Structure for peptidase S14.001: peptidase Clp (type 1)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
1TYF_A	Escherichia coli	2.20 Å	homotetradecamer
Only one monomer is shown. Catalytic residues are shown in ball-and-stick representation: Ser111 in orange, His136 in purple and Asp185 in pink.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Arabidopsis thaliana
mature peptidase	0.00 Å	1R99	1R99	1R99	1R99	1R99	1R99
Bacillus subtilis
mature peptidase	2.40 Å	3KTG	3KTG	3KTG	3KTG	3KTG	3KTG	Lee et al., 2010
mature peptidase	3.00 Å	3KTH	3KTH	3KTH	3KTH	3KTH	3KTH	Lee et al., 2010
mature peptidase	2.00 Å	3KTI	3KTI	3KTI	3KTI	3KTI	3KTI	Lee et al., 2010
mature peptidase	2.60 Å	3KTJ	3KTJ	3KTJ	3KTJ	3KTJ	3KTJ	Lee et al., 2010
mature peptidase	2.60 Å	3KTK	3KTK	3KTK	3KTK	3KTK	3KTK	Lee et al., 2010
mature peptidase	2.59 Å	3TT6	3TT6	3TT6	3TT6	3TT6	3TT6	Lee et al., 2011
mature peptidase	2.56 Å	3TT7	3TT7	3TT7	3TT7	3TT7	3TT7	Lee et al., 2011
Coxiella burnetii
mature peptidase	2.50 Å	3Q7H	3Q7H	3Q7H	3Q7H	3Q7H	3Q7H
Escherichia coli
homotetradecamer	2.20 Å	1TYF	1TYF	1TYF	1TYF	1TYF	1TYF	Wang et al., 1997
clpp	1.90 Å	1YG6	1YG6	1YG6	1YG6	1YG6	1YG6
crystal structure of e. coli clpp with a peptide chloromethyl ketone covalently bound at the active site	1.90 Å	2FZS	2FZS	2FZS	2FZS	2FZS	2FZS
crystal structure of clpp a153c mutant with inter-heptamer disulfide bonds	3.20 Å	3HLN	3HLN	3HLN	3HLN	3HLN	3HLN
complex with adep1	1.90 Å	3MT6	3MT6	3MT6	3MT6	3MT6	3MT6
Francisella tularensis
crystal structure of atp-dependent clp protease subunit p from francisella tularensis	2.29 Å	3P2L	3P2L	3P2L	3P2L	3P2L	3P2L
compressed conformation of francisella tularensis clpp at 2.84 a	2.84 Å	5G1Q	5G1Q	5G1Q	5G1Q	5G1Q	5G1Q
open conformation of francisella tularensis clpp at 1.9 a	1.90 Å	5G1R	5G1R	5G1R	5G1R	5G1R	5G1R
Helicobacter pylori
mature peptidase	2.60 Å	2ZL0	2ZL0	2ZL0	2ZL0	2ZL0	2ZL0
complex with the peptide NVLGFTQ	2.50 Å	2ZL2	2ZL2	2ZL2	2ZL2	2ZL2	2ZL2	Kim & Kim, 2008
Ser99Ala mutant	2.81 Å	2ZL3	2ZL3	2ZL3	2ZL3	2ZL3	2ZL3
Ser99Ala mutant; complex with the peptide (Ala)4	2.50 Å	2ZL4	2ZL4	2ZL4	2ZL4	2ZL4	2ZL4
Listeria monocytogenes
mature peptidase	2.00 Å	4JCQ	4JCQ	4JCQ	4JCQ	4JCQ	4JCQ	Zeiler et al., 2013
mature peptidase	2.60 Å	4JCT	4JCT	4JCT	4JCT	4JCT	4JCT	Zeiler et al., 2013
complex with ClpP2	2.80 Å	4RYF	4RYF	4RYF	4RYF	4RYF	4RYF	Dahmen et al., 2015
complex with ClpP1	2.80 Å	4RYF	4RYF	4RYF	4RYF	4RYF	4RYF	Dahmen et al., 2015
Neisseria meningitidis
complex with agonist adepa54556.	2.38 Å	5DKP	5DKP	5DKP	5DKP	5DKP	5DKP
Peptoclostridium difficile
crystal structure of clpp1 from clostridium difficile 630.	2.50 Å	6MX2	6MX2	6MX2	6MX2	6MX2	6MX2
Staphylococcus aureus
crystal structure of clpp from staphylococcus aureus	2.10 Å	3QWD	3QWD	3QWD	3QWD	3QWD	3QWD
mature peptidase	2.43 Å	3ST9	3ST9	3ST9	3ST9	3ST9	3ST9	Zhang et al., 2011
mature peptidase	2.28 Å	3STA	3STA	3STA	3STA	3STA	3STA	Zhang et al., 2011
crystal structure of clpp from staphylococcus aureus in the active, extended conformation	2.30 Å	3V5E	3V5E	3V5E	3V5E	3V5E	3V5E
the crystal structure of the mutant clpp s98a (staphylococcus aureus)	2.80 Å	3V5I	3V5I	3V5I	3V5I	3V5I	3V5I
mature peptidase	2.40 Å	4EMM	4EMM	4EMM	4EMM	4EMM	4EMM	Ye et al., 2013
mature peptidase	2.70 Å	4EMP	4EMP	4EMP	4EMP	4EMP	4EMP	Ye et al., 2013
clpp ser98dha	2.30 Å	4MXI	4MXI	4MXI	4MXI	4MXI	4MXI
staphylococcus aureus clpp mutant - y63a	1.75 Å	5C90	5C90	5C90	5C90	5C90	5C90
complex with av145	3.00 Å	5DL1	5DL1	5DL1	5DL1	5DL1	5DL1
complex with acyldepsipeptide	2.26 Å	5VZ2	5VZ2	5VZ2	5VZ2	5VZ2	5VZ2
Val7Ala mutant	3.70 Å	6DKF	6DKF	6DKF	6DKF	6DKF	6DKF
s. aureus clpp bound to anti-4a	1.96 Å	6N80	6N80	6N80	6N80	6N80	6N80
Streptococcus pneumoniae
Ala153Pro mutant	2.51 Å	1Y7O	1Y7O	1Y7O	1Y7O	1Y7O	1Y7O	Gribun et al., 2005