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Literature for peptidase C19.052: ubiquitin-specific peptidase 46

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Gao,S., Wang,Y., Xu,Y., Liu,L. and Liu,S. \<br\>USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis\<br\>Biochim Biophys Acta (2024) 1870, 167011. PubMed  Europe PubMed DOI
  2. Shu,J., Yang,C., Miao,Y., Li,J., Zheng,T., Xiao,J., Kong,W., Xu,Z. and Feng,H. \<br\>USP46 promotes the interferon antiviral signaling in black carp by deubiquitinating TBK1\<br\>Dev Comp Immunol (2024) 156, 105170. PubMed  Europe PubMed DOI  K
    3. 2023
  3. Ke,L., Jia,Z., Gao,W. and Luo,L. \<br\>Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis\<br\>Cell Biol Int (2023) 47, 41-51. PubMed  Europe PubMed DOI  K
  4. Liu,N., Lin,M.M. and Wang,Y. \<br\>The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases\<br\>Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
  5. Ng,V.H., Spencer,Z., Neitzel,L.R., Nayak,A., Loberg,M.A., Shen,C., Kassel,S.N., Kroh,H.K., An,Z., Anthony,C.C., Bryant,J.M., Lawson,A., Goldsmith,L., Benchabane,H., Hansen,A.G., Li,J., D'Souza,S., Lebensohn,A.M., Rohatgi,R., Weiss,W.A., Weiss,V.L., Williams,C., Hong,C.C., Robbins,D.J., Ahmed,Y. and Lee,E. \<br\>The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling\<br\>Nat Commun (2023) 14, 6173. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Wen,M., Xu,H., Peng,H., Sheng,Y., Yang,W. and Yan,J. \<br\>MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma\<br\>Chem Biol Drug Des (2022) 100, 280-289. PubMed  Europe PubMed DOI
    7. 2021
  7. Kiran,S., Wilson,B., Saha,S., Graff,J.A. and Dutta,A. \<br\>HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes\<br\>Cancers (Basel) (2021) 14, PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Qiu,Y., Huang,D., Sheng,Y., Huang,J., Li,N., Zhang,S., Hong,Z., Yin,X. and Yan,J. \<br\>Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1\<br\>Exp Cell Res (2021) 405, 112646. PubMed  Europe PubMed DOI  K
  9. Seo,J.H., Kim,T.Y., Kim,S.J., Choi,J.H., So,H.S. and Kang,J.I. \<br\>Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene With Post-traumatic Stress Disorder\<br\>Front Psychiatry (2021) 12, 663647. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2020
  10. Tian,M., Zhu,R., Ding,F. and Liu,Z. \<br\>Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma\<br\>Exp Cell Res (2020) 112188. PubMed  Europe PubMed DOI
  11. Wang,W., Chen,M., Xu,H., Lv,D., Zhou,S. and Yang,H. \<br\>USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway\<br\>Biomed Res Int (2020) 2020, 2509529. PubMed  Europe PubMed DOI  PMC  EPMC  K
    12. 2019
  12. Gui,D., Peng,W., Jiang,W., Huang,G., Liu,G., Ye,Z., Wang,Y., Xu,Z., Fu,J., Luo,S. and Zhao,Y. \<br\>Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation\<br\>Biochem Biophys Res Commun (2019) 519, 689-696. PubMed  Europe PubMed DOI
    13. 2018
  13. Kiran,S., Dar,A., Singh,S.K., Lee,K.Y. and Dutta,A. \<br\>The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers\<br\>Mol Cell (2018) 72, 823-835. PubMed  Europe PubMed DOI
    14. 2017
  14. Hodul,M., Dahlberg,C.L. and Juo,P. \<br\>Function of the deubiquitinating enzyme USP46 in the nervous system and its regulation by WD40-repeat proteins\<br\>Front Synaptic Neurosci (2017) 9, 16. PubMed  Europe PubMed DOI  PMC  EPMC  V
    15. 2015
  15. Huo,Y., Khatri,N., Hou,Q., Gilbert,J., Wang,G. and Man,H.Y. \<br\>The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking\<br\>J Neurochem (2015) 134, 1067-1080. PubMed  Europe PubMed DOI
  16. Ribeiro,F.C., Santos,L.E. and Ferreira,S.T. \<br\>USP46: a new piece of the memory puzzle?\<br\>J Neurochem (2015) 134, 979-981. PubMed  Europe PubMed DOI
  17. Umemura,S., Imai,S., Mimura,A., Fujiwara,M. and Ebihara,S. \<br\>Impaired maternal behavior in Usp46 mutant mice: a model for trans-generational transmission of maternal care\<br\>PLoS ONE (2015) 10, e0136016. PubMed  Europe PubMed DOI  PMC  EPMC  M
  18. Yin,J., Schoeffler,A.J., Wickliffe,K., Newton,K., Starovasnik,M.A., Dueber,E.C. and Harris,S.F. \<br\>Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46\<br\>Structure (2015) 23, 2043-2054. PubMed  Europe PubMed DOI  S
    19. 2013
  19. Imai,S., Kano,M., Nonoyama,K. and Ebihara,S. \<br\>Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice\<br\>PLoS ONE (2013) 8, e58566. PubMed  Europe PubMed DOI  PMC  EPMC  M
    20. 2012
  20. Imai,S., Mamiya,T., Tsukada,A., Sakai,Y., Mouri,A., Nabeshima,T. and Ebihara,S. \<br\>Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system\<br\>PLoS ONE (2012) 7, e39084. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2011
  21. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K. \<br\>The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types\<br\>Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
  22. Fukuo,Y., Kishi,T., Kushima,I., Yoshimura,R., Okochi,T., Kitajima,T., Matsunaga,S., Kawashima,K., Umene-Nakano,W., Naitoh,H., Inada,T., Nakamura,J., Ozaki,N. and Iwata,N. \<br\>Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population\<br\>J Affect Disord (2011) 133, 150-157. PubMed  Europe PubMed DOI  M
  23. Joo,H.Y., Jones,A., Yang,C., Zhai,L., Smith,A.D., Zhang,Z., Chandrasekharan,M.B., Sun,Z.W., Renfrow,M.B., Wang,Y., Chang,C. and Wang,H. \<br\>Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46\<br\>J Biol Chem (2011) 286, 7190-7201. PubMed  Europe PubMed DOI
  24. Zhang,W., Tian,Q.B., Li,Q.K., Wang,J.M., Wang,C.N., Liu,T., Liu,D.W. and Wang,M.W. \<br\>Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity\<br\>PLoS ONE (2011) 6, e26297. PubMed  Europe PubMed DOI  PMC  EPMC  M
    25. 2010
  25. Ebihara,S. and Tomida,S. \<br\>[Identification of a gene regulating "behavioral despair" in mice]\<br\>Nihon Shinkei Seishin Yakurigaku Zasshi (2010) 30, 19-22. PubMed  Europe PubMed  M
  26. Kushima,I., Aleksic,B., Ito,Y., Nakamura,Y., Nakamura,K., Mori,N., Kikuchi,M., Inada,T., Kunugi,H., Nanko,S., Kato,T., Yoshikawa,T., Ujike,H., Suzuki,M., Iwata,N. and Ozaki,N. \<br\>Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population\<br\>J Hum Genet (2010) 55, 133-136. PubMed  Europe PubMed DOI  M
    27. 2009
  27. Tomida,S., Mamiya,T., Sakamaki,H., Miura,M., Aosaki,T., Masuda,M., Niwa,M., Kameyama,T., Kobayashi,J., Iwaki,Y., Imai,S., Ishikawa,A., Abe,K., Yoshimura,T., Nabeshima,T. and Ebihara,S. \<br\>Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests\<br\>Nat Genet (2009) 41, 688-695. PubMed  Europe PubMed DOI  M
    28. 2004
  28. [YEAR:30-1-2004]Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C., Cal,S. and Lopez-Otin,C. \<br\>Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases\<br\>Biochem Biophys Res Commun (30-1-2004) 314, 54-62. PubMed  Europe PubMed DOI

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