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Substrates for peptidase C48.002: SENP1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
ac-Gln-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin ac-Gln-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin S Gln Tyr Gly Gly AFC - - - Drag et al., 2008
ac-Gln-Thr-Gly-Gly-amino-trifluoromethylcoumarin ac-Gln-Thr-Gly-Gly+amino-trifluoromethylcoumarin S Gln Thr Gly Gly AFC - - - Drag et al., 2008
ac-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin ac-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin S Gln Tyr Gly Gly AFC - - - Drag et al., 2008
ac-Glu-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin ac-Glu-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin S Gln Tyr Gly Gly AFC - - - Drag et al., 2008
Boc-Gln-Thr-Gly-Gly-amino-trifluoromethylcoumarin Boc-Gln-Thr-Gly-Gly+amino-trifluoromethylcoumarin S Gln Thr Gly Gly AFC - - - Drag et al., 2008
PfSUMO Q8I444 1-100 Peptide-Gly98+Ser-Phe P CS Gln Thr Gly Gly Ser Phe - - Ponder et al., 2011
PolySUMO2/SUMO3 P61956 peptide-Gly93+Lys11-peptide N Gln Thr Gly Gly Lys Thr Glu Asn Mendes et al., 2015
polysumoylated ETS translocation variant 4 P63165/P43268 1-97 peptide-Gly97+Lys96-peptide P Gln Thr Gly Gly Lys Lys Glu Pro Guo & Sharrocks, 2009
polysumoylated ETS translocation variant 4 P63165/P43268 1-97 peptide-Gly97+Lys226-peptide P Gln Thr Gly Gly Lys Gln Glu Tyr Guo & Sharrocks, 2009
polysumoylated ETS translocation variant 4 P63165/P43268 1-97 peptide-Gly97+Lys260-peptide P Gln Thr Gly Gly Lys Gln Glu Gln Guo & Sharrocks, 2009
Ran GTPase-activating protein 1–polySUMO-2/SUMO-3 conjugate P46060 peptide-Gly93+Lys8-peptide N Gln Thr Gly Gly Lys Leu Ala Glu Mendes et al., 2015
Ran GTPase-activating protein 1–SUMO-1 conjugate P46060 peptide-Gly93+Lys8-peptide N Gln Thr Gly Gly Lys Leu Ala Glu Mendes et al., 2015
Ran GTPase-activating protein 1–SUMO-2 conjugate P46060 418-587 peptide-Gly93+Lys524-peptide N Gln Thr Gly Gly Lys Ser Glu Asp Shen et al., 2009
SUMO-1 precursor P63165 2-97 peptide-Gly97+His-Ser-Thr-Val P Gln Thr Gly Gly His Ser Thr Val Mendes et al., 2015 16365
SUMO-2 precursor P61956 1-95 Peptide-Gly93+Val-Tyr P CS Gln Thr Gly Gly Val Tyr - - Ponder et al., 2011
SUMO-3 precursor P55854 1-103 Peptide-Gly92+Val-Peptide P CS Gln Thr Gly Gly Val Pro Glu Ser Ponder et al., 2011
SUMO-Lys-91-VDR conjugate P11473 1-427 Peptide-Gly93+Lys91-Peptide P MU Gln Thr Gly Gly Lys Glu Phe Ile Lee et al., 2014
sumoylated circadian locomoter output cycles protein kaput P63165/Q92674 2-97 Peptide-Gly97+Lys67-peptide P Gln Thr Gly Gly Lys Met Asp Lys Li et al., 2013
sumoylated circadian locomoter output cycles protein kaput P63165/Q92674 2-97 Peptide-Gly97+Lys842-peptide P Gln Thr Gly Gly Lys Val Gln Pro Li et al., 2013
sumoylated ETS translocation variant 4 P55854/P43268 1-92 Peptide-Gly92+Lys226-peptide P Gln Thr Gly Gly Lys Gln Glu Tyr Guo & Sharrocks, 2009
sumoylated ETS translocation variant 4 P55854/P43268 1-92 Peptide-Gly92+Lys260-peptide P Gln Thr Gly Gly Lys Gln Glu Gln Guo & Sharrocks, 2009
sumoylated ETS translocation variant 4 P55854/P43268 1-92 Peptide-Gly92+Lys96-peptide P Gln Thr Gly Gly Lys Lys Glu Pro Guo & Sharrocks, 2009
sumoylated histone deacetylase 1 P63165/Q13547 1-97 peptide-Gly97+Lys444-peptide P Gln Thr Gly Gly Lys Thr Glu Asp Cheng et al., 2004
sumoylated histone deacetylase 1 P63165/Q13547 1-97 peptide-Gly97+Lys476-peptide P Gln Thr Gly Gly Lys Glu Glu Val Cheng et al., 2004
sumoylated homeodomain-interacting protein kinase 1 P63165/Q86Z02 2-97 peptide-Gly+Lys25-peptide P Gln Thr Gly Gly Lys Ile Glu Pro Li et al., 2008
sumoylated homeodomain-interacting protein kinase 1 P63165/Q86Z02 2-97 peptide-Gly+Lys1203-peptide P Gln Thr Gly Gly Lys Ile Ser Gln Li et al., 2008
sumoylated homeodomain-interacting protein kinase 2 P63165/Q9H2X6 2-97 peptide-Gly+Lys32-peptide P Gln Thr Gly Gly Lys Ile Glu Pro Kim et al., 2005
sumoylated homeodomain-interacting protein kinase 2 P63165/Q9H2X6 2-97 peptide-Gly+Lys1191-peptide P Gln Thr Gly Gly Lys Val Asn Gln Kim et al., 2005
sumoylated hypoxia-inducible factor 1-alpha P63165/Q16665 2-97 peptide-Gly+Lys391-peptide P Gln Thr Gly Gly Lys Lys Glu Pro Cheng et al., 2007
sumoylated hypoxia-inducible factor 1-alpha P63165/Q16665 2-97 peptide-Gly+Lys477-peptide P Gln Thr Gly Gly Lys Leu Glu Pro Cheng et al., 2007
sumoylated inhibitor of nuclear factor kappa-B kinase subunit epsilon P63165/Q14164 2-97 peptide-Gly+Lys231-peptide P Gln Thr Gly Gly Lys Glu Ile Met Renner et al., 2010
sumoylated transient receptor potential cation channel subfamily M member 4 P63165/Q8TD43 2-97 peptide-Gly+Lys231-peptide P Gln Thr Gly Gly Lys Xaa Xaa Xaa Kruse et al., 2009

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