Structure for peptidase A01.023: plasmepsin-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1SME	Plasmodium falciparum	2.70 Å	complex with pepstatin A
One molecule of the dimer is shown. Active site residues are shown in ball-and-stick representation: Asp158 and Asp338 in pink, Tyr201 in green. Pepstatin is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Plasmodium falciparum
theoretical model	0.00 Å	1J8J	1J8J	1J8J	1J8J	1J8J	1J8J
complex with inhibitor RS367	1.90 Å	1LEE	1LEE	1LEE	1LEE	1LEE	1LEE	Asojo et al., 2002
complex with inhibitor RS370	1.80 Å	1LF2	1LF2	1LF2	1LF2	1LF2	1LF2	Asojo et al., 2002
complex with EH58 inhibitor	2.70 Å	1LF3	1LF3	1LF3	1LF3	1LF3	1LF3	Asojo et al., 2003
mature peptidase	1.90 Å	1LF4	1LF4	1LF4	1LF4	1LF4	1LF4	Asojo et al., 2003
complex with pepstatin A	2.40 Å	1M43	1M43	1M43	1M43	1M43	1M43
complex with a statine based inhibitor	2.70 Å	1ME6	1ME6	1ME6	1ME6	1ME6	1ME6
precursor	1.85 Å	1PFZ	1PFZ	1PFZ	1PFZ	1PFZ	1PFZ	Bernstein et al., 1999
complex with pepstatin A	2.70 Å	1SME	1SME	1SME	1SME	1SME	1SME	Silva et al., 1996
complex with TIT inhibitor	2.24 Å	1W6H	1W6H	1W6H	1W6H	1W6H	1W6H
complex with pepstatin A	2.70 Å	1W6I	1W6I	1W6I	1W6I	1W6I	1W6I
complex with pepstatin A	1.70 Å	1XDH	1XDH	1XDH	1XDH	1XDH	1XDH
complex with a pepstatin analogue	2.40 Å	1XE5	1XE5	1XE5	1XE5	1XE5	1XE5
complex with a pepstatin analogue	2.80 Å	1XE6	1XE6	1XE6	1XE6	1XE6	1XE6
complex with N-(R-carboxy-ethyl)-alpha-(S)-(2-phenylethyl)	1.56 Å	2BJU	2BJU	2BJU	2BJU	2BJU	2BJU	Prade et al., 2005
mature peptidase	0.00 Å	2BL3	2BL3	2BL3	2BL3	2BL3	2BL3
achiral, cheap and potent inhibitors of plasmepsins ii	1.70 Å	2IGX	2IGX	2IGX	2IGX	2IGX	2IGX	Boss et al., 2006
achiral, cheap and potent inhibitors of plasmepsins ii	2.60 Å	2IGY	2IGY	2IGY	2IGY	2IGY	2IGY	Boss et al., 2006
complex with KPFS-(CH2-NH)-LQF	2.80 Å	2R9B	2R9B	2R9B	2R9B	2R9B	2R9B	Liu et al., 2009
re-refinement of uncomplexed plasmepsin ii from plasmodium falciparum.	1.90 Å	3F9Q	3F9Q	3F9Q	3F9Q	3F9Q	3F9Q	Asojo et al., 2003
mature peptidase	1.85 Å	4CKU	4CKU	4CKU	4CKU	4CKU	4CKU	Jaudzems et al., 2014
mature peptidase	2.27 Å	4Y6M	4Y6M	4Y6M	4Y6M	4Y6M	4Y6M	Recacha et al., 2015
mature peptidase	3.30 Å	4YA8	4YA8	4YA8	4YA8	4YA8	4YA8	Recacha et al., 2015