Sequence features for peptidase C01.036: cathepsin K

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0689748 Acanthisitta chloris 289 75-289 Q93, C99, H236, N256 GENBANK:XP_009069032
MER0233540 Ailuropoda melanoleuca 330 109-330 Q134, C140, H277, N297 UNIPROT:D2HBT7
MER0233540 Ailuropoda melanoleuca 330 109-330 Q134, C140, H277, N297 UNIPROT:D2HBT7
MER0257853 Alligator mississippiensis 379 166-379 Q183, C189, H326, N346 GENBANK:XP_006274673
MER0297181 Alligator sinensis 1106 893-1106 Q910, C916, H1053, N1073 GENBANK:XP_006038663
MER0297196 Alligator sinensis 379 166-379 Q183, C189, H326, N346 GENBANK:XP_006038664
MER0323513 Anas platyrhynchos 358 144-358 Q162, C168, H305, N325 GENBANK:XP_005026820
MER0292875 Anolis carolinensis 289 75-283 Q93, C99, H236, N256 GENBANK:XP_003229322
MER0687031 Aptenodytes forsteri 331 117-331 Q135, C141, H278, N298 GENBANK:XP_009279467
MER0686810 Aquila chrysaetos 404 190-404 Q208, C214, H351, N371 GENBANK:XP_011596851
MER0365905 Astyanax mexicanus 331 117-331 Q134, C140, H277, N298 UNIPROT:W5LHM9
MER0365905 Astyanax mexicanus 331 117-331 Q134, C140, H277, N298 UNIPROT:W5LHM9
MER0398375 Balaenoptera acutorostrata 358 144-358 Q162, C168, H305, N325 GENBANK:XP_007178065
MER0681561 Balearica regulorum 288 75-288 Q92, C98, H235, N255 GENBANK:XP_010296177
MER0679436 Bison bison 334 120-334 Q138, C144, H281, N301 GENBANK:XP_010836992
MER0228567 Bos grunniens 338 125-332 Q142, C148, H285, N305 UNIPROT:L8IKT6
MER0228567 Bos grunniens 338 125-332 Q142, C148, H285, N305 UNIPROT:L8IKT6
MER0048532 Bos taurus 334 113-334 Q138, C144, H281, N301 UNIPROT:Q5E968
MER0048532 Bos taurus 334 113-334 Q138, C144, H281, N301 UNIPROT:Q5E968
MER0048532 Bos taurus 334 113-334 Q138, C144, H281, N301 UNIPROT:Q5E968
MER0579737 Bubalus bubalis 335 121-335 Q139, C145, H282, N302 GENBANK:XP_006058188
MER0344476 Callithrix jacchus 329 116-323 Q133, C139, H276, N296 UNIPROT:F6PYT2
MER0344476 Callithrix jacchus 329 116-323 Q133, C139, H276, N296 UNIPROT:F6PYT2
MER0582386 Calypte anna 333 170-327 Q188, C194, H280, N300 GENBANK:XP_008502841
MER0678048 Camelus dromedarius 330 116-330 Q134, C140, H277, N297 GENBANK:XP_010995040
MER0524391 Camelus ferus 330 116-330 Q134, C140, H277, N297 GENBANK:XP_006186682
MER0677317 Camelus ferus 1649 760-945 Q782, C788, H925, N945 UNIPROT:S9Y6J3
MER0677317 Camelus ferus 1649 760-945 Q782, C788, H925, N945 UNIPROT:S9Y6J3
MER0053414 Canis lupus familiaris 330 109-330 Q134, C140, H277, N297 UNIPROT:Q3ZKN1
MER0053414 Canis lupus familiaris 330 109-330 Q134, C140, H277, N297 UNIPROT:Q3ZKN1
MER0053414 Canis lupus familiaris 330 109-330 Q134, C140, H277, N297 UNIPROT:Q3ZKN1
MER0053414 Canis lupus familiaris 330 109-330 Q134, C140, H277, N297 UNIPROT:Q3ZKN1
MER0557821 Capra hircus 330 117-330 Q134, C140, H277, N297 GENBANK:XP_005677713
MER0118327 Carassius auratus 332 118-332 Q135, C141, H278, N299 UNIPROT:A4PBJ5
MER0118327 Carassius auratus 332 118-332 Q135, C141, H278, N299 UNIPROT:A4PBJ5
MER0675296 Cariama cristata 134 26-132 Q45, C51, H105, N125 GENBANK:XP_009702752
MER0512487 Ceratotherium simum 330 116-330 Q134, C140, H277, N297 GENBANK:XP_004436031
MER0587204 Cercopithecus sabaeus 348 134-348 Q152, C158, H295, N315 GENBANK:XP_008017474
MER0672818 Chaetura pelagica 340 126-340 Q144, C150, H287, N307 GENBANK:XP_009991968
MER0672342 Charadrius vociferus 331 117-331 Q135, C141, H278, N298 GENBANK:XP_009882197
MER0579614 Chelonia mydas 1089 159-595 Q429, C435, H574, N594 UNIPROT:M7ATD2
MER0579614 Chelonia mydas 1089 159-595 Q429, C435, H574, N594 UNIPROT:M7ATD2
MER0591964 Chelonia mydas 335 120-335 Q137, C143, H282, N302 GENBANK:XP_007068204
MER0591970 Chelonia mydas 341 118-341 Q135, C141, H288, N308 GENBANK:XP_007068165
MER0695220 Chelonia mydas 1098 862-1087 Q879, C885, H1045, N1065 UNIPROT:M7BI69
MER0695220 Chelonia mydas 1098 862-1087 Q879, C885, H1045, N1065 UNIPROT:M7BI69
MER0582788 Chinchilla lanigera 329 115-329 Q133, C139, H276, N296 GENBANK:XP_005414514
MER0428241 Chlamydomonas reinhardtii 58 2-58 missing, missing, H11, N27 UNIPROT:A8JC90
MER0428241 Chlamydomonas reinhardtii 58 2-58 missing, missing, H11, N27 UNIPROT:A8JC90
MER0577387 Chrysemys picta 335 119-335 Q137, C143, H282, N302 GENBANK:XP_005293741
MER0577391 Chrysemys picta 335 122-335 Q139, C145, H282, N302 GENBANK:XP_005293742
MER0574734 Chrysochloris asiatica 329 116-329 Q133, C139, H276, N296 GENBANK:XP_006861442
MER0669161 Colobus angolensis 348 134-348 Q152, C158, H295, N315 GENBANK:XP_011793194
MER0228658 Columba livia 304 117-294 Q134, C140, H247, N267 UNIPROT:R7VTC3
MER0228658 Columba livia 304 117-294 Q134, C140, H247, N267 UNIPROT:R7VTC3
MER0573308 Condylura cristata 330 117-330 Q134, C140, H277, N297 GENBANK:XP_004689505
MER0573015 Corvus brachyrhynchos 255 117-249 Q135, C141, H202, N222 GENBANK:XP_008636400
MER0663440 Cuculus canorus 351 138-351 Q156, C162, H298, N318 GENBANK:XP_009566863
MER0568112 Cynoglossus semilaevis 331 117-331 Q134, C140, H277, N298 GENBANK:XP_008322033
MER0702522 Cyprinus carpio 333 118-326 Q136, C142, H279, N300 UNIPROT:A0A024A1T3
MER0702522 Cyprinus carpio 333 118-326 Q136, C142, H279, N300 UNIPROT:A0A024A1T3
MER0361582 Desmodus rotundus 331 117-325 Q135, C141, H278, N298 UNIPROT:K9IRQ8
MER0361582 Desmodus rotundus 331 117-325 Q135, C141, H278, N298 UNIPROT:K9IRQ8
MER0565363 Elephantulus edwardii 329 115-329 Q133, C139, H276, N296 GENBANK:XP_006900186
MER0564378 Eptesicus fuscus 330 116-330 Q134, C140, H277, N297 GENBANK:XP_008154063
MER0098351 Equus caballus 329 108-329 Q133, C139, H276, N296 UNIPROT:F7A8R5
MER0098351 Equus caballus 329 108-329 Q133, C139, H276, N296 UNIPROT:F7A8R5
MER0661963 Esox lucius 331 117-331 Q134, C140, H277, N298 GENBANK:XP_010866992
MER0560098 Falco cherrug 321 127-321 Q144, C150, H268, N288 GENBANK:XP_005442690
MER0544440 Falco peregrinus 339 126-339 Q144, C150, H286, N306 GENBANK:XP_005244382
MER0361523 Felis catus 330 117-324 Q134, C140, H277, N297 GENBANK:XP_003990643
MER0656900 Fukomys damarensis 328 115-328 Q132, C138, H275, N295 GENBANK:XP_010614740
MER0001933 Gallus gallus 334 119-334 Q138, C144, H281, N301 GENBANK:-
MER0001933 Gallus gallus 334 119-334 Q138, C144, H281, N301 GENBANK:-
MER0520379 Geospiza fortis 331 117-331 Q135, C141, H278, N298 GENBANK:XP_005430374
MER0361402 Gorilla gorilla 329 116-323 Q133, C139, H276, N296 UNIPROT:G3RH85
MER0361402 Gorilla gorilla 329 116-323 Q133, C139, H276, N296 UNIPROT:G3RH85
MER0651537 Haliaeetus leucocephalus 334 120-334 Q138, C144, H281, N301 GENBANK:XP_010563819
MER0292868 Heterocephalus glaber 329 116-323 Q133, C139, H276, N296 GENBANK:EHA97338
MER0000644 Homo sapiens 329 115-329 Q133, C139, H276, N296 GENBANK:AAC84397
MER0000644 Homo sapiens 329 115-329 Q133, C139, H276, N296 GENBANK:AAC84397
MER0232420 Ictalurus furcatus 331 117-331 Q134, C140, H277, N298 UNIPROT:E3TD48
MER0232420 Ictalurus furcatus 331 117-331 Q134, C140, H277, N298 UNIPROT:E3TD48
MER0694746 Ictalurus punctatus 331 116-322 Q134, C140, H277, N298 UNIPROT:E3TE31
MER0694746 Ictalurus punctatus 331 116-322 Q134, C140, H277, N298 UNIPROT:E3TE31
MER0106656 Ictidomys tridecemlineatus 329 115-329 Q133, C139, H276, N296 UNIPROT:I3MLU5
MER0106656 Ictidomys tridecemlineatus 329 115-329 Q133, C139, H276, N296 UNIPROT:I3MLU5
MER0547465 Jaculus jaculus 329 115-329 Q133, C139, H276, N296 GENBANK:XP_004667194
MER0702392 Latimeria menadoensis 333 119-324 Q137, C143, H280, N300 UNIPROT:X2D2S9
MER0702392 Latimeria menadoensis 333 119-324 Q137, C143, H280, N300 UNIPROT:X2D2S9
MER0553802 Lepisosteus oculatus 286 71-286 Q88, C94, H232, N253 GENBANK:XP_006641844
MER0695315 Lepisosteus oculatus 341 124-337 Q142, C148, H285, N306 GENBANK:-
MER0552350 Leptonychotes weddellii 258 44-258 Q62, C68, H205, N225 GENBANK:XP_006728458
MER0694907 Leptosomus discolor 182 1-172 Q18, C24, H131, N151 UNIPROT:A0A091QVR8
MER0694907 Leptosomus discolor 182 1-172 Q18, C24, H131, N151 UNIPROT:A0A091QVR8
MER0549208 Lipotes vexillifer 329 115-329 Q133, C139, H276, N296 GENBANK:XP_007460294
MER0103146 Loxodonta africana 329 115-329 Q133, C139, H276, N296 UNIPROT:G3T774
MER0103146 Loxodonta africana 329 115-329 Q133, C139, H276, N296 UNIPROT:G3T774
MER0183938 Lutjanus argentimaculatus 330 116-330 Q133, C139, H276, N297 UNIPROT:C3UWE0
MER0183938 Lutjanus argentimaculatus 330 116-330 Q133, C139, H276, N297 UNIPROT:C3UWE0
MER0644955 Mandrillus leucophaeus 348 134-348 Q152, C158, H295, N315 GENBANK:XP_011828982
MER0542631 Maylandia zebra 330 116-328 Q133, C139, H276, N297 GENBANK:XP_004560206
MER0695011 Meleagris gallopavo 233 39-230 Q56, C62, H198, N218 UNIPROT:G3X8J6
MER0544872 Mesocricetus auratus 329 115-329 Q133, C139, H276, N296 GENBANK:XP_005084328
MER0538338 Microtus ochrogaster 330 116-330 Q134, C140, H277, N297 GENBANK:XP_005357030
MER0165395 Monodelphis domestica 422 202-422 Q226, C232, H369, N389 GENBANK:XP_001371004
MER0002412 Mus musculus 329 115-329 Q133, C139, H276, N296 UNIPROT:P55097
MER0002412 Mus musculus 329 115-329 Q133, C139, H276, N296 UNIPROT:P55097
MER0002412 Mus musculus 329 115-329 Q133, C139, H276, N296 UNIPROT:P55097
MER0292874 Mustela putorius 329 117-324 Q134, C140, H277, N297 UNIPROT:M1EJK5
MER0292874 Mustela putorius 329 117-324 Q134, C140, H277, N297 UNIPROT:M1EJK5
MER0569156 Myotis brandtii 330 116-330 Q134, C140, H277, N297 GENBANK:XP_005867421
MER0361708 Myotis davidii 897 684-891 Q701, C707, H844, N864 UNIPROT:L5MDA5
MER0361708 Myotis davidii 897 684-891 Q701, C707, H844, N864 UNIPROT:L5MDA5
MER0639248 Nannospalax galili 329 115-329 Q133, C139, H276, N296 GENBANK:XP_008825299
MER0704658 Neovison vison 330 117-320 Q134, C140, H277, N297 UNIPROT:U6CUT2
MER0704658 Neovison vison 330 117-320 Q134, C140, H277, N297 UNIPROT:U6CUT2
MER0638488 Nestor notabilis 236 74-234 Q91, C97, H183, N203 GENBANK:XP_010017509
MER0636348 Nipponia nippon 331 117-331 Q135, C141, H278, N298 GENBANK:XP_009465357
MER0292870 Nomascus leucogenys 329 116-323 Q133, C139, H276, N296 GENBANK:XP_003259241
MER0534272 Ochotona princeps 329 115-329 Q133, C139, H276, N296 GENBANK:XP_004588921
MER0533066 Octodon degus 329 115-329 Q133, C139, H276, N296 GENBANK:XP_004632444
MER0531869 Odobenus rosmarus 330 116-330 Q134, C140, H277, N297 GENBANK:XP_004404279
MER0530279 Orcinus orca 329 115-329 Q133, C139, H276, N296 GENBANK:XP_004285210
MER0097967 Ornithorhynchus anatinus 618 398-618 Q422, C428, H565, N585 GENBANK:XP_001518002
MER0528802 Orycteropus afer 329 115-329 Q133, C139, H276, N296 GENBANK:XP_007949121
MER0000645 Oryctolagus cuniculus 329 114-329 Q133, C139, H276, N296 GENBANK:AAC84398
MER0000645 Oryctolagus cuniculus 329 114-329 Q133, C139, H276, N296 GENBANK:AAC84398
MER0183924 Osmerus mordax 331 117-331 Q134, C140, H277, N298 UNIPROT:C1BL99
MER0183924 Osmerus mordax 331 117-331 Q134, C140, H277, N298 UNIPROT:C1BL99
MER0344482 Otolemur garnettii 329 116-323 Q133, C139, H276, N296 UNIPROT:H0WQ28
MER0344482 Otolemur garnettii 329 116-323 Q133, C139, H276, N296 UNIPROT:H0WQ28
MER0361394 Ovis aries 330 117-324 Q134, C140, H277, N297 UNIPROT:W5QI78
MER0361394 Ovis aries 330 117-324 Q134, C140, H277, N297 UNIPROT:W5QI78
MER0344477 Pan paniscus 343 130-337 Q147, C153, H290, N310 GENBANK:XP_003817340
MER0518029 Panthera tigris 330 116-330 Q134, C140, H277, N297 GENBANK:XP_007088140
MER0517303 Pantholops hodgsonii 330 117-330 Q134, C140, H277, N297 GENBANK:XP_005970761
MER0361410 Papio anubis 348 135-342 Q152, C158, H295, N315 GENBANK:XP_003892642
MER0142304 Paralichthys olivaceus 330 116-330 Q133, C139, H276, N297 UNIPROT:B2Z447
MER0142304 Paralichthys olivaceus 330 116-330 Q133, C139, H276, N297 UNIPROT:B2Z447
MER0525132 Pelodiscus sinensis 331 118-331 Q135, C141, H278, N298 GENBANK:XP_006132119
MER0519612 Physeter catodon 357 143-357 Q161, C167, H304, N324 GENBANK:XP_007130487
MER0518895 Poecilia formosa 333 118-333 Q135, C141, H280, N300 GENBANK:XP_006110501
MER0523198 Poecilia formosa 330 116-330 Q133, C139, H276, N297 UNIPROT:A0A087XPV0
MER0523198 Poecilia formosa 330 116-330 Q133, C139, H276, N297 UNIPROT:A0A087XPV0
MER0513575 Poecilia reticulata 330 116-330 Q133, C139, H276, N297 GENBANK:XP_008429095
MER0292869 Pongo abelii 329 116-323 Q133, C139, H276, N296 GENBANK:XP_002810309
MER0361494 Pteropus alecto 330 117-324 Q134, C140, H277, N297 GENBANK:ELK06034
MER0442022 Python bivittatus 388 175-388 Q192, C198, H335, N355 GENBANK:XP_007427981
MER0003747 Rattus norvegicus 329 114-329 Q133, C139, H276, N296 UNIPROT:O35186
MER0003747 Rattus norvegicus 329 114-329 Q133, C139, H276, N296 UNIPROT:O35186
MER0003747 Rattus norvegicus 329 114-329 Q133, C139, H276, N296 UNIPROT:O35186
MER0571310 Rhinopithecus roxellana 348 134-348 Q152, C158, H295, N315 GENBANK:XP_010385548
MER0361423 Saimiri boliviensis 383 170-377 Q187, C193, H330, N350 GENBANK:XP_003942009
MER0144119 Salmo salar 331 117-331 Q134, C140, H277, N298 GENBANK:NP_001133871
MER0344479 Sarcophilus harrisii 332 119-326 Q136, C142, H279, N299 GENBANK:XP_003769964
MER0551282 Serinus canaria 317 117-317 Q135, C141, H264, N284 GENBANK:XP_009097474
MER0597331 Sorex araneus 330 117-330 Q134, C140, H277, N297 GENBANK:XP_004618132
MER0472520 Stegastes partitus 330 116-330 Q133, C139, H276, N297 GENBANK:XP_008287179
MER0504194 Struthio camelus 292 78-292 Q96, C102, H239, N259 GENBANK:XP_009666028
MER0014559 Sus scrofa 330 116-330 Q134, C140, H277, N297 GENBANK:XP_005663523
MER0014559 Sus scrofa 330 116-330 Q134, C140, H277, N297 GENBANK:XP_005663523
MER0427848 Sus scrofa 71 4-71 missing, missing, H66, missing UNIPROT:Q0Q4G9
MER0427848 Sus scrofa 71 4-71 missing, missing, H66, missing UNIPROT:Q0Q4G9
MER0418130 Tarsius syrichta 356 142-356 Q160, C166, H303, N323 GENBANK:XP_008048154
MER0126698 Tetraodon nigroviridis 336 122-336 Q139, C145, H282, N303 UNIPROT:Q4SW27
MER0126698 Tetraodon nigroviridis 336 122-336 Q139, C145, H282, N303 UNIPROT:Q4SW27
MER0488544 Trichechus manatus 329 115-329 Q133, C139, H276, N296 GENBANK:XP_004389625
MER0228639 Tupaia chinensis 329 116-329 Q133, C139, H276, N296 GENBANK:XP_006168515
MER0269244 Ursus maritimus 330 116-330 Q134, C140, H277, N297 GENBANK:XP_008693914
MER0117331 Xenopus laevis 331 115-331 Q135, C141, H278, N298 UNIPROT:A8WH59
MER0117331 Xenopus laevis 331 115-331 Q135, C141, H278, N298 UNIPROT:A8WH59
MER0052064 Xenopus tropicalis 329 108-329 Q133, C139, H276, N296 UNIPROT:Q6DJA7
MER0052064 Xenopus tropicalis 329 108-329 Q133, C139, H276, N296 UNIPROT:Q6DJA7
MER0088844 Xenopus tropicalis 331 114-331 Q135, C141, H278, N298 UNIPROT:Q0IIR8
MER0088844 Xenopus tropicalis 331 114-331 Q135, C141, H278, N298 UNIPROT:Q0IIR8
MER0694988 Xenopus tropicalis 339 125-332 Q143, C149, H286, N306 GENBANK:-
MER0695052 Xenopus tropicalis 323 117-320 Q135, C141, H270, N290 GENBANK:-
MER0695103 Xenopus tropicalis 310 117-307 Q135, C141, H257, N277 GENBANK:-
MER0451673 Xiphophorus maculatus 289 75-289 Q92, C98, H235, N256 GENBANK:XP_005814112