Structure for peptidase M10.013: matrix metallopeptidase-13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1CXV	Mus musculus	2.00 Å	catalytic domain
The catalytic zinc is shown as a light grey CPK sphere. Structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His223, His227 and His233 in purple. The catalytic Glu224 is shown in blue. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
NMR structure; catalytic domain; complex with non-peptidic sulfonomide inhibitor	0.00 Å	1EUB	1EUB	1EUB	1EUB	1EUB	1EUB	Zhang et al., 2000
NMR structure; catalytic domain; complex with inhibitor WAY-151693	0.00 Å	1FLS	1FLS	1FLS	1FLS	1FLS	1FLS	Moy et al., 2000
NMR structure; catalytic domain; complex with inhibitor WAY-151693	0.00 Å	1FM1	1FM1	1FM1	1FM1	1FM1	1FM1	Moy et al., 2000
C-terminal hemopexin-like domain	2.70 Å	1PEX	1PEX	1PEX	1PEX	1PEX	1PEX	Gomis-Ruth et al., 1996
theoretical model	0.00 Å	1UC1	1UC1	1UC1	1UC1	1UC1	1UC1
matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1.70 Å	1XUC	1XUC	1XUC	1XUC	1XUC	1XUC	Engel et al., 2005
matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1.80 Å	1XUD	1XUD	1XUD	1XUD	1XUD	1XUD	Wasserman, 2005
matrix metalloproteinase-13 complexed with non-zinc binding inhibitor	1.85 Å	1XUR	1XUR	1XUR	1XUR	1XUR	1XUR	Wasserman, 2005
catalytic domain; complex with pyrimidinetrione inhibitor 5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione	2.30 Å	1YOU	1YOU	1YOU	1YOU	1YOU	1YOU	Blagg et al., 2005
catalytic domain; complex with WAY-033	2.00 Å	1ZTQ	1ZTQ	1ZTQ	1ZTQ	1ZTQ	1ZTQ	Wu et al., 2005
catalytic domain; complex with hydroxamic acid inhibitor SM-25453	2.37 Å	2D1N	2D1N	2D1N	2D1N	2D1N	2D1N	Kohno et al., 2006
complex with TIMP-2	2.00 Å	2E2D	2E2D	2E2D	2E2D	2E2D	2E2D	Maskos et al., 2007
catalytic domain; complex with benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-[1,3]thiazolo[3,2-C]pyrimidine-2-carboxylate	1.74 Å	2OW9	2OW9	2OW9	2OW9	2OW9	2OW9	Johnson et al., 2007
mmp13 catalytic domain complexed with 4-[1-methyl-2,4- dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin- 3(2h)-yl]methylbenzoic acid	2.30 Å	2OZR	2OZR	2OZR	2OZR	2OZR	2OZR	Johnson et al., 2007
catalytic domain; complex with WAY-344	2.80 Å	2PJT	2PJT	2PJT	2PJT	2PJT	2PJT	Huang et al., 2007
mature peptidase	1.70 Å	2YIG	2YIG	2YIG	2YIG	2YIG	2YIG	De et al., 2011
mature peptidase	1.90 Å	3ELM	3ELM	3ELM	3ELM	3ELM	3ELM	Monovich et al., 2009
mature peptidase	1.95 Å	3I7G	3I7G	3I7G	3I7G	3I7G	3I7G	Heim-Riether et al., 2009
mature peptidase	2.21 Å	3I7I	3I7I	3I7I	3I7I	3I7I	3I7I	Heim-Riether et al., 2009
mature peptidase	2.05 Å	3KEC	3KEC	3KEC	3KEC	3KEC	3KEC	Schnute et al., 2010
mature peptidase	2.30 Å	3KEJ	3KEJ	3KEJ	3KEJ	3KEJ	3KEJ	Schnute et al., 2010
mature peptidase	1.97 Å	3KEK	3KEK	3KEK	3KEK	3KEK	3KEK	Schnute et al., 2010
mature peptidase	1.90 Å	3KRY	3KRY	3KRY	3KRY	3KRY	3KRY	Becker et al., 2010
mature peptidase	2.00 Å	3LJZ	3LJZ	3LJZ	3LJZ	3LJZ	3LJZ	Shieh et al., 2011
mature peptidase	1.90 Å	3O2X	3O2X	3O2X	3O2X	3O2X	3O2X
mature peptidase	2.43 Å	3TVC	3TVC	3TVC	3TVC	3TVC	3TVC	Devel et al., 2012
mature peptidase	1.98 Å	3WV1	3WV1	3WV1	3WV1	3WV1	3WV1	Nara et al., 2014
mature peptidase	2.30 Å	3WV2	3WV2	3WV2	3WV2	3WV2	3WV2	Nara et al., 2014
mature peptidase	1.60 Å	3WV3	3WV3	3WV3	3WV3	3WV3	3WV3	Nara et al., 2014
mature peptidase	1.30 Å	3ZXH	3ZXH	3ZXH	3ZXH	3ZXH	3ZXH	Tommasi et al., 2011
catalytic domain; complex with 2-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-tetrahydro-pyran-4-yl-N-hydroxy-acetamide	2.40 Å	456C	456C	456C	456C	456C	456C	Lovejoy et al., 1999
mature peptidase	2.20 Å	4A7B	4A7B	4A7B	4A7B	4A7B	4A7B	De et al., 2012
mature peptidase	2.85 Å	4FU4	4FU4	4FU4	4FU4	4FU4	4FU4	Stura et al., 2013
mature peptidase	2.44 Å	4FVL	4FVL	4FVL	4FVL	4FVL	4FVL	Stura et al., 2013
mature peptidase	2.54 Å	4G0D	4G0D	4G0D	4G0D	4G0D	4G0D	Stura et al., 2013
mature peptidase	1.43 Å	4JP4	4JP4	4JP4	4JP4	4JP4	4JP4	De Savi et al., 2013
mature peptidase	2.00 Å	4JPA	4JPA	4JPA	4JPA	4JPA	4JPA	De Savi et al., 2013
mature peptidase	1.66 Å	4L19	4L19	4L19	4L19	4L19	4L19	Spicer et al., 2014
catalytic domain; complex with n- phenyl-4-((4h-1,2,4-triazol-3-ylsulfanyl)methyl)-1,3-thiazol-2-amine	1.20 Å	5B5O	5B5O	5B5O	5B5O	5B5O	5B5O
catalytic domain; complex with 4- oxo-n-(3-(2-(1h-1,2,4-triazol-3-ylsulfanyl)ethoxy)benzyl)-3,4- dihydroquinazoline-2-carboxamide	1.60 Å	5B5P	5B5P	5B5P	5B5P	5B5P	5B5P
mature peptidase	1.85 Å	5BOT	5BOT	5BOT	5BOT	5BOT	5BOT	Taylor et al., 2011
mature peptidase	2.03 Å	5BOY	5BOY	5BOY	5BOY	5BOY	5BOY	Taylor et al., 2011
mature peptidase	1.79 Å	5BPA	5BPA	5BPA	5BPA	5BPA	5BPA	Taylor et al., 2011
complex with selective inhibitor compound (s)-10a	1.60 Å	5UWK	5UWK	5UWK	5UWK	5UWK	5UWK
complex with selective inhibitor compound (s)-17a	2.55 Å	5UWL	5UWL	5UWL	5UWL	5UWL	5UWL
complex with selective inhibitor compound (r)-17a	1.62 Å	5UWM	5UWM	5UWM	5UWM	5UWM	5UWM
complex with selective inhibitor compound 10d	3.20 Å	5UWN	5UWN	5UWN	5UWN	5UWN	5UWN
complex with the peptide imisf	1.71 Å	6HV2	6HV2	6HV2	6HV2	6HV2	6HV2
catalytic domain; complex with 4-[4-(4-chloro-phenoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-carboxylic acid hydroxyamide	1.60 Å	830C	830C	830C	830C	830C	830C	Lovejoy et al., 1999
Mus musculus
catalytic domain	2.00 Å	1CXV	1CXV	1CXV	1CXV	1CXV	1CXV	Botos et al., 1999