Substrates for peptidase C19.057: ubiquitin-specific peptidase 44

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Lys48-linked tetra-ubiquitin	P0CG47	1-76	Peptide-Gly76+Lys48-Peptide	P	Leu	Arg	Gly	Gly	Lys	Gln	Leu	Glu	Moon et al., 2009
Lys63-linked polyubiquitin	P0CG47	1-76	Peptide-Gly76+Lys63-Peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Virdee et al., 2010
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Met1-peptide	N	Leu	Arg	Gly	Gly	Met	His	Gly	Ser	Quesada et al., 2004
ubiquitinated cell division cycle protein 20 homolog	P0CG47/Q12834	1-76	Peptide-Gly76+Lys-Peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Stegmeier et al., 2007