Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.243: lumbrokinase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Liao,J., Ren,X., Yang,B., Li,H., Zhang,Y. and Yin,Z. \<br\>Targeted thrombolysis by using c-RGD-modified N,N,N-trimethyl chitosan nanoparticles loaded with lumbrokinase\<br\>Drug Dev Ind Pharm (2019) 45, 88-95. PubMed  Europe PubMed DOI  U
    2. 2018
  2. Akazawa,S.I., Tokuyama,H., Sato,S., Watanabe,T., Shida,Y. and Ogasawara,W. \<br\>High-pressure tolerance of earthworm fibrinolytic and digestive enzymes\<br\>J Biosci Bioeng (2018) 125, 155-159. PubMed  Europe PubMed DOI
  3. Hu,B., Yan,Y., Tong,F., Xu,L., Zhu,J., Xu,G. and Shen,R. \<br\>Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer\<br\>Int J Nanomedicine (2018) 13, 3625-3640. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Wang,Y.H., Li,S.A., Huang,C.H., Su,H.H., Chen,Y.H., Chang,J.T. and Huang,S.S. \<br\>Sirt1 activation by post-ischemic treatment with lumbrokinase protects against myocardial ischemia-reperfusion injury\<br\>Front Pharmacol (2018) 9, 636. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2017
  5. Dickey,A., Wang,N., Cooper,E., Tull,L., Breedlove,D., Mason,H., Liu,D. and Wang,K.Y. \<br\>Transient expression of lumbrokinase (PI239) in tobacco (Nicotiana tabacum) using a geminivirus-based single replicon system dissolves fibrin and blood clots\<br\>Evid Based Complement Alternat Med (2017) 2017, 6093017. PubMed  Europe PubMed DOI  PMC  EPMC  E
  6. Jin,M., Jin,G., Huang,W. and Gao,Z. \<br\>PEGylation of lumbrokinase improves pharmacokinetic profile and enhances antithrombotic effect in a rat carotid artery thrombosis model\<br\>Mol Med Report (2017) 16, 4909-4914. PubMed  Europe PubMed DOI  U
  7. Verma,M.K. and Pulicherla,K.K. \<br\>Broad substrate affinity and catalytic diversity of fibrinolytic enzyme from Pheretima posthumous. Purification and molecular characterization study\<br\>Int J Biol Macromol (2017) 95, 1011-1021. PubMed  Europe PubMed DOI
    8. 2015
  8. Fu,Y.T., Sheu,S.Y., Chen,Y.S., Chen,K.Y. and Yao,C.H. \<br\>Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair\<br\>Bone (2015) 78, 15-22. PubMed  Europe PubMed DOI  U
  9. Lee,H.C., Hsu,Y.M., Tsai,C.C., Ke,C.J., Yao,C.H. and Chen,Y.S. \<br\>Improved peripheral nerve regeneration in streptozotocin-induced diabetic rats by oral lumbrokinase\<br\>Am J Chin Med (2015) 43, 215-230. PubMed  Europe PubMed DOI
    10. 2014
  10. Guan,C., Ji,J., Jin,C., Wang,G., Li,X. and Guan,W. \<br\>Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis\<br\>Biotechnol Prog (2014) 30, 1029-1039. PubMed  Europe PubMed DOI
    11. 2013
  11. Cao,Y.J., Zhang,X., Wang,W.H., Zhai,W.Q., Qian,J.F., Wang,J.S., Chen,J., You,N.X., Zhao,Z., Wu,Q.Y., Xu,Y., Yuan,L., Li,R.X. and Liu,C.F. \<br\>Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial\<br\>Chin Med J (Engl) (2013) 126, 4060-4065. PubMed  Europe PubMed DOI  U
  12. Joo,H.S., Ra,K.S., Park,H.S. and Choi,J.W. \<br\>Molecular cloning and functional expression of a fibrinolytic protease gene from the polychaeta, Periserrula leucophryna\<br\>Biotechnol Bioprocess Eng (2013) 18, 209-217. DOI
  13. Wang,K.Y., Tull,L., Cooper,E., Wang,N. and Liu,D. \<br\>Recombinant protein production of earthworm lumbrokinase for potential antithrombotic application\<br\>Evid Based Complement Alternat Med (2013) 2013, 783971. PubMed  Europe PubMed DOI  PMC  EPMC  E
    14. 2012
  14. Wang,Y.Y., Fu,W.L., Wang,M., Zou,M.J., Xu,T., Wang,J.X., Zhang,H. and Xu,D.G. \<br\>[Quantitative method for detection of plasma lumbrokinase content and its assessment]\<br\>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2012) 20, 1492-1495. PubMed  Europe PubMed  A
  15. Zhou,Y. and He,R.Q. \<br\>Earthworm fibrinolytic enzymes\<br\>[ISSN:978-0-12-407742-3] (2012) 3, 2953-2958. DOI
    16. 2011
  16. Pan,R., Zhou,Y., He,H.J. and He,R.Q. \<br\>An enzyme from the earthworm Eisenia fetida is not only a protease but also a deoxyribonuclease\<br\>Biochem Biophys Res Commun (2011) 407, 113-117. PubMed  Europe PubMed DOI
  17. Sharma,A., Sonah,H., Deshmukh,R.K., Gupta,N.K., Singh,N.K. and Sharma,T.R. \<br\>Cloning of fibrinolytic protease-0 (Efp-0) gene from diverse earthworm individuals\<br\>Indian J Biotechnol (2011) 10, 270-273.
  18. Ueda,M., Yamashita,T., Nakazawa,M., Miyatake,K., Ohki,S., Sakaguchi,M. and Inouye,K. \<br\>Purification and characterization of a new serine protease (EF-SP2) with anti-plant viral activity from Eisenia foetida: analysis of anti-plant viral activity of EF-SP2\<br\>Process Biochem (2011) 46, 1711-1716. DOI
    19. 2010
  19. Xu,Z.R., Yang,Y.M., Gui,Q.F., Zhang,L.N. and Hu,L. \<br\>Expression, purification, and characterization of recombinant lumbrokinase PI239 in Escherichia coli\<br\>Protein Expr Purif (2010) 69, 198-203. PubMed  Europe PubMed DOI  E
  20. Yan,X.M., Kim,C.H., Lee,C.K., Shin,J.S., Cho,I.H. and Sohn,U.D. \<br\>Intestinal absorption of fibrinolytic and proteolytic lumbrokinase extracted from earthworm, Eisenia andrei\<br\>Korean J Physiol Pharmacol (2010) 14, 71-75. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2007
  21. Zhao,J., Xiao,R., He,J., Pan,R., Fan,R., Wu,C., Liu,X., Liu,Y. and He,R.Q. \<br\>In situ localization and substrate specificity of earthworm protease-II and protease-III-1 from Eisenia fetida\<br\>Int J Biol Macromol (2007) 40, 67-75. PubMed  Europe PubMed DOI
  22. Zhao,J., Pan,R., He,J., Liu,Y., Li,D.F. and He,R.Q. \<br\>Eisenia fetida protease-III-1 functions in both fibrinolysis and fibrogenesis\<br\>J Biomed Biotechnol (2007) 2007, 97654. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2006
  23. Zhao,X.Y., Gao,S., Cui,D.L. and Geng,F.T. \<br\>[In silico cloning of EfP-0, a novel earthworm fibrinolytic enzyme gene and verification of its coding region by RT-PCR]\<br\>Sheng Wu Gong Cheng Xue Bao (2006) 22, 897-901. PubMed  Europe PubMed DOI
    24. 2005
  24. [YEAR:6-5-2005]Wang,F., Wang,C., Li,M., Zhang,J.P., Gui,L.L., An,X.M. and Chang,W.R. \<br\>Crystal structure of earthworm fibrinolytic enzyme component B: a novel, glycosylated two-chained trypsin\<br\>J Mol Biol (6-5-2005) 348, 671-685. PubMed  Europe PubMed DOI  S
    25. 2004
  25. [YEAR:30-9-2004]Cho,I.H., Choi,E.S. and Lee,H.H. \<br\>Molecular cloning, sequencing, and expression of a fibrinolytic serine-protease gene from the earthworm Lumbricus rubellus\<br\>J Biochem Mol Biol (30-9-2004) 37, 574-581. PubMed  Europe PubMed
  26. Cho,I.H., Choi,E.S., Lim,H.G. and Lee,H.H. \<br\>Purification and characterization of six fibrinolytic serine-proteases from earthworm Lumbricus rubellus\<br\>J Biochem Mol Biol (2004) 37, 199-205. PubMed  Europe PubMed
  27. Dong,G.Q., Yuan,X.L., Shan,Y.J., Zhao,Z.H., Chen,J.P. and Cong,Y.W. \<br\>Molecular cloning and characterization of cDNA encoding fibrinolytic enzyme-3 from earthworm Eisenia foetida\<br\>Acta Biochim Biophys Sin (Shanghai) (2004) 36, 303-308. PubMed  Europe PubMed
  28. Nakajima,N., Ishihara,K. and Sugimoto,M. \<br\>Earthworm fibrinolytic enzymes\<br\>[ISSN:0-12-079610-4] (2004) 2, 1689-1691.  V
    29. 2002
  29. Nakajima,N., Ishihara,K., Sugimoto,M., Nakahara,T. and Tsuji,H. \<br\>Further stabilization of earthworm serine protease by chemical modification and immobilization\<br\>Biosci Biotechnol Biochem (2002) 66, 2739-2742. PubMed  Europe PubMed DOI
    30. 2001
  30. [YEAR:15-6-2001]Fan,Q., Wu,C., Li,L., Fan,R., Wu,C., Hou,Q.M. and He,R.Q. \<br\>Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus\<br\>Biochim Biophys Acta (15-6-2001) 1526, 286-292. PubMed  Europe PubMed DOI
  31. Sugimoto,M. and Nakajima,N. \<br\>Molecular cloning, sequencing, and expression of cDNA encoding serine protease with fibrinolytic activity from earthworm\<br\>Biosci Biotechnol Biochem (2001) 65, 1575-1580. PubMed  Europe PubMed DOI
    32. 2000
  32. Jin,L., Jin,H., Zhang,G. and Xu,G. \<br\>Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase\<br\>Clin Hemorheol Microcirc (2000) 23, 213-218. PubMed  Europe PubMed
    33. 1999
  33. Nakajima,N., Sugimoto,M., Ishihara,K., Nakamura,K. and Hamada,H. \<br\>Further characterization of earthworm serine proteases: cleavage specificity against peptide substrates and on autolysis\<br\>Biosci Biotechnol Biochem (1999) 63, 2031-2033. PubMed  Europe PubMed DOI
  34. Park,Y., Ryu,E., Kim,H., Jeong,J., Kim,J., Shim,J., Jeon,S., Jo,Y., Kim,W. and Min,B. \<br\>Characterization of antithrombotic activity of lumbrokinase-immobilized polyurethane valves in the total artificial heart\<br\>Artif Organs (1999) 23, 210-214. PubMed  Europe PubMed DOI
    35. 1996
  35. Nakajima,N., Ishihara,K., Sugimoto,M., Sumi,H., Mikuni,K. and Hamada,H. \<br\>Chemical modification of earthworm fibrinolytic enzyme with human serum albumin fragment and characterization of the protease as a therapeutic enzyme\<br\>Biosci Biotechnol Biochem (1996) 60, 293-300. PubMed  Europe PubMed DOI
    36. 1995
  36. Ryu,G.H., Han,D.K., Park,S., Kim,M., Kim,Y.H. and Min,B. \<br\>Surface characteristics and properties of lumbrokinase-immobilized polyurethane\<br\>J Biomed Mater Res (1995) 29, 403-409. PubMed  Europe PubMed DOI
    37. 1994
  37. Ryu,G.H., Park,S., Kim,M., Han,D.K., Kim,Y.H. and Min,B. \<br\>Antithrombogenicity of lumbrokinase-immobilized polyurethane\<br\>J Biomed Mater Res (1994) 28, 1069-1077. PubMed  Europe PubMed DOI
    38. 1993
  38. Kim,J.S., Kang,J.K., Chang,H.C., Lee,M., Kim,G.S., Lee,D.K., Kim,S.T., Kim,M. and Park,S. \<br\>The thrombolytic effect of lumbrokinase is not as potent as urokinase in a rabbit cerebral embolism model\<br\>J Korean Med Sci (1993) 8, 117-120. PubMed  Europe PubMed
  39. Nakajima,N., Mihara,H. and Sumi,H. \<br\>Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus\<br\>Biosci Biotechnol Biochem (1993) 57, 1726-1730. PubMed  Europe PubMed DOI
  40. Ryu,G.H., Park,S., Han,D.K., Kim,Y.H. and Min,B. \<br\>Antithrombotic activity of a lumbrokinase immobilized polyurethane surface\<br\>ASAIO J (1993) 39, M314-M318. PubMed  Europe PubMed DOI
    41. 1991
  41. Mihara,H., Sumi,H., Yoneta,T., Mizumoto,H., Ikeda,R., Seiki,M. and Maruyama,M. \<br\>A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus\<br\>Jpn J Physiol (1991) 41, 461-472. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2023 EBI
Terms of use