Structure for peptidase M10.004: matrix metallopeptidase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1L6J	Homo sapiens	2.50 Å	mature
The catalytic and structural zinc ions are shown as light grey CPK spheres. The structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His401, His405 and His411 in purple. The catalytic Glu402 is shown in blue.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
catalytic domain; complex with reverse hydroxamate inhibitor N~2~-[(2R)-2-[formyl(hydroxy)amino]methyl- 4-methylpentanoyl]-N,3-dimethyl-L-valinamide	2.30 Å	1GKC	1GKC	1GKC	1GKC	1GKC	1GKC	Rowsell et al., 2002
catalytic domain; complex with a reverse hydroxamate inhibitor	2.10 Å	1GKD	1GKD	1GKD	1GKD	1GKD	1GKD	Rowsell et al., 2002
mature peptidase	1.95 Å	1ITV	1ITV	1ITV	1ITV	1ITV	1ITV	Cha et al., 2002
mature peptidase	2.50 Å	1L6J	1L6J	1L6J	1L6J	1L6J	1L6J	Elkins et al., 2002
precursor; theoretical model	0.00 Å	1LKG	1LKG	1LKG	1LKG	1LKG	1LKG
mmp-9 active site mutant with barbiturate inhibitor	2.00 Å	2OVX	2OVX	2OVX	2OVX	2OVX	2OVX	Tochowicz et al., 2007
mmp-9 active site mutant with phosphinate inhibitor	2.00 Å	2OVZ	2OVZ	2OVZ	2OVZ	2OVZ	2OVZ	Tochowicz et al., 2007
mmp-9 active site mutant with iodine-labeled carboxylate inhibitor	2.00 Å	2OW0	2OW0	2OW0	2OW0	2OW0	2OW0	Tochowicz et al., 2007
mmp-9 active site mutant with trifluoromethyl hydroxamate inhibitor	2.20 Å	2OW1	2OW1	2OW1	2OW1	2OW1	2OW1	Tochowicz et al., 2007
mmp-9 active site mutant with difluoro butanoic acid inhibitor	2.90 Å	2OW2	2OW2	2OW2	2OW2	2OW2	2OW2	Tochowicz et al., 2007
mature peptidase	1.59 Å	4H1Q	4H1Q	4H1Q	4H1Q	4H1Q	4H1Q	Antoni et al., 2013
mature peptidase	2.90 Å	4H2E	4H2E	4H2E	4H2E	4H2E	4H2E	Antoni et al., 2013
mature peptidase	1.76 Å	4H3X	4H3X	4H3X	4H3X	4H3X	4H3X	Antoni et al., 2013
mature peptidase	1.90 Å	4H82	4H82	4H82	4H82	4H82	4H82	Antoni et al., 2013
mature peptidase	1.94 Å	4HMA	4HMA	4HMA	4HMA	4HMA	4HMA	Antoni et al., 2013
mature peptidase	1.70 Å	4JIJ	4JIJ	4JIJ	4JIJ	4JIJ	4JIJ	Tranchant et al., 2014
mature peptidase	1.85 Å	4JQG	4JQG	4JQG	4JQG	4JQG	4JQG	Tranchant et al., 2014
mature peptidase	1.65 Å	4WZV	4WZV	4WZV	4WZV	4WZV	4WZV	Nuti et al., 2015
mature peptidase	1.30 Å	4XCT	4XCT	4XCT	4XCT	4XCT	4XCT	Nuti et al., 2015
complex with a constrained hydroxamate based inhibitor lt4	1.83 Å	5CUH	5CUH	5CUH	5CUH	5CUH	5CUH
catalytic domain; complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (dc27).	1.59 Å	5I12	5I12	5I12	5I12	5I12	5I12
structure determination of a potent, selective antibody inhibitor of human mmp9 (apo mmp9)	1.70 Å	5TH6	5TH6	5TH6	5TH6	5TH6	5TH6
structure determination of a potent, selective antibody inhibitor of human mmp9 (gs-5745 bound to mmp-9)	3.00 Å	5TH9	5TH9	5TH9	5TH9	5TH9	5TH9
prommp-9desfnii	1.60 Å	5UE3	5UE3	5UE3	5UE3	5UE3	5UE3
prommp-9desfnii complex to jnj0966 inhibitor	1.80 Å	5UE4	5UE4	5UE4	5UE4	5UE4	5UE4
complex with inhibitor be4.	1.10 Å	6ESM	6ESM	6ESM	6ESM	6ESM	6ESM