Substrates for peptidase M41.013: Ftsh peptidase (Thermus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
alpha-S1-casein	P02662	16-214	peptide-Leu110+Glu-peptide	N	Leu	Gly	Tyr	Leu	Glu	Gln	Leu	Leu	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Leu157+Ala-peptide	N	Asn	Gln	Glu	Leu	Ala	Tyr	Phe	Tyr	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Ala158+Tyr-peptide	N	Gln	Glu	Leu	Ala	Tyr	Phe	Tyr	Pro	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Ala144+Gln-peptide	N	Gly	Ile	His	Ala	Gln	Gln	Lys	Glu	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Leu164+Phe-peptide	N	Tyr	Pro	Glu	Leu	Phe	Arg	Gln	Phe	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Phe165+Arg-peptide	N	Pro	Glu	Leu	Phe	Arg	Gln	Phe	Tyr	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Leu171+Asp-peptide	N	Phe	Tyr	Gln	Leu	Asp	Ala	Tyr	Pro	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Tyr180+Tyr-peptide	N	Gly	Ala	Trp	Tyr	Tyr	Val	Pro	Leu	Asahara et al., 2000
alpha-S1-casein	P02662	16-214	peptide-Phe38+Phe-peptide	N	Leu	Leu	Arg	Phe	Phe	Val	Ala	Pro	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Gly78+Ile-peptide	N	Gly	Thr	Ile	Gly	Ile	Gly	Thr	Pro	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Phe86+Thr-peptide	N	Ala	Gln	Asp	Phe	Thr	Val	Ile	Phe	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Ala125+Thr-peptide	N	Thr	Phe	Glu	Ala	Thr	Ser	Gln	Glu	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Leu171+Tyr-peptide	N	Gly	Ser	Phe	Leu	Tyr	Tyr	Ala	Pro	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Tyr172+Tyr-peptide	N	Ser	Phe	Leu	Tyr	Tyr	Ala	Pro	Phe	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Pro185+Ser-peptide	N	Leu	Ala	Tyr	Pro	Ser	Ile	Ser	Ala	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Trp200+Asp-peptide	N	Asp	Asn	Leu	Trp	Asp	Gln	Gly	Leu	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Phe210+Ser-peptide	N	Gln	Asp	Leu	Phe	Ser	Val	Tyr	Leu	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Leu225+Leu-peptide	N	Ser	Val	Val	Leu	Leu	Gly	Gly	Ile	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Tyr233+Tyr-peptide	N	Asp	Ser	Ser	Tyr	Tyr	Thr	Gly	Ser	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Asn239+Trp-peptide	N	Gly	Ser	Leu	Asn	Trp	Val	Pro	Val	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Gly247+Tyr-peptide	N	Ser	Val	Glu	Gly	Tyr	Trp	Gln	Ile	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Trp249+Gln-peptide	N	Glu	Gly	Tyr	Trp	Gln	Ile	Thr	Leu	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Met258+Asp-peptide	N	Ser	Ile	Thr	Met	Asp	Gly	Glu	Thr	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Ala271+Ile-peptide	N	Gly	Cys	Gln	Ala	Ile	Val	Asp	Thr	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Val273+Asp-peptide	N	Gln	Ala	Ile	Val	Asp	Thr	Gly	Thr	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Leu279+Leu-peptide	N	Gly	Thr	Ser	Leu	Leu	Thr	Gly	Pro	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Leu280+Thr-peptide	N	Thr	Ser	Leu	Leu	Thr	Gly	Pro	Thr	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Ser292+Asp-peptide	N	Asn	Ile	Gln	Ser	Asp	Ile	Gly	Ala	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Gly323+Val-peptide	N	Thr	Ile	Asn	Gly	Val	Gln	Tyr	Pro	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Ile365+Arg-peptide	N	Asp	Val	Phe	Ile	Arg	Gln	Tyr	Tyr	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Tyr369+Thr-peptide	N	Arg	Gln	Tyr	Tyr	Thr	Val	Phe	Asp	Asahara et al., 2000
pepsin A	P00791	60-385	peptide-Phe372+Asp-peptide	N	Tyr	Thr	Val	Phe	Asp	Arg	Ala	Asn	Asahara et al., 2000