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Literature for peptidase S08.044: subtilisin NAT

Summary Alignment Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Modi,A., Raval,I., Doshi,P., Joshi,M., Joshi,C. and Patel,A.K. \<br\>Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM\<br\>Protein Expr Purif (2023) 203, 106198. PubMed  Europe PubMed DOI
  2. Suzuki,K., Nakamura,M., Sato,N., Futamura,K., Matsunaga,K. and Yagami,A. \<br\>Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto\<br\>Allergol Int (2023) 72, 279-285. PubMed  Europe PubMed DOI
    3. 2021
  3. Xiao,S., Hu,D., Gao,Y., Ai,Y., Luo,S., Chen,S., Wang,B., Zhou,L., Dong,Y. and Wang,Y. \<br\>Safety assessment of subtilisin QK in rats\<br\>BMC Pharmacol Toxicol (2021) 22, 38. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Yang,M., Wu,J., Huang,Q. and Jia,Y. \<br\>Probing the Role of Catalytic Triad on the Cleavage between Intramolecular Chaperone and NK Mature Peptide\<br\>J Agric Food Chem (2021) 69, 2348-2353. PubMed  Europe PubMed DOI
    5. 2020
  5. Song,X., Yang,Y., Liang,N., Yang,F., Chen,S., Zhou,L., Zhou,K. and Wang,Y. \<br\>Quantitative pharmacokinetic evaluation of subtilisin QK-2 after a bolus IV injection in a rat model using a novel sandwich enzyme-linked immunosorbent assay\<br\>J Pharm Biomed Anal (2020) 186, 113264. PubMed  Europe PubMed DOI
    6. 2019
  6. Liu,Z., Zheng,W., Ge,C., Cui,W., Zhou,L. and Zhou,Z. \<br\>High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters\<br\>BMC Microbiol (2019) 19, 89. PubMed  Europe PubMed DOI  PMC  EPMC  E
  7. Liu,Z., Zhao,H., Han,L., Cui,W., Zhou,L. and Zhou,Z. \<br\>Improvement of the acid resistance, catalytic efficiency, and thermostability of nattokinase by multisite-directed mutagenesis\<br\>Biotechnol Bioeng (2019) 116, 1833-1843. PubMed  Europe PubMed DOI
  8. Pan,X., Liang,P., Teng,L., Ren,Y., Peng,J., Liu,W. and Yang,Y. \<br\>Study on molecular mechanisms of nattokinase in pharmacological action based on label-free liquid chromatography-tandem mass spectrometry\<br\>Food Sci Nutr (2019) 7, 3185-3193. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Sharma,C., Salem,G.E.M., Sharma,N., Gautam,P. and Singh,R. \<br\>Thrombolytic potential of novel thiol-dependent fibrinolytic protease from Bacillus cereus RSA1\<br\>Biomolecules (2019) 10, PubMed  Europe PubMed DOI
  10. Wu,H., Wang,H., Xu,F., Chen,J., Duan,L. and Zhang,F. \<br\>Acute toxicity and genotoxicity evaluations of Nattokinase, a promising agent for cardiovascular diseases prevention\<br\>Regul Toxicol Pharmacol (2019) 103, 205-209. PubMed  Europe PubMed DOI  U
    11. 2018
  11. Cui,W., Suo,F., Cheng,J., Han,L., Hao,W., Guo,J. and Zhou,Z. \<br\>Stepwise modifications of genetic parts reinforce the secretory production of nattokinase in Bacillus subtilis\<br\>Microb Biotechnol (2018) 11, 930-942. PubMed  Europe PubMed DOI
  12. Mohammadi,F., Nezafat,N., Berenjian,A., Negahdaripour,M., Zamani,M., Ghoshoon,M.B., Morowvat,M.H., Hemmati,S. and Ghasemi,Y. \<br\>Extracellular production of a potent and chemically resistant nattokinase in immobilized Escherichia coli using response surface methodology\<br\>Curr Pharm Biotechnol (2018) 19, 856-868. PubMed  Europe PubMed DOI
  13. Wu,C., Gao,C., Lu,S., Xu,X., Wen,N., Zhang,S. and Liu,M. \<br\>Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis\<br\>J Biomed Mater Res A (2018) 106, 440-449. PubMed  Europe PubMed DOI  U
    14. 2017
  14. Cai,D., Zhu,C. and Chen,S. \<br\>Microbial production of nattokinase: current progress, challenge and prospect\<br\>World J Microbiol Biotechnol (2017) 33, 84. PubMed  Europe PubMed DOI  E
  15. Selvarajan,E. \<br\>Nattokinase: an updated critical review on challenges and perspectives\<br\>Cardiovasc Hematol Agents Med Chem (2017) PubMed  Europe PubMed DOI  V  U
    16. 2016
  16. Lampe,B.J. and English,J.C. \<br\>Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto\<br\>Food Chem Toxicol (2016) 88, 87-99. PubMed  Europe PubMed DOI
  17. Mao,R., Zhou,K., Han,Z. and Wang,Y. \<br\>Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles\<br\>Microb Cell Fact (2016) 15, 80. PubMed  Europe PubMed DOI  PMC  EPMC  E
  18. Wei,G., Tian,N., Siezen,R., Schuppan,D. and Helmerhorst,E.J. \<br\>Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease\<br\>Am J Physiol Gastrointest Liver Physiol (2016) 311, G571-G580. PubMed  Europe PubMed DOI
    19. 2015
  19. Hitosugi,M., Hamada,K. and Misaka,K. \<br\>Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases\<br\>Int J Gen Med (2015) 8, 41-46. PubMed  Europe PubMed DOI  PMC  EPMC  U
  20. Wei,X., Zhou,Y., Chen,J., Cai,D., Wang,D., Qi,G. and Chen,S. \<br\>Efficient expression of nattokinase in Bacillus licheniformis: host strain construction and signal peptide optimization\<br\>J Ind Microbiol Biotechnol (2015) 42, 287-295. PubMed  Europe PubMed DOI  E
  21. Weng,M., Deng,X., Bao,W., Zhu,L., Wu,J., Cai,Y., Jia,Y., Zheng,Z. and Zou,G. \<br\>Improving the activity of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation\<br\>Biochem Biophys Res Commun (2015) 465, 580-586. PubMed  Europe PubMed DOI
    22. 2014
  22. Dabbagh,F., Negahdaripour,M., Berenjian,A., Behfar,A., Mohammadi,F., Zamani,M., Irajie,C. and Ghasemi,Y. \<br\>Nattokinase: production and application\<br\>Appl Microbiol Biotechnol (2014) 98, 9199-9206. PubMed  Europe PubMed DOI
  23. Jia,Y., Cao,X., Deng,Y., Bao,W., Tang,C., Ding,H., Zheng,Z. and Zou,G. \<br\>Four residues of propeptide are essential for precursor folding of nattokinase\<br\>Acta Biochim Biophys Sin (Shanghai) (2014) 46, 957-964. PubMed  Europe PubMed DOI
  24. Xu,J., Du,M., Yang,X., Chen,Q., Chen,H. and Lin,D.H. \<br\>Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis\<br\>Acta Haematol (2014) 132, 247-253. PubMed  Europe PubMed DOI  U
    25. 2013
  25. Yanagisawa,Y., Chatake,T., Naito,S., Ohsugi,T., Yatagai,C., Sumi,H., Kawaguchi,A., Chiba-Kamosida,K., Ogawa,M., Adachi,T. and Morimoto,Y. \<br\>X-ray structure determination and deuteration of nattokinase\<br\>J Synchrotron Radiat (2013) 20, 875-879. PubMed  Europe PubMed DOI  PMC  EPMC  S
    26. 2012
  26. Graycar,T.P., Bott,R.R., Power,S.D. and Estell,D.A. \<br\>Subtilisins\<br\>[ISSN:978-0-12-407742-3] (2012) 3, 3148-3155. DOI
    27. 2011
  27. Yongjun,C., Wei,B., Shujun,J., Meizhi,W., Yan,J., Yan,Y., Zhongliang,Z. and Goulin,Z. \<br\>Directed evolution improves the fibrinolytic activity of nattokinase from Bacillus natto\<br\>FEMS Microbiol Lett (2011) 325, 155-161. PubMed  Europe PubMed DOI
    28. 2010
  28. Jia,Y., Liu,H., Bao,W., Weng,M., Chen,W., Cai,Y., Zheng,Z. and Zou,G. \<br\>Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase\<br\>FEBS Lett (2010) 584, 4789-4796. PubMed  Europe PubMed DOI
    29. 2009
  29. Hsia,C.H., Shen,M.C., Lin,J.S., Wen,Y.K., Hwang,K.L., Cham,T.M. and Yang,N.C. \<br\>Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects\<br\>Nutr Res (2009) 29, 190-196. PubMed  Europe PubMed DOI
  30. Hsu,R.L., Lee,K.T., Wang,J.H., Lee,L.Y. and Chen,R.P. \<br\>Amyloid-degrading ability of nattokinase from Bacillus subtilis Natto\<br\>J Agric Food Chem (2009) 57, 503-508. PubMed  Europe PubMed DOI  U
  31. Ku,T.W., Tsai,R.L. and Pan,T.M. \<br\>A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis Natto\<br\>J Agric Food Chem (2009) 57, 292-296. PubMed  Europe PubMed DOI
  32. Weng,M., Zheng,Z., Bao,W., Cai,Y., Yin,Y. and Zou,G. \<br\>Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli\<br\>Biochim Biophys Acta (2009) 1794, 1566-1572. PubMed  Europe PubMed DOI
  33. Yan,F., Yan,J., Sun,W., Yao,L., Wang,J., Qi,Y. and Xu,H. \<br\>Thrombolytic effect of subtilisin QK on carrageenan induced thrombosis model in mice\<br\>J Thromb Thrombolysis (2009) 28, 444-448. PubMed  Europe PubMed DOI
    34. 2007
  34. Wu,S., Feng,C., Zhong,J. and Huan,L. \<br\>Roles of S3 site residues of nattokinase on its activity and substrate specificity\<br\>J Biochem (2007) 142, 357-364. PubMed  Europe PubMed DOI
    35. 2006
  35. Pais,E., Alexy,T., Holsworth,R.E., Jr. and Meiselman,H.J. \<br\>Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity\<br\>Clin Hemorheol Microcirc (2006) 35, 139-142. PubMed  Europe PubMed
  36. Upadhyay,V.K., Kelly,A.L. and McSweeney,P.L.H. \<br\>Use of nattokinase, a subtilisin-like serine proteinase, to accelerate proteolysis in Cheddar cheese during ripening\<br\>Lait (2006) 86, 227-240. DOI
  37. [YEAR:17-1-2006]Zheng,Z.L., Ye,M.Q., Zuo,Z.Y., Liu,Z.G., Tai,K.C. and Zou,G.L. \<br\>Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation\<br\>Biochem J (17-1-2006) 395, 509-515. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2005
  38. [YEAR:15-6-2005]Chiang,C.J., Chen,H.C., Chao,Y.P. and Tzen,J.T. \<br\>Efficient system of artificial oil bodies for functional expression and purification of recombinant nattokinase in Escherichia coli\<br\>J Agric Food Chem (15-6-2005) 53, 4799-4804. PubMed  Europe PubMed DOI  E
  39. Ko,J., Yan,J., Zhu,L. and Qi,Y. \<br\>Subtilisin QK, a fibrinolytic enzyme, inhibits the exogenous nitrite and hydrogen peroxide induced protein nitration, in vitro and in vivo\<br\>J Biochem Mol Biol (2005) 38, 577-583. PubMed  Europe PubMed
    40. 2004
  40. Graycar,T.P., Ballinger,M.D. and Wells,J.A. \<br\>Subtilisins\<br\>[ISSN:0-12-079610-4] (2004) 2, 1786-1792.  V
    41. 2001
  41. [YEAR:6-7-2001]Urano,T., Ihara,H., Umemura,K., Suzuki,Y., Oike,M., Akita,S., Tsukamoto,Y., Suzuki,I. and Takada,A. \<br\>The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1\<br\>J Biol Chem (6-7-2001) 276, 24690-24696. PubMed  Europe PubMed DOI
    42. 1992
  42. Nakamura,T., Yamagata,Y. and Ichishima,E. \<br\>Nucleotide sequence of the subtilisin NAT gene, aprN, of Bacillus subtilis (natto)\<br\>Biosci Biotechnol Biochem (1992) 56, 1869-1871. PubMed  Europe PubMed
    43. 1989
  43. Kamata,H., Yamagata,Y., Nakamura,T., Nakajima,T., Oda,K., Murao,S. and Ichishima,E. \<br\>Characterization of the complex between alpha2-macroglobulin and a serine proteinase from Bacillus natto\<br\>Agric Biol Chem (1989) 53, 2695-2702. DOI

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