Substrates for peptidase M19.001: membrane dipeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Cys-Gly Cys+Gly N - - - Cys Gly - - - Hooper, 2004
Gly-D-Phe Gly+D-Phe N - - - Gly DPh - - - Hooper, 2004
Gly-dehydroPhe Gly+dehydroPhe N - - - Gly DFH - - - Hooper, 2004
leukotriene D4 n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-Cys)+Gly P - - - Cys Gly - - - Habib et al., 2003