Structure for peptidase M01.004: leukotriene A4 hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1HS6_A	Homo sapiens	1.95 Å	complex with bestatin
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His295 and His299 in purple, and Glu318 in dark blue. The catalytic Glu296 is also shown in ball-and-stick representation in dark blue. Bound bestatin is shown in grey in ball-and-stick representation.

		Show surface

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
Asp375Asn mutant	2.20 Å	1GW6	1GW6	1GW6	1GW6	1GW6	1GW6	Rudberg et al., 2002
Glu271Gln mutant	2.10 Å	1H19	1H19	1H19	1H19	1H19	1H19	Rudberg et al., 2002
complex with bestatin	1.95 Å	1HS6	1HS6	1HS6	1HS6	1HS6	1HS6	Thunnissen et al., 2001
structure of [r563a] leukotriene a4 hydrolase	2.30 Å	1SQM	1SQM	1SQM	1SQM	1SQM	1SQM	Rudberg et al., 2004
leukotriene a4 hydrolase complexed with inhibitor rb3041	1.89 Å	2R59	2R59	2R59	2R59	2R59	2R59	Thunnissen et al., 2001
mature peptidase	1.80 Å	2VJ8	2VJ8	2VJ8	2VJ8	2VJ8	2VJ8	Thunnissen et al., 2002
leukotriene a4 hydrolase complexed with inhibitor rb3040	1.81 Å	3B7R	3B7R	3B7R	3B7R	3B7R	3B7R	Thunnissen et al., 2001
Glu296Gln mutant; complex with RSR substrate	1.47 Å	3B7S	3B7S	3B7S	3B7S	3B7S	3B7S	Thunnissen et al., 2001
Glu296Gln mutant; complex with Arg-Ala-Arg substrate	2.30 Å	3B7T	3B7T	3B7T	3B7T	3B7T	3B7T	Thunnissen et al., 2001
leukotriene a4 hydrolase complexed with kelatorphan	1.90 Å	3B7U	3B7U	3B7U	3B7U	3B7U	3B7U	Thunnissen et al., 2001
complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide	1.80 Å	3CHO	3CHO	3CHO	3CHO	3CHO	3CHO	Kirkland et al., 2008
complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl) amino]butanoic acid	2.10 Å	3CHP	3CHP	3CHP	3CHP	3CHP	3CHP	Kirkland et al., 2008
complex with N5-[4-(phenylmethoxy)phenyl]-L-glutamine	2.09 Å	3CHQ	3CHQ	3CHQ	3CHQ	3CHQ	3CHQ	Kirkland et al., 2008
complex with 4-amino-N-[4-(phenylmethoxy)phenyl]-butanamide	2.20 Å	3CHR	3CHR	3CHR	3CHR	3CHR	3CHR	Kirkland et al., 2008
complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl- ethoxy]phenyl]amino]-5-oxo-pentanoic acid	2.55 Å	3CHS	3CHS	3CHS	3CHS	3CHS	3CHS	Kirkland et al., 2008
mature peptidase	1.63 Å	3FH5	3FH5	3FH5	3FH5	3FH5	3FH5	Sandanayaka et al., 2010
mature peptidase	2.05 Å	3FH7	3FH7	3FH7	3FH7	3FH7	3FH7	Sandanayaka et al., 2010
mature peptidase	1.67 Å	3FH8	3FH8	3FH8	3FH8	3FH8	3FH8	Sandanayaka et al., 2010
mature peptidase	2.16 Å	3FHE	3FHE	3FHE	3FHE	3FHE	3FHE	Sandanayaka et al., 2010
mature peptidase	2.33 Å	3FTS	3FTS	3FTS	3FTS	3FTS	3FTS	Davies et al., 2009
mature peptidase	1.90 Å	3FTU	3FTU	3FTU	3FTU	3FTU	3FTU	Davies et al., 2009
mature peptidase	1.70 Å	3FTV	3FTV	3FTV	3FTV	3FTV	3FTV	Davies et al., 2009
mature peptidase	1.85 Å	3FTW	3FTW	3FTW	3FTW	3FTW	3FTW	Davies et al., 2009
mature peptidase	1.96 Å	3FTX	3FTX	3FTX	3FTX	3FTX	3FTX	Davies et al., 2009
mature peptidase	2.15 Å	3FTY	3FTY	3FTY	3FTY	3FTY	3FTY	Davies et al., 2009
mature peptidase	2.00 Å	3FTZ	3FTZ	3FTZ	3FTZ	3FTZ	3FTZ	Sandanayaka et al., 2010
mature peptidase	1.80 Å	3FU0	3FU0	3FU0	3FU0	3FU0	3FU0	Davies et al., 2009
mature peptidase	2.00 Å	3FU3	3FU3	3FU3	3FU3	3FU3	3FU3	Davies et al., 2009
mature peptidase	2.30 Å	3FU5	3FU5	3FU5	3FU5	3FU5	3FU5	Davies et al., 2009
mature peptidase	2.05 Å	3FU6	3FU6	3FU6	3FU6	3FU6	3FU6	Davies et al., 2009
mature peptidase	2.20 Å	3FUD	3FUD	3FUD	3FUD	3FUD	3FUD	Davies et al., 2009
mature peptidase	2.38 Å	3FUE	3FUE	3FUE	3FUE	3FUE	3FUE	Davies et al., 2009
mature peptidase	2.60 Å	3FUF	3FUF	3FUF	3FUF	3FUF	3FUF	Davies et al., 2009
mature peptidase	1.80 Å	3FUH	3FUH	3FUH	3FUH	3FUH	3FUH	Davies et al., 2009
mature peptidase	2.20 Å	3FUI	3FUI	3FUI	3FUI	3FUI	3FUI	Davies et al., 2009
mature peptidase	1.90 Å	3FUJ	3FUJ	3FUJ	3FUJ	3FUJ	3FUJ	Davies et al., 2009
mature peptidase	1.95 Å	3FUK	3FUK	3FUK	3FUK	3FUK	3FUK	Davies et al., 2009
mature peptidase	2.39 Å	3FUL	3FUL	3FUL	3FUL	3FUL	3FUL	Sandanayaka et al., 2010
mature peptidase	2.15 Å	3FUM	3FUM	3FUM	3FUM	3FUM	3FUM	Davies et al., 2009
mature peptidase	1.58 Å	3FUN	3FUN	3FUN	3FUN	3FUN	3FUN	Davies et al., 2009
mature peptidase	1.25 Å	3U9W	3U9W	3U9W	3U9W	3U9W	3U9W
mature peptidase	2.02 Å	4DPR	4DPR	4DPR	4DPR	4DPR	4DPR
mature peptidase	1.65 Å	4L2L	4L2L	4L2L	4L2L	4L2L	4L2L	Stsiapanava et al., 2014
mature peptidase	1.62 Å	4MKT	4MKT	4MKT	4MKT	4MKT	4MKT	Stsiapanava et al., 2014
mature peptidase	1.72 Å	4MS6	4MS6	4MS6	4MS6	4MS6	4MS6	Stsiapanava et al., 2014
mature peptidase	1.66 Å	4R7L	4R7L	4R7L	4R7L	4R7L	4R7L
mature peptidase	1.93 Å	4RSY	4RSY	4RSY	4RSY	4RSY	4RSY
mature peptidase	1.93 Å	4RVB	4RVB	4RVB	4RVB	4RVB	4RVB
mature peptidase	1.86 Å	5AEN	5AEN	5AEN	5AEN	5AEN	5AEN	Moser et al., 2015
complex with inhibitor 4az	2.03 Å	5BPP	5BPP	5BPP	5BPP	5BPP	5BPP
apo form	2.05 Å	5FWQ	5FWQ	5FWQ	5FWQ	5FWQ	5FWQ
crystal structure of lta4h bound to a selective inhibitor against ltb4generation	2.30 Å	5N3W	5N3W	5N3W	5N3W	5N3W	5N3W
lta4h Glu271Ala mutant; complex with lta4 (crystal form I)	1.50 Å	5NI2	5NI2	5NI2	5NI2	5NI2	5NI2
lta4h Glu271Ala mutant; complex with lta4 (crystal form II)	1.90 Å	5NI4	5NI4	5NI4	5NI4	5NI4	5NI4
Asp375Asn mutant; complex with lta4	1.54 Å	5NI6	5NI6	5NI6	5NI6	5NI6	5NI6
crystal structure of human lta4h mutant d375n in open conformation (crystal form i)	1.76 Å	5NIA	5NIA	5NIA	5NIA	5NIA	5NIA
crystal structure of human lta4h mutant d375n in open conformation (crystal form ii)	1.57 Å	5NID	5NID	5NID	5NID	5NID	5NID
crystal structure of human lta4h mutant r563a in open conformation	2.60 Å	5NIE	5NIE	5NIE	5NIE	5NIE	5NIE
lta4 hydrolase (e297q) mutant in complex with pro-gly-pro peptide	1.84 Å	6ENB	6ENB	6ENB	6ENB	6ENB	6ENB
lta4 hydrolase in complex with compound11	1.95 Å	6ENC	6ENC	6ENC	6ENC	6ENC	6ENC
lta4 hydrolase in complex with compound15	2.24 Å	6END	6END	6END	6END	6END	6END
Xenopus laevis
complex with inhibitor bestatin	2.26 Å	4GAA	4GAA	4GAA	4GAA	4GAA	4GAA