Substrates for peptidase M23.003: Mername-AA291 peptidase

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Glu-Gly-Gln-Gln-His-His-Leu-Gly-Gly-Ala-Lys(Tfa)-Gln-Ala-NH2 Ac-Glu-Gly-Gln-Gln-His-His-Leu-Gly-Gly+Ala-Lys(Tfa)-Gln-Ala-NH2 S His Leu Gly Gly Ala Lyt Gln Val Kessler & Ohman, 2004
Ac-Leu-Gly-Ala-Lys(Tfa)-Gln-Ala-NH2 Ac-Leu-Gly+Ala-Lys(Tfa)-Gln-Ala-NH2 S - Ac Leu Gly Ala Lyt Gln Ala Kessler & Ohman, 2004
Ac-Leu-Gly-Gly-Ala-Lys(Tfa)-Gln-Ala-NH2 Ac-Leu-Gly-Gly+Ala-Lys(Tfa)-Gln-Ala-NH2 S Ac Leu Gly Gly Ala Lyt Gln Ala Kessler & Ohman, 2004
fibrinogen gamma chain P02679 27-453 peptide-Gly404+Ala-peptide P His Leu Gly Gly Ala Lys Gln Val Kessler & Ohman, 2004 17068
Suc-Gly-Gly-Ala-NH2 Suc-Gly-Gly+Ala-NH2 S - Suc Gly Gly Ala NH2 - - Kessler & Ohman, 2004
Suc-Gly-Gly-Nph-NH2 Suc-Gly-Gly+Nph-NH2 S - Suc Gly Gly Nph NH2 - - Kessler & Ohman, 2004
Suc-Gly-Gly-Phe-NH2 Suc-Gly-Gly+Phe-NH2 S - Suc Gly Gly Phe NH2 - - Kessler & Ohman, 2004