Structure for peptidase M10.003: matrix metallopeptidase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1CK7_A Homo sapiens 2.80 Å mature
The catalytic and structural zinc ions are shown as light grey CPK spheres. The structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His403, His407 and His413 in purple. The catalytic Glu404 is shown in blue (Glu mutated to Ala).
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
mature  peptidase 2.80 Å 1CK7 1CK7 1CK7 1CK7 1CK7 1CK7 Morgunova et al., 1999
NMR structure; type II fibronectin-like domain 2 0.00 Å 1CXW 1CXW 1CXW 1CXW 1CXW 1CXW Briknarova et al., 1999
Glu404Gln mutant; catalytic domain 2.66 Å 1EAK 1EAK 1EAK 1EAK 1EAK 1EAK
C-terminal domain 2.15 Å 1GEN 1GEN 1GEN 1GEN 1GEN 1GEN Libson et al., 1995
precursor; complex with TIMP-2 3.10 Å 1GXD 1GXD 1GXD 1GXD 1GXD 1GXD Morgunova et al., 2002
NMR structure; catalytic domain; complex with SC-74020 0.00 Å 1HOV 1HOV 1HOV 1HOV 1HOV 1HOV Feng et al., 2002
NMR structure; fibronectin type II domain 3 0.00 Å 1J7M 1J7M 1J7M 1J7M 1J7M 1J7M Briknarova et al., 2001
mature  peptidase 0.00 Å 1KS0 1KS0 1KS0 1KS0 1KS0 1KS0 Gehrmann et al., 2002
catalytic domain with fibronectin domain deleted 2.80 Å 1QIB 1QIB 1QIB 1QIB 1QIB 1QIB
haemopexin domain 2.60 Å 1RTG 1RTG 1RTG 1RTG 1RTG 1RTG Gohlke et al., 1996
mature  peptidase 2.00 Å 3AYU 3AYU 3AYU 3AYU 3AYU 3AYU Hashimoto et al., 2011