Literature for peptidase S26.016: SpsB signal peptidase

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Park,Y., Sisley,T.A., Stone,M.C., Corrigan,R.M., Vickery,C.R., Grundling,A. and Walker,S.
   SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in Staphylococcus aureus
   Proc Natl Acad Sci U S A (2025) 122, e2426464122-e2426464122. PubMed  Europe PubMed DOI  PMC  EPMC
2. Zhang,R., Jia,Y., Scaffidi,S.J., Madsen,J.J. and Yu,W.
   Signal peptidase SpsB coordinates staphylococcal cell cycle, surface protein septal trafficking, and LTA synthesis
   MBio (2025) , e0267324-e0267324. PubMed  Europe PubMed DOI
2024
3. Schum,D., Elsen,F.A.V., Ruddell,S., Schorpp,K., Junca,H., Musken,M., Chen,S.Y., Fiedler,M.K., Pickl,T., Pieper,D.H., Hadian,K., Zacharias,M. and Sieber,S.A.
   Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action
   JACS Au (2024) 4, 3125-3134. PubMed  Europe PubMed DOI  PMC  EPMC  I
2017
4. Hazenbos,W.L., Skippington,E. and Tan,M.W.
   Staphylococcus aureus type I signal peptidase: essential or not essential, that's the question
   Microb Cell (2017) 4, 108-111. PubMed  Europe PubMed DOI  PMC  EPMC
2016
5. Morisaki,J.H., Smith,P.A., Date,S.V., Kajihara,K.K., Truong,C.L., Modrusan,Z., Yan,D., Kang,J., Xu,M., Shah,I.M., Mintzer,R., Kofoed,E.M., Cheung,T.K., Arnott,D., Koehler,M.F., Heise,C.E., Brown,E.J., Tan,M.W. and Hazenbos,W.L.
   A putative bacterial ABC transporter circumvents the essentiality of signal peptidase
   MBio (2016) 7 PubMed  Europe PubMed DOI  I
6. Ting,Y.T., Harris,P.W.R., Batot,G., Brimble,M.A., Baker,E.N. and Young,P.G.
   Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization
   IUCrJ (2016) 3, 10-19. PubMed  Europe PubMed DOI  S
2015
7. Ting,Y.T., Batot,G., Baker,E.N. and Young,P.G.
   Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus
   Acta Crystallogr F Struct Biol Commun (2015) 71, 61-65. PubMed  Europe PubMed DOI  E
2012
8. Harris,D.A. and Romesberg,F.E.
   SpsB signal peptidase
   [ISSN:978-0-12-407742-3] (2012) 3, 3501-3508. DOI
9. Schallenberger,M.A., Niessen,S., Shao,C., Fowler,B.J. and Romesberg,F.E.
   Type I signal peptidase and protein secretion in Staphylococcus aureus
   J Bacteriol (2012) 194, 2677-2686. PubMed  Europe PubMed DOI  I
10. Therien,A.G., Huber,J.L., Wilson,K.E., Beaulieu,P., Caron,A., Claveau,D., Deschamps,K., Donald,R.G., Galgoci,A.M., Gallant,M., Gu,X., Kevin,N.J., Lafleur,J., Leavitt,P.S., Lebeau-Jacob,C., Lee,S.S., Lin,M.M., Michels,A.A., Ogawa,A.M., Painter,R.E., Parish,C.A., Park,Y.W., Benton-Perdomo,L., Petcu,M., Phillips,J.W., Powles,M.A., Skorey,K.I., Tam,J., Tan,C.M., Young,K., Wong,S., Waddell,S.T. and Miesel,L.
    Broadening the spectrum of beta-lactam antibiotics through inhibition of signal peptidase type I
    Antimicrob Agents Chemother (2012) 56, 4662-4670. PubMed  Europe PubMed DOI  I
2011
11. Powers,M.E., Smith,P.A., Roberts,T.C., Fowler,B.J., King,C.C., Trauger,S.A., Siuzdak,G. and Romesberg,F.E.
    Type I signal peptidase and protein secretion in Staphylococcus epidermidis
    J Bacteriol (2011) 193, 340-348. PubMed  Europe PubMed DOI  I
12. Wormann,M.E., Reichmann,N.T., Malone,C.L., Horswill,A.R. and Grundling,A.
    Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase
    J Bacteriol (2011) 193, 5279-5291. PubMed  Europe PubMed DOI
2009
13. Bockstael,K., Geukens,N., Rao,C.V., Herdewijn,P., Anne,J. and Van Aerschot,A.
    An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors
    J Microbiol Methods (2009) 78, 231-237. PubMed  Europe PubMed DOI  A
14. Bockstael,K., Geukens,N., Van Mellaert,L., Herdewijn,P., Anne,J. and Van Aerschot,A.
    Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis
    Microbiology (Reading) (2009) 155, 3719-3729. PubMed  Europe PubMed DOI  I
15. Buzder-Lantos,P., Bockstael,K., Anne,J. and Herdewijn,P.
    Substrate based peptide aldehyde inhibits bacterial type I signal peptidase
    Bioorg Med Chem Lett (2009) 19, 2880-2883. PubMed  Europe PubMed DOI  I
16. Rao,S., Bockstael,K., Nath,S., Engelborghs,Y., Anne,J. and Geukens,N.
    Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB - implications for the search for novel antibiotics
    FEBS J (2009) 276, 3222-3234. PubMed  Europe PubMed DOI  P
2007
17. Kavanaugh,J.S., Thoendel,M. and Horswill,A.R.
    A role for type I signal peptidase in Staphylococcus aureus quorum sensing
    Mol Microbiol (2007) 65, 780-798. PubMed  Europe PubMed DOI
2003
18. Bruton,G., Huxley,A., O'Hanlon,P., Orlek,B., Eggleston,D., Humphries,J., Readshaw,S., West,A., Ashman,S., Brown,M., Moore,K., Pope,A., O'Dwyer,K. and Wang,L.
    Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors
    Eur J Med Chem (2003) 38, 351-356. PubMed  Europe PubMed DOI  I
2002
19. [YEAR:22-2-2002]Sharkov,N.A. and Cai,D.
    Discovery of substrate for type I signal peptidase SpsB from Staphylococcus aureus
    J Biol Chem (22-2-2002) 277, 5796-5803. PubMed  Europe PubMed DOI
1996
20. Cregg,K.M., Wilding,I. and Black,M.T.
    Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus
    J Bacteriol (1996) 178, 5712-5718. PubMed  Europe PubMed  PMC  EPMC