Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.132: mannan-binding lectin-associated serine peptidase-3

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, K Knockout, R Splicing, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Dani,R., Oroszlan,G., Martinusz,R., Farkas,B., Dobos,B., Vadas,E., Zavodszky,P., Gal,P. and Dobo,J. \<br\>Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D\<br\>Front Immunol (2023) 14, 1197023. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Gullipalli,D., Miwa,T., Golla,M., Sato,S., Angampalli,S. and Song,W.C. \<br\>MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity\<br\>J Immunol (2023) 210, 1543-1551. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2022
  3. Dobo,J., Kocsis,A., Dani,R. and Gal,P. \<br\>Proprotein Convertases and the Complement System\<br\>Front Immunol (2022) 13, 958121. PubMed  Europe PubMed DOI  PMC  EPMC  V
  4. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G. \<br\>Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation\<br\>J Biol Chem (2022) 298, 101985. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2021
  5. Rosbjerg,A., Wurzner,R., Garred,P. and Skjoedt,M.O. \<br\>MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis\<br\>J Innate Immun (2021) 1-14. PubMed  Europe PubMed DOI
    6. 2020
  6. Cedzynski,M. and Swierzko,A.S. \<br\>Components of the Lectin Pathway of Complement in Haematologic Malignancies\<br\>Cancers (Basel) (2020) 12, PubMed  Europe PubMed DOI
  7. Fuentes-Prior,P. \<br\>Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection\<br\>J Biol Chem (2020) PubMed  Europe PubMed DOI  V
  8. Gajek,G., Swierzko,A.S. and Cedzynski,M. \<br\>Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome\<br\>Int J Mol Sci (2020) 21, PubMed  Europe PubMed DOI
    9. 2017
  9. Pihl,R., Jensen,L., Hansen,A.G., Thogersen,I.B., Andres,S., Dagnaes-Hansen,F., Oexle,K., Enghild,J.J. and Thiel,S. \<br\>Analysis of factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale patients highlights the role of MASP-3 as a maturase in the alternative pathway of complement\<br\>J Immunol (2017) PubMed  Europe PubMed DOI
    10. 2016
  10. Banda,N.K., Acharya,S., Scheinman,R.I., Mehta,G., Coulombe,M., Takahashi,M., Sekine,H., Thiel,S., Fujita,T. and Holers,V.M. \<br\>Mannan-binding lectin-associated serine protease 1/3 cleavage of pro-factor D into factor D in vivo and attenuation of collagen antibody-induced arthritis through their targeted inhibition by RNA interference-mediated gene silencing\<br\>J Immunol (2016) 197, 3680-3694. PubMed  Europe PubMed DOI
  11. Dobo,J., Szakacs,D., Oroszlan,G., Kortvely,E., Kiss,B., Boros,E., Szasz,R., Zavodszky,P., Gal,P. and Pal,G. \<br\>MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked\<br\>Sci Rep (2016) 6, 31877. PubMed  Europe PubMed DOI
  12. Dobo,J., Pal,G., Cervenak,L. and Gal,P. \<br\>The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond\<br\>Immunol Rev (2016) 274, 98-111. PubMed  Europe PubMed DOI
    13. 2014
  13. Rosbjerg,A., Munthe-Fog,L., Garred,P. and Skjoedt,M.O. \<br\>Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1\<br\>J Immunol (2014) 192, 4352-4360. PubMed  Europe PubMed DOI
    14. 2013
  14. Fraile,J.M., Ordonez,G.R., Quiros,P.M., Astudillo,A., Galvan,J.A., Colomer,D., Lopez-Otin,C., Freije,J.M. and Puente,X.S. \<br\>Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas\<br\>Oncotarget (2013) 4, 1931-1932. PubMed  Europe PubMed
  15. Gaboriaud,C., Gupta,R.K., Martin,L., Lacroix,M., Serre,L., Teillet,F., Arlaud,G.J., Rossi,V. and Thielens,N.M. \<br\>The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin\<br\>PLoS ONE (2013) 8, e67962. PubMed  Europe PubMed DOI  PMC  EPMC  S
  16. Yongqing,T., Wilmann,P.G., Reeve,S.B., Coetzer,T.H., Smith,A.I., Whisstock,J.C., Pike,R.N. and Wijeyewickrema,L.C. \<br\>The X-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome\<br\>J Biol Chem (2013) 288, 22399-22407. PubMed  Europe PubMed DOI  M  P  S
    17. 2012
  17. Schwaeble,W.J., Lynch,N.J., Gal,P. and Zavodszky,P. \<br\>Mannan-binding lectin-associated serine proteases\<br\>[ISSN:978-0-12-407742-3] (2012) 3, 2857-2863. DOI
  18. Yongqing,T., Drentin,N., Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N. \<br\>Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?\<br\>Biochim Biophys Acta (2012) 1824, 253-262. PubMed  Europe PubMed DOI  V  R
    19. 2011
  19. Banda,N.K., Takahashi,M., Takahashi,K., Stahl,G.L., Hyatt,S., Glogowska,M., Wiles,T.A., Endo,Y., Fujita,T., Michael Holers,V. and Arend,W.P. \<br\>Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement\<br\>Mol Immunol (2011) 49, 281-289. PubMed  Europe PubMed DOI
  20. Iwaki,D., Kanno,K., Takahashi,M., Endo,Y., Matsushita,M. and Fujita,T. \<br\>The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway\<br\>J Immunol (2011) 187, 3751-3758. PubMed  Europe PubMed DOI
  21. Takahashi,K., Chang,W.C., Takahashi,M., Pavlov,V., Ishida,Y., La Bonte,L., Shi,L., Fujita,T., Stahl,G.L. and Van Cott,E.M. \<br\>Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation\<br\>Immunobiology (2011) 216, 96-102. PubMed  Europe PubMed DOI
    22. 2010
  22. Degn,S.E., Jensen,L., Gal,P., Dobo,J., Holmvad,S.H., Jensenius,J.C. and Thiel,S. \<br\>Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system\<br\>J Immunol Methods (2010) 361, 37-50. PubMed  Europe PubMed DOI  R
  23. Skjoedt,M.O., Hummelshoj,T., Palarasah,Y., Honore,C., Koch,C., Skjodt,K. and Garred,P. \<br\>A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation\<br\>J Biol Chem (2010) 285, 8234-8243. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2009
  24. Degn,S.E., Hansen,A.G., Steffensen,R., Jacobsen,C., Jensenius,J.C. and Thiel,S. \<br\>MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation\<br\>J Immunol (2009) 183, 7371-7378. PubMed  Europe PubMed DOI
    25. 2008
  25. Takahashi,M., Iwaki,D., Kanno,K., Ishida,Y., Xiong,J., Matsushita,M., Endo,Y., Miura,S., Ishii,N., Sugamura,K. and Fujita,T. \<br\>Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway\<br\>J Immunol (2008) 180, 6132-6138. PubMed  Europe PubMed  K
  26. Teillet,F., Gaboriaud,C., Lacroix,M., Martin,L., Arlaud,G.J. and Thielens,N.M. \<br\>Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins\<br\>J Biol Chem (2008) 283, 25715-25724. PubMed  Europe PubMed DOI  S
    27. 2007
  27. Gal,P., Barna,L., Kocsis,A. and Zavodszky,P. \<br\>Serine proteases of the classical and lectin pathways: similarities and differences\<br\>Immunobiology (2007) 212, 267-277. PubMed  Europe PubMed DOI  V
  28. Takahashi,M., Mori,S., Shigeta,S. and Fujita,T. \<br\>Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway\<br\>Adv Exp Med Biol (2007) 598, 93-104. PubMed  Europe PubMed DOI  V
  29. Weiss,G., Madsen,H.O. and Garred,P. \<br\>A novel mannose-binding lectin-associated serine protease 1/3 gene variant\<br\>Scand J Immunol (2007) 65, 430-434. PubMed  Europe PubMed DOI  M
    30. 2006
  30. Cortesio,C.L. and Jiang,W. \<br\>Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5\<br\>Arch Biochem Biophys (2006) 449, 164-170. PubMed  Europe PubMed DOI  P
    31. 2004
  31. [YEAR:18-6-2004]Chen,C.B. and Wallis,R. \<br\>Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases\<br\>J Biol Chem (18-6-2004) 279, 26058-26065. PubMed  Europe PubMed DOI
  32. Schwaeble,W.J., Stover,C. and Reid,K.B.M. \<br\>Mannan-binding lectin-associated serine proteases\<br\>[ISSN:0-12-079610-4] (2004) 2, 1623-1627.  V
  33. [YEAR:1-4-2004]Zundel,S., Cseh,S., Lacroix,M., Dahl,M.R., Matsushita,M., Andrieu,J.P., Schwaeble,W.J., Jensenius,J.C., Fujita,T., Arlaud,G.J. and Thielens,N.M. \<br\>Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2\<br\>J Immunol (1-4-2004) 172, 4342-4350. PubMed  Europe PubMed
    34. 2003
  34. [YEAR:1-5-2003]Endo,Y., Nonaka,M., Saiga,H., Kakinuma,Y., Matsushita,A., Takahashi,M., Matsushita,M. and Fujita,T. \<br\>Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus\<br\>J Immunol (1-5-2003) 170, 4701-4707. PubMed  Europe PubMed
  35. Presanis,J.S., Kojima,M. and Sim,R.B. \<br\>Biochemistry and genetics of mannan-binding lectin (MBL)\<br\>Biochem Soc Trans (2003) 31, 748-752. PubMed  Europe PubMed DOI
    36. 2002
  36. Endo,Y., Takahashi,M., Kuraya,M., Matsushita,M., Stover,C.M., Schwaeble,W.J. and Fujita,T. \<br\>Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter\<br\>Int Immunol (2002) 14, 1193-1201. PubMed  Europe PubMed
  37. Fujita,T. \<br\>Evolution of the lectin-complement pathway and its role in innate immunity\<br\>Nat Rev Immunol (2002) 2, 346-353. PubMed  Europe PubMed DOI
  38. Hajela,K., Kojima,M., Ambrus,G., Wong,K.H., Moffatt,B.E., Ferluga,J., Hajela,S., Gal,P. and Sim,R.B. \<br\>The biological functions of MBL-associated serine proteases (MASPs)\<br\>Immunobiology (2002) 205, 467-475. PubMed  Europe PubMed
  39. [YEAR:15-10-2002]Neth,O., Jack,D.L., Johnson,M., Klein,N.J. and Turner,M.W. \<br\>Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus\<br\>J Immunol (15-10-2002) 169, 4430-4436. PubMed  Europe PubMed
  40. Nonaka,M. and Miyazawa,S. \<br\>Evolution of the initiating enzymes of the complement system\<br\>Genome Biol (2002) 3, REVIEWS1001. PubMed  Europe PubMed  PMC  EPMC
  41. Schwaeble,W., Dahl,M.R., Thiel,S., Stover,C. and Jensenius,J.C. \<br\>The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes\<br\>Immunobiology (2002) 205, 455-466. PubMed  Europe PubMed DOI  R
    42. 2001
  42. Dahl,M.R., Thiel,S., Matsushita,M., Fujita,T., Willis,A.C., Christensen,T., Vorup-Jensen,T. and Jensenius,J.C. \<br\>MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway\<br\>Immunity (2001) 15, 127-135. PubMed  Europe PubMed DOI  R
    43. 2000
  43. Sim,R.B. and Laich,A. \<br\>Serine proteases of the complement system\<br\>Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2023 EBI
Terms of use