Structure for peptidase M12.221: ADAMTS4 peptidase

PDB	Organism	Resolution	Comment
2RJP_A	Homo sapiens	2.80 Å	complex with inhibitor N-(4'-[(4-isobutyrylphenoxy)methyl]biphenyl- 4-ylsulfonyl)-D-valine
One monomer of the tetramer is shown. The catalytic zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His361, His365 and His371 in purple. The catalytic Glu362 (engineered to Gln) is shown in blue ball-and-stick representation. The structural calcium atoms are shown as yellow CPK spheres. The bound inhibitor is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
complex with inhibitor N-(4'-[(4-isobutyrylphenoxy)methyl]biphenyl- 4-ylsulfonyl)-D-valine	2.80 Å	2RJP	2RJP	2RJP	2RJP	2RJP	2RJP	Mosyak et al., 2008
apo form	2.80 Å	3B2Z	3B2Z	3B2Z	3B2Z	3B2Z	3B2Z	Mosyak et al., 2008
mature peptidase	1.24 Å	4WK7	4WK7	4WK7	4WK7	4WK7	4WK7	Durham et al., 2014
mature peptidase	1.62 Å	4WKE	4WKE	4WKE	4WKE	4WKE	4WKE	Durham et al., 2014
mature peptidase	1.60 Å	4WKI	4WKI	4WKI	4WKI	4WKI	4WKI	Durham et al., 2014