and Juliano,M.A. \<br\>Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana\<br\>Eur J Biochem (2004) 271, 1046-1053. PubMed  Europe PubMed DOI  P
  36. Juliano,M.A., Brooks,D.R., Selzer,P.M., Pandolfo,H.L., Judice,W.A., Juliano,L., Meldal,M., Sanderson,S.J., Mottram,J.C. and Coombs,G.H. \<br\>Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes\<br\>Eur J Biochem (2004) 271, 3704-3714. PubMed  Europe PubMed DOI  P
  37. Mottram,J.C. and Coombs,G.H. \<br\>Leishmania CPA, CPB and CPC cysteine proteases\<br\>[ISSN:0-12-079610-4] (2004) 2, 1166-1169.  V
  38. Mottram,J.C., Coombs,G.H. and Alexander,J. \<br\>Cysteine peptidases as virulence factors of Leishmania\<br\>Curr Opin Microbiol (2004) 7, 375-381. PubMed  Europe PubMed DOI
  39. [YEAR:7-5-2004]Zadeh-Vakili,A., Taheri,T., Taslimi,Y., Doustdari,F., Salmanian,A.H. and Rafati,S. \<br\>Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis\<br\>Vaccine (7-5-2004) 22, 1930-1940. PubMed  Europe PubMed DOI
    40. 2003
  40. [YEAR:1-10-2003]Buxbaum,L.U., Denise,H., Coombs,G.H., Alexander,J., Mottram,J.C. and Scott,P. \<br\>Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity\<br\>J Immunol (1-10-2003) 171, 3711-3717. PubMed  Europe PubMed
  41. Chibale,K. and Musonda,C.C. \<br\>The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors\<br\>Curr Med Chem (2003) 10, 1863-1889. PubMed  Europe PubMed DOI  I
  42. Denise,H., McNeil,K., Brooks,D.R., Alexander,J., Coombs,G.H. and Mottram,J.C. \<br\>Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo\<br\>Infect Immun (2003) 71, 3190-3195. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Pascalis,H., Lavergne,A., Bourreau,E., Prevot-Linguet,G., Kariminia,A., Pradinaud,R., Rafati,S. and Launois,P. \<br\>Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis\<br\>Infect Immun (2003) 71, 2924-2926. PubMed  Europe PubMed DOI  PMC  EPMC
  44. [YEAR:15-2-2003]Pollock,K.G., McNeil,K.S., Mottram,J.C., Lyons,R.E., Brewer,J.M., Scott,P., Coombs,G.H. and Alexander,J. \<br\>The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses\<br\>J Immunol (15-2-2003) 170, 1746-1753. PubMed  Europe PubMed
  45. Rafati,S., Nakhaee,A., Taheri,T., Ghashghaii,A., Salmanian,A.H., Jimenez,M., Mohebali,M., Masina,S. and Fasel,N. \<br\>Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis\<br\>Exp Parasitol (2003) 103, 143-151. PubMed  Europe PubMed DOI
    46. 2002
  46. Sajid,M. and McKerrow,J.H. \<br\>Cysteine proteases of parasitic organisms\<br\>Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
  47. [YEAR:9-5-2002]St Hilaire,P.M., Alves,L.C., Herrera,F., Renil,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,M.A., Juliano,L., Arevalo,J. and Meldal,M. \<br\>Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B\<br\>J Med Chem (9-5-2002) 45, 1971-1982. PubMed  Europe PubMed DOI  I
    48. 2001
  48. Alves,L.C., Judice,W.A., St Hilaire,P.M., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A. \<br\>Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana\<br\>Mol Biochem Parasitol (2001) 116, 1-9. PubMed  Europe PubMed DOI  P
  49. Alves,L.C., Melo,R.L., Cezari,M.H., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A. \<br\>Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids\<br\>Mol Biochem Parasitol (2001) 117, 137-143. PubMed  Europe PubMed DOI  P
  50. Alves,L.C., Melo,R.L., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A. \<br\>S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids\<br\>Eur J Biochem (2001) 268, 1206-1212. PubMed  Europe PubMed DOI  P
  51. [YEAR:25-4-2001]Alves,L.C., St Hilaire,P.M., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A. \<br\>Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana\<br\>Mol Biochem Parasitol (25-4-2001) 114, 81-88. PubMed  Europe PubMed DOI
  52. [YEAR:14-12-2001]Brooks,D.R., Denise,H., Westrop,G.D., Coombs,G.H. and Mottram,J.C. \<br\>The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element\<br\>J Biol Chem (14-12-2001) 276, 47061-47069. PubMed  Europe PubMed DOI
  53. [YEAR:15-3-2001]Das,L., Datta,N., Bandyopadhyay,S. and Das,P.K. \<br\>Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response\<br\>J Immunol (15-3-2001) 166, 4020-4028. PubMed  Europe PubMed
  54. Graven,A., St,H.P.M., Sanderson,S.J., Mottram,J.C., Coombs,G.H. and Meldal,M. \<br\>Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana\<br\>J Comb Chem (2001) 3, 441-452. PubMed  Europe PubMed DOI  I
  55. [YEAR:14-5-2001]Rafati,S., Salmanian,A.H., Taheri,T., Vafa,M. and Fasel,N. \<br\>A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major\<br\>Vaccine (14-5-2001) 19, 3369-3375. PubMed  Europe PubMed DOI
  56. Rafati,S., Salmanian,A.H., Hashemi,K., Schaff,C., Belli,S. and Fasel,N. \<br\>Identification of Leishmania major cysteine proteinases as targets of the immune response in humans\<br\>Mol Biochem Parasitol (2001) 113, 35-43. PubMed  Europe PubMed DOI
    57. 2000
  57. Brooks,D.R., Tetley,L., Coombs,G.H. and Mottram,J.C. \<br\>Processing and trafficking of cysteine proteases in Leishmania mexicana\<br\>J Cell Sci (2000) 113, 4035-4041. PubMed  Europe PubMed  K
  58. Frame,M.J., Mottram,J.C. and Coombs,G.H. \<br\>Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction\<br\>Parasitology (2000) 121, 367-377. PubMed  Europe PubMed DOI  K
  59. [YEAR:15-4-2000]Sanderson,S.J., Pollock,K.G., Hilley,J.D., Meldal,M., St Hilaire,P., Juliano,M.A., Juliano,L., Mottram,J.C. and Coombs,G.H. \<br\>Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana\<br\>Biochem J (15-4-2000) 347, 383-388. PubMed  Europe PubMed DOI  PMC  EPMC  E
  60. [YEAR:18-8-2000]St Hilaire,P.M., Alves,L.C., Sanderson,S.J., Mottram,J.C., Juliano,M.A., Juliano,L., Coombs,G.H. and Meldal,M. \<br\>The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach\<br\>Chembiochem (18-8-2000) 1, 115-122. PubMed  Europe PubMed  P
    61. 1999
  61. [YEAR:28-9-1999]Selzer,P.M., Pingel,S., Hsieh,I., Ugele,B., Chan,V.J., Engel,J.C., Bogyo,M., Russell,D.G., Sakanari,J.A. and McKerrow,J.H. \<br\>Cysteine protease inhibitors as chemotherapy: lessons from a parasite target\<br\>Proc Natl Acad Sci U S A (28-9-1999) 96, 11015-11022. PubMed  Europe PubMed DOI  PMC  EPMC
    62. 1998
  62. [YEAR:15-12-1998]Alexander,J., Coombs,G.H. and Mottram,J.C. \<br\>Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a TH1 response\<br\>J Immunol (15-12-1998) 161, 6794-6801. PubMed  Europe PubMed  K
  63. Mottram,J.C., Brooks,D.R. and Coombs,G.H. \<br\>Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions\<br\>Curr Opin Microbiol (1998) 1, 455-460. PubMed  Europe PubMed
    64. 1997
  64. Mottram,J.C., Frame,M.J., Brooks,D.R., Tetley,L., Hutchison,J.E., Souza,A.E. and Coombs,G.H. \<br\>The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences\<br\>J Biol Chem (1997) 272, 14285-14293. PubMed  Europe PubMed DOI
  65. [YEAR:1-12-1997]Omara-Opyene,A.L. and Gedamu,L. \<br\>Molecular cloning, characterization and overexpression of two distinct cysteine protease cDNAs from Leishmania donovani chagasi\<br\>Mol Biochem Parasitol (1-12-1997) 90, 247-267. PubMed  Europe PubMed DOI
  66. Sakanari,J.A., Nadler,S.A., Chan,V.J., Engel,J.C., Leptak,C. and Bouvier,J. \<br\>Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids\<br\>Exp Parasitol (1997) 85, 63-76. PubMed  Europe PubMed DOI
  67. Selzer,P.M., Chen,X., Chan,V.J., Cheng,M., Kenyon,G.L., Kuntz,I.D., Sakanari,J.A., Cohen,F.E. and McKerrow,J.H. \<br\>Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors\<br\>Exp Parasitol (1997) 87, 212-221. PubMed  Europe PubMed DOI
    68. 1996
  68. Mottram,J.C., Souza,A.E., Hutchison,J.E., Carter,R., Frame,M.J. and Coombs,G.H. \<br\>Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors\<br\>Proc Natl Acad Sci U S A (1996) 93, 6008-6013. PubMed  Europe PubMed DOI  PMC  EPMC  K
    69. 1995
  69. De Souza Leao,S., Lang,T., Prina,E., Hellio,R. and Antoine,J.C. \<br\>Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells\<br\>J Cell Sci (1995) 108, 3219-3231. PubMed  Europe PubMed
    70. 1994
  70. Duboise,S.M., Vannier-Santos,M.A., Costa-Pinto,D., Rivas,L., Pan,A.A., Traub-Cseko,Y., de Souza,W. and McMahon-Pratt,D. \<br\>The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases\<br\>Mol Biochem Parasitol (1994) 68, 119-132. PubMed  Europe PubMed DOI
  71. Robertson,C.D. and Coombs,G.H. \<br\>Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array\<br\>Microbiology (Reading, Engl.) (1994) 140, 417-424. PubMed  Europe PubMed
    72. 1993
  72. Traub-Cseko,Y.M., Duboise,M., Boukai,L.K. and McMahon-Pratt,D. \<br\>Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction\<br\>Mol Biochem Parasitol (1993) 57, 101-115. PubMed  Europe PubMed DOI
    73. 1992
  73. [YEAR:19-10-1992]Souza,A.E., Waugh,S., Coombs,G.H. and Mottram,J.C. \<br\>Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana\<br\>FEBS Lett (19-10-1992) 311, 124-127. PubMed  Europe PubMed DOI
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