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Structure for peptidase S01.216: coagulation factor Xa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1HCG Homo sapiens 2.20 Å factor Xa
Catalytic residues are shown in ball-and-stick representation: His276 in purple, Asp322 in pink and Ser419 in orange. The N-terminal light chain is shown in yellow.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Bos taurus
NMR structure of EGF-like module 0.00 Å 1APO 1APO 1APO 1APO 1APO 1APO Ullner et al., 1992
NMR structure; N-terminal EGF-like module 0.00 Å 1CCF 1CCF 1CCF 1CCF 1CCF 1CCF Selander-Sunnerhagen et al., 1992
mature  peptidase 2.30 Å 1IOD 1IOD 1IOD 1IOD 1IOD 1IOD Mizuno et al., 2001
complex with Ornithidoros moubata inhibitor 3.00 Å 1KIG 1KIG 1KIG 1KIG 1KIG 1KIG Wei et al., 1998
NMR structure; Gla and EGF-like domains 0.00 Å 1WHE 1WHE 1WHE 1WHE 1WHE 1WHE Sunnerhagen et al., 1996
NMR structure; Gla and EGF-like domains 0.00 Å 1WHF 1WHF 1WHF 1WHF 1WHF 1WHF Sunnerhagen et al., 1996
Homo sapiens
mature  peptidase 1.95 Å 1C5M 1C5M 1C5M 1C5M 1C5M 1C5M Katz et al., 2000
complex with inhibitor RPR128515 2.20 Å 1EZQ 1EZQ 1EZQ 1EZQ 1EZQ 1EZQ Maignan et al., 2000
complex with inhibitor RPR208815 2.10 Å 1F0R 1F0R 1F0R 1F0R 1F0R 1F0R Maignan et al., 2000
complex with inhibitor RPR208707 2.10 Å 1F0S 1F0S 1F0S 1F0S 1F0S 1F0S Maignan et al., 2000
complex with synthetic inhibitor DX-9065a 3.00 Å 1FAX 1FAX 1FAX 1FAX 1FAX 1FAX Brandstetter et al., 1996
complex with inhibitor ZK-807834 1.92 Å 1FJS 1FJS 1FJS 1FJS 1FJS 1FJS Adler et al., 2000
chimaera with human trypsin I; complex with D-Phe-Pro-Arg-chloromethyl ketone 2.15 Å 1FXY 1FXY 1FXY 1FXY 1FXY 1FXY Hopfner et al., 1998
complex with inhibitor T87 1.90 Å 1G2L 1G2L 1G2L 1G2L 1G2L 1G2L Nar et al., 2001
complex with R11 inhibitor 3.02 Å 1G2M 1G2M 1G2M 1G2M 1G2M 1G2M Nar et al., 2001
factor Xa 2.20 Å 1HCG 1HCG 1HCG 1HCG 1HCG 1HCG Padmanabhan et al., 1993
complex with M55532 2.90 Å 1IOE 1IOE 1IOE 1IOE 1IOE 1IOE
complex with M55590 2.90 Å 1IQE 1IQE 1IQE 1IQE 1IQE 1IQE
complex with M55165 3.20 Å 1IQF 1IQF 1IQF 1IQF 1IQF 1IQF
complex with M55159 2.60 Å 1IQG 1IQG 1IQG 1IQG 1IQG 1IQG
complex with M55143 3.00 Å 1IQH 1IQH 1IQH 1IQH 1IQH 1IQH
complex with M55125 2.90 Å 1IQI 1IQI 1IQI 1IQI 1IQI 1IQI
complex with M55124 3.00 Å 1IQJ 1IQJ 1IQJ 1IQJ 1IQJ 1IQJ
complex with M55113 3.20 Å 1IQK 1IQK 1IQK 1IQK 1IQK 1IQK
complex with M54476 2.70 Å 1IQL 1IQL 1IQL 1IQL 1IQL 1IQL
complex with M54471 2.60 Å 1IQM 1IQM 1IQM 1IQM 1IQM 1IQM
complex with M55192 2.60 Å 1IQN 1IQN 1IQN 1IQN 1IQN 1IQN
complex with FXV673 2.10 Å 1KSN 1KSN 1KSN 1KSN 1KSN 1KSN Guertin et al., 2002
complex with (R)-2-(3-adamantan-1-yl-ureido)-3- (3-carbamimidoyl-phenyl)-N-phenethyl-propionamide 2.22 Å 1KYE 1KYE 1KYE 1KYE 1KYE 1KYE Mueller et al., 2002
complex with [4-([5-benzyloxy-1-(3-carbamimidoyl-benzyl)-1H-indole-2-carbonyl]-amino-methyl)-phenyl]-trimethyl-ammonium 2.00 Å 1LPG 1LPG 1LPG 1LPG 1LPG 1LPG Matter et al., 2002
complex with 1-(3-carbamimidoyl-benzyl)-1H-indole-2-carboxylic acid 3-carbamimidoyl-benzylester 2.20 Å 1LPK 1LPK 1LPK 1LPK 1LPK 1LPK Matter et al., 2002
complex with 1-(3-carbamimidoyl-benzyl)-4-methyl-1H-indole-2-carboxylic acid 3,5-dichloro-benzylamide 2.40 Å 1LPZ 1LPZ 1LPZ 1LPZ 1LPZ 1LPZ Matter et al., 2002
complex with 1-(3-carbamimidoyl-benzyl)-4-methyl-1H-indole-2-carboxylic acid 3,5-dimethyl-benzylamide 2.70 Å 1LQD 1LQD 1LQD 1LQD 1LQD 1LQD Matter et al., 2002
complex with 3-chloro-n-[4-chloro-2-[[(4- chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1- piperazinyl)methyl]-2-thiophenecarboxamide 2.10 Å 1MQ5 1MQ5 1MQ5 1MQ5 1MQ5 1MQ5 Adler et al., 2002
complex with 3-chloro-n-[4-chloro-2-[[(5-chloro-2- pyridinyl)amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5- dihydro-2-oxazolyl)methylamino]methyl]-2- thiophenecarboxamide 2.10 Å 1MQ6 1MQ6 1MQ6 1MQ6 1MQ6 1MQ6 Adler et al., 2002
mature  peptidase 0.00 Å 1MSX 1MSX 1MSX 1MSX 1MSX 1MSX
complex with RPR132747 2.05 Å 1NFU 1NFU 1NFU 1NFU 1NFU 1NFU Maignan et al., 2003
complex with RPR209685 2.10 Å 1NFW 1NFW 1NFW 1NFW 1NFW 1NFW Maignan et al., 2003
complex with RPR208944 2.15 Å 1NFX 1NFX 1NFX 1NFX 1NFX 1NFX Maignan et al., 2003
complex with RPR200095 2.10 Å 1NFY 1NFY 1NFY 1NFY 1NFY 1NFY Maignan et al., 2003
mature  peptidase 0.00 Å 1NL8 1NL8 1NL8 1NL8 1NL8 1NL8
complex with ecotin Met84Arg mutant 2.80 Å 1P0S 1P0S 1P0S 1P0S 1P0S 1P0S Wang et al., 2003
complex with the inhibitor 1-[6-methyl-4,5,6,7- tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2- carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine 2.20 Å 1V3X 1V3X 1V3X 1V3X 1V3X 1V3X Haginoya et al., 2004
factor xa in complex with the inhibitor 4-[(5-chloroindol-2- yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine 2.30 Å 1WU1 1WU1 1WU1 1WU1 1WU1 1WU1 Komoriya et al., 2005
complex with (2S)-3'-amidino-3-biphenylyl)-5-(4-pyridylamino) pentanoic acid inhibitor 2.30 Å 1XKA 1XKA 1XKA 1XKA 1XKA 1XKA Kamata et al., 1998
complex with (2S)-3'-amidino-3-biphenylyl)-5-(4-pyridylamino) pentanoic acid inhibitor 2.40 Å 1XKB 1XKB 1XKB 1XKB 1XKB 1XKB Kamata et al., 1998
complex with razaxaban 1.80 Å 1Z6E 1Z6E 1Z6E 1Z6E 1Z6E 1Z6E Quan et al., 2005
complex with compound 50 2.70 Å 2BMG 2BMG 2BMG 2BMG 2BMG 2BMG Matter et al., 2005
complex with compound 1 2.20 Å 2BOH 2BOH 2BOH 2BOH 2BOH 2BOH Nazare et al., 2005
factor xa- cation 1.64 Å 2BOK 2BOK 2BOK 2BOK 2BOK 2BOK Scharer et al., 2005
complex with compound 21 3.00 Å 2BQ6 2BQ6 2BQ6 2BQ6 2BQ6 2BQ6 Nazare et al., 2005
complex with compound 43 2.20 Å 2BQ7 2BQ7 2BQ7 2BQ7 2BQ7 2BQ7 Nazare et al., 2005
complex with compound 45 2.95 Å 2BQW 2BQW 2BQW 2BQW 2BQW 2BQW Nazare et al., 2005
complex with 6-chloro-N-(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl-2-naphthalenesulfonamide 2.10 Å 2CJI 2CJI 2CJI 2CJI 2CJI 2CJI Watson et al., 2006
complex with the inhibitor 2-[[4-[(5- chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide 2.20 Å 2D1J 2D1J 2D1J 2D1J 2D1J 2D1J Komoriya et al., 2005
complex with the inhibitor (-)-cis-n1-[(5- chloroindol-2-yl)carbonyl]-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediami 2.30 Å 2EI6 2EI6 2EI6 2EI6 2EI6 2EI6 Nagata et al., 2007
complex with the inhibitor trans-n1-[(5- chloroindol-2-yl)carbonyl]-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediamine 2.30 Å 2EI7 2EI7 2EI7 2EI7 2EI7 2EI7
complex with the inhibitor (1s,2r,4s)-n1-[(5- chloroindol-2-yl)carbonyl]-4-(n,n-dimethylcarbamoyl)-n2- [(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl) c 2.10 Å 2EI8 2EI8 2EI8 2EI8 2EI8 2EI8
mature  peptidase 2.20 Å 2FZZ 2FZZ 2FZZ 2FZZ 2FZZ 2FZZ Pinto et al., 2006
mature  peptidase 2.10 Å 2G00 2G00 2G00 2G00 2G00 2G00 Pinto et al., 2006
complex with antithrombin-Ser195Ala and pentasaccharide 3.30 Å 2GD4 2GD4 2GD4 2GD4 2GD4 2GD4 Johnson et al., 2006
complex with selectide and NAPC2 2.20 Å 2H9E 2H9E 2H9E 2H9E 2H9E 2H9E Murakami et al., 2007
complex with 5-chloro-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-5-chloro-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-sulfonamide 1.90 Å 2J2U 2J2U 2J2U 2J2U 2J2U 2J2U Senger et al., 2006
complex with 6-chloro-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl-1-benzothiophene-2-sulfonamide 2.01 Å 2J34 2J34 2J34 2J34 2J34 2J34 Senger et al., 2006
complex with 5-chloro-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl-1-benzothiophene-2-sulfonamide 2.10 Å 2J38 2J38 2J38 2J38 2J38 2J38 Senger et al., 2006
complex with 1-pyrrolidineacetamide,3-[[(6-chloro-2-naphthalenyl)sulfonyl]amino]-alpha-methyl-N-(1-methylethyl)-N-[2-[(methylsulfonyl)amino]ethyl]- 2-oxo-,(alphas,3S)- 1.80 Å 2J4I 2J4I 2J4I 2J4I 2J4I 2J4I Young et al., 2006
complex with 5-(5-chloro-2-thienyl)-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl-1H-1,2,4-triazole-3-sulfonamide 2.10 Å 2J94 2J94 2J94 2J94 2J94 2J94
complex with 5'-chloro-N-(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl-2,2'-bithiophene-5-sulfonamide 2.01 Å 2J95 2J95 2J95 2J95 2J95 2J95
factor xa - cation inhibitor complex 1.25 Å 2JKH 2JKH 2JKH 2JKH 2JKH 2JKH Salonen et al., 2009
complex with the inhibitor apixaban (bms- 562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1- piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4- c]pyridine 2.30 Å 2P16 2P16 2P16 2P16 2P16 2P16 Pinto et al., 2007
complex with NAP5 3.10 Å 2P3F 2P3F 2P3F 2P3F 2P3F 2P3F Rios-Steiner et al., 2007
complex with 3- chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2- carboxylic acid [4-chloro-2-(5-chloro-pyridin-2- ylcarbamoyl)- 1.92 Å 2P3T 2P3T 2P3T 2P3T 2P3T 2P3T Ye et al., 2007
complex with 3- chloro-N-(4-chloro-2-[(5-chloropyridin-2-yl) amino]carbonyl-6-methoxyphenyl)-4-[(1-methyl-1h-imidazol- 2-yl)methyl]thi 1.62 Å 2P3U 2P3U 2P3U 2P3U 2P3U 2P3U
complex with the inhibitor 5-chloro-n-(2-(4-(2- oxopyridin-1(2h)-yl)benzamido)ethyl)thiophene-2-carboxamide 1.90 Å 2P93 2P93 2P93 2P93 2P93 2P93 Qiao et al., 2007
complex with the inhibitor 3-chloro-n-((1r,2s)- 2-(4-(2-oxopyridin-1(2h)-yl)benzamido)cyclohexyl)-1h- indole-6-carboxamide 1.80 Å 2P94 2P94 2P94 2P94 2P94 2P94 Qiao et al., 2007
complex with the inhibitor 5-chloro-n-((1r,2s)- 2-(4-(2-oxopyridin-1(2h)-yl)benzamido) cyclopentyl) thiophene-2-carboxamide 2.20 Å 2P95 2P95 2P95 2P95 2P95 2P95 Qiao et al., 2007
an orally efficacious factor xa inhibitor 2.30 Å 2PHB 2PHB 2PHB 2PHB 2PHB 2PHB Kohrt et al., 2007
factor xa inhibitor 1.50 Å 2PR3 2PR3 2PR3 2PR3 2PR3 2PR3 Van et al., 2007
the discovery of glycine and related amino acid-based factor xa inhibitors 1.90 Å 2Q1J 2Q1J 2Q1J 2Q1J 2Q1J 2Q1J Kohrt et al., 2006
x-ray structure of fxa in complex with 7-fluoroindazole 2.30 Å 2RA0 2RA0 2RA0 2RA0 2RA0 2RA0 Lee et al., 2008
selective and dual action orally active inhibitors of thrombin and factor xa 1.90 Å 2UWL 2UWL 2UWL 2UWL 2UWL 2UWL Young et al., 2007
selective and dual action orally active inhibitors of thrombin and factor xa 1.75 Å 2UWO 2UWO 2UWO 2UWO 2UWO 2UWO Young et al., 2007
factor xa inhibitor complex 1.75 Å 2UWP 2UWP 2UWP 2UWP 2UWP 2UWP Young et al., 2007
structure and property based design of factor xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs 1.70 Å 2VH0 2VH0 2VH0 2VH0 2VH0 2VH0 Young et al., 2008
structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs 1.95 Å 2VH6 2VH6 2VH6 2VH6 2VH6 2VH6 Young et al., 2008
mature  peptidase 1.95 Å 2VVC 2VVC 2VVC 2VVC 2VVC 2VVC Zbinden et al., 2009
mature  peptidase 2.30 Å 2VVU 2VVU 2VVU 2VVU 2VVU 2VVU Zbinden et al., 2009
mature  peptidase 1.73 Å 2VVV 2VVV 2VVV 2VVV 2VVV 2VVV Zbinden et al., 2009
mature  peptidase 1.80 Å 2VWL 2VWL 2VWL 2VWL 2VWL 2VWL Zbinden et al., 2009
mature  peptidase 1.96 Å 2VWM 2VWM 2VWM 2VWM 2VWM 2VWM Zbinden et al., 2009
mature  peptidase 1.61 Å 2VWN 2VWN 2VWN 2VWN 2VWN 2VWN Zbinden et al., 2009
mature  peptidase 1.60 Å 2VWO 2VWO 2VWO 2VWO 2VWO 2VWO Zbinden et al., 2009
complex with bay59-7939 2.08 Å 2W26 2W26 2W26 2W26 2W26 2W26 Roehrig et al., 2005
complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2 1.90 Å 2W3I 2W3I 2W3I 2W3I 2W3I 2W3I Van et al., 2009
complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1 2.05 Å 2W3K 2W3K 2W3K 2W3K 2W3K 2W3K Van et al., 2009
mature  peptidase 1.88 Å 2WYG 2WYG 2WYG 2WYG 2WYG 2WYG Kleanthous et al., 2010
mature  peptidase 2.38 Å 2WYJ 2WYJ 2WYJ 2WYJ 2WYJ 2WYJ Kleanthous et al., 2010
mature  peptidase 1.66 Å 2XBV 2XBV 2XBV 2XBV 2XBV 2XBV Anselm et al., 2010
mature  peptidase 1.72 Å 2XBW 2XBW 2XBW 2XBW 2XBW 2XBW Anselm et al., 2010
mature  peptidase 1.85 Å 2XBX 2XBX 2XBX 2XBX 2XBX 2XBX Anselm et al., 2010
mature  peptidase 2.02 Å 2XBY 2XBY 2XBY 2XBY 2XBY 2XBY Anselm et al., 2010
mature  peptidase 2.05 Å 2XC0 2XC0 2XC0 2XC0 2XC0 2XC0 Anselm et al., 2010
mature  peptidase 1.67 Å 2XC4 2XC4 2XC4 2XC4 2XC4 2XC4 Anselm et al., 2010
mature  peptidase 1.70 Å 2XC5 2XC5 2XC5 2XC5 2XC5 2XC5 Anselm et al., 2010
mature  peptidase 1.29 Å 2Y5F 2Y5F 2Y5F 2Y5F 2Y5F 2Y5F Salonen et al., 2012
mature  peptidase 1.29 Å 2Y5G 2Y5G 2Y5G 2Y5G 2Y5G 2Y5G Salonen et al., 2012
mature  peptidase 1.33 Å 2Y5H 2Y5H 2Y5H 2Y5H 2Y5H 2Y5H Salonen et al., 2012
mature  peptidase 1.90 Å 2Y7X 2Y7X 2Y7X 2Y7X 2Y7X 2Y7X Watson et al., 2011
mature  peptidase 1.84 Å 2Y7Z 2Y7Z 2Y7Z 2Y7Z 2Y7Z 2Y7Z Young et al., 2011
mature  peptidase 1.90 Å 2Y80 2Y80 2Y80 2Y80 2Y80 2Y80 Young et al., 2011
mature  peptidase 1.70 Å 2Y81 2Y81 2Y81 2Y81 2Y81 2Y81 Young et al., 2011
mature  peptidase 2.20 Å 2Y82 2Y82 2Y82 2Y82 2Y82 2Y82 Young et al., 2011
factor xa in complex with the inhibitor n-(2-(((5-chloro-2- pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2h)- pyridinyl)benzamide 1.60 Å 3CEN 3CEN 3CEN 3CEN 3CEN 3CEN Corte et al., 2008
factor xa in complex with the inhibitor 1-(4-methoxyphenyl)- 6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3- (trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-c]pyridin- 7(4 2.20 Å 3CS7 3CS7 3CS7 3CS7 3CS7 3CS7 Qiao et al., 2008
complex with methyl (2Z)- 3-[(3-chloro-1h-indol-7-yl)amino]-2-cyano-3-[(3s)-2-oxo-1- (2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]aminoacrylat 2.30 Å 3ENS 3ENS 3ENS 3ENS 3ENS 3ENS Shi et al., 2008
mature  peptidase 1.54 Å 3FFG 3FFG 3FFG 3FFG 3FFG 3FFG Quan et al., 2010
mature  peptidase 2.19 Å 3HPT 3HPT 3HPT 3HPT 3HPT 3HPT Shi et al., 2009
mature  peptidase 1.80 Å 3IIT 3IIT 3IIT 3IIT 3IIT 3IIT Yoshikawa et al., 2009
mature  peptidase 1.90 Å 3K9X 3K9X 3K9X 3K9X 3K9X 3K9X Shi et al., 2009
mature  peptidase 1.45 Å 3KL6 3KL6 3KL6 3KL6 3KL6 3KL6 Fujimoto et al., 2010
mature  peptidase 2.25 Å 3KQB 3KQB 3KQB 3KQB 3KQB 3KQB Quan et al., 2010
mature  peptidase 2.20 Å 3KQC 3KQC 3KQC 3KQC 3KQC 3KQC Quan et al., 2010
mature  peptidase 2.75 Å 3KQD 3KQD 3KQD 3KQD 3KQD 3KQD Quan et al., 2010
mature  peptidase 2.35 Å 3KQE 3KQE 3KQE 3KQE 3KQE 3KQE Quan et al., 2010
mature  peptidase 2.22 Å 3LIW 3LIW 3LIW 3LIW 3LIW 3LIW Mueller et al., 2002
mature  peptidase 2.15 Å 3M36 3M36 3M36 3M36 3M36 3M36 Pruitt et al., 2003
mature  peptidase 1.90 Å 3M37 3M37 3M37 3M37 3M37 3M37 Pruitt et al., 2003
mature  peptidase 2.00 Å 3Q3K 3Q3K 3Q3K 3Q3K 3Q3K 3Q3K Yoshikawa et al., 2011
mature  peptidase 2.42 Å 3SW2 3SW2 3SW2 3SW2 3SW2 3SW2 Shi et al., 2011
mature  peptidase 2.20 Å 3TK5 3TK5 3TK5 3TK5 3TK5 3TK5
mature  peptidase 1.80 Å 3TK6 3TK6 3TK6 3TK6 3TK6 3TK6
mature  peptidase 2.40 Å 4A7I 4A7I 4A7I 4A7I 4A7I 4A7I Nazare et al., 2012
mature  peptidase 2.30 Å 4BTI 4BTI 4BTI 4BTI 4BTI 4BTI Meneyrol et al., 2013
mature  peptidase 2.59 Å 4BTT 4BTT 4BTT 4BTT 4BTT 4BTT Meneyrol et al., 2013
mature  peptidase 2.37 Å 4BTU 4BTU 4BTU 4BTU 4BTU 4BTU Meneyrol et al., 2013
mature  peptidase 1.55 Å 4Y6D 4Y6D 4Y6D 4Y6D 4Y6D 4Y6D
mature  peptidase 1.80 Å 4Y71 4Y71 4Y71 4Y71 4Y71 4Y71
mature  peptidase 2.00 Å 4Y76 4Y76 4Y76 4Y76 4Y76 4Y76 Chan et al., 2007
mature  peptidase 2.10 Å 4Y79 4Y79 4Y79 4Y79 4Y79 4Y79 Chan et al., 2007
mature  peptidase 1.99 Å 4Y7A 4Y7A 4Y7A 4Y7A 4Y7A 4Y7A
mature  peptidase 1.79 Å 4Y7B 4Y7B 4Y7B 4Y7B 4Y7B 4Y7B
factor xa complex with gtc000006 1.80 Å 4ZH8 4ZH8 4ZH8 4ZH8 4ZH8 4ZH8
factor xa complex with gtc000102 1.86 Å 4ZHA 4ZHA 4ZHA 4ZHA 4ZHA 4ZHA
complex with synthetic inhibitor benzylsulfonyl- dser(benzyl)-gly-4-amidinobenzylamide 2.20 Å 5K0H 5K0H 5K0H 5K0H 5K0H 5K0H
desgla-xas195a bound to aptamer 11f7t 2.00 Å 5VOE 5VOE 5VOE 5VOE 5VOE 5VOE
desgla-xas195a bound to aptamer 11f7t and rivaroxaban ***caveat 5vof 2.25 Å 5VOF 5VOF 5VOF 5VOF 5VOF 5VOF

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