Structure for peptidase M24.002: methionyl aminopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1B6A	Homo sapiens	1.60 Å	complex with TNP-470 inhibitor
The catalytic cobalt ions are shown as dark blue CPK spheres. The cobalt ligands are shown in ball-and-stick representation: Asp251 and Asp262 in light pink, His331 in purple, and Glu364 and Glu459 in dark blue. The catalytic His231 is shown in ball-and-stick representation in purple. The bound inhibitor is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
complex with ovalicin	1.80 Å	1B59	1B59	1B59	1B59	1B59	1B59	Liu et al., 1998
complex with TNP-470 inhibitor	1.60 Å	1B6A	1B6A	1B6A	1B6A	1B6A	1B6A	Liu et al., 1998
mature peptidase	1.80 Å	1BN5	1BN5	1BN5	1BN5	1BN5	1BN5	Liu et al., 1998
complex with fumagillin inhibitor	1.80 Å	1BOA	1BOA	1BOA	1BOA	1BOA	1BOA	Liu et al., 1998
mature peptidase	2.00 Å	1KQ0	1KQ0	1KQ0	1KQ0	1KQ0	1KQ0	Nonato et al., 2006
mature peptidase	1.90 Å	1KQ9	1KQ9	1KQ9	1KQ9	1KQ9	1KQ9	Nonato et al., 2006
mature peptidase	1.60 Å	1QZY	1QZY	1QZY	1QZY	1QZY	1QZY	Towbin et al., 2003
mature peptidase	1.90 Å	1R58	1R58	1R58	1R58	1R58	1R58	Sheppard et al., 2004
mature peptidase	2.00 Å	1R5G	1R5G	1R5G	1R5G	1R5G	1R5G	Sheppard et al., 2004
mature peptidase	2.40 Å	1R5H	1R5H	1R5H	1R5H	1R5H	1R5H	Sheppard et al., 2004
mature peptidase	1.85 Å	1YW7	1YW7	1YW7	1YW7	1YW7	1YW7	Sheppard et al., 2006
mature peptidase	2.65 Å	1YW8	1YW8	1YW8	1YW8	1YW8	1YW8	Sheppard et al., 2006
mature peptidase	1.64 Å	1YW9	1YW9	1YW9	1YW9	1YW9	1YW9	Sheppard et al., 2006
mature peptidase	1.90 Å	2ADU	2ADU	2ADU	2ADU	2ADU	2ADU	Kallander et al., 2005
mature peptidase	2.50 Å	2EA2	2EA2	2EA2	2EA2	2EA2	2EA2	Wang et al., 2007
mature peptidase	2.35 Å	2EA4	2EA4	2EA4	2EA4	2EA4	2EA4	Wang et al., 2007
mature peptidase	1.95 Å	2GA2	2GA2	2GA2	2GA2	2GA2	2GA2	Kawai et al., 2006
mature peptidase	1.90 Å	2OAZ	2OAZ	2OAZ	2OAZ	2OAZ	2OAZ	Marino et al., 2007
complex with spiroepoxytriazole inhibitor (+)-31a	1.75 Å	5CLS	5CLS	5CLS	5CLS	5CLS	5CLS
structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b	1.49 Å	5D6E	5D6E	5D6E	5D6E	5D6E	5D6E
complex with spiroepoxytriazole inhibitor (+)-31b	1.55 Å	5D6F	5D6F	5D6F	5D6F	5D6F	5D6F
potent, reversible metap2 inhibitors via fragment based drug discovery	1.60 Å	5JFR	5JFR	5JFR	5JFR	5JFR	5JFR
potent, reversible metap2 inhibitors via fbdd	1.80 Å	5JHU	5JHU	5JHU	5JHU	5JHU	5JHU
potent, reversible metap2 inhibitors via fbdd	2.15 Å	5JI6	5JI6	5JI6	5JI6	5JI6	5JI6
complex with an inhibitor 6-((r)-2-o-tolyloxymethyl-pyrrolidin-1-yl)-9h- purine	1.69 Å	5LYW	5LYW	5LYW	5LYW	5LYW	5LYW
complex with an inhibitor 5-((r)-1-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl- pyrrolidin-2-ylmethoxy)-isoquinoline	1.90 Å	5LYX	5LYX	5LYX	5LYX	5LYX	5LYX
complex with an inhibitor (s)-3-hydroxy-2-oxo-1-(2-oxo-1,2,3,4-tetrahydro- quinolin-6-yl)-pyrrolidine-3-carboxylic acid 3-chloro-5-fluoro- benzylamide	1.80 Å	6QED	6QED	6QED	6QED	6QED	6QED
complex withan inhibitor (s)-3-hydroxy-2-oxo-1-phenyl-pyrrolidine-3-carboxylic acid 3-chloro-5-fluoro-benzylamide	1.79 Å	6QEF	6QEF	6QEF	6QEF	6QEF	6QEF
complex withan inhibitor 2-oxo-1-phenyl-pyrrolidine-3-carboxylic acid (2- thiophen-2-yl-ethyl)-amide	2.08 Å	6QEG	6QEG	6QEG	6QEG	6QEG	6QEG
complex withan inhibitor 5-chloro-quinolin-8-ol	2.17 Å	6QEH	6QEH	6QEH	6QEH	6QEH	6QEH
complex withan inhibitor 5,6-difluoro-3-(2-isopropoxy-4-piperazin-1-yl-phenyl)- 1h-indole-2-carboxylic acid amide	1.80 Å	6QEI	6QEI	6QEI	6QEI	6QEI	6QEI
complex withan inhibitor thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4h-[1,2, 4]triazol-3-ylmethyl)-amide	1.62 Å	6QEJ	6QEJ	6QEJ	6QEJ	6QEJ	6QEJ