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Literature for peptidase C65.002: otubain-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Nan,Y., Wu,X., Luo,Q., Chang,W., Zhao,P., Zhang,L. and Liu,Z. \<br\>OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition\<br\>Proc Natl Acad Sci U S A (2024) 121, e2315348121. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Gan,J., de Vries,J., Akkermans,J.J.L.L., Mohammed,Y., Tjokrodirijo,R.T.N., de Ru,A.H., Kim,R.Q., Vargas,D.A., Pol,V., Fasan,R., van Veelen,P.A., Neefjes,J., van Dam,H., Ovaa,H., Sapmaz,A. and Geurink,P.P. \<br\>Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2\<br\>ACS Chem Biol (2023) 18, 2003-2013. PubMed  Europe PubMed DOI  PMC  EPMC  I
  3. Song,Y. and Wu,Q. \<br\>RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling\<br\>Environ Toxicol (2023) 38, 2155-2164. PubMed  Europe PubMed DOI  K
  4. Zhang,Q., Zhang,J., Yao,A., Tian,X., Han,Z., Yuan,Y., Tao,K. and Yang,X. \<br\>OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway\<br\>Cell Biol Int (2023) 47, 428-438. PubMed  Europe PubMed DOI
    5. 2022
  5. Chang,W., Luo,Q., Wu,X., Nan,Y., Zhao,P., Zhang,L., Luo,A., Jiao,W., Zhu,Q., Fu,Y. and Liu,Z. \<br\>OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis\<br\>Cell Rep (2022) 41, 111561. PubMed  Europe PubMed DOI
  6. Hu,G., Yang,J., Zhang,H., Huang,Z. and Yang,H. \<br\>OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation\<br\>Cell Mol Bioeng (2022) 15, 281-292. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Li,J., Zhang,N., Li,M., Hong,T., Meng,W. and Ouyang,T. \<br\>The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function\<br\>Front Cell Dev Biol (2022) 10, 820781. PubMed  Europe PubMed DOI  PMC  EPMC  V
  8. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W. \<br\>OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer\<br\>Cell Death Discov (2022) 8, 45. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Ouyang,S., Zeng,Z., Liu,Z., Zhang,Z., Sun,J., Wang,X., Ma,M., Ye,X., Yu,J. and Kang,W. \<br\>Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer\<br\>Cell Death Discov (2022) 8, 211. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Liu,G., Guo,W., Qin,J. and Lin,Z. \<br\>OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties\<br\>Front Oncol (2021) 11, 711735. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Sivakumar,D. and Stein,M. \<br\>Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases\<br\>Biomolecules (2021) 11, PubMed  Europe PubMed DOI  PMC  EPMC
  12. Yu,S., Zang,W., Qiu,Y., Liao,L. and Zheng,X. \<br\>Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis\<br\>Oncogene (2021) PubMed  Europe PubMed DOI
  13. Zhu,Q., Fu,Y., Li,L., Liu,C.H. and Zhang,L. \<br\>The functions and regulation of Otubains in protein homeostasis and diseases\<br\>Ageing Res Rev (2021) 67, 101303. PubMed  Europe PubMed DOI  V
    14. 2020
  14. Gu,Z.L., Huang,J. and Zhen,L.L. \<br\>Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling\<br\>Kaohsiung J Med Sci (2020) PubMed  Europe PubMed DOI  K
  15. Sivakumar,D., Kumar,V., Naumann,M. and Stein,M. \<br\>Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases\<br\>J Biol Chem (2020) 295, 6972-6982. PubMed  Europe PubMed DOI
  16. Wan,Q., Chen,Q., Cai,D., Zhao,Y. and Wu,X. \<br\>OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer\<br\>Cell Transplant (2020) 29, 963689720931433. PubMed  Europe PubMed DOI  K
    17. 2019
  17. Li,J., Cheng,D., Zhu,M., Yu,H., Pan,Z., Liu,L., Geng,Q., Pan,H., Yan,M. and Yao,M. \<br\>OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer\<br\>Theranostics (2019) 9, 179-195. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Resnick,E., Bradley,A., Gan,J., Douangamath,A., Krojer,T., Sethi,R., Geurink,P.P., Aimon,A., Amitai,G., Bellini,D., Bennett,J., Fairhead,M., Fedorov,O., Gabizon,R., Gan,J., Guo,J., Plotnikov,A., Reznik,N., Ruda,G.F., Diaz-Saez,L., Straub,V.M., Szommer,T., Velupillai,S., Zaidman,D., Zhang,Y., Coker,A.R., Dowson,C.G., Barr,H.M., Wang,C., Huber,K.V.M., Brennan,P.E., Ovaa,H., von Delft,F. and London,N. \<br\>Rapid covalent-probe discovery by electrophile-fragment screening\<br\>J Am Chem Soc (2019) 141, 8951-8968. PubMed  Europe PubMed DOI  I
  19. Zhang,Z., Du,J., Wang,S., Shao,L., Jin,K., Li,F., Wei,B., Ding,W., Fu,P., van Dam,H., Wang,A., Jin,J., Ding,C., Yang,B., Zheng,M., Feng,X.H., Guan,K.L. and Zhang,L. \<br\>OTUB2 Promotes cancer metastasis via Hippo-independent activation of YAP and TAZ\<br\>Mol Cell (2019) 73, 7-21. PubMed  Europe PubMed DOI
    20. 2018
  20. Li,X.Y., Mao,X.F., Tang,X.Q., Han,Q.Q., Jiang,L.X., Qiu,Y.M., Dai,J. and Wang,Y.X. \<br\>Regulation of Gli2 stability by deubiquitinase OTUB2\<br\>Biochem Biophys Res Commun (2018) 505, 113-118. PubMed  Europe PubMed DOI
    21. 2015
  21. Altun,M., Walter,T.S., Kramer,H.B., Herr,P., Iphofer,A., Bostrom,J., David,Y., Komsany,A., Ternette,N., Navon,A., Stuart,D.I., Ren,J. and Kessler,B.M. \<br\>The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages\<br\>PLoS ONE (2015) 10, e0115344. PubMed  Europe PubMed DOI  PMC  EPMC  S
    22. 2013
  22. Beck,A., Vinik,Y., Shatz-Azoulay,H., Isaac,R., Streim,S., Jona,G., Boura-Halfon,S. and Zick,Y. \<br\>Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets\<br\>Diabetologia (2013) 56, 1317-1326. PubMed  Europe PubMed DOI
    23. 2012
  23. Kessler,B.M. \<br\>Otubains\<br\>[ISSN:978-0-12-407743-0] (2012) 3, 2113-2120. DOI
    24. 2004
  24. Nanao,M.H., Tcherniuk,S.O., Chroboczek,J., Dideberg,O., Dessen,A. and Balakirev,M.Y. \<br\>Crystal structure of human otubain 2\<br\>EMBO Rep (2004) 5, 783-788. PubMed  Europe PubMed DOI  PMC  EPMC  S
    25. 2003
  25. Balakirev,M.Y., Tcherniuk,S.O., Jaquinod,M. and Chroboczek,J. \<br\>Otubains: a new family of cysteine proteases in the ubiquitin pathway\<br\>EMBO Rep (2003) 4, 517-522. PubMed  Europe PubMed DOI  PMC  EPMC  I

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