Structure for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
3DFJ Homo sapiens 1.45 Å mature
The catalytic residues are shown in ball-and-stick representation: His85 in purple, Asp134 in pink and Ser238 in orange.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
mature  peptidase 1.45 Å 3DFJ 3DFJ 3DFJ 3DFJ 3DFJ 3DFJ Rickert et al., 2008
complex with guanidinobenzoic acid 2.00 Å 3DFL 3DFL 3DFL 3DFL 3DFL 3DFL Rickert et al., 2008
the x-ray structure of human prostasin in complex with dffr- chloromethyl ketone inhibitor 1.70 Å 3E0N 3E0N 3E0N 3E0N 3E0N 3E0N Spraggon et al., 2009
the x-ray structure of human prostasin in complex with a covalent benzoxazole inhibitor 1.70 Å 3E0P 3E0P 3E0P 3E0P 3E0P 3E0P Tully et al., 2008
complex with benzyl [(1S)-5-amino-1-[(1S)-1-((1S)-5- amino-1-[(S)-1,3-benzoxazol-2-yl(hydroxy)methyl]pentylcarbamoyl)- 3-phenylpropyl]carbamoylpentyl]carbamate 1.60 Å 3E16 3E16 3E16 3E16 3E16 3E16 Tully et al., 2008
the crystal structure of apo prostasin at 1.7 angstroms resolution 1.70 Å 3E1X 3E1X 3E1X 3E1X 3E1X 3E1X Spraggon et al., 2009
the crystal structure of prostasin complexed with camostat at 1.6 angstroms resolution 1.60 Å 3FVF 3FVF 3FVF 3FVF 3FVF 3FVF Spraggon et al., 2009
complex with calcium 1.30 Å 3GYL 3GYL 3GYL 3GYL 3GYL 3GYL Spraggon et al., 2009
complex with aprotinin 2.80 Å 3GYM 3GYM 3GYM 3GYM 3GYM 3GYM Spraggon et al., 2009