TERTIARY STRUCTURE DATA |
Escherichia coli
|
complex with methionine |
1.80 Å |
1C21 |
1C21 |
1C21 |
1C21 |
1C21 |
1C21 |
Lowther et al., 1999 |
complex with trifluoromethionine |
1.75 Å |
1C22 |
1C22 |
1C22 |
1C22 |
1C22 |
1C22 |
Lowther et al., 1999 |
complex with methionine phosphonate |
2.00 Å |
1C23 |
1C23 |
1C23 |
1C23 |
1C23 |
1C23 |
Lowther et al., 1999 |
complex with methionine phosphinate |
1.70 Å |
1C24 |
1C24 |
1C24 |
1C24 |
1C24 |
1C24 |
Lowther et al., 1999 |
complex with norleucine phosphonate |
1.95 Å |
1C27 |
1C27 |
1C27 |
1C27 |
1C27 |
1C27 |
Lowther et al., 1999 |
mature peptidase |
2.40 Å |
1MAT |
1MAT |
1MAT |
1MAT |
1MAT |
1MAT |
Roderick & Matthews, 1993 |
complex with 5-(2-chlorophenyl)furan-2-carboxylic acid |
1.52 Å |
1XNZ |
1XNZ |
1XNZ |
1XNZ |
1XNZ |
1XNZ |
Ye et al., 2004 |
mature peptidase |
1.60 Å |
1YVM |
1YVM |
1YVM |
1YVM |
1YVM |
1YVM |
Schiffmann et al., 2005 |
mature peptidase |
1.70 Å |
2BB7 |
2BB7 |
2BB7 |
2BB7 |
2BB7 |
2BB7 |
Huang et al., 2006 |
complex with 5-(2-(trifluoromethyl)phenyl)furan-2- carboxylic acid |
1.60 Å |
2EVC |
2EVC |
2EVC |
2EVC |
2EVC |
2EVC |
Xie et al., 2006 |
complex with 5-(2,5-dichlorophenyl)furan-2-carboxylic acid |
1.70 Å |
2EVM |
2EVM |
2EVM |
2EVM |
2EVM |
2EVM |
Xie et al., 2006 |
complex with n-cyclopentyl-n-(thiazol-2-yl)oxalamide |
1.70 Å |
2EVO |
2EVO |
2EVO |
2EVO |
2EVO |
2EVO |
Xie et al., 2006 |
novel bacterial methionine aminopeptidase inhibitors |
1.28 Å |
2GG0 |
2GG0 |
2GG0 |
2GG0 |
2GG0 |
2GG0 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.00 Å |
2GG2 |
2GG2 |
2GG2 |
2GG2 |
2GG2 |
2GG2 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.45 Å |
2GG3 |
2GG3 |
2GG3 |
2GG3 |
2GG3 |
2GG3 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
2.12 Å |
2GG5 |
2GG5 |
2GG5 |
2GG5 |
2GG5 |
2GG5 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.12 Å |
2GG7 |
2GG7 |
2GG7 |
2GG7 |
2GG7 |
2GG7 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.80 Å |
2GG8 |
2GG8 |
2GG8 |
2GG8 |
2GG8 |
2GG8 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.05 Å |
2GG9 |
2GG9 |
2GG9 |
2GG9 |
2GG9 |
2GG9 |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
2.13 Å |
2GGB |
2GGB |
2GGB |
2GGB |
2GGB |
2GGB |
Evdokimov et al., 2007 |
novel bacterial methionine aminopeptidase inhibitors |
1.00 Å |
2GGC |
2GGC |
2GGC |
2GGC |
2GGC |
2GGC |
Evdokimov et al., 2007 |
structural basis of catalysis by mononuclear methionine aminopeptidase |
2.00 Å |
2GTX |
2GTX |
2GTX |
2GTX |
2GTX |
2GTX |
Ye et al., 2006 |
complex with nlep, 1: 0.5, di-metalated |
1.80 Å |
2GU4 |
2GU4 |
2GU4 |
2GU4 |
2GU4 |
2GU4 |
Ye et al., 2006 |
complex with nlep, 1: 1, di-metalated |
1.60 Å |
2GU5 |
2GU5 |
2GU5 |
2GU5 |
2GU5 |
2GU5 |
Ye et al., 2006 |
complex with nlep, 1: 2, di-metalated |
1.70 Å |
2GU6 |
2GU6 |
2GU6 |
2GU6 |
2GU6 |
2GU6 |
Ye et al., 2006 |
e. coli methionine aminopeptidase unliganded, 1:0.5 |
2.00 Å |
2GU7 |
2GU7 |
2GU7 |
2GU7 |
2GU7 |
2GU7 |
Ye et al., 2006 |
mature peptidase |
1.90 Å |
2MAT |
2MAT |
2MAT |
2MAT |
2MAT |
2MAT |
Lowther et al., 1999 |
complex with inhibitor YE7 |
0.00 Å |
2P98 |
2P98 |
2P98 |
2P98 |
2P98 |
2P98 |
Huang et al., 2007 |
complex with inhibitor YE6 |
0.00 Å |
2P99 |
2P99 |
2P99 |
2P99 |
2P99 |
2P99 |
Huang et al., 2007 |
complex with inhibitor YE6 |
0.00 Å |
2P9A |
2P9A |
2P9A |
2P9A |
2P9A |
2P9A |
Huang et al., 2007 |
e. coli methionine aminopeptidase mn-form with inhibitor b23 |
1.90 Å |
2Q92 |
2Q92 |
2Q92 |
2Q92 |
2Q92 |
2Q92 |
Ma et al., 2007 |
e. coli methionine aminopeptidase mn-form with inhibitor b21 |
1.60 Å |
2Q93 |
2Q93 |
2Q93 |
2Q93 |
2Q93 |
2Q93 |
Ma et al., 2007 |
e. coli methionine aminopeptidase mn-form with inhibitor a04 |
1.63 Å |
2Q94 |
2Q94 |
2Q94 |
2Q94 |
2Q94 |
2Q94 |
Ma et al., 2007 |
e. coli methionine aminopeptidase mn-form with inhibitor a05 |
1.70 Å |
2Q95 |
2Q95 |
2Q95 |
2Q95 |
2Q95 |
2Q95 |
Ma et al., 2007 |
e. coli methionine aminopeptidase mn-form with inhibitor a18 |
1.60 Å |
2Q96 |
2Q96 |
2Q96 |
2Q96 |
2Q96 |
2Q96 |
Ma et al., 2007 |
e. coli methionine aminopeptidase with fe inhibitor w29 |
2.20 Å |
3D27 |
3D27 |
3D27 |
3D27 |
3D27 |
3D27 |
Wang et al., 2008 |
Arg175Gln mutant; complex with amino-hydroxyheptanyl-Ala-Leu-Val-Phe |
2.00 Å |
3MAT |
3MAT |
3MAT |
3MAT |
3MAT |
3MAT |
Lowther et al., 1999 |
x-ray structures of oxazole hydroxamate ecmetap-mn complexes |
1.46 Å |
4A6V |
4A6V |
4A6V |
4A6V |
4A6V |
4A6V |
|
x-ray structures of oxazole hydroxamate ecmetap-mn complexes |
1.46 Å |
4A6W |
4A6W |
4A6W |
4A6W |
4A6W |
4A6W |
|
His79Ala mutant |
2.00 Å |
4MAT |
4MAT |
4MAT |
4MAT |
4MAT |
4MAT |
Lowther et al., 1999 |
e. coli methionine aminopeptidase in complex with inhibitor 7-methoxy-2-methylen-3,4-dihydronaphthalen-1(2h)-one |
1.54 Å |
4PNC |
4PNC |
4PNC |
4PNC |
4PNC |
4PNC |
|
novel inhibitors of bacterial methionine aminopeptidase with broad- spectrum biochemical activity |
1.43 Å |
4Z7M |
4Z7M |
4Z7M |
4Z7M |
4Z7M |
4Z7M |
|
e. coli methionine aminopeptidase crystal structure fitted into the cryo-em density map of e. coli 70s ribosome in complex with methionine aminopeptidase |
11.80 Å |
6IZ7 |
6IZ7 |
6IZ7 |
6IZ7 |
6IZ7 |
6IZ7 |
|
crystal structure of e. coli peptide deformylase and methionine aminopeptidase fitted into the cryo-em density map of the complex |
11.80 Å |
6IZI |
6IZI |
6IZI |
6IZI |
6IZI |
6IZI |
|
crystal structure of e. coli methionine aminopeptidase enzyme and chaperone trigger factor fitted into the cryo-em density map of the complex |
14.20 Å |
6J0A |
6J0A |
6J0A |
6J0A |
6J0A |
6J0A |
|
Pseudomonas aeruginosa
|
pseudomonas aeruginosa metap, in mn form |
1.80 Å |
4FO7 |
4FO7 |
4FO7 |
4FO7 |
4FO7 |
4FO7 |
|
pseudomonas aeruginosa metap with met, in mn form |
1.90 Å |
4FO8 |
4FO8 |
4FO8 |
4FO8 |
4FO8 |
4FO8 |
|
pseudomonas aeruginosa metap t2n mutant, in mn form |
2.20 Å |
4JUQ |
4JUQ |
4JUQ |
4JUQ |
4JUQ |
4JUQ |
|
Rickettsia prowazekii
|
mature peptidase |
2.00 Å |
3MR1 |
3MR1 |
3MR1 |
3MR1 |
3MR1 |
3MR1 |
|
mature peptidase |
1.70 Å |
3MX6 |
3MX6 |
3MX6 |
3MX6 |
3MX6 |
3MX6 |
|