Literature for peptidase S01.140: chymase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Pejler,G., Paivandy,A., Rabelo Melo,F., Allam,V.S.R.R., Oberg,A., Wen,Q., Bergsten,P. and Zhao,X.O. Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma Inflammation (2026) 49 PubMed Europe PubMed DOI PMC EPMC

2025

Chen,X., Guo,Y., Qing,Y., Li,R., Luo,H., Ieong,H.C., Guo,B., Huang,Z., Teng,Y., Li,R., Li,W., Chen,D., Cao,Y., Wang,W. and Zhou,C. Non-Syndromic Hereditary Gingival Fibromatosis Driven by Chymase Deficiency Is Attenuated by Verteporfin-Loaded Exosomes J Clin Periodontol (2025) PubMed Europe PubMed DOI

2024

Furstner,C., Ackerstaff,J., Meier,H., Straub,A., Mittendorf,J., Schamberger,J., Schafer,M., Borngen,K., Jorissen,H., Zubov,D., Zimmermann,K., Tersteegen,A., Geiss,V., Hartmann,E., Albrecht-Kupper,B., D'Orleans-Juste,P., Lapointe,C., Vincent,L., Heitmeier,S. and Tinel,H. Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution J Med Chem (2024) PubMed Europe PubMed DOI I

2023

Ferrario,C.M., Ahmad,S., Speth,R. and Dell'Italia,L.J. Is chymase 1 a therapeutic target in cardiovascular disease? Expert Opin Ther Targets (2023) 27, 645-656. PubMed Europe PubMed DOI PMC EPMC V
Morales-Maldonado,A., Humphry,M., Figg,N. and Clarke,M.C. Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1beta Atherosclerosis (2023) , 117308-117308. PubMed Europe PubMed DOI
Yapijakis,C., Gintoni,I., Charalampidou,S., Angelopoulou,A., Papakosta,V., Vassiliou,S. and Chrousos,G.P. Angiotensinogen, Angiotensin-Converting Enzyme, and Chymase Gene Polymorphisms as Biomarkers for Basal Cell Carcinoma Susceptibility Adv Exp Med Biol (2023) 1423, 175-180. PubMed Europe PubMed DOI

2022

Fairhurst-Hunter,Z., Walters,R.G., Zink,A., Lin,K., Guo,Y., Yu,C., Lv,J., Li,L., Freitag,D.F., Chen,Z. and Millwood,I.Y. Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1 J Cardiovasc Transl Res (2022) PubMed Europe PubMed DOI
Lind,T., Melo,F.R., Gustafson,A.M., Sundqvist,A., Zhao,X.O., Moustakas,A., Melhus,H. and Pejler,G. Mast cell chymase has a negative impact on human osteoblasts Matrix Biol (2022) 112, 1-19. PubMed Europe PubMed DOI
Zhang,N., Schumacher,A., Fink,B., Bauer,M., Zenclussen,A.C. and Meyer,N. Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC

2021

Abassi,Z., Skorecki,K., Hamo-Giladi,D.B., Kruzel-Davila,E. and Heyman,S.N. Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease Am J Physiol Lung Cell Mol Physiol (2021) PubMed Europe PubMed DOI
Cruz-Lopez,E.O., Uijl,E. and Danser,A.H.J. Cardiac Angiotensin II Is Generated Locally by ACE and Not Chymase J Am Coll Cardiol (2021) 78, 540-541. PubMed Europe PubMed DOI
Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M. Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2 Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Zhao,X.O., Lampinen,M., Rollman,O., Sommerhoff,C.P., Paivandy,A. and Pejler,G. Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma J Allergy Clin Immunol (2021) PubMed Europe PubMed DOI

2020

Berglund,P., Akula,S., Fu,Z., Thorpe,M. and Hellman,L. Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Dungen,H.D., Kim,R.J., Zahger,D., Orvin,K., Kornowski,R., Admon,D., Kettner,J., Shimony,A., Otto,C., Becka,M., Kanefendt,F., Romo,A.I., Hasin,T., Ostadal,P., Rojas,G.C. and Senni,M. Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction: results of the chymase inhibitor in adverse remodeling after myocardial infarction (CHIARA MIA) 2 trial Am Heart J (2020) 224, 129-137. PubMed Europe PubMed DOI I
Ferrario,C.M., Groban,L., Wang,H., Cheng,C.P., VonCannon,J.L., Wright,K.N., Sun,X. and Ahmad,S. The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system Mol Cell Endocrinol (2020) , 111119-111119. PubMed Europe PubMed DOI
Li,C.Y., Yap,K., Swedberg,J.E., Craik,D.J. and de Veer,S.J. Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors J Med Chem (2020) 63, 816-826. PubMed Europe PubMed DOI
Rathore,A.P.S., Senanayake,M., Athapathu,A.S., Gunasena,S., Karunaratna,I., Leong,W.Y., Lim,T., Mantri,C.K., Wilder-Smith,A. and St John,A.L. Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients Sci Rep (2020) 10, 11856-11856. PubMed Europe PubMed DOI PMC EPMC
Sahu,A.K., Aggarwal,P., Ekka,M., Nayer,J., Bhoi,S., Kumar,A. and Luthra,K. Assessing the Serum Chymase Level as an Early Predictor of Dengue Severity J Med Virol (2020) PubMed Europe PubMed DOI
Vibhushan,S., Bratti,M., Montero-Hernandez,J.E., El Ghoneimi,A., Benhamou,M., Charles,N., Daugas,E. and Blank,U. Mast Cell Chymase and Kidney Disease Int J Mol Sci (2020) 22 PubMed Europe PubMed DOI PMC EPMC V

2019

Ahmad,S., Wright,K.N., Sun,X., Groban,L. and Ferrario,C.M. Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate Biochem Biophys Res Commun (2019) 518, 651-656. PubMed Europe PubMed DOI
Bivona,B.J., Takai,S., Seth,D.M., Satou,R. and Harrison-Bernard,L.M. Chymase inhibition retards albuminuria in type 2 diabetes Physiol Rep (2019) 7, e14302-e14302. PubMed Europe PubMed DOI PMC EPMC I
Fu,Z., Akula,S., Thorpe,M., Chahal,G., de Garavilla,L., Kervinen,J. and Hellman,L. Extended cleavage specificity of sheep mast cell protease-2: a classical chymase with preference to aromatic P1 substrate residues Dev Comp Immunol (2019) 92, 160-169. PubMed Europe PubMed DOI P
Fu,Z., Akula,S., Thorpe,M. and Hellman,L. Highly selective cleavage of TH2-promoting cytokines by the human and the mouse mast cell tryptases, indicating a potent negative feedback loop on TH2 immunity Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI P
Jin,D., Takai,S., Nonaka,Y., Yamazaki,S., Fujiwara,M. and Nakamura,Y. A chymase inhibitory RNA aptamer improves cardiac function and survival after myocardial infarction Mol Ther Nucleic Acids (2019) 14, 41-51. PubMed Europe PubMed DOI PMC EPMC I
Kanefendt,F., Thuss,U., Becka,M., Boxnick,S., Berse,M., Schultz,A. and Otto,C. Pharmacokinetics, safety, and tolerability of the novel chymase inhibitor BAY 1142524 in healthy male volunteers Clin Pharmacol Drug Dev (2019) 8, 467-479. PubMed Europe PubMed DOI I
Lipitsa,T., Siiskonen,H., Naukkarinen,A. and Harvima,I.T. Mast cell chymase degrades fibrinogen and fibrin Br J Dermatol (2019) 181, 296-303. PubMed Europe PubMed DOI
Ozawa,S.I., Takahashi,M., Yamaotsu,N. and Hirono,S. Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping J Mol Graph Model (2019) 89, 102-108. PubMed Europe PubMed DOI I
Tomimori,Y., Manno,A., Tanaka,T., Futamura-Takahashi,J., Muto,T. and Nagahira,K. ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice Eur J Pharmacol (2019) 856, 172403-172403. PubMed Europe PubMed DOI I

2018

Ahmad,S. and Ferrario,C.M. Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018) Expert Opin Ther Pat (2018) 28, 755-764. PubMed Europe PubMed DOI I
Ansary,T.M., Urushihara,M., Fujisawa,Y., Nagata,S., Urata,H., Nakano,D., Hirofumi,H., Kitamura,K., Kagami,S. and Nishiyama,A. Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice Exp Physiol (2018) 103, 1524-1531. PubMed Europe PubMed DOI I
Dell'Italia,L.J., Collawn,J.F. and Ferrario,C.M. Multifunctional role of chymase in acute and chronic tissue injury and remodeling Circ Res (2018) 122, 319-336. PubMed Europe PubMed DOI PMC EPMC V
Dubey,A., Dotolo,S., Ramteke,P.W., Facchiano,A. and Marabotti,A. Searching for chymase inhibitors among chamomile compounds using a computational-based approach Biomolecules (2018) 9 PubMed Europe PubMed DOI I
Futamura-Takahashi,J., Tanaka,T., Sugawara,H., Iwashita,S., Imajo,S., Oyama,Y. and Muto,T. Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors Bioorg Med Chem Lett (2018) 28, 188-192. PubMed Europe PubMed DOI I
Kareinen,I., Baumann,M., Nguyen,S.D., Maaninka,K., Anisimov,A., Tozuka,M., Jauhiainen,M., Lee-Rueckert,M. and Kovanen,P.T. Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192) and compromises its cardioprotective activity J Lipid Res (2018) 59, 945-957. PubMed Europe PubMed DOI
Zhang,H., Wang,J., Wang,L., Zhan,M., Li,S., Fang,Z., Xu,C., Zheng,Y. and He,S. Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism Br J Pharmacol (2018) 175, 678-692. PubMed Europe PubMed DOI

2017

Froogh,G., Pinto,J.T., Le,Y., Kandhi,S., Aleligne,Y., Huang,A. and Sun,D. Chymase-dependent production of angiotensin II: an old enzyme in old hearts Am J Physiol Heart Circ Physiol (2017) 312, H223-H231. PubMed Europe PubMed DOI
Fu,Z., Thorpe,M., Alemayehu,R., Roy,A., Kervinen,J., de Garavilla,L., Abrink,M. and Hellman,L. Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G J Immunol (2017) 198, 1474-1483. PubMed Europe PubMed DOI P
Grujic,M., Paivandy,A., Gustafson,A.M., Thomsen,A.R., Ohrvik,H. and Pejler,G. The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung Oncotarget (2017) 8, 25066-25079. PubMed Europe PubMed DOI
Gu,Y., Lewis,D.F., Alexander,J.S. and Wang,Y. Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia Hypertens Res (2017) 40, 976-981. PubMed Europe PubMed DOI
Reyes,S., Varagic,J., Ahmad,S., VonCannon,J., Kon,N.D., Wang,H., Groban,L., Cheng,C.P., Dell'Italia,L.J. and Ferrario,C.M. Novel cardiac intracrine mechanisms based on Ang-(1-12)/chymase axis require a revision of therapeutic approaches in human heart disease Curr Hypertens Rep (2017) 19, 16-16. PubMed Europe PubMed DOI
Shubin,N.J., Glukhova,V.A., Clauson,M., Truong,P., Abrink,M., Pejler,G., White,N.J., Deutsch,G.H., Reeves,S.R., Vaisar,T., James,R.G. and Piliponsky,A.M. Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation J Allergy Clin Immunol (2017) 139, 323-334. PubMed Europe PubMed DOI
Stevens,R.L., McNeil,H.P., Wensing,L.A., Shin,K., Wong,G.W., Hansbro,P.M. and Krilis,S.A. Experimental arthritis is dependent on mouse mast cell protease-5 J Biol Chem (2017) 292, 5392-5404. PubMed Europe PubMed DOI K
Verma,S., Singh,A., Kumari,A., Goyal,S., Jamal,S., Sinha,S. and Grover,A. Dissecting the role of mutations in chymase inhibition: free energy and decomposition analysis Gene (2017) 609, 68-79. PubMed Europe PubMed DOI M

2016

Dubey,A., Marabotti,A., Ramteke,P.W. and Facchiano,A. Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations Biochem Biophys Res Commun (2016) 473, 449-454. PubMed Europe PubMed DOI I
Dubey,A., Facchiano,A., Ramteke,P.W. and Marabotti,A. In silico approach to find chymase inhibitors among biogenic compounds Future Med Chem (2016) 8, 841-851. PubMed Europe PubMed DOI I
Sansoe,G., Aragno,M., Mastrocola,R., Mengozzi,G., Novo,E. and Parola,M. Role of chymase in the development of liver cirrhosis and its complications: experimental and human data PLoS ONE (2016) 11, e0162644-e0162644. PubMed Europe PubMed DOI PMC EPMC I
Takai,S. and Jin,D. Improvement of cardiovascular remodelling by chymase inhibitor Clin Exp Pharmacol Physiol (2016) 43, 387-393. PubMed Europe PubMed DOI I
Zhang,M., Huang,W., Bai,J., Nie,X. and Wang,W. Chymase inhibition protects diabetic rats from renal lesions Mol Med Rep (2016) 14, 121-128. PubMed Europe PubMed DOI I
Zhang,R., Zhang,C.J., Feng,G., Hu,F., Wang,J. and Liu,B. Specific light-up probe with aggregation-induced emission for facile detection of chymase Anal Chem (2016) 88, 9111-9117. PubMed Europe PubMed DOI L

2015

Arooj,M., Sakkiah,S., Cao,G.P., Kim,S., Arulalapperumal,V. and Lee,K.W. Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach Proteins (2015) 83, 1209-1224. PubMed Europe PubMed DOI I
Devarajan,S., Yahiro,E., Uehara,Y., Habe,S., Nishiyama,A., Miura,S., Saku,K. and Urata,H. Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension Am J Physiol Heart Circ Physiol (2015) 309, H1987-H1996. PubMed Europe PubMed DOI I
Semaan,W., Desbiens,L., Houde,M., Labonte,J., Gagnon,H., Yamamoto,D., Takai,S., Laidlaw,T., Bkaily,G., Schwertani,A., Pejler,G., Levesque,C., Desjardins,R., Day,R. and D'Orleans-Juste,P. Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase Biochem Pharmacol (2015) 94, 91-100. PubMed Europe PubMed DOI I
Wang,R., Chen,J., Zhang,Z. and Cen,Y. Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids Drug Des Devel Ther (2015) 9, 4979-4988. PubMed Europe PubMed DOI PMC EPMC T

2014

Ahmad,S., Varagic,J., Groban,L., Dell'Italia,L.J., Nagata,S., Kon,N.D. and Ferrario,C.M. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate Curr Hypertens Rep (2014) 16, 429-429. PubMed Europe PubMed DOI
Fei,X., Yuan,Y., Lee,Y.-M., Jeong,K.W. and Seo,S.-Y. Synthesis, biological evaluation of SPF-32629A-based 2- and 4-pyridone analogs as chymase inhibitors Bull Korean Chem Soc (2014) 35, 2547-2550. DOI I
Lysvand,H., Hagen,L., Klubicka,L., Slupphaug,G. and Iversen,O.J. Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase Biochim Biophys Acta (2014) 1842, 734-738. PubMed Europe PubMed DOI
Rafiq,K., Fan,Y.Y., Sherajee,S.J., Takahashi,Y., Matsuura,J., Hase,N., Mori,H., Nakano,D., Kobara,H., Hitomi,H., Masaki,T., Urata,H. and Nishiyama,A. Chymase activities and survival in endotoxin-induced human chymase transgenic mice Int J Med Sci (2014) 11, 222-225. PubMed Europe PubMed DOI PMC EPMC
Smith,E.T., Perry,E.T., Sears,M.B. and Johnson,D.A. Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris Protein Expr Purif (2014) 102, 69-75. PubMed Europe PubMed DOI E

2013

Ahooghalandari,P., Hanke,N., Thorpe,M., Witte,A., Messinger,J. and Hellman,L. Mutations in Arg143 and Lys192 of the human mast cell chymase markedly affect the activity of five potent human chymase inhibitors PLoS ONE (2013) 8, e65988-e65988. PubMed Europe PubMed DOI PMC EPMC I
Arooj,M., Kim,S., Sakkiah,S., Cao,G.P., Lee,Y. and Lee,K.W. Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design PLoS ONE (2013) 8, e62740-e62740. PubMed Europe PubMed DOI PMC EPMC I
Matsumoto,Y., Kakuda,S., Koizumi,M., Mizuno,T., Muroga,Y., Kawamura,T. and Takimoto-Kamimura,M. Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor J Synchrotron Radiat (2013) 20, 914-918. PubMed Europe PubMed DOI PMC EPMC S I
Tanaka,T., Sugawara,H., Maruoka,H., Imajo,S. and Muto,T. Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design Bioorg Med Chem (2013) 21, 4233-4249. PubMed Europe PubMed DOI I
Taylor,S.J., Padyana,A.K., Abeywardane,A., Liang,S., Hao,M.H., De Lombaert,S., Proudfoot,J., Farmer,B.S., III, Li,X., Collins,B., Martin,L., Albaugh,D.R., Hill-Drzewi,M., Pullen,S.S. and Takahashi,H. Discovery of potent, selective chymase inhibitors via fragment linking strategies J Med Chem (2013) 56, 4465-4481. PubMed Europe PubMed DOI I
Wu,Y., Yang,H., Yang,B., Yang,K. and Xiao,C. Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population J Renin Angiotensin Aldosterone Syst (2013) 14, 263-270. PubMed Europe PubMed DOI M
Yahiro,E., Miura,S., Imaizumi,S., Uehara,Y. and Saku,K. Chymase inhibitors Curr Pharm Des (2013) 19, 3065-3071. PubMed Europe PubMed DOI I

2012

Campbell,D.J. Angiotensin II generation in vivo: does it involve enzymes other than renin and angiotensin-converting enzyme? J Renin Angiotensin Aldosterone Syst (2012) 13, 314-316. PubMed Europe PubMed DOI
Caughey,G.H. Chymases [ISSN:978-0-12-407742-3] (2012) 3, 2675-2683. DOI
Heuston,S. and Hyland,N. Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders? Br J Pharmacol (2012) 167, 732-740. PubMed Europe PubMed DOI V
Maeda,Y., Inoguchi,T., Takei,R., Hendarto,H., Ide,M., Inoue,T., Kobayashi,K., Urata,H., Nishiyama,A. and Takayanagi,R. Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters J Diabetes Investig (2012) 3, 354-361. PubMed Europe PubMed DOI PMC EPMC I
Parlee,S.D., McNeil,J.O., Muruganandan,S., Sinal,C.J. and Goralski,K.B. Elastase and tryptase govern TNFalpha-mediated production of active chemerin by adipocytes PLoS ONE (2012) 7, e51072-e51072. PubMed Europe PubMed DOI PMC EPMC
Takai,S., Jin,D. and Miyazaki,M. Multiple mechanisms for the action of chymase inhibitors J Pharmacol Sci (2012) 118, 311-316. PubMed Europe PubMed DOI I
Thorpe,M., Yu,J., Boinapally,V., Ahooghalandari,P., Kervinen,J., Garavilla,L. and Hellman,L. Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase Int Immunol (2012) 24, 771-782. PubMed Europe PubMed DOI P

2011

Ahmad,S., Simmons,T., Varagic,J., Moniwa,N., Chappell,M.C. and Ferrario,C.M. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue PLoS ONE (2011) 6, e28501-e28501. PubMed Europe PubMed DOI PMC EPMC I
Arooj,M., Thangapandian,S., John,S., Hwang,S., Park,J.K. and Lee,K.W. 3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors Int J Mol Sci (2011) 12, 9236-9264. PubMed Europe PubMed DOI PMC EPMC I
Diaconu,N.C., Rummukainen,J., Naukkarinen,A., Matto,M., Harvima,R.J., Pelkonen,J. and Harvima,I.T. Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro Arch Dermatol Res (2011) 303, 499-512. PubMed Europe PubMed DOI
Korkmaz,B., Jegot,G., Lau,L.C., Thorpe,M., Pitois,E., Juliano,L., Walls,A.F., Hellman,L. and Gauthier,F. Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates FEBS J (2011) 278, 2635-2646. PubMed Europe PubMed DOI A P
Lo,H.Y., Nemoto,P.A., Kim,J.M., Hao,M.H., Qian,K.C., Farrow,N.A., Albaugh,D.R., Fowler,D.M., Schneiderman,R.D., Michael August,E., Martin,L., Hill-Drzewi,M., Pullen,S.S., Takahashi,H. and De Lombaert,S. Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region Bioorg Med Chem Lett (2011) 21, 4533-4539. PubMed Europe PubMed DOI I
Oyamada,S., Bianchi,C., Takai,S., Chu,L.M. and Sellke,F.W. Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion J Pharmacol Exp Ther (2011) 339, 143-151. PubMed Europe PubMed DOI I
Rafiq,K., Sherajee,S.J., Fan,Y.Y., Fujisawa,Y., Takahashi,Y., Matsuura,J., Hase,N., Urata,H., Nakano,D., Hitomi,H. and Nishiyama,A. Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice Chin J Physiol (2011) 54, 30-35. PubMed Europe PubMed DOI
Takai,S., Jin,D. and Miyazaki,M. Targets of chymase inhibitors Expert Opin Ther Targets (2011) 15, 519-527. PubMed Europe PubMed DOI I

2010

Andersson,M.K., Thorpe,M. and Hellman,L. Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates FEBS J (2010) 277, 2255-2267. PubMed Europe PubMed DOI
Gallwitz,M., Enoksson,M., Thorpe,M., Ge,X. and Hellman,L. The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase Int Immunol (2010) 22, 421-431. PubMed Europe PubMed DOI P
Kervinen,J., Crysler,C., Bayoumy,S., Abad,M.C., Spurlino,J., Deckman,I., Greco,M.N., Maryanoff,B.E. and de Garavilla,L. Potency variation of small-molecule chymase inhibitors across species Biochem Pharmacol (2010) 80, 1033-1041. PubMed Europe PubMed DOI I
Lang,Y.D., Chang,S.F., Wang,L.F. and Chen,C.M. Chymase mediates paraquat-induced collagen production in human lung fibroblasts Toxicol Lett (2010) 193, 19-25. PubMed Europe PubMed DOI
Maeda,Y., Inoguchi,T., Takei,R., Sawada,F., Sasaki,S., Fujii,M., Kobayashi,K., Urata,H., Nishiyama,A. and Takayanagi,R. Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters Am J Physiol Renal Physiol (2010) 299, F1328-F1338. PubMed Europe PubMed DOI I
Pat,B., Chen,Y., Killingsworth,C., Gladden,J.D., Shi,K., Zheng,J., Powell,P.C., Walcott,G., Ahmed,M.I., Gupta,H., Desai,R., Wei,C.C., Hase,N., Kobayashi,T., Sabri,A., Granzier,H., Denney,T., Tillson,M., Dillon,A.R., Husain,A. and Dell'Italia,L.J. Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation Circulation (2010) 122, 1488-1495. PubMed Europe PubMed DOI I
Pejler,G., Ronnberg,E., Waern,I. and Wernersson,S. Mast cell proteases: multifaceted regulators of inflammatory disease Blood (2010) 115, 4981-4990. PubMed Europe PubMed DOI V
Takai,S., Jin,D. and Miyazaki,M. Chymase as an important target for preventing complications of metabolic syndrome Curr Med Chem (2010) 17, 3223-3229. PubMed Europe PubMed T
Trivedi,N.N. and Caughey,G.H. Mast cell peptidases: chameleons of innate immunity and host defense Am J Respir Cell Mol Biol (2010) 42, 257-267. PubMed Europe PubMed DOI

2009

Andersson,M.K., Enoksson,M., Gallwitz,M. and Hellman,L. The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile Int Immunol (2009) 21, 95-104. PubMed Europe PubMed DOI P
Matsumoto,C., Hayashi,T., Kitada,K., Yamashita,C., Miyamura,M., Mori,T., Ukimura,A., Ohkita,M., Jin,D., Takai,S., Miyazaki,M., Okada,Y., Kitaura,Y. and Matsumura,Y. Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice Hypertension (2009) 54, 164-171. PubMed Europe PubMed DOI I
Raymond,W.W., Su,S., Makarova,A., Wilson,T.M., Carter,M.C., Metcalfe,D.D. and Caughey,G.H. Alpha2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity J Immunol (2009) 182, 5770-5777. PubMed Europe PubMed DOI PMC EPMC A

2008

Caughey,G.H., Beauchamp,J., Schlatter,D., Raymond,W.W., Trivedi,N.N., Banner,D., Mauser,H. and Fingerle,J. Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases J Biol Chem (2008) 283, 13943-13951. PubMed Europe PubMed DOI PMC EPMC P
D'Orleans-Juste,P., Houde,M., Rae,G.A., Bkaily,G., Carrier,E. and Simard,E. Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies Vascul Pharmacol (2008) 49, 51-62. PubMed Europe PubMed DOI I
Doggrell,S.A. Therapeutic potential of non-peptide chymase inhibitors Expert Opin Ther Pat (2008) 18, 485-499. DOI T I
Musch,W., Wege,A.K., Mannel,D.N. and Hehlgans,T. Generation and characterization of alpha-chymase-Cre transgenic mice Genesis (2008) 46, 163-166. PubMed Europe PubMed DOI
Reimer,J.M., Enoksson,M., Samollow,P.B. and Hellman,L. Extended substrate specificity of opossum chymase - implications for the origin of mast cell chymases Mol Immunol (2008) 45, 2116-2125. PubMed Europe PubMed DOI P
Sugimoto,M., Furuta,T., Kodaira,C., Nishino,M., Yamade,M., Ikuma,M., Sugimura,H. and Hishida,A. Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan J Gastroenterol (2008) 43, 751-761. PubMed Europe PubMed DOI M

2007

Chen,Z.Q., Huang,Z., He,T.W., Lu,T.T., Liang,X.D. and He,S.H. [Prokaryotic expression of human mast cell chymase gene and preparation of its polyclonal antibody] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2007) 23, 1025-1027. PubMed Europe PubMed E
Greco,M.N., Hawkins,M.J., Powell,E.T., Almond,H.R., Jr., de Garavilla,L., Hall,J., Minor,L.K., Wang,Y., Corcoran,T.W., Di Cera,E., Cantwell,A.M., Savvides,S.N., Damiano,B.P. and Maryanoff,B.E. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase J Med Chem (2007) 50, 1727-1730. PubMed Europe PubMed DOI I
Hamuro,T., Kido,H., Asada,Y., Hatakeyama,K., Okumura,Y., Kunori,Y., Kamimura,T., Iwanaga,S. and Kamei,S. Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis FEBS J (2007) 274, 3065-3077. PubMed Europe PubMed DOI P
Jin,D., Ueda,H., Takai,S., Muramatsu,M., Furubayashi,K., Ibaraki,T., Kishi,K., Katsuoka,Y. and Miyazaki,M. Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations Life Sci (2007) 81, 1291-1300. PubMed Europe PubMed DOI I
Maruoka,H., Muto,T., Tanaka,T., Imajo,S., Tomimori,Y., Fukuda,Y. and Nakatsuka,T. Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors Bioorg Med Chem Lett (2007) 17, 3435-3439. PubMed Europe PubMed DOI I
Tanaka,T., Muto,T., Maruoka,H., Imajo,S., Fukami,H., Tomimori,Y., Fukuda,Y. and Nakatsuka,T. Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors Bioorg Med Chem Lett (2007) 17, 3431-3434. PubMed Europe PubMed DOI I

2006

Bacani,C. and Frishman,W.H. Chymase: a new pharmacologic target in cardiovascular disease Cardiol Rev (2006) 14, 187-193. PubMed Europe PubMed DOI T
[YEAR:29-6-2006]Gallwitz,M., Reimer,J.M. and Hellman,L. Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution Immunogenetics (29-6-2006) 58, 655-669. PubMed Europe PubMed DOI
[YEAR:29-6-2006]Gallwitz,M. and Hellman,L. Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution Immunogenetics (29-6-2006) 58, 641-654. PubMed Europe PubMed DOI
Kanemitsu,H., Takai,S., Tsuneyoshi,H., Nishina,T., Yoshikawa,K., Miyazaki,M., Ikeda,T. and Komeda,M. Chymase inhibition prevents cardiac fibrosis and dysfunction after myocardial infarction in rats Hypertens Res (2006) 29, 57-64. PubMed Europe PubMed DOI I
[YEAR:27-1-2006]Kruit,A., Grutters,J.C., Ruven,H.J., Sato,H., Izumi,T., Nagai,S., Welsh,K.I., du Bois,R.M. and van den Bosch,J.M. Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients Respiration (27-1-2006) 73, 623-633. PubMed Europe PubMed DOI M
[YEAR:15-12-2006]Omoto,Y., Tokime,K., Yamanaka,K., Habe,K., Morioka,T., Kurokawa,I., Tsutsui,H., Yamanishi,K., Nakanishi,K. and Mizutani,H. Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment J Immunol (15-12-2006) 177, 8315-8319. PubMed Europe PubMed P
Shimatani,T., Hosotani,N., Ohnishi,M., Kumagai,K. and Saji,I. SPF-32629 A and B, novel human chymase inhibitors produced by Penicillium sp J Antibiot (Tokyo) (2006) 59, 29-34. PubMed Europe PubMed DOI I

2005

[YEAR:28-2-2005]de Garavilla,L., Greco,M.N., Sukumar,N., Chen,Z.W., Pineda,A.O., Mathews,F.S., Di Cera,E., Giardino,E.C., Wells,G.I., Haertlein,B.J., Kauffman,J.A., Corcoran,T.W., Derian,C.K., Eckardt,A.J., Damiano,B.P., Andrade-Gordon,P. and Maryanoff,B.E. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo J Biol Chem (28-2-2005) 280, 18001-18007. PubMed Europe PubMed DOI I
Leckie,B.J. Targeting the renin-angiotensin system: what's new? Curr Med Chem Cardiovasc Hematol Agents (2005) 3, 23-32. PubMed Europe PubMed DOI V
[YEAR:26-5-2005]Lockhart,B.E., Vencill,J.R., Felix,C.M. and Johnson,D.A. Recombinant human mast-cell chymase: an improved procedure for expression in Pichia pastoris and purification of the highly active enzyme Biotechnol Appl Biochem (26-5-2005) 41, 89-95. PubMed Europe PubMed DOI
[YEAR:26-2-2005]Nishio,H., Takai,S., Miyazaki,M., Horiuchi,H., Osawa,M., Uemura,K., Yoshida,K., Mukaida,M., Ueno,Y. and Suzuki,K. Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis Int J Legal Med (26-2-2005) 119, 331-334. PubMed Europe PubMed DOI
Sharma,S., Rajan,U.M., Kumar,A., Soni,A. and Ghosh,B. A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels J Hum Genet (2005) 50, 276-282. PubMed Europe PubMed DOI M
Weidinger,S., Rummler,L., Klopp,N., Wagenpfeil,S., Baurecht,H.J., Fischer,G., Holle,R., Gauger,A., Schafer,T., Jakob,T., Ollert,M., Behrendt,H., Wichmann,H.E., Ring,J. and Illig,T. Association study of mast cell chymase polymorphisms with atopy Allergy (2005) 60, 1256-1261. PubMed Europe PubMed DOI M

2004

Alagille,D., Pfeiffer,B., Scalbert,E., Ferry,G., Boutin,J.A., Renard,P. and Viaud-Massuard,M.C. Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors J Enzyme Inhib Med Chem (2004) 19, 137-143. PubMed Europe PubMed DOI I
Caughey,G.H. Chymases [ISSN:0-12-079610-4] (2004) 2, 1531-1535. V
[YEAR:1-3-2004]Doggrell,S.A. and Wanstall,J.C. Vascular chymase: pathophysiological role and therapeutic potential of inhibition Cardiovasc Res (1-3-2004) 61, 653-662. PubMed Europe PubMed DOI I
Jin,D., Takai,S., Okamoto,Y., Muramatsu,M. and Miyazaki,M. Chymase-derived angiotensin II and arrhythmias after myocardial infarction Nippon Yakurigaku Zasshi (2004) 124, 77-82. PubMed Europe PubMed DOI
[YEAR:12-2-2004]Maryanoff,B.E. Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G J Med Chem (12-2-2004) 47, 769-787. PubMed Europe PubMed DOI I
Takai,S., Jin,D., Muramatsu,M. and Miyazaki,M. Chymase as a novel target for the prevention of vascular diseases Trends Pharmacol Sci (2004) 25, 518-522. PubMed Europe PubMed DOI
[YEAR:6-10-2004]Takai,S., Jin,D., Muramatsu,M., Okamoto,Y. and Miyazaki,M. Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis Eur J Pharmacol (6-10-2004) 501, 1-8. PubMed Europe PubMed DOI I
Takai,S., Jin,D., Sakaguchi,M. and Miyazaki,M. A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins J Pharmacol Sci (2004) 94, 443-448. PubMed Europe PubMed DOI I

2003

Hoshino,F., Urata,H., Inoue,Y., Saito,Y., Yahiro,E., Ideishi,M., Arakawa,K. and Saku,K. Chymase inhibitor improves survival in hamsters with myocardial infarction J Cardiovasc Pharmacol (2003) 41 Suppl 1, S11-S18. PubMed Europe PubMed I
Huang,X.R., Chen,W.Y., Truong,L.D. and Lan,H.Y. Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease J Am Soc Nephrol (2003) 14, 1738-1747. PubMed Europe PubMed DOI
Koga,T., Urata,H., Inoue,Y., Hoshino,T., Okamoto,T., Matsunaga,A., Suzuki,M., Miyazaki,J., Ideishi,M., Arakawa,K. and Saku,K. Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy Hypertens Res (2003) 26, 759-768. PubMed Europe PubMed DOI
[YEAR:6-1-2003]Koide,Y., Tatsui,A., Hasegawa,T., Murakami,A., Satoh,S., Yamada,H., Kazayama,S. and Takahashi,A. Identification of a stable chymase inhibitor using a pharmacophore-based database search Bioorg Med Chem Lett (6-1-2003) 13, 25-29. PubMed Europe PubMed DOI I
Leskinen,M.J., Lindstedt,K.A., Wang,Y. and Kovanen,P.T. Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions Arterioscler Thromb Vasc Biol (2003) 23, 238-243. PubMed Europe PubMed DOI
[YEAR:17-11-2003]Masaki,H., Mizuno,Y., Tatui,A., Murakami,A., Koide,Y., Satoh,S. and Takahashi,A. Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors Bioorg Med Chem Lett (17-11-2003) 13, 4085-4088. PubMed Europe PubMed DOI I
[YEAR:27-5-2003]Matsumoto,T., Wada,A., Tsutamoto,T., Ohnishi,M., Isono,T. and Kinoshita,M. Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure Circulation (27-5-2003) 107, 2555-2558. PubMed Europe PubMed DOI
[YEAR:5-9-2003]Raymond,W.W., Ruggles,S.W., Craik,C.S. and Caughey,G.H. Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site J Biol Chem (5-9-2003) 278, 34517-34524. PubMed Europe PubMed DOI P
[YEAR:11-3-2003]Reiling,K.K., Krucinski,J., Miercke,L.J., Raymond,W.W., Caughey,G.H. and Stroud,R.M. Structure of human pro-chymase: a model for the activating transition of granule-associated proteases Biochemistry (11-3-2003) 42, 2616-2624. PubMed Europe PubMed DOI S
Takai,S., Sakonjo,H., Fukuda,K., Jin,D., Sakaguchi,M., Kamoshita,K., Ishida,K., Sukenaga,Y. and Miyazaki,M. A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury J Pharmacol Exp Ther (2003) 304, 841-844. PubMed Europe PubMed DOI I

2002

[YEAR:15-7-2002]Lazaar,A.L., Plotnick,M.I., Kucich,U., Crichton,I., Lotfi,S., Das,S.K., Kane,S., Rosenbloom,J., Panettieri,R.A., Jr., Schechter,N.M. and Pure,E. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells J Immunol (15-7-2002) 169, 1014-1020. PubMed Europe PubMed
[YEAR:29-4-2002]Muilenburg,D.J., Raymond,W.W., Wolters,P.J. and Caughey,G.H. Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase Biochim Biophys Acta (29-4-2002) 1596, 346-356. PubMed Europe PubMed DOI
Murakami,Y., Takei,M., Shindo,K., Kitazume,C., Tanaka,J., Higa,T. and Fukamachi,H. Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge J Nat Prod (2002) 65, 259-261. PubMed Europe PubMed DOI I
[YEAR:4-10-2002]Muramatsu,M., Yamada,M., Takai,S. and Miyazaki,M. Suppression of basic fibroblast growth factor-induced angiogenesis by a specific chymase inhibitor, BCEAB, through the chymase-angiotensin-dependent pathway in hamster sponge granulomas Br J Pharmacol (4-10-2002) 137, 554-560. PubMed Europe PubMed DOI PMC EPMC I
Okamoto,Y., Takai,S., Yamada,M. and Miyazaki,M. Chymase inhibitors may prevent postoperative adhesion formation Fertil Steril (2002) 77, 1044-1048. PubMed Europe PubMed DOI I
[YEAR:13-2-2002]Solivan,S., Selwood,T., Wang,Z.M. and Schechter,N.M. Evidence for diversity of substrate specificity among members of the chymase family of serine proteases FEBS Lett (13-2-2002) 512, 133-138. PubMed Europe PubMed DOI P
Suzuki,T., Kaki,H., Naya,S., Murayama,S., Tatsui,A., Nagai,A., Takai,S. and Miyazaki,M. Recombinant human chymase produced by silkworm-baculovirus expression system: its application for a chymase detection kit Jpn J Pharmacol (2002) 90, 210-213. PubMed Europe PubMed DOI E

2001

Aoyama,Y., Uenaka,M., Kii,M., Tanaka,M., Konoike,T., Hayasaki-Kajiwara,Y., Naya,N. and Nakajima,M. Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors Bioorg Med Chem (2001) 9, 3065-3075. PubMed Europe PubMed DOI I
[YEAR:9-7-2001]Aoyama,Y., Konoike,T., Kanda,A., Naya,N. and Nakajima,M. Total synthesis of human chymase inhibitor methyllinderone and structure-activity relationships of its derivatives Bioorg Med Chem Lett (9-7-2001) 11, 1695-1697. PubMed Europe PubMed DOI I
Ferry,G., Gillet,L., Bruneau,V., Banales,J.M., Beauverger,P., Coge,F., Galizzi,J.P., Scalbert,E., Okamoto,T., Urata,H. and Boutin,J.A. Development of new assays and improved procedures for the purification of recombinant human chymase Eur J Biochem (2001) 268, 5885-5893. PubMed Europe PubMed DOI A E
Frank,B.T., Rossall,J.C., Caughey,G.H. and Fang,K.C. Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase J Immunol (2001) 166, 2783-2792. PubMed Europe PubMed
Neumann,U., Schechter,N.M. and Gutschow,M. Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones Bioorg Med Chem (2001) 9, 947-954. PubMed Europe PubMed DOI I

2000

[YEAR:6-11-2000]Aoyama,Y., Uenaka,M., Konoike,T., Iso,Y., Nishitani,Y., Kanda,A., Naya,N. and Nakajima,M. 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma Bioorg Med Chem Lett (6-11-2000) 10, 2403-2406. PubMed Europe PubMed I
[YEAR:14-7-2000]Caughey,G.H., Raymond,W.W. and Wolters,P.J. Angiotensin II generation by mast cell alpha- and beta-chymases Biochim Biophys Acta (14-7-2000) 1480, 245-257. PubMed Europe PubMed DOI
[YEAR:7-2-2000]Hayashi,Y., Iijima,K., Katada,J. and Kiso,Y. Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors Bioorg Med Chem Lett (7-2-2000) 10, 199-201. PubMed Europe PubMed DOI I
[YEAR:15-3-2000]Nakakubo,H., Fukuyama,H., Nakajima,M., Imada,T., Uno,S., Shiota,N., Takai,S., Miyazaki,M. and Nakamura,N. Secretory production of recombinant human chymase as an active form in Pichia pastoris Yeast (15-3-2000) 16, 315-323. PubMed Europe PubMed DOI E
Nakakubo,H., Morita,M., Imada,T., Takai,S., Shiota,N., Miyazaki,M. and Nakamura,N. Functional reconstitution of an active recombinant human chymase from Pichia pastoris cell lysate Yeast (2000) 16, 1387-1396. PubMed Europe PubMed DOI E
Takai,S., Sumi,S., Aoike,M., Sakaguchi,M., Itoh,Y., Jin,D., Matsumura,E. and Miyazaki,M. Characterization of recombinant human chymase expressed in Escherichia coli Jpn J Pharmacol (2000) 82, 144-149. PubMed Europe PubMed DOI E

1999

[YEAR:2-8-1999]Groutas,W.C., Schechter,N.M., He,S., Yu,H., Huang,P. and Tu,J. Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold Bioorg Med Chem Lett (2-8-1999) 9, 2199-2204. PubMed Europe PubMed DOI I
[YEAR:12-2-1999]Pereira,P.J., Wang,Z.M., Rubin,H., Huber,R., Bode,W., Schechter,N.M. and Strobl,S. The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity J Mol Biol (12-2-1999) 286, 163-173. PubMed Europe PubMed DOI S I
[YEAR:10-8-1999]Takai,S., Jin,D., Sakaguchi,M. and Miyazaki,M. Chymase-dependent angiotensin II formation in human vascular tissue Circulation (10-8-1999) 100, 654-658. PubMed Europe PubMed
[YEAR:15-8-1999]Walter,M., Sutton,R.M. and Schechter,N.M. Highly efficient inhibition of human chymase by alpha(2)-macroglobulin Arch Biochem Biophys (15-8-1999) 368, 276-284. PubMed Europe PubMed DOI

1998

Eda,M., Ashimori,A., Akahoshi,F., Yoshimura,T., Inoue,Y., Fukaya,C., Nakajima,M., Fukuyama,H., Imada,T., Takai,S., Shiota,N., Miyazaki,M. and Nakamura,N. Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site Bioorg Med Chem Lett (1998) 8, 919-924. PubMed Europe PubMed DOI I
[YEAR:15-7-1998]Shiota,N., Fukamizu,A., Okunishi,H., Takai,S., Murakami,K. and Miyazaki,M. Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts Biochem J (15-7-1998) 333, 417-424. PubMed Europe PubMed PMC EPMC
Wang,Z., Walter,M., Selwood,T., Rubin,H. and Schechter,N.M. Recombinant expression of human mast cell proteases chymase and tryptase Biol Chem (1998) 379, 167-174. PubMed Europe PubMed E

1997

[YEAR:1-11-1997]Caughey,G.H., Blount,J.L., Koerber,K.L., Kitamura,M. and Fang,K.C. Cloning and expression of the dog mast cell alpha-chymase gene J Immunol (1-11-1997) 159, 4367-4375. PubMed Europe PubMed
Fang,K.C., Raymond,W.W., Blount,J.L. and Caughey,G.H. Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain J Biol Chem (1997) 272, 25628-25635. PubMed Europe PubMed DOI
[YEAR:25-11-1997]McGrath,M.E., Mirzadegan,T. and Schmidt,B.F. Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A Biochemistry (25-11-1997) 36, 14318-14324. PubMed Europe PubMed DOI S
McGrath,M.E., Osawa,A.E., Barnes,M.G., Clark,J.M., Mortara,K.D. and Schmidt,B.F. Production of crystallizable human chymase from a Bacillus subtilis system FEBS Lett (1997) 413, 486-488. PubMed Europe PubMed DOI S

1995

Bastos,M., Maeji,N.J. and Abeles,R.H. Inhibitors of human heart chymase based on a peptide library Proc Natl Acad Sci U S A (1995) 92, 6738-6742. PubMed Europe PubMed DOI PMC EPMC I
Wang,Z.M., Rubin,H. and Schechter,N.M. Production of active recombinant human chymase from a construct containing the enterokinase cleavage site of trypsinogen in place of the native propeptide sequence Biol Chem Hoppe Seyler (1995) 376, 681-684. PubMed Europe PubMed E

1994

Huang,R. and Hellman,L. Genes for mast-cell serine protease and their molecular evolution Immunogenetics (1994) 40, 397-414. PubMed Europe PubMed

1993

Caughey,G.H., Schaumberg,T.H., Zerweck,E.H., Butterfield,J.H., Hanson,R.D., Silverman,G.A. and Ley,T.J. The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression Genomics (1993) 15, 614-620. PubMed Europe PubMed DOI
Gurish,M.F., Nadeau,J.H., Johnson,K.R., McNeil,H.P., Grattan,K.M., Austen,K.F. and Stevens,R.L. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14 J Biol Chem (1993) 268, 11372-11379. PubMed Europe PubMed

1991

Caughey,G.H., Zerweck,E.H. and Vanderslice,P. Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase J Biol Chem (1991) 266, 12956-12963. PubMed Europe PubMed
Urata,H., Kinoshita,A., Perez,D.M., Misono,K.S., Bumpus,F.M., Graham,R.M. and Husain,A. Cloning of the gene and cDNA for human heart chymase J Biol Chem (1991) 266, 17173-17179. PubMed Europe PubMed

1990

Caughey,G.H., Raymond,W.W. and Vanderslice,P. Dog mast cell chymase: molecular cloning and characterization Biochemistry (1990) 29, 5166-5171. PubMed Europe PubMed
Nelson,R.B. and Siman,R. Clipsin, a chymotrypsin-like protease in rat brain which is irreversibly inhibited by alpha-1-antichymotrypsin J Biol Chem (1990) 265, 3836-3843. PubMed Europe PubMed
Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and Serafin,W.E. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases Proc Natl Acad Sci U S A (1990) 87, 3230-3234. PubMed Europe PubMed PMC EPMC

1988

Caughey,G.H., Viro,N.F., Calonico,L.D., McDonald,D.M., Lazarus,S.C. and Gold,W.M. Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining J Histochem Cytochem (1988) 36, 1053-1060. PubMed Europe PubMed
Caughey,G.H., Lazarus,S.C., Viro,N.F., Gold,W.M. and Nadel,J.A. Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines Immunology (1988) 63, 339-344. PubMed Europe PubMed PMC EPMC
Schechter,N.M., Slavin,D., Fetter,R.D., Lazarus,G.S. and Fraki,J.E. Purification and identification of two serine class proteinases from dog mast cells biochemically and immunologically similar to human proteinases tryptase and chymase Arch Biochem Biophys (1988) 262, 232-244. PubMed Europe PubMed

1987

Sayama,S., Iozzo,R.V., Lazarus,G.S. and Schechter,N.M. Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans J Biol Chem (1987) 262, 6808-6815. PubMed Europe PubMed

1986

Johnson,L.A., Moon,K.E. and Eisenberg,M. Purification to homogeneity of the human skin chymotryptic proteinase "chymase" Anal Biochem (1986) 155, 358-364. PubMed Europe PubMed

1985

[YEAR:9-4-1985]Powers,J.C., Tanaka,T., Harper,J.W., Minematsu,Y., Barker,L., Lincoln,D., Crumley,K.V., Fraki,J.E., Schechter,N.M., Lazarus,G.G., Nakajima,K., Nakashino,K., Neurath,H. and Woodbury,R.G. Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors Biochemistry (9-4-1985) 24, 2048-2058. PubMed Europe PubMed I

1983

Schechter,N.M., Fraki,J.E., Geesin,J.C. and Lazarus,G.S. Human skin chymotryptic proteinase. Isolation and relation to cathepsin G and rat mast cell proteinase I J Biol Chem (1983) 258, 2973-2978. PubMed Europe PubMed

1979

Everitt,M.T. and Neurath,H. Purification and partial characterization of an alpha-chymotrypsin-like protease of rat peritoneal mast cells Biochimie (1979) 61, 653-662. PubMed Europe PubMed