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Literature for peptidase M15.011: vanX D-Ala-D-Ala dipeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, M Mutation, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Konuma,T., Takai,T., Tsuchiya,C., Nishida,M., Hashiba,M., Yamada,Y., Shirai,H., Motoda,Y., Nagadoi,A., Chikaishi,E., Akagi,K.I., Akashi,S., Yamazaki,T., Akutsu,H. and Ikegami,T. \<br\>Analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria\<br\>Protein Sci (2024) 33, e5002. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2019
  2. Lv,M., Zhang,Y.J., Zhou,F., Ge,Y., Zhao,M.H., Liu,Y. and Yang,K.W. \<br\>Real-time monitoring of D-Ala-D-Ala dipeptidase activity of VanX in living bacteria by isothermal titration calorimetry\<br\>Anal Biochem (2019) 578, 29-35. PubMed  Europe PubMed DOI  A
    3. 2018
  3. Binda,E., Cappelletti,P., Marinelli,F. and Marcone,G.L. \<br\>Specificity of induction of glycopeptide antibiotic resistance in the producing actinomycetes\<br\>Antibiotics (Basel) (2018) 7, 36. PubMed  Europe PubMed DOI
  4. Hansen,T.A., Pedersen,M.S., Nielsen,L.G., Ma,C.M.G., Soes,L.M., Worning,P., Ostergaard,C., Westh,H., Pinholt,M. and Schonning,K. \<br\>Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX\<br\>J Antimicrob Chemother (2018) 73, 2936-2940. PubMed  Europe PubMed DOI  M
    5. 2016
  5. van der Aart,L.T., Lemmens,N., Van Wamel,W.J. and van Wezel,G.P. \<br\>Substrate inhibition of VanA by D-alanine reduces vancomycin resistance in a VanX-dependent manner\<br\>Antimicrobial Agents Chemother (2016) 60, 4930-4939. PubMed  Europe PubMed DOI
  6. Wu,N., Kamioka,T. and Kuroda,Y. \<br\>A novel screening system based on VanX-mediated autolysis-Application to Gaussia luciferase\<br\>Biotechnol Bioeng (2016) 113, 1413-1420. PubMed  Europe PubMed DOI
    7. 2014
  7. Muthyala,R., Rastogi,N., Shin,W.S., Peterson,M.L. and Sham,Y.Y. \<br\>Cell permeable vanX inhibitors as vancomycin re-sensitizing agents\<br\>Bioorg Med Chem Lett (2014) 24, 2535-2538. PubMed  Europe PubMed DOI  I
  8. Sohya,S., Kamioka,T., Fujita,C., Maki,T., Ohta,Y. and Kuroda,Y. \<br\>Biochemical and biophysical characterization of an unexpected bacteriolytic activity of VanX, a member of the vancomycin-resistance vanA gene cluster\<br\>J Biol Chem (2014) 289, 35686-35694. PubMed  Europe PubMed DOI
    9. 2013
  9. Kamioka,T., Sohya,S., Wu,N., Maki,T., Matsuda,T., Ikegami,T., Nakamura,H. and Kuroda,Y. \<br\>Extraction of recombinant protein from Escherichia coli by using a novel cell autolysis activity of VanX\<br\>Anal Biochem (2013) 439, 212-217. PubMed  Europe PubMed DOI
    10. 2012
  10. Jia,C., Yang,K.W., Liu,C.C., Feng,L., Xiao,J.M., Zhou,L.S. and Zhang,Y.L. \<br\>Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX\<br\>Bioorg Med Chem Lett (2012) 22, 482-484. PubMed  Europe PubMed DOI  I
  11. Lessard,I.A.D. \<br\>VanX D-,D-dipeptidase\<br\>[ISSN:978-0-12-407744-7] (2012) 3, 1395-1401. DOI
    12. 2011
  12. Yang,K.W., Cheng,X., Zhao,C., Liu,C.C., Jia,C., Feng,L., Xiao,J.M., Zhou,L.S., Gao,H.Z., Yang,X. and Zhai,L. \<br\>Synthesis and activity study of phosphonamidate dipeptides as potential inhibitors of VanX\<br\>Bioorg Med Chem Lett (2011) 21, 7224-7227. PubMed  Europe PubMed DOI  I
    13. 2006
  13. [YEAR:24-8-2006]Chang,Y.P., Tseng,M.J. and Chu,Y.H. \<br\>Using surface plasmon resonance to directly measure slow binding of low-molecular mass inhibitors to a VanX chip\<br\>Anal Biochem (24-8-2006) 359, 63-71. PubMed  Europe PubMed DOI  I
  14. Crowder,M.W. \<br\>Combating vancomycin resistance in bacteria: targeting the D-ala-D-ala dipeptidase VanX\<br\>Infect Disord Drug Targets (2006) 6, 147-158. PubMed  Europe PubMed DOI  T
  15. [YEAR:27-4-2006]Hsieh,M.L., Tseng,M.J., Tseng,M.C. and Chu,Y.H. \<br\>Identification of a new chromophoric substrate in the library of amino acid p-nitroanilides for continuous assay of VanX, a d,d-dipeptidase essential for vancomycin resistance\<br\>Anal Biochem (27-4-2006) 354, 104-110. PubMed  Europe PubMed DOI  A
  16. [YEAR:11-10-2006]Matthews,M.L., Periyannan,G., Hajdin,C., Sidgel,T.K., Bennett,B. and Crowder,M.W. \<br\>Probing the reaction mechanism of the d-ala-d-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme\<br\>J Am Chem Soc (11-10-2006) 128, 13050-13051. PubMed  Europe PubMed DOI
    17. 2005
  17. [YEAR:17-1-2005]Breece,R.M., Costello,A., Bennett,B., Sigdel,T.K., Matthews,M.L., Tierney,D.L. and Crowder,M.W. \<br\>A five-coordinate metal center in Co(II)-substituted VanX\<br\>J Biol Chem (17-1-2005) 280, 11074-11081. PubMed  Europe PubMed DOI
    18. 2004
  18. [YEAR:15-8-2004]Golich,F.C., Sigdel,T., Breece,R.M., Detar,L., Herron,L.R. and Crowder,M.W. \<br\>L-alanine-p-nitroanilide is not a substrate for VanX\<br\>Anal Biochem (15-8-2004) 331, 398-400. PubMed  Europe PubMed DOI
  19. Lessard,I.A.D. \<br\>VanX D-,D-dipeptidase\<br\>[ISSN:0-12-079610-4] (2004) 2, 860-866.  V
    20. 2003
  20. Anissimova,M., Yaouancq,L., Noor,F., Badet-Denisot,M.A. and Badet,B. \<br\>New chromogenic dipeptide substrate for continuous assay of the D-alanyl-D-alanine dipeptidase VanX required for high-level vancomycin resistance\<br\>J Pept Res (2003) 62, 88-95. PubMed  Europe PubMed DOI  A
    21. 2002
  21. Gao,Y. \<br\>Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance\<br\>Nat Prod Rep (2002) 19, 100-107. PubMed  Europe PubMed DOI  I
  22. Tan,A.L., Loke,P. and Sim,T.S. \<br\>Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2)\<br\>Res Microbiol (2002) 153, 27-32. PubMed  Europe PubMed DOI
    23. 2000
  23. [YEAR:26-12-2000]Araoz,R., Anhalt,E., Rene,L., Badet-Denisot,M.A., Courvalin,P. and Badet,B. \<br\>Mechanism-based inactivation of VanX, a D-alanyl-D-alanine dipeptidase necessary for vancomycin resistance\<br\>Biochemistry (26-12-2000) 39, 15971-15979. PubMed  Europe PubMed DOI
  24. Brandt,J.J., Chatwood,L.L. and Crowder,M.W. \<br\>Analysis of three overexpression systems for VanX, the zinc(II) dipeptidase required for high-level vancomycin resistance in bacteria\<br\>Protein Expr Purif (2000) 20, 300-307. PubMed  Europe PubMed DOI  E
  25. Patel,R., Piper,K., Cockerill,F.R., III, Steckelberg,J.M. and Yousten,A.A. \<br\>The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster\<br\>Antimicrobial Agents Chemother (2000) 44, 705-709. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 1999
  26. [YEAR:15-7-1999]Brandt,J.J., Chatwood,L.L., Yang,K.W. and Crowder,M.W. \<br\>Continuous assay for VanX, the D-alanyl-D-alanine dipeptidase required for high-level vancomycin resistance\<br\>Anal Biochem (15-7-1999) 272, 94-99. PubMed  Europe PubMed DOI  A
  27. Hilbert,F., Del Portillo,F.G. and Groisman,E.A. \<br\>A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica\<br\>J Bacteriol (1999) 181, 2158-2165. PubMed  Europe PubMed  PMC  EPMC
  28. Lessard,I.A. and Walsh,C.T. \<br\>Mutational analysis of active-site residues of the enterococcal D-Ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-ala-D-Ala ligase and D-ala-D-Ala carboxypeptidase VanY\<br\>Chem Biol (1999) 6, 177-187. PubMed  Europe PubMed DOI
  29. [YEAR:28-9-1999]Lessard,I.A. and Walsh,C.T. \<br\>VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?\<br\>Proc Natl Acad Sci U S A (28-9-1999) 96, 11028-11032. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 1998
  30. Arthur,M., Depardieu,F., Cabanie,L., Reynolds,P. and Courvalin,P. \<br\>Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci\<br\>Mol Microbiol (1998) 30, 819-830. PubMed  Europe PubMed DOI
  31. Bussiere,D.E., Pratt,S.D., Katz,L., Severin,J.M., Holzman,T. and Park,C.H. \<br\>The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance\<br\>Mol Cell (1998) 2, 75-84. PubMed  Europe PubMed  S
  32. Lessard,I.A., Pratt,S.D., McCafferty,D.G., Bussiere,D.E., Hutchins,C., Wanner,B.L., Katz,L. and Walsh,C.T. \<br\>Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function\<br\>Chem Biol (1998) 5, 489-504. PubMed  Europe PubMed
  33. Reynolds,P.E. \<br\>Control of peptidoglycan synthesis in vancomycin-resistant enterococci: D,D-peptidases and D,D-carboxypeptidases\<br\>Cell Mol Life Sci (1998) 54, 325-331. PubMed  Europe PubMed DOI
  34. [YEAR:15-11-1998]Tu,J. and Chu,Y.H. \<br\>Vancomycin resistance in Enterococcus faecium: a capillary electrophoresis-based assay for VanX enzyme\<br\>Anal Biochem (15-11-1998) 264, 293-296. PubMed  Europe PubMed DOI  A
    35. 1997
  35. McCafferty,D.G., Lessard,I.A. and Walsh,C.T. \<br\>Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX\<br\>Biochemistry (1997) 36, 10498-10505. PubMed  Europe PubMed DOI
    36. 1996
  36. Walsh,C.T., Fisher,S.L., Park,I.S., Prahalad,M. and Wu,Z. \<br\>Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story\<br\>Chem Biol (1996) 3, 21-28. PubMed  Europe PubMed
  37. Wu,Z. and Walsh,C. \<br\>Dithiol compounds: potent, time-dependent inhibitors of VanX, a zinc-dependent D,D-dipeptidase required for vancomycin resistance in Enterococcus faecium\<br\>J Am Chem Soc (1996) 118, 1785-1786.  I
    38. 1995
  38. Wu,Z., Wright,G.D. and Walsh,C.T. \<br\>Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147\<br\>Biochemistry (1995) 34, 2455-2463. PubMed  Europe PubMed
  39. Wu,Z. and Walsh,C.T. \<br\>Phosphinate analogs of D-, D-dipeptides: Slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium\<br\>Proc Natl Acad Sci U S A (1995) 92, 11603-11607. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 1994
  40. Reynolds,P.E., Depardieu,F., Dutka-Malen,S., Arthur,M. and Courvalin,P. \<br\>Glycopeptide resistance mediated by enterococcal transposon tn1546 requires production of vanX for hydrolysis of D-alanyl-D- alanine\<br\>Mol Microbiol (1994) 13, 1065-1070. PubMed  Europe PubMed
    41. 1993
  41. [YEAR:16-7-1993]Walsh,C.T. \<br\>Vancomycin resistance: decoding the molecular logic\<br\>Science (16-7-1993) 261, 308-309. PubMed  Europe PubMed

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